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Entry version 172 (18 Sep 2019)
Sequence version 2 (23 Sep 2008)
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Protein

DNA-directed RNA polymerase III subunit RPC1

Gene

POLR3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi69Zinc 1By similarity1
Metal bindingi72Zinc 1By similarity1
Metal bindingi79Zinc 1By similarity1
Metal bindingi82Zinc 1By similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi156Zinc 2By similarity1
Metal bindingi499Magnesium; catalyticBy similarity1
Metal bindingi501Magnesium; catalyticBy similarity1
Metal bindingi503Magnesium; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processAntiviral defense, Immunity, Innate immunity, Transcription
LigandMagnesium, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC1 (EC:2.7.7.6)
Short name:
RNA polymerase III subunit C1
Alternative name(s):
DNA-directed RNA polymerase III largest subunit
DNA-directed RNA polymerase III subunit A
RNA polymerase III 155 kDa subunit
Short name:
RPC155
RNA polymerase III subunit C160
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR3A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30074 POLR3A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614258 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O14802

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD7)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodegenerative disorder characterized by childhood onset of progressive motor decline manifest as spasticity, ataxia, tremor, and cerebellar signs, as well as mild cognitive regression. Other features may include hypodontia or oligodontia and hypogonadotropic hypogonadism. There is considerable inter- and intrafamilial variability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07233891P → L in HLD7. 1 PublicationCorresponds to variant dbSNP:rs1375717376Ensembl.1
Natural variantiVAR_072339310W → C in HLD7. 1 PublicationCorresponds to variant dbSNP:rs1217230904Ensembl.1
Natural variantiVAR_066516372D → N in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608673EnsemblClinVar.1
Natural variantiVAR_072340387A → G in HLD7. 1 PublicationCorresponds to variant dbSNP:rs1307896663Ensembl.1
Natural variantiVAR_066517558F → L in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608668EnsemblClinVar.1
Natural variantiVAR_072341602S → R in HLD7. 1 PublicationCorresponds to variant dbSNP:rs762708292Ensembl.1
Natural variantiVAR_066518636S → Y in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608676EnsemblClinVar.1
Natural variantiVAR_066519672G → E in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608670EnsemblClinVar.1
Natural variantiVAR_066520724C → Y in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608679EnsemblClinVar.1
Natural variantiVAR_066521775N → I in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608672EnsemblClinVar.1
Natural variantiVAR_072342804I → T in HLD7. 1 Publication1
Natural variantiVAR_066522852M → V in HLD7. 2 PublicationsCorresponds to variant dbSNP:rs267608671EnsemblClinVar.1
Natural variantiVAR_067004897I → N in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608681EnsemblClinVar.1
Natural variantiVAR_0665231005R → C in HLD7. 2 PublicationsCorresponds to variant dbSNP:rs267608682EnsemblClinVar.1
Natural variantiVAR_0665241247T → TT in HLD7. 1 Publication1
Natural variantiVAR_0723431261E → K in HLD7. 1 PublicationCorresponds to variant dbSNP:rs371703979Ensembl.1
Wiedemann-Rautenstrauch syndrome (WDRTS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, neonatal progeroid disorder characterized by intrauterine growth retardation, failure to thrive, short stature, hypotonia, variable mental impairment, and a progeroid appearance. Clinical features include apparent macrocephaly, sparse hair, prominent scalp veins, entropion, greatly widened anterior fontanelles, malar hypoplasia, and generalized lipoatrophy. Death usually occurs in early childhood but survival to third decade has been reported.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_081999254 – 1390Missing in WDRTS. 2 PublicationsAdd BLAST1137
Natural variantiVAR_082000669 – 1390Missing in WDRTS. 1 PublicationAdd BLAST722
Natural variantiVAR_082001825 – 1390Missing in WDRTS. 1 PublicationAdd BLAST566
Natural variantiVAR_082002873 – 1390Missing in WDRTS. 1 PublicationAdd BLAST518
Natural variantiVAR_082003903G → R in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0820041069R → Q in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0820051131K → R in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0820061292D → N in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0820071335G → R in WDRTS; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation, Leukodystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
11128

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
POLR3A

MalaCards human disease database

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MalaCardsi
POLR3A
MIMi264090 phenotype
607694 phenotype

Open Targets

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OpenTargetsi
ENSG00000148606

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
137639 Hypomyelinating leukodystrophy-ataxia-hypodontia-hypomyelination syndrome
447893 Hypomyelination-cerebellar atrophy-hypoplasia of the corpus callosum syndrome
88637 Hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome
77295 Odontoleukodystrophy
447896 Tremor-ataxia-central hypomyelination syndrome
3455 Wiedemann-Rautenstrauch syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134900426

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O14802

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
POLR3A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739471 – 1390DNA-directed RNA polymerase III subunit RPC1Add BLAST1390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei445N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O14802

