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Entry version 179 (16 Oct 2019)
Sequence version 3 (13 Sep 2005)
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Protein

Muscle M-line assembly protein unc-89

Gene

unc-89

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments (PubMed:15313609, PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:23283987, PubMed:27009202). The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role (PubMed:15313609, PubMed:16453163, PubMed:22768340). Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles (PubMed:27009202). By binding mel-26, a substrate adapter of the cul-3 E3 ubiquitin-protein ligase complex, regulates the organization of myosin thick filaments, likely by preventing the degradation of microtubule severing protein mei-1 (PubMed:22621901). Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase rho-1 but not ced-10, mig-2 and cdc-42 (PubMed:18801371). The large isoforms regulate Ca2+ signaling during muscle contraction by ensuring the correct localization of sarco-endoplamic reticulum Ca2+ ATPase sca-1 and ryanodine receptor unc-68 (PubMed:22768340). By controlling the contraction and/or organization of pharyngeal muscles, plays a role in the formation of pharyngeal gland cell extension (PubMed:21868609). In contrast to obscurins in other species, unlikely to have serine/threonine kinase activity as both protein kinase domains are predicted to be catalytically inactive (Probable).Curated9 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMuscle protein, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-114608 Platelet degranulation
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-210990 PECAM1 interactions
R-CEL-216083 Integrin cell surface interactions
R-CEL-432142 Platelet sensitization by LDL
R-CEL-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O01761

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscle M-line assembly protein unc-89
Alternative name(s):
ObscurinCurated
Uncoordinated protein 89
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-89
ORF Names:C09D1.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
C09D1.1a ; CE30426 ; WBGene00006820 ; unc-89
C09D1.1b ; CE34251 ; WBGene00006820 ; unc-89
C09D1.1c ; CE34252 ; WBGene00006820 ; unc-89
C09D1.1d ; CE37701 ; WBGene00006820 ; unc-89
C09D1.1e ; CE37702 ; WBGene00006820 ; unc-89
C09D1.1f ; CE37703 ; WBGene00006820 ; unc-89
C09D1.1g ; CE52389 ; WBGene00006820 ; unc-89

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants lacking isoform a, isoform b, isoform e and isoform f have an abnormal organization of the myofilament lattice of body wall and pharyngeal muscles (PubMed:16453163, PubMed:18801371, PubMed:22621901, PubMed:27009202). In body wall muscles, unc-15/paramyosin accumulates in large foci outside thick filaments and myosin heavy chains unc-54 and myo-3 fail to assemble into parallel myofibrils (PubMed:27009202). In addition, myosin thick filaments are disorganized with the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A bands (PubMed:18801371, PubMed:22621901). In mutants lacking isoform b, isoform c, isoform d and isoform f, myo-3 fails to assemble into parallel myofibrils whereas unc-54 and unc-15 localization is normal (PubMed:27009202). Mutants lacking isoform b, isoform c, isoform d and isoform f have defects only in body wall muscle structure (PubMed:16453163). RNAi-mediated knockdown of isoform a or isoform b, isoform c and isoform d causes similar defects in the organization although RNAi-mediated knockdown of isoform c causes a less severe defect in myofilament organization (PubMed:15313609). In mutants lacking isoform a, isoform b, isoform e and isoform f, mei-1 protein levels are decreased by 20 percent (PubMed:22621901). RNAi-mediated knockdown of isoform a, isoform b, isoform e and isoform f but not of isoforms c and d disrupts sca-1 localization to linear punctate structures along in the M line in body wall muscles (PubMed:22768340). RNAi-mediated knockdown has no effect on ovulation (PubMed:17326220).7 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000727041 – 8081Muscle M-line assembly protein unc-89Add BLAST8081

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi568 ↔ 621PROSITE-ProRule annotationCurated
Disulfide bondi2582 ↔ 2635PROSITE-ProRule annotation
Disulfide bondi2908 ↔ 2964PROSITE-ProRule annotation
Disulfide bondi3015 ↔ 3065PROSITE-ProRule annotationCurated
Disulfide bondi3707 ↔ 3759PROSITE-ProRule annotationCurated
Disulfide bondi3838 ↔ 3890PROSITE-ProRule annotation
Disulfide bondi5298 ↔ 5350PROSITE-ProRule annotationCurated
Disulfide bondi5404 ↔ 5456PROSITE-ProRule annotation
Disulfide bondi5508 ↔ 5560PROSITE-ProRule annotationCurated
Disulfide bondi5616 ↔ 5669PROSITE-ProRule annotationCurated
Disulfide bondi5836 ↔ 5888PROSITE-ProRule annotation
Disulfide bondi5946 ↔ 5998PROSITE-ProRule annotationCurated
Disulfide bondi7549 ↔ 7600PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O01761

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O01761

PeptideAtlas

More...
PeptideAtlasi
O01761

PRoteomics IDEntifications database

More...
PRIDEi
O01761

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O01761

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body-wall, pharyngeal muscles and a few muscle cells of the tail (at protein level) (PubMed:8603916, PubMed:18337465, PubMed:19244614, PubMed:22621901, PubMed:22768340, PubMed:23283987, PubMed:27009202). Expressed in gonadal myoepithelial sheath cells (at protein level) (PubMed:17326220). Isoform c: Expressed in body wall and vulval muscles but not in pharyngeal muscles (PubMed:15313609). Isoform d: Specifically expressed in vulval, intestinal, anal depressor and anal sphincter muscles (PubMed:15313609).9 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryos (PubMed:23283987). Isoform a: Expressed in embryo, throughout larval development and in adults (PubMed:15313609). Isoform b: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609). Isoform c: Expressed in embryo, throughout larval development and in adults and is one of the most abundant (PubMed:15313609). Isoform d: Expressed in embryo, throughout larval development and in adults (PubMed:15313609).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006820 Expressed in 5 organ(s), highest expression level in material anatomical entity

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O01761 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and protein kinase domain 1 or C-terminus of the interkinase region) with lim-9 (via LIM zinc-binding domain) (PubMed:19244614). May interact (via fibronectin type-III domain 1, Ig-like C2-type domain 48/49 and kinase protein domain 1 or Ig-like C2-type domain 50, fibronectin type-III domain 2 and kinase protein domain 2) with scpl-1 isoforms a and b (via FCP1 homology domain); the interaction may act as a molecular bridge to bring two unc-89 molecules together or to stabilize a loop between the 2 kinase domains (PubMed:18337465, PubMed:19244614). May interact (via SH3 domain) with unc-15 (PubMed:27009202). May interact (via Ig-like C2-type domain 1-3) with cpna-1 (via VWFA domain) (PubMed:23283987). May interact (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) with mel-26 (via MATH domain) (PubMed:22621901). May interact (via DH and PH domains) with rho-1, ced-10, mig-2 and cdc-42 (PubMed:18801371).

