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Entry version 60 (16 Oct 2019)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Notch, isoform B

Gene

N

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi468Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi471Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi491Calcium 2UniRule annotation1
Metal bindingi505Calcium 2UniRule annotation1
Metal bindingi529Calcium 3UniRule annotation1
Metal bindingi543Calcium 3UniRule annotation1
Metal bindingi544Calcium 3; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Notch, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NImported
Synonyms:1.1Imported, 16-178Imported, 16-55Imported, anon-EST:Liang-1.12Imported, AxImported, ChpImported, clone 1.12Imported, CoImported, coImported, CT13012Imported, Dmel\CG3936Imported, dNotchImported, EG:140G11.1Imported, EG:163A10.2Imported, faImported, l(1)3CbImported, l(1)AxImported, l(1)NImported, n[fah]Imported, ndImported, NECDImported, NICDImported, NicdImported, notchImported, RICNImported, shdImported, splImported, swbImported
ORF Names:CG3936Imported, Dmel_CG3936Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004647 N

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi85 ↔ 94PROSITE-ProRule annotation
Disulfide bondi126 ↔ 135PROSITE-ProRule annotation
Disulfide bondi166 ↔ 175PROSITE-ProRule annotation
Disulfide bondi186 ↔ 203PROSITE-ProRule annotation
Disulfide bondi205 ↔ 214PROSITE-ProRule annotation
Disulfide bondi243 ↔ 252PROSITE-ProRule annotation
Disulfide bondi281 ↔ 290PROSITE-ProRule annotation
Disulfide bondi319 ↔ 328PROSITE-ProRule annotation
Disulfide bondi360 ↔ 369PROSITE-ProRule annotation
Disulfide bondi398 ↔ 407PROSITE-ProRule annotation
Disulfide bondi418 ↔ 435PROSITE-ProRule annotation
Disulfide bondi437 ↔ 446PROSITE-ProRule annotation
Disulfide bondi453 ↔ 465UniRule annotation
Disulfide bondi459 ↔ 474UniRule annotation
Disulfide bondi476 ↔ 485UniRule annotation
Disulfide bondi492 ↔ 503UniRule annotation
Disulfide bondi497 ↔ 512UniRule annotation
Disulfide bondi514 ↔ 523UniRule annotation
Disulfide bondi530 ↔ 541UniRule annotation
Disulfide bondi535 ↔ 550UniRule annotation
Disulfide bondi552 ↔ 561UniRule annotation
Disulfide bondi590 ↔ 599PROSITE-ProRule annotation
Disulfide bondi606 ↔ 616PROSITE-ProRule annotation
Disulfide bondi627 ↔ 636PROSITE-ProRule annotation
Disulfide bondi665 ↔ 674PROSITE-ProRule annotation
Disulfide bondi703 ↔ 712PROSITE-ProRule annotation
Disulfide bondi741 ↔ 750PROSITE-ProRule annotation
Disulfide bondi779 ↔ 788PROSITE-ProRule annotation
Disulfide bondi817 ↔ 826PROSITE-ProRule annotation
Disulfide bondi855 ↔ 864PROSITE-ProRule annotation
Disulfide bondi876 ↔ 893PROSITE-ProRule annotation
Disulfide bondi895 ↔ 904PROSITE-ProRule annotation
Disulfide bondi934 ↔ 943PROSITE-ProRule annotation
Disulfide bondi972 ↔ 981PROSITE-ProRule annotation
Disulfide bondi1010 ↔ 1019PROSITE-ProRule annotation
Disulfide bondi1048 ↔ 1057PROSITE-ProRule annotation
Disulfide bondi1086 ↔ 1095PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1133PROSITE-ProRule annotation
Disulfide bondi1171 ↔ 1180PROSITE-ProRule annotation
Disulfide bondi1209 ↔ 1218PROSITE-ProRule annotation
Disulfide bondi1247 ↔ 1256PROSITE-ProRule annotation
Disulfide bondi1285 ↔ 1294PROSITE-ProRule annotation
Disulfide bondi1306 ↔ 1323PROSITE-ProRule annotation
Disulfide bondi1325 ↔ 1334PROSITE-ProRule annotation
Disulfide bondi1363 ↔ 1372PROSITE-ProRule annotation
Disulfide bondi1379 ↔ 1389PROSITE-ProRule annotation
Disulfide bondi1402 ↔ 1411PROSITE-ProRule annotation
Disulfide bondi1441 ↔ 1450PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
M9NE67

