Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 47 (16 Oct 2019)
Sequence version 1 (18 Apr 2012)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

TFIIS N-terminal domain-containing protein

Gene

IWS1

Organism
Latimeria chalumnae (Coelacanth)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TFIIS N-terminal domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IWS1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatimeria chalumnae (Coelacanth)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7897 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiCoelacanthiformesCoelacanthidaeLatimeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008672 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7897.ENSLACP00000017266

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini592 – 670TFIIS N-terminalInterPro annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 497DisorderedSequence analysisAdd BLAST497
Regioni674 – 708DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 367PolyampholyteSequence analysisAdd BLAST319
Compositional biasi375 – 436PolyampholyteSequence analysisAdd BLAST62
Compositional biasi441 – 465AcidicSequence analysisAdd BLAST25
Compositional biasi466 – 497PolyampholyteSequence analysisAdd BLAST32
Compositional biasi676 – 693PolyampholyteSequence analysisAdd BLAST18

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1793 Eukaryota
COG5139 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00720000108834

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
H3B5U5

KEGG Orthology (KO)

More...
KOi
K17498

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFDMMLQ

Database of Orthologous Groups

More...
OrthoDBi
380765at2759

TreeFam database of animal gene trees

More...
TreeFami
TF315504

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08711 Med26, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47676 SSF47676, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51319 TFIIS_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

H3B5U5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVEEAGYYS GNQSDDGGAT PVQDEHDSGS ELEDELTAQR SGSDFGSTGH
60 70 80 90 100
RSENEHSDHE GNIREEEREQ QEDQRSEVSG SDNEDDLPKP NASDSENEGF
110 120 130 140 150
PRHKDSDSER GDSPQRKDSD SEHRGSPRRK DSDSEPGGSP RRKDSDSEHG
160 170 180 190 200
GSPLHKDSDS EHRGSPRCKD SDSEREGSPQ RKDSDSEHES SPRHKDSDSE
210 220 230 240 250
HGGSPRRKDS DSEHGGSPRR KDSDSEHGGS PRRKNSDFKH KDSRKHIDSD
260 270 280 290 300
SENERSPKLK RTSDSENEGS PKSKRVIESD DEGDSDRGEQ SDGKKARSTV
310 320 330 340 350
QDSDSEAEVR RPREDSDSEA EDKPPRGAGS DKDSDDDSPK QRKISDSDDE
360 370 380 390 400
EEDGEKPMKR KNTILSDSED EDDQEEKMPA KKSRLVSDEE DSESDTRSEK
410 420 430 440 450
DRQILRALGS DSEDEEEKKE EPENKKDEKD LFGSDSGSEN EEENLIADIF
460 470 480 490 500
GESGDEEEEE FTGFNQEDLE GDKGKAEAEK HQKVTAADSD SDDGVNRGRD
510 520 530 540 550
YDFVSDFDMM MQRKKNMSGK RRRNRDGGTF ISDADDVVSA MIVKMNEAAE
560 570 580 590 600
EDRQLNIQKK PALKKLTLLP TVVMHLKKQD LKETFIDSGV MSAIKEWLTP
610 620 630 640 650
LPDRSLPAMK IREELLKILQ ELPSVSQETL KHSGIGRAVM YLYKHPKESR
660 670 680 690 700
PNKDLAGKLI NEWSRPIFGL TSNYKGMTRE EREQRDLDQM PQKRRHSSSG
710 720 730 740 750
GQTPRRDLEK VLTGEEKALR PGDPGFCARA RVPMPSNRDY VVRPKWNVDV
760 770 780 790
EMSRSGSTKK GISRLEKHKR RIAEQRKLTR MQRAIKLNIE GNGMPL
Length:796
Mass (Da):89,778
Last modified:April 18, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD412DD52FB55E256
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AFYH01032268 Genomic DNA No translation available.
AFYH01032269 Genomic DNA No translation available.
AFYH01032270 Genomic DNA No translation available.
AFYH01032271 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_005991248.1, XM_005991186.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLACT00000017393; ENSLACP00000017266; ENSLACG00000015209

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102366848

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lcm:102366848

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AFYH01032268 Genomic DNA No translation available.
AFYH01032269 Genomic DNA No translation available.
AFYH01032270 Genomic DNA No translation available.
AFYH01032271 Genomic DNA No translation available.
RefSeqiXP_005991248.1, XM_005991186.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7897.ENSLACP00000017266

Genome annotation databases

EnsembliENSLACT00000017393; ENSLACP00000017266; ENSLACG00000015209
GeneIDi102366848
KEGGilcm:102366848

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55677

Phylogenomic databases

eggNOGiKOG1793 Eukaryota
COG5139 LUCA
GeneTreeiENSGT00720000108834
InParanoidiH3B5U5
KOiK17498
OMAiDFDMMLQ
OrthoDBi380765at2759
TreeFamiTF315504

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
PfamiView protein in Pfam
PF08711 Med26, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS51319 TFIIS_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiH3B5U5_LATCH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: H3B5U5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: October 16, 2019
This is version 47 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again