6 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
37462, 5 interactors

Protein interaction database and analysis system

More...
IntActi
O01761, 11 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C09D1.1b

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

18081
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O01761

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O01761

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 127SH3PROSITE-ProRule annotationAdd BLAST65
Domaini152 – 330DHPROSITE-ProRule annotationAdd BLAST179
Domaini342 – 498PHPROSITE-ProRule annotationAdd BLAST157
Domaini547 – 633Ig-like C2-type 1Add BLAST87
Domaini648 – 736Ig-like C2-type 2Add BLAST89
Domaini748 – 838Ig-like C2-type 3Add BLAST91
Domaini946 – 1033Ig-like C2-type 4Add BLAST88
Domaini1044 – 1132Ig-like C2-type 5Add BLAST89
Domaini1140 – 1227Ig-like C2-type 6Add BLAST88
Domaini1375 – 1475RCSD 1CuratedAdd BLAST101
Domaini1479 – 1585RCSD 2CuratedAdd BLAST107
Domaini1597 – 1695RCSD 3CuratedAdd BLAST99
Domaini1700 – 1799RCSD 4CuratedAdd BLAST100
Domaini1982 – 2067Ig-like C2-type 7Add BLAST86
Domaini2071 – 2163Ig-like C2-type 8Add BLAST93
Domaini2171 – 2261Ig-like C2-type 9Add BLAST91
Domaini2269 – 2359Ig-like C2-type 10Add BLAST91
Domaini2367 – 2455Ig-like C2-type 11Add BLAST89
Domaini2463 – 2564Ig-like C2-type 12Add BLAST102
Domaini2563 – 2651Ig-like C2-type 13Add BLAST89
Domaini2657 – 2746Ig-like C2-type 14Add BLAST90
Domaini2754 – 2858Ig-like C2-type 15Add BLAST105
Domaini2887 – 2980Ig-like C2-type 16Add BLAST94
Domaini2994 – 3081Ig-like C2-type 17Add BLAST88
Domaini3087 – 3183Ig-like C2-type 18Add BLAST97
Domaini3189 – 3280Ig-like C2-type 19Add BLAST92
Domaini3286 – 3376Ig-like C2-type 20Add BLAST91
Domaini3384 – 3469Ig-like C2-type 21Add BLAST86
Domaini3482 – 3572Ig-like C2-type 22Add BLAST91
Domaini3580 – 3667Ig-like C2-type 23Add BLAST88
Domaini3686 – 3777Ig-like C2-type 24Add BLAST92
Domaini3817 – 3908Ig-like C2-type 25Add BLAST92
Domaini3920 – 4009Ig-like C2-type 26Add BLAST90
Domaini4018 – 4106Ig-like C2-type 27Add BLAST89
Domaini4109 – 4201Ig-like C2-type 28Add BLAST93
Domaini4212 – 4297Ig-like C2-type 29Add BLAST86
Domaini4302 – 4387Ig-like C2-type 30Add BLAST86
Domaini4400 – 4485Ig-like C2-type 31Add BLAST86
Domaini4489 – 4580Ig-like C2-type 32Add BLAST92
Domaini4588 – 4678Ig-like C2-type 33Add BLAST91
Domaini4681 – 4771Ig-like C2-type 34Add BLAST91
Domaini4873 – 4961Ig-like C2-type 35Add BLAST89
Domaini4965 – 5057Ig-like C2-type 36Add BLAST93
Domaini5067 – 5160Ig-like C2-type 37Add BLAST94
Domaini5171 – 5260Ig-like C2-type 38Add BLAST90
Domaini5277 – 5366Ig-like C2-type 39Add BLAST90
Domaini5383 – 5472Ig-like C2-type 40Add BLAST90
Domaini5487 – 5578Ig-like C2-type 41Add BLAST92
Domaini5595 – 5685Ig-like C2-type 42Add BLAST91
Domaini5701 – 5790Ig-like C2-type 43Add BLAST90
Domaini5815 – 5904Ig-like C2-type 44Add BLAST90
Domaini5925 – 6014Ig-like C2-type 45Add BLAST90
Domaini6038 – 6130Ig-like C2-type 46Add BLAST93
Domaini6150 – 6239Ig-like C2-type 47Add BLAST90
Domaini6278 – 6374Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini6413 – 6502Ig-like C2-type 48Add BLAST90
Domaini6507 – 6596Ig-like C2-type 49Add BLAST90
Domaini6592 – 6878Protein kinase 1PROSITE-ProRule annotationAdd BLAST287
Domaini7528 – 7617Ig-like C2-type 50Add BLAST90
Domaini7623 – 7721Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini7785 – 8035Protein kinase 2PROSITE-ProRule annotationAdd BLAST251

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi936 – 941Poly-Glu6
Compositional biasi1272 – 1315Thr-richAdd BLAST44
Compositional biasi1372 – 1886Lys-richAdd BLAST515
Compositional biasi7125 – 7128Poly-Gln4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Protein kinase domains 1 and 2 are predicted to be catalytically inactive (PubMed:16453163). The two kinase domains are required for the organization of thick filament component myosin heavy chain myo-3 but not of myosin heavy chain unc-54 and unc-15/paramyosin (PubMed:27009202).1 PublicationPROSITE-ProRule annotation1 Publication
The SH3 domain is required for the organization of thick filament components myosin heavy chain unc-54 and myo-3 and unc-15/paramyosin.1 Publication
The PH domain does not bind inositol 1,4,5-trisphosphate. The PH domain has an unusual closed conformation of the lipid binding site which is lined by negative charged amino acids which probably prevents binding to membrane lipids.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0032 Eukaryota
KOG0689 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171516