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004647 Expressed in 30 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
M9NE67 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
M9NE67

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 95EGF-likeInterPro annotationAdd BLAST38
Domaini96 – 136EGF-likeInterPro annotationAdd BLAST41
Domaini139 – 176EGF-likeInterPro annotationAdd BLAST38
Domaini177 – 215EGF-likeInterPro annotationAdd BLAST39
Domaini217 – 253EGF-likeInterPro annotationAdd BLAST37
Domaini255 – 291EGF-likeInterPro annotationAdd BLAST37
Domaini293 – 329EGF-likeInterPro annotationAdd BLAST37
Domaini331 – 370EGF-likeInterPro annotationAdd BLAST40
Domaini372 – 408EGF-likeInterPro annotationAdd BLAST37
Domaini409 – 447EGF-likeInterPro annotationAdd BLAST39
Domaini449 – 486EGF-likeInterPro annotationAdd BLAST38
Domaini488 – 524EGF-likeInterPro annotationAdd BLAST37
Domaini526 – 562EGF-likeInterPro annotationAdd BLAST37
Domaini564 – 600EGF-likeInterPro annotationAdd BLAST37
Domaini602 – 637EGF-likeInterPro annotationAdd BLAST36
Domaini639 – 675EGF-likeInterPro annotationAdd BLAST37
Domaini677 – 713EGF-likeInterPro annotationAdd BLAST37
Domaini715 – 751EGF-likeInterPro annotationAdd BLAST37
Domaini753 – 789EGF-likeInterPro annotationAdd BLAST37
Domaini791 – 827EGF-likeInterPro annotationAdd BLAST37
Domaini829 – 865EGF-likeInterPro annotationAdd BLAST37
Domaini867 – 905EGF-likeInterPro annotationAdd BLAST39
Domaini907 – 944EGF-likeInterPro annotationAdd BLAST38
Domaini946 – 982EGF-likeInterPro annotationAdd BLAST37
Domaini984 – 1020EGF-likeInterPro annotationAdd BLAST37
Domaini1022 – 1058EGF-likeInterPro annotationAdd BLAST37
Domaini1060 – 1096EGF-likeInterPro annotationAdd BLAST37
Domaini1098 – 1134EGF-likeInterPro annotationAdd BLAST37
Domaini1151 – 1181EGF-likeInterPro annotationAdd BLAST31
Domaini1183 – 1219EGF-likeInterPro annotationAdd BLAST37
Domaini1221 – 1257EGF-likeInterPro annotationAdd BLAST37
Domaini1259 – 1295EGF-likeInterPro annotationAdd BLAST37
Domaini1297 – 1335EGF-likeInterPro annotationAdd BLAST39
Domaini1337 – 1373EGF-likeInterPro annotationAdd BLAST37
Domaini1375 – 1412EGF-likeInterPro annotationAdd BLAST38
Domaini1415 – 1451EGF-likeInterPro annotationAdd BLAST37
Domaini1482 – 1521LNRInterPro annotationAdd BLAST40
Domaini1522 – 1557LNRInterPro annotationAdd BLAST36
Domaini1559 – 1599LNRInterPro annotationAdd BLAST41
Domaini1894 – 2136ANK_REP_REGIONInterPro annotationAdd BLAST243
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1950 – 1982ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1983 – 2008ANKPROSITE-ProRule annotationAdd BLAST26
Repeati2017 – 2049ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2050 – 2082ANKPROSITE-ProRule annotationAdd BLAST33
Repeati2083 – 2115ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1810 – 1850DisorderedSequence analysisAdd BLAST41
Regioni2172 – 2257DisorderedSequence analysisAdd BLAST86
Regioni2399 – 2452DisorderedSequence analysisAdd BLAST54
Regioni2488 – 2524DisorderedSequence analysisAdd BLAST37
Regioni2579 – 2620DisorderedSequence analysisAdd BLAST42
Regioni2632 – 2703DisorderedSequence analysisAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2541 – 2568Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2172 – 2199PolarSequence analysisAdd BLAST28
Compositional biasi2224 – 2248PolarSequence analysisAdd BLAST25
Compositional biasi2402 – 2433PolarSequence analysisAdd BLAST32
Compositional biasi2588 – 2620PolarSequence analysisAdd BLAST33
Compositional biasi2632 – 2692PolarSequence analysisAdd BLAST61

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR7G Eukaryota
COG0666 LUCA

KEGG Orthology (KO)

More...
KOi
K02599

Identification of Orthologs from Complete Genome Data

More...
OMAi
NEGSCLD

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
M9NE67

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF11936 DUF3454, 1 hit
PF00008 EGF, 24 hits
PF07645 EGF_CA, 3 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002279 Notch, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452 LNOTCHREPEAT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 7 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 34 hits
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 10 hits
PS50258 LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

M9NE67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSQRSRRRS RAPNTWICFW INKMHAVASL PASLPLLLLT LAFANLPNTV
60 70 80 90 100
RGTDTALVAA SCTSVGCQNG GTCVTQLNGK TYCACDSHYV GDYCEHRNPC
110 120 130 140 150
NSMRCQNGGT CQVTFRNGRP GISCKCPLGF DESLCEIAVP NACDHVTCLN
160 170 180 190 200
GGTCQLKTLE EYTCACANGY TGERCETKNL CASSPCRNGA TCTALAGSSS
210 220 230 240 250
FTCSCPPGFT GDTCSYDIEE CQSNPCKYGG TCVNTHGSYQ CMCPTGYTGK
260 270 280 290 300
DCDTKYKPCS PSPCQNGGIC RSNGLSYECK CPKGFEGKNC EQNYDDCLGH
310 320 330 340 350
LCQNGGTCID GISDYTCRCP PNFTGRFCQD DVDECAQRDH PVCQNGATCT
360 370 380 390 400
NTHGSYSCIC VNGWAGLDCS NNTDDCKQAA CFYGATCIDG VGSFYCQCTK
410 420 430 440 450
GKTGLLCHLD DACTSNPCHA DAICDTSPIN GSYACSCATG YKGVDCSEDI
460 470 480 490 500
DECDQGSPCE HNGICVNTPG SYRCNCSQGF TGPRCETNIN ECESHPCQNE
510 520 530 540 550
GSCLDDPGTF RCVCMPGFTG TQCEIDIDEC QSNPCLNDGT CHDKINGFKC
560 570 580 590 600
SCALGFTGAR CQINIDDCQS QPCRNRGICH DSIAGYSCEC PPGYTGTSCE
610 620 630 640 650
ININDCDSNP CHRGKCIDDV NSFKCLCDPG YTGYICQKQI NECESNPCQF
660 670 680 690 700
DGHCQDRVGS YYCQCQAGTS GKNCEVNVNE CHSNPCNNGA TCIDGINSYK
710 720 730 740 750
CQCVPGFTGQ HCEKNVDECI SSPCANNGVC IDQVNGYKCE CPRGFYDAHC
760 770 780 790 800
LSDVDECASN PCVNEGRCED GINEFICHCP PGYTGKRCEL DIDECSSNPC
810 820 830 840 850
QHGGTCYDKL NAFSCQCMPG YTGQKCETNI DDCVTNPCGN GGTCIDKVNG
860 870 880 890 900
YKCVCKVPFT GRDCESKMDP CASNRCKNEA KCTPSSNFLD FSCTCKLGYT
910 920 930 940 950
GRYCDEDIDE CSLSSPCRNG ASCLNVPGSY RCLCTKGYEG RDCAINTDDC
960 970 980 990 1000
ASFPCQNGGT CLDGIGDYSC LCVDGFDGKH CETDINECLS QPCQNGATCS
1010 1020 1030 1040 1050
QYVNSYTCTC PLGFSGINCQ TNDEDCTESS CLNGGSCIDG INGYNCSCLA
1060 1070 1080 1090 1100
GYSGANCQYK LNKCDSNPCL NGATCHEQNN EYTCHCPSGF TGKQCSEYVD
1110 1120 1130 1140 1150
WCGQSPCENG ATCSQMKHQF SCKCSAGWTG KLCDVQTISC QDAADRKGLS