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O01761

Identification of Orthologs from Complete Genome Data

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OMAi
PKTVKWY

Database of Orthologous Groups

More...
OrthoDBi
184at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O01761

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits
cd00160 RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 55 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR007850 RCSD
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 51 hits
PF00069 Pkinase, 2 hits
PF05177 RCSD, 6 hits
PF00621 RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 51 hits
SM00408 IGc2, 45 hits
SM00406 IGv, 5 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 53 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 50 hits
PS50003 PH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform b (identifier: O01761-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MASRRQKQFD RKYSSYRKFT ATEDVNYSTH SSRSSYRSES LTSRTDGRGR
60 70 80 90 100
STSSEIIAGS ESRSYPVYIA IQDYTPDKED VEAIPLEQGQ IVEVLDKKNS
110 120 130 140 150
VRWLVRTKAR PPRSGWVPGS YFETPTEFYK QRRRTREIEN VSLSDEQAAL
160 170 180 190 200
VKRDQVYHEL LRSEEEFVSS LRTCVDDYIK VLDDPEVPEA VKKNREELTL
210 220 230 240 250
NIPELYNFHA NVMLKGLNYY SDDPGKVGQT FVRLEKDFES HVEFYKQYAD
260 270 280 290 300
TLKLLEEPEI KRFFEGLSAK NDAGASSFVD HVKEIADRMV QYQNYFKEFV
310 320 330 340 350
KYSARAHGSS KSIQKALELV TTIPQRVHDL EFTNNLKQHP GDTGKLGRII
360 370 380 390 400
RHDAFQVWEG DEPPKLRYVF LFRNKIMFTE QDASTSPPSY THYSSIRLDK
410 420 430 440 450
YNIRQHTTDE DTIVLQPQEP GLPSFRIKPK DFETSEYVRK AWLRDIAEEQ
460 470 480 490 500
EKYAAERDAI SMTATSEMTA SSVDFDMNAS DQQSEFSEWS GSRKSSLFPG
510 520 530 540 550
PEEGGPPRKK VKSPPVISPT GSSTSIYSGG SSSIDWTTTG TTLEMQGTRV
560 570 580 590 600
TRTQYGFRTL QESSAKMCLK VTGYPLPDIT WYKDDVQLHE DERHTFYSDE
610 620 630 640 650
DGFFAMTIDP VQVTDTGRYT CMATNEYGQA STSAFFRVLK VEKEAAPPAF
660 670 680 690 700
VTKLRDKECK EGDVIDFECE VEGWPEPELV WLVDDQPLRP SHDFRLQYDG
710 720 730 740 750
QTAKLEIRDA QPDDTGVYTV KIQNEFGSIE SKAELFVQAD PDKNHVAPEF
760 770 780 790 800
QATIEYVECD EGEEVRFKSV ITGDPNPEII WFINGKPLSE SEKVKFISED
810 820 830 840 850
GICILTIKDV TRHFDGMVTC QGSNRLGSAS CDGRLKVRVP PAPPTFNKPL
860 870 880 890 900
EDKTVQEKST VVFEVDVSGW PEPTLTFTLC GKELKNGEEG VEIVGHDGFY
910 920 930 940 950
RISIPNTSMD KHDGEIVAKA QNEHGTAESR ARLTVEQEEE ESRSAPTFLK
960 970 980 990 1000
DIEDQTVKTG EFAVFETTVR GNPNPEVTWF INGHKMDQGS PGVKIEAHNH
1010 1020 1030 1040 1050
DHKLTIDSAQ YAGTVLCRAE NAVGRFETKA RLVVLAPEKQ KKPPKFVEIL
1060 1070 1080 1090 1100
VDKTETVDNT VVFEVRVEGE PKPTVTWYLK GEELKQSDRV EIREFDGSIK
1110 1120 1130 1140 1150
ISIKNIKIED AGEIRAVATN SEGSDETKAK LTVQKKPFAP EFDLRPVSLT
1160 1170 1180 1190 1200
VEKGSEAVFS AHAFGIPLPT YEWSVNGRKV RDGQEGARVT RDESTVDGAS
1210 1220 1230 1240 1250
ILTIDTATYY SEVNHLTISV VAENTLGAEE TGAQLTIEPK KESVVVEKQD
1260 1270 1280 1290 1300
LSSSEVQKEI AQQVKEASPE ATTTITMETS LTSTKTTTMS TTEVTSTVGG
1310 1320 1330 1340 1350
VTVETKESES ESATTVIGGG SGGVTEGSIS VSKIEVVSKT DSQTDVREGT
1360 1370 1380 1390 1400
PKRRVSFAEE ELPKEVIDSD RKKKKSPSPD KKEKSPEKTE EKPASPTKKT
1410 1420 1430 1440 1450
GEEVKSPKEK SPASPTKKEK SPAAEEVKSP TKKEKSPSSP TKKEKSPSSP
1460 1470 1480 1490 1500
TKKTGDEVKE KSPPKSPTKK EKSPEKPEDV KSPVKKEKSP DATNIVEVSS
1510 1520 1530 1540 1550
ETTIEKTETT MTTEMTHESE ESRTSVKKEK TPEKVDEKPK SPTKKDKSPE
1560 1570 1580 1590 1600
KSITEEIKSP VKKEKSPEKV EEKPASPTKK EKSPEKPASP TKKSENEVKS
1610 1620 1630 1640 1650
PTKKEKSPEK SVVEELKSPK EKSPEKADDK PKSPTKKEKS PEKSATEDVK
1660 1670 1680 1690 1700
SPTKKEKSPE KVEEKPTSPT KKESSPTKKT DDEVKSPTKK EKSPQTVEEK
1710 1720 1730 1740 1750
PASPTKKEKS PEKSVVEEVK SPKEKSPEKA EEKPKSPTKK EKSPEKSAAE
1760 1770 1780 1790 1800
EVKSPTKKEK SPEKSAEEKP KSPTKKESSP VKMADDEVKS PTKKEKSPEK
1810 1820 1830 1840 1850
VEEKPASPTK KEKTPEKSAA EELKSPTKKE KSPSSPTKKT GDESKEKSPE
1860 1870 1880 1890 1900
KPEEKPKSPT PKKSPPGSPK KKKSKSPEAE KPPAPKLTRD LKLQTVNKTD
1910 1920 1930 1940 1950
LAHFEVVVEH ATECKWFLDG KEITTAQGVT VSKDDQFEFR CSIDTTMFGS
1960 1970 1980 1990 2000
GTVSVVASNA AGSVETKTEL KVLETPKETK KPEFTDKLRD MEVTKGDTVQ
2010 2020 2030 2040 2050
MDVIALHSPL YKWYQNGNLL EDGKNGVTIK NEENKSSLII PNAQDSGKIT
2060 2070 2080 2090 2100
VEASNEVGSS ESSAQLTVNP PSTTPIVVDG PKSVTIKETE TAEFKATISG
2110 2120 2130 2140 2150
FPAPTVKWTI NEKIVEESRT ITTIKTEDVY TLKISNAKIE QTGTVKVTAQ
2160 2170 2180 2190 2200
NSAGQDSKQA DLKVEPNVKA PKFKSQLTDK VADEGEPLRW NLELDGPSPG
2210 2220 2230 2240 2250
TEVSWLLNGQ PLTKSDTVQV VDHGDGTYHV TIAEAKPEMS GTLTAKAKNA
2260 2270 2280 2290 2300
AGECETSAKV TVNGGNKKPE FVQAPQNHET TLEESVKFSA IVTGKPMPNV
2310 2320 2330 2340 2350
TWYLNNKKLI QSEEVKVKYV HETGKTSIRI QKPLMEHNGT IRVEAENVSG
2360 2370 2380 2390 2400
KVQATAQLKV DKKTEVPKFT TNMDDRQVKE GEDVKFTANV EGYPEPSVAW
2410 2420 2430 2440 2450
TLNGEPVSKH PNITVTDKDG EHTIEISAVT PEQAGELSCE ATNPVGSKKR
2460 2470 2480 2490 2500
DVQLAVKKVG DAPTFAKNLE DRLITEGELT LMDAKLNIVK PKPKITWLKD
2510 2520 2530 2540 2550
GVEITSDGHY KIVEEEDGSL KLSILQTKLE DKGRITIKAE SEFGVAECSA
2560 2570 2580 2590 2600
SLGVVKGRPM AKPAFQSDIA PINLTEGDTL ECKLLITGDP TPFVKWYIGT
2610 2620 2630 2640 2650
QLVCATEDTE ISNANGVYTM KIHGVTADMT GKIKCVAYNK AGEVSTEGPL
2660 2670 2680 2690 2700
KVVAPIPVEF ETSLCDATCR EGDTLKLRAV LLGEPEPVVS WYVNGKKLEE
2710 2720 2730 2740 2750
SQNIKIHSEK GTYTVTIKDI TCDYSGQVVC EAINEYGKAT SEATLLVLPR
2760 2770 2780 2790 2800
GEPPDFLEWL SNVRARTGTK VVHKVVFTGD PKPSLTWYIN NKEILNSDLY
2810 2820 2830 2840 2850
TIVTDDKTST LTINSFNPDV HVGEIICKAE NDAGEVSCTA NMITYTSDMF
2860 2870 2880 2890 2900
SESESEAQAE EFVGDDLTED ESLREEMHRT PTPVMAPKFI TKIKDTKAKK
2910 2920 2930 2940 2950
GHSAVFECVV PDTKGVCCKW LKDGKEIELI ARIRVQTRTG PEGHITQELV
2960 2970 2980 2990 3000
LDNVTPEDAG KYTCIVENTA GKDTCEATLT VIESLEKKSE KKAPEFIVAL
3010 3020 3030 3040 3050
QDKTTKTSEK VVLECKVIGE PKPKVSWLHD NKTITQESIT VESVEGVERV
3060 3070 3080 3090 3100
TITSSELSHQ GKYTCIAENT EGTSKTEAFL TVQGEAPVFT KELQNKELSI
3110 3120 3130 3140 3150
GEKLVLSCSV KGSPQPHVDF YSFSETTKVE TKITSSSRIA IEHDQTNTHW
3160 3170 3180 3190 3200
RMVISQITKE DIVSYKAIAT NSIGTATSTS KITTKVEAPV FEQGLKKTSV
3210 3220 3230 3240 3250
KEKEEIKMEV KVGGSAPDVE WFKDDKPVSE DGNHEMKKNP ETGVFTLVVK
3260 3270 3280 3290 3300
QAATTDAGKY TAKASNPAGT AESSAEAEVT QSLEKPTFVR ELVTTEVKIN
3310 3320 3330 3340 3350
ETATLSVTVK GVPDPSVEWL KDGQPVQTDS SHVIAKVEGS GSYSITIKDA
3360 3370 3380 3390 3400
RLEDSGKYAC RATNPAGEAK TEANFAVVKN LVPPEFVEKL SPLEVKEKES
3410 3420 3430 3440 3450
TTLSVKVVGT PEPSVEWFKD DTPISIDNVH VIQKQTAVGS FSLTINDARQ
3460 3470 3480 3490 3500
GDVGIYSCRA RNEAGEALTT ANFGIIRDSI PPEFTQKLRP LEVREQETLD
3510 3520 3530 3540 3550
LKVTVIGTPV PNVEWFKDDK PINIDNSHIF AKDEGSGHHT LTIKQARGED
3560 3570 3580 3590 3600
VGVYTCKATN EAGEAKTTAN MAVQEEIEAP LFVQGLKPYE VEQGKPAELV
3610 3620 3630 3640 3650
VRVEGKPEPE VKWFKDGVPI AIDNQHVIEK KGENGSHTLV IKDTNNADFG
3660 3670 3680 3690 3700
KYTCQATNKA GKDETVGELK IPKYSFEKQT AEEVKPLFIE PLKETFAVEG
3710 3720 3730 3740 3750
DTVVLECKVN KESHPQIKFF KNDQPVEIGQ HMQLEVLEDG NIKLTIQNAK
3760 3770 3780 3790 3800
KEDVGAYRCE AVNVAGKANT NADLKIQFAA KVEEHVTDES GQLEEIGQFE
3810 3820 3830 3840 3850
TVGDTASSKT DTGRGAPEFV ELLRSCTVTE KQQAILKCKV KGEPRPKIKW