1160 1170 1180 1190 1200
LRQLCNNGTC KDYGNSHVCY CSQGYAGSYC QKEIDECQSQ PCQNGGTCRD
1210 1220 1230 1240 1250
LIGAYECQCR QGFQGQNCEL NIDDCAPNPC QNGGTCHDRV MNFSCSCPPG
1260 1270 1280 1290 1300
TMGIICEINK DDCKPGACHN NGSCIDRVGG FECVCQPGFV GARCEGDINE
1310 1320 1330 1340 1350
CLSNPCSNAG TLDCVQLVNN YHCNCRPGHM GRHCEHKVDF CAQSPCQNGG
1360 1370 1380 1390 1400
NCNIRQSGHH CICNNGFYGK NCELSGQDCD SNPCRVGNCV VADEGFGYRC
1410 1420 1430 1440 1450
ECPRGTLGEH CEIDTLDECS PNPCAQGAAC EDLLGDYECL CPSKWKGKRC
1460 1470 1480 1490 1500
DIYDANYPGW NGGSGSGNDR YAADLEQQRA MCDKRGCTEK QGNGICDSDC
1510 1520 1530 1540 1550
NTYACNFDGN DCSLGINPWA NCTANECWNK FKNGKCNEEC NNAACHYDGH
1560 1570 1580 1590 1600
DCERKLKSCD SLFDAYCQKH YGDGFCDYGC NNAECSWDGL DCENKTQSPV
1610 1620 1630 1640 1650
LAEGAMSVVM LMNVEAFREI QAQFLRNMSH MLRTTVRLKK DALGHDIIIN
1660 1670 1680 1690 1700
WKDNVRVPEI EDTDFARKNK ILYTQQVHQT GIQIYLEIDN RKCTECFTHA
1710 1720 1730 1740 1750
VEAAEFLAAT AAKHQLRNDF QIHSVRGIKN PGDEDNGEPP ANVKYVITGI
1760 1770 1780 1790 1800
ILVIIALAFF GMVLSTQRKR AHGVTWFPEG FRAPAAVMSR RRRDPHGQEM
1810 1820 1830 1840 1850
RNLNKQVAMQ SQGVGQPGAH WSDDESDMPL PKRQRSDPVS GVGLGNNGGY
1860 1870 1880 1890 1900
ASDHTMVSEY EEADQRVWSQ AHLDVVDVRA IMTPPAHQDG GKHDVDARGP
1910 1920 1930 1940 1950
CGLTPLMIAA VRGGGLDTGE DIENNEDSTA QVISDLLAQG AELNATMDKT
1960 1970 1980 1990 2000
GETSLHLAAR FARADAAKRL LDAGADANCQ DNTGRTPLHA AVAADAMGVF
2010 2020 2030 2040 2050
QILLRNRATN LNARMHDGTT PLILAARLAI EGMVEDLITA DADINAADNS
2060 2070 2080 2090 2100
GKTALHWAAA VNNTEAVNIL LMHHANRDAQ DDKDETPLFL AAREGSYEAC
2110 2120 2130 2140 2150
KALLDNFANR EITDHMDRLP RDVASERLHH DIVRLLDEHV PRSPQMLSMT
2160 2170 2180 2190 2200
PQAMIGSPPP GQQQPQLITQ PTVISAGNGG NNGNGNASGK QSNQTAKQKA
2210 2220 2230 2240 2250
AKKAKLIEGS PDNGLDATGS LRRKASSKKT SAASKKAANL NGLNPGQLTG
2260 2270 2280 2290 2300
GVSGVPGVPP TNSAAQAAAA AAAAVAAMSH ELEGSPVGVG MGGNLPSPYD
2310 2320 2330 2340 2350
TSSMYSNAMA APLANGNPNT GAKQPPSYED CIKNAQSMQS LQGNGLDMIK
2360 2370 2380 2390 2400
LDNYAYSMGS PFQQELLNGQ GLGMNGNGQR NGVGPGVLPG GLCGMGGLSG
2410 2420 2430 2440 2450
AGNGNSHEQG LSPPYSNQSP PHSVQSSLAL SPHAYLGSPS PAKSRPSLPT
2460 2470 2480 2490 2500
SPTHIQAMRH ATQQKQFGGS NLNSLLGGAN GGGVVGGGGG GGGGVGQGPQ
2510 2520 2530 2540 2550
NSPVSLGIIS PTGSDMGIML APPQSSKNSA IMQTISPQQQ QQQQQQQQQQ
2560 2570 2580 2590 2600
HQQQQQQQQQ QQQQQQQQLG GLEFGSAGLD LNGFCGSPDS FHSGQMNPPS
2610 2620 2630 2640 2650
IQSSMSGSSP STNMLSPSSQ HNQQAFYQYL TPSSQHSGGH TPQHLVQTLD
2660 2670 2680 2690 2700
SYPTPSPESP GHWSSSSPRS NSDWSEGVQS PAANNLYISG GHQANKGSEA