3860 3870 3880 3890 3900
TKEGKEVEMS ARVRAEHKDD GTLTLTFDNV TQADAGEYRC EAENEYGSAW
3910 3920 3930 3940 3950
TEGPIIVTLE GAPKIDGEAP DFLQPVKPAV VTVGETAVLE GKISGKPKPS
3960 3970 3980 3990 4000
VKWYKNGEEL KPSDRVKIEN LDDGTQRLTV TNAKLDDMDE YRCEASNEFG
4010 4020 4030 4040 4050
DVWSDVTLTV KEPAQVAPGF FKELSAIQVK ETETAKFECK VSGTKPDVKW
4060 4070 4080 4090 4100
FKDGTPLKED KRVHFESTDD GTQRLVIEDS KTDDQGNYRI EVSNDAGVAN
4110 4120 4130 4140 4150
SKVPLTVVPS ETLKIKKGLT DVNVTQGTKI LLSVEVEGKP KTVKWYKGTE
4160 4170 4180 4190 4200
TVTSSQTTKI VQVTESEYKL EIESAEMSDT GAYRVVLSTD SFSVESSATV
4210 4220 4230 4240 4250
TVTKAAEKIS LPSFKKGLAD QSVPKGTPLV LEVEIEGKPK DVKWYKNGDE
4260 4270 4280 4290 4300
IKDGKVEDLG NGKYRLTIPD FQEKDVGEYS VTAANEAGEI ESKAKVNVSA
4310 4320 4330 4340 4350
KPEIVSGLVP TTVKQGETAT FNVKVKGPVK GVKWYKNGKE IPDAKTKDNG
4360 4370 4380 4390 4400
DGSYSLEIPN AQVEDAADYK VVVSNDAGDA DSSAALTVKL ADDGKDKVKP
4410 4420 4430 4440 4450
EIVSGLIPTT VKQGETATFN VKVKGPVKQV KWYKNGKEIP NAKAKDNGDG
4460 4470 4480 4490 4500
SYSLEIPNAQ LDDTADYKVV VSNDAGDADS SAALTVKLPG IAIVKGLEDA
4510 4520 4530 4540 4550
EVPKGKKAVL QVETNKKPKE IKWYKNGKEI TPSDKAQPGS DGDNKPQLVI
4560 4570 4580 4590 4600
PDAGDDDAAE YKVVLTDEDG NTADSSCALT VKLPAKEPKI IKGLEDQVVS
4610 4620 4630 4640 4650
IGSPIKLEIE TSGSPKTVKW YKNGKELPGA AAKTIKIQKI DDNKYVLEIP
4660 4670 4680 4690 4700
SSVVEDTGDY KVEVANEAGS ANSSGKITVE PKITFLKPLK DQSITEGENA
4710 4720 4730 4740 4750
EFSVETNTKP RIVKWYKNGQ EIKPNSRFII EQKTDTKYQL VIKNAVRDDA
4760 4770 4780 4790 4800
DTYKIVLENT AGEAESSAQL TVKKAKAGLC KIVKGLEDQV VAKGAKMVFE
4810 4820 4830 4840 4850
VKIQGEPEDV RWLRDANVIS AGANAIIEKI DDTTYRLIIP SADLKDAGEY
4860 4870 4880 4890 4900
TVEVINESGK AKSDAKGEVD EKPEIVRGLE NIEIPEGDDD VFKVEVSAPV
4910 4920 4930 4940 4950
RQVKWYKNDQ EIKPNSHLEA KKIGPKKYEL AINRAQLDDG ADYKVVLSNA
4960 4970 4980 4990 5000
AGDCDSSAAL TVVKPNVLKI VDGLKDVDVE EPQPVELKVK VEGIPKVIKW
5010 5020 5030 5040 5050
YKNGQELKPD ADGFKFEEKP ESGEFSLTIP SSKKSDGGAY RVVLGNDKGE
5060 5070 5080 5090 5100
VYSGSVVHVK SAKSSEPTSG ANFLSPLKDT EVEEGDMLTL QCTIAGEPFP
5110 5120 5130 5140 5150
EVIWEKDGVV LQKDDRITMR VALDGTATLR IRSAKKSDIG QYRVTAKNEA
5160 5170 5180 5190 5200
GSATSDCKVT VTEQGEQPSK PKFVIPLKTG AALPGDKKEF NVKVRGLPKP
5210 5220 5230 5240 5250
TLQWFLNGIP IKFDDRITLD DMADGNYCLT IRDVREEDFG TLKCIAKNEN
5260 5270 5280 5290 5300
GTDETVCEFQ QGAGHDDGSR DDLRYPPRFN VPLWDRRIPV GDPMFIECHV
5310 5320 5330 5340 5350
DANPTAEVEW FKDGKKIEHT AHTEIRNTVD GACRIKIIPF EESDIGVYMC
5360 5370 5380 5390 5400
VAVNELGQAE TQATYQVEIL EHVEEEKRRE YAPKINPPLE DKTVNGGQPI
5410 5420 5430 5440 5450
RLSCKVDAIP RASVVWYKDG LPLRADSRTS IQYEEDGTAT LAINDSTEED
5460 5470 5480 5490 5500
IGAYRCVATN AHGTINTSCS VNVKVPKQEV KKEGEEPFFT KGLVDLWADR
5510 5520 5530 5540 5550
GDSFTLKCAV TGDPFPEIKW YRNGQLLRNG PRTVIETSPD GSCSLTVNES
5560 5570 5580 5590 5600
TMSDEGIYRC EAENAHGKAK TQATAHVQMA LGKTEKPKMD EGKPPKFILE
5610 5620 5630 5640 5650
LSDMSVSLGN VIDLECKVTG LPNPSVKWSK DGGPLIEDSR FEWSNEASKG
5660 5670 5680 5690 5700
VYQLRIKNAT VHDEGTYRCV ATNENGSATT KSFVRMDDGL GSGVVTASQP
5710 5720 5730 5740 5750
PRFTLKMGDV RTTEGQPLKL ECKVDASPLP EMVWYKDGAI VTPSDRIQIS
5760 5770 5780 5790 5800
LSPDGVATLL IPSCVYDDDG IYRVIATNPS GTAQDKGTAT VKKLPRDSGA
5810 5820 5830 5840 5850
RRSADRDVFD ANKAPKLMEP LENIRIPEKQ SFRLRCKFSG DPKPTIKWFK
5860 5870 5880 5890 5900
DGERVFPYGR LQLIESPDGV CELVVDSATR QDAGGYRCVA ENTYGSARTS
5910 5920 5930 5940 5950
CDVNVIRGDR KPRDIDSSIR EGKAPGFTTP LTIRRAKPGD SVTFECLPFG
5960 5970 5980 5990 6000
NPFPSIKWLK DGLELFSDEK IKMEAAADGT QRLILSDVTF LSEGYFRCVA
6010 6020 6030 6040 6050
TNEHGTASTK AELVIEGDRT IGSRPLPEVN GEPEECKPRI RRGLYNMSIH
6060 6070 6080 6090 6100
EGNVVEMIVC ATGIPTPTVK WYKDGQEIVG DGPDGKRVIF TDERGIHHLV
6110 6120 6130 6140 6150
IVNASPDDEG EYSLEATNKL GSAKTEGSLN IIRPRHIADA DERGGMPFPP
6160 6170 6180 6190 6200
GFVRQLKNKH VFNHMPTIFD CLVVGHPAPE VEWFHNGKKI VPGGRIKIQS
6210 6220 6230 6240 6250
CGGGSHALII LDTTLEDAGE YVATAKNSHG SASSSAVLDV TVPFLDSIKF
6260 6270 6280 6290 6300
NGEIDVTPYL TEEYGFKKLN TASLPTPPDR GPFIKEVTGH YLTLSWIPTK
6310 6320 6330 6340 6350
RAPPRYPQVT YVIEIRELPE KQWSLLEYNI PEPVCKVRNL ELGKSYQFRV
6360 6370 6380 6390 6400
RAENIYGISD PSPASPPSRL MAPPQPVFDR RTNKVIPLLD PYAEKALDMR
6410 6420 6430 6440 6450
YSEQYACAPW FSPGVVEKRY CAENDTLTIV LNVSGFPDPD IKWKFRGWDI
6460 6470 6480 6490 6500
DTSSPTSKCK VYTYGGSETT LAITGFSKEN VGQYQCFAKN DYGDAQQNIM
6510 6520 6530 6540 6550
VDLATRPNFI QPLVNKTFSS AQPMRMDVRV DGEPFPELKW MKEWRPIVES
6560 6570 6580 6590 6600
SRIKFVQDGP YLCSLIINDP MWRDSGIYSC VAVNDAGQAT TSCTVTVEAE
6610 6620 6630 6640 6650
GDYNDVELPR RRVTIESRRV RELYEISEKD EKLAAEGAPF RVKEKATGRE
6660 6670 6680 6690 6700
FLAQLRPIDD ALMRHVDIHN SLDHPGIVQM HRVLRDEKLA LVVFDNANST
6710 6720 6730 6740 6750
IDGLSSLAHP GVEIAEPKGV NRETCVRVFV RQLLLALKHM HDLRIAHLDL
6760 6770 6780 6790 6800
RPETILLQDD KLKLADFGQA RRLLRGLITG EIKGSPEFVS PEIVRSYPLT
6810 6820 6830 6840 6850
LATDMWSTGV LTYVLLTGLS PFHGDNDNET LANVDSCQFD SSPLGNFSYD
6860 6870 6880 6890 6900
AGDFVKKLLT EIPVSRLTVD EALDHPWIND EKLKTEPLSA DTLREFKYQH
6910 6920 6930 6940 6950
KWLERRVFVQ QTPSEQILEA ILGPATAQAQ QNAPVAPEGR RPAEIYDYLR
6960 6970 6980 6990 7000
IQPKKPPPTV EYVPQPRKEH PPFIDEFGQL IDGDAFDRPE GTGFEGPHRQ
7010 7020 7030 7040 7050
PPQIPPQPQR PNQAAHDSRR HEQQPQHQGQ PQRIPVDQYG RPLVDPRYLN
7060 7070 7080 7090 7100
DPSHRPSSLD DAPFYVDKYG NPVHFDKYGR PMAPQNLEKR KLIPQDKGET
7110 7120 7130 7140 7150
PSHSKKEKTQ HPVATPILAS PGGDQQQQKI PMRMIRGERR EIEEEIANRI
7160 7170 7180 7190 7200
LSDISEEGSI AGSLASLEDF EIPKDFQVEA SEPSTPTLTP EVTIRETIPK
7210 7220 7230 7240 7250
PTPSPTSPQK SPVPQPQGLL IPAKVTYSDS ILAGLPAADK KVLEDAENDP
7260 7270 7280 7290 7300
SIPVGAPLFL EGLHGSDLTI DTTSASGLIK VTSPAINLSP NPKSPRRSTP
7310 7320 7330 7340 7350
GTKSPVVLSP RQEHSMEVLI ATKRGKPGFL PPGELAEDID DEDAFMDDRK
7360 7370 7380 7390 7400
KQVKPKDHDG ENDFKDEKER LEKDKNRRTV NLDDLDKYRP SAFYKDDSDF
7410 7420 7430 7440 7450
GHPGYDIDAT PWDSHYQIGP DTYLMAARGA AFNSRVRNYR EELFGMGAPT
7460 7470 7480 7490 7500
VKQGFLGVRN RDITVRERRR YTDILRETTQ GLEPKSHEQS TALLQKAPSA
7510 7520 7530 7540 7550
TAIERIKADI EKVTPCATKK NDDGTFAPIF TARLRDVYLR KNQPAIFECA
7560 7570 7580 7590 7600
VSASPAPKVT WDFQGKILES NDRVTIEQDN NVARLILNHA APYDLGEYVC
7610 7620 7630 7640 7650
TAINEYGTDK SSCRLISGET PSRPGRPEAE LSSDTEIFIQ WEAPEGPTYL
7660 7670 7680 7690 7700
EGITYRLEYR VAGPNDHGDP WITVSEKIDD ESVIVKHLSP LGIYQFRVTA
7710 7720 7730 7740 7750
QNGFGLGLPS LSSRIVQTHG KGAPKLQIDV LKSEIRLNVV SMPQKSTNQL
7760 7770 7780 7790 7800
GGISEESEED SEARTANEDM KSNLQLQTDD PTGRFQIGGL KFKGRFSVIR
7810 7820 7830 7840 7850
DAVDSTTEGH AHCAVKIRHP SSEAISEYES LRDGQHENVQ RLIAAFNNSN
7860 7870 7880 7890 7900
FLYLLSERLY EDVFSRFVFN DYYTEEQVAL TMRQVTSALH FLHFKGIAHL
7910 7920 7930 7940 7950
DVNPHNIMFQ SKRSWVVKLV DFGRAQKVSG AVKPVDFDTK WASPEFHIPE
7960 7970 7980 7990 8000
TPVTVQSDMW GMGVVTFCLL AGFHPFTSEY DREEEIKENV INVKCDPNLI
8010 8020 8030 8040 8050
PVNASQECLS FATWALKKSP VRRMRTDEAL SHKFLSSDPS MVRRRESIKY
8060 8070 8080
SASRLRKLAA MIRQPTFSQP ISEELESKYG K
Length:8,081
Mass (Da):894,252
Last modified:September 13, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67C804953CF62228
GO
Isoform a (identifier: O01761-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6633-8081: Missing.