IYI
Length:2,703
Mass (Da):288,853
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EAE23F426FECD7B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P07207NOTCH_DROME
Neurogenic locus Notch protein
N CG3936
2,703Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07224.1

NCBI Reference Sequences

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RefSeqi
NP_001245510.1, NM_001258581.2
NP_476859.2, NM_057511.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0070507; FBpp0070483; FBgn0004647
FBtr0304659; FBpp0293201; FBgn0004647

Database of genes from NCBI RefSeq genomes

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GeneIDi
31293

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3936

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AFH07224.1
RefSeqiNP_001245510.1, NM_001258581.2
NP_476859.2, NM_057511.4

3D structure databases

SMRiM9NE67
ModBaseiSearch...

Proteomic databases

PRIDEiM9NE67

Genome annotation databases

EnsemblMetazoaiFBtr0070507; FBpp0070483; FBgn0004647
FBtr0304659; FBpp0293201; FBgn0004647
GeneIDi31293
KEGGidme:Dmel_CG3936

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
109544
FlyBaseiFBgn0004647 N

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
KOiK02599
OMAiNEGSCLD
OrthoDBi7525at2759
PhylomeDBiM9NE67

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
N fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31293

Gene expression databases

BgeeiFBgn0004647 Expressed in 30 organ(s), highest expression level in embryo
ExpressionAtlasiM9NE67 baseline and differential

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR024600 DUF3454_notch
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PF11936 DUF3454, 1 hit
PF00008 EGF, 24 hits
PF07645 EGF_CA, 3 hits
PF12661 hEGF, 2 hits
PF06816 NOD, 1 hit
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 1 hit
PRINTSiPR01452 LNOTCHREPEAT
SMARTiView protein in SMART
SM00248 ANK, 7 hits
SM01334 DUF3454, 1 hit
SM00181 EGF, 36 hits
SM00179 EGF_CA, 33 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 22 hits
PS00022 EGF_1, 34 hits
PS01186 EGF_2, 28 hits
PS50026 EGF_3, 36 hits
PS01187 EGF_CA, 10 hits
PS50258 LNR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM9NE67_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: M9NE67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: October 16, 2019
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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