Show »
Length:6,632
Mass (Da):731,685
Checksum:i262D3EDD62960E89
GO
Isoform c (identifier: O01761-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6688: Missing.
     6689-6696: LALVVFDN → MVRFTINC

Note: No experimental confirmation available.
Show »
Length:1,393
Mass (Da):156,297
Checksum:iF947C1BCE4EB9CE9
GO
Isoform d (identifier: O01761-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6685: Missing.
     6686-6696: DEKLALVVFDN → MFRLVEDCELC

Note: No experimental confirmation available.
Show »
Length:1,396
Mass (Da):156,671
Checksum:iF42D06301E7185C2
GO
Isoform e (identifier: O01761-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.
     6633-8081: Missing.

Note: No experimental confirmation available.
Show »
Length:5,992
Mass (Da):661,677
Checksum:i7E5F00BF18A251D4
GO
Isoform f (identifier: O01761-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1241-1880: Missing.

Show »
Length:7,441
Mass (Da):824,244
Checksum:i4B102760FC1131D7
GO
Isoform g (identifier: O01761-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6632-6695: Missing.
     7175-7186: DFQVEASEPSTP → VTEGDGCNMCGE
     7187-8081: Missing.

Note: No experimental confirmation available.
Show »
Length:7,122
Mass (Da):786,772
Checksum:iE0AADE021082BD5B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2C9C2S8A0A2C9C2S8_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
8,059Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C2W9A0A2C9C2W9_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
7,508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C3B7A0A2C9C3B7_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
7,361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C2G8A0A2C9C2G8_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
6,888Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C2V3A0A2C9C2V3_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
7,035Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C2V5A0A2C9C2V5_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
7,586Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C330A0A2C9C330_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
6,610Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C332A0A2C9C332_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
6,968Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2C9C365A0A2C9C365_CAEEL
Muscle M-line assembly protein unc-...
unc-89 C09D1.1, CELE_C09D1.1
5,912Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2137A → P in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti2245 – 2247AKA → PKP in AAB00542 (PubMed:8603916).Curated3
Sequence conflicti2258A → P in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti2284E → G in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti2297M → I in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti3531A → G in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti3884 – 3888DAGEY → RRRRI in AAB00542 (PubMed:8603916).Curated5
Sequence conflicti3929A → V in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti5134A → P in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti5145T → S in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti5185G → A in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti5199K → N in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti5202L → F in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti5213F → L in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti6178A → G in AAB00542 (PubMed:8603916).Curated1
Sequence conflicti6268K → E in AAB00542 (PubMed:8603916).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0155411 – 6688Missing in isoform c. CuratedAdd BLAST6688
Alternative sequenceiVSP_0155421 – 6685Missing in isoform d. CuratedAdd BLAST6685
Alternative sequenceiVSP_0155431241 – 1880Missing in isoform e and isoform f. CuratedAdd BLAST640
Alternative sequenceiVSP_0155446632 – 6695Missing in isoform g. CuratedAdd BLAST64
Alternative sequenceiVSP_0155456633 – 8081Missing in isoform a and isoform e. CuratedAdd BLAST1449
Alternative sequenceiVSP_0155466686 – 6696DEKLALVVFDN → MFRLVEDCELC in isoform d. CuratedAdd BLAST11
Alternative sequenceiVSP_0155476689 – 6696LALVVFDN → MVRFTINC in isoform c. Curated8
Alternative sequenceiVSP_0155487175 – 7186DFQVE…EPSTP → VTEGDGCNMCGE in isoform g. CuratedAdd BLAST12
Alternative sequenceiVSP_0155497187 – 8081Missing in isoform g. CuratedAdd BLAST895

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33058 Genomic DNA Translation: AAB00542.1
FO080458 Genomic DNA Translation: CCD63864.1
FO080458 Genomic DNA Translation: CCD63865.1
FO080458 Genomic DNA Translation: CCD63866.1
FO080458 Genomic DNA Translation: CCD63867.1
FO080458 Genomic DNA Translation: CCD63868.1
FO080458 Genomic DNA Translation: CCD63869.1
FO080458 Genomic DNA Translation: CCD63870.1
AY724774 mRNA Translation: AAU21474.1
AY714779 mRNA Translation: AAU14146.1

Protein sequence database of the Protein Information Resource

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PIRi
T29757

NCBI Reference Sequences

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RefSeqi
NP_001020984.1, NM_001025813.1 [O01761-2]
NP_001020985.1, NM_001025814.2 [O01761-1]
NP_001020988.1, NM_001025817.2 [O01761-5]
NP_001020989.1, NM_001025818.1 [O01761-6]
NP_001020990.1, NM_001025819.1
NP_001293453.1, NM_001306524.1 [O01761-3]
NP_001293454.1, NM_001306525.1 [O01761-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C09D1.1a.1; C09D1.1a.1; WBGene00006820 [O01761-2]
C09D1.1b.1; C09D1.1b.1; WBGene00006820 [O01761-1]
C09D1.1c.1; C09D1.1c.1; WBGene00006820 [O01761-3]
C09D1.1d.1; C09D1.1d.1; WBGene00006820 [O01761-4]
C09D1.1e.1; C09D1.1e.1; WBGene00006820 [O01761-5]
C09D1.1f.1; C09D1.1f.1; WBGene00006820 [O01761-6]
C09D1.1g.1; C09D1.1g.1; WBGene00006820

Database of genes from NCBI RefSeq genomes

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GeneIDi
171990

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_C09D1.1

UCSC genome browser

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UCSCi
C09D1.1g c. elegans [O01761-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33058 Genomic DNA Translation: AAB00542.1
FO080458 Genomic DNA Translation: CCD63864.1
FO080458 Genomic DNA Translation: CCD63865.1
FO080458 Genomic DNA Translation: CCD63866.1
FO080458 Genomic DNA Translation: CCD63867.1
FO080458 Genomic DNA Translation: CCD63868.1
FO080458 Genomic DNA Translation: CCD63869.1
FO080458 Genomic DNA Translation: CCD63870.1
AY724774 mRNA Translation: AAU21474.1
AY714779 mRNA Translation: AAU14146.1
PIRiT29757
RefSeqiNP_001020984.1, NM_001025813.1 [O01761-2]
NP_001020985.1, NM_001025814.2 [O01761-1]
NP_001020988.1, NM_001025817.2 [O01761-5]
NP_001020989.1, NM_001025818.1 [O01761-6]
NP_001020990.1, NM_001025819.1
NP_001293453.1, NM_001306524.1 [O01761-3]
NP_001293454.1, NM_001306525.1 [O01761-4]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FHONMR-A341-458[»]
SMRiO01761
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi37462, 5 interactors
IntActiO01761, 11 interactors
STRINGi6239.C09D1.1b

PTM databases

iPTMnetiO01761

Proteomic databases

EPDiO01761
PaxDbiO01761
PeptideAtlasiO01761
PRIDEiO01761

Genome annotation databases

EnsemblMetazoaiC09D1.1a.1; C09D1.1a.1; WBGene00006820 [O01761-2]
C09D1.1b.1; C09D1.1b.1; WBGene00006820 [O01761-1]
C09D1.1c.1; C09D1.1c.1; WBGene00006820 [O01761-3]
C09D1.1d.1; C09D1.1d.1; WBGene00006820 [O01761-4]
C09D1.1e.1; C09D1.1e.1; WBGene00006820 [O01761-5]
C09D1.1f.1; C09D1.1f.1; WBGene00006820 [O01761-6]
C09D1.1g.1; C09D1.1g.1; WBGene00006820
GeneIDi171990
KEGGicel:CELE_C09D1.1
UCSCiC09D1.1g c. elegans [O01761-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3346201
WormBaseiC09D1.1a ; CE30426 ; WBGene00006820 ; unc-89
C09D1.1b ; CE34251 ; WBGene00006820 ; unc-89
C09D1.1c ; CE34252 ; WBGene00006820 ; unc-89
C09D1.1d ; CE37701 ; WBGene00006820 ; unc-89
C09D1.1e ; CE37702 ; WBGene00006820 ; unc-89
C09D1.1f ; CE37703 ; WBGene00006820 ; unc-89
C09D1.1g ; CE52389 ; WBGene00006820 ; unc-89

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
KOG0689 Eukaryota
KOG4475 Eukaryota
ENOG410XQFD LUCA
GeneTreeiENSGT00940000171516
InParanoidiO01761
OMAiPKTVKWY
OrthoDBi184at2759
PhylomeDBiO01761

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-210990 PECAM1 interactions
R-CEL-216083 Integrin cell surface interactions
R-CEL-432142 Platelet sensitization by LDL
R-CEL-6798695 Neutrophil degranulation
SignaLinkiO01761

Miscellaneous databases

EvolutionaryTraceiO01761

Protein Ontology

More...
PROi
PR:O01761

Gene expression databases

BgeeiWBGene00006820 Expressed in 5 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiO01761 baseline and differential

Family and domain databases

CDDicd00063 FN3, 2 hits
cd00160 RhoGEF, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
2.60.40.10, 55 hits
InterProiView protein in InterPro
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR011009 Kinase-like_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000719 Prot_kinase_dom
IPR007850 RCSD
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 51 hits
PF00069 Pkinase, 2 hits
PF05177 RCSD, 6 hits
PF00621 RhoGEF, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00409 IG, 51 hits
SM00408 IGc2, 45 hits
SM00406 IGv, 5 hits
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF48726 SSF48726, 53 hits
SSF49265 SSF49265, 2 hits
SSF50044 SSF50044, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS50010 DH_2, 1 hit
PS50853 FN3, 2 hits
PS50835 IG_LIKE, 50 hits
PS50003 PH_DOMAIN, 1 hit
PS50011 PROTEIN_KINASE_DOM, 2 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC89_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O01761
Secondary accession number(s): Q17362
, Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: September 13, 2005
Last modified: October 16, 2019
This is version 179 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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