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O14802

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O14802

MaxQB - The MaxQuant DataBase

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MaxQBi
O14802

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O14802

PeptideAtlas

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PeptideAtlasi
O14802

PRoteomics IDEntifications database

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PRIDEi
O14802

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
48248

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O14802

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O14802

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O14802

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the brain, in the cortex and the white matter (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148606 Expressed in 201 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O14802 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O14802 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037926

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116301, 90 interactors

Protein interaction database and analysis system

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IntActi
O14802, 35 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000361446

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni844 – 856Bridging helixBy similarityAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0260 Eukaryota
COG0086 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00930000151028

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000222974

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O14802

KEGG Orthology (KO)

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KOi
K03018

Identification of Orthologs from Complete Genome Data

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OMAi
AVCPPYN

Database of Orthologous Groups

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OrthoDBi
591636at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O14802

TreeFam database of animal gene trees

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TreeFami
TF103054

Family and domain databases

Conserved Domains Database

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CDDi
cd02736 RNAP_III_Rpc1_C, 1 hit
cd02583 RNAP_III_RPC1_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR042102 RNA_pol_Rpb1_3_sf
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR035698 RNAP_III_Rpc1_C
IPR035697 RNAP_III_RPC1_N
IPR038120 Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00663 RPOLA_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O14802-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKEQFRETD VAKKISHICF GMKSPEEMRQ QAHIQVVSKN LYSQDNQHAP
60 70 80 90 100
LLYGVLDHRM GTSEKDRPCE TCGKNLADCL GHYGYIDLEL PCFHVGYFRA
110 120 130 140 150
VIGILQMICK TCCHIMLSQE EKKQFLDYLK RPGLTYLQKR GLKKKISDKC
160 170 180 190 200
RKKNICHHCG AFNGTVKKCG LLKIIHEKYK TNKKVVDPIV SNFLQSFETA
210 220 230 240 250
IEHNKEVEPL LGRAQENLNP LVVLNLFKRI PAEDVPLLLM NPEAGKPSDL
260 270 280 290 300
ILTRLLVPPL CIRPSVVSDL KSGTNEDDLT MKLTEIIFLN DVIKKHRISG
310 320 330 340 350
AKTQMIMEDW DFLQLQCALY INSELSGIPL NMAPKKWTRG FVQRLKGKQG
360 370 380 390 400
RFRGNLSGKR VDFSGRTVIS PDPNLRIDEV AVPVHVAKIL TFPEKVNKAN
410 420 430 440 450
INFLRKLVQN GPEVHPGANF IQQRHTQMKR FLKYGNREKM AQELKYGDIV
460 470 480 490 500
ERHLIDGDVV LFNRQPSLHK LSIMAHLARV KPHRTFRFNE CVCTPYNADF
510 520 530 540 550
DGDEMNLHLP QTEEAKAEAL VLMGTKANLV TPRNGEPLIA AIQDFLTGAY
560 570 580 590 600
LLTLKDTFFD RAKACQIIAS ILVGKDEKIK VRLPPPTILK PVTLWTGKQI
610 620 630 640 650
FSVILRPSDD NPVRANLRTK GKQYCGKGED LCANDSYVTI QNSELMSGSM
660 670 680 690 700
DKGTLGSGSK NNIFYILLRD WGQNEAADAM SRLARLAPVY LSNRGFSIGI
710 720 730 740 750
GDVTPGQGLL KAKYELLNAG YKKCDEYIEA LNTGKLQQQP GCTAEETLEA
760 770 780 790 800
LILKELSVIR DHAGSACLRE LDKSNSPLTM ALCGSKGSFI NISQMIACVG
810 820 830 840 850
QQAISGSRVP DGFENRSLPH FEKHSKLPAA KGFVANSFYS GLTPTEFFFH
860 870 880 890 900
TMAGREGLVD TAVKTAETGY MQRRLVKSLE DLCSQYDLTV RSSTGDIIQF
910 920 930 940 950
IYGGDGLDPA AMEGKDEPLE FKRVLDNIKA VFPCPSEPAL SKNELILTTE
960 970 980 990 1000
SIMKKSEFLC CQDSFLQEIK KFIKGVSEKI KKTRDKYGIN DNGTTEPRVL
1010 1020 1030 1040 1050
YQLDRITPTQ VEKFLETCRD KYMRAQMEPG SAVGALCAQS IGEPGTQMTL
1060 1070 1080 1090 1100
KTFHFAGVAS MNITLGVPRI KEIINASKAI STPIITAQLD KDDDADYARL
1110 1120 1130 1140 1150
VKGRIEKTLL GEISEYIEEV FLPDDCFILV KLSLERIRLL RLEVNAETVR
1160 1170 1180 1190 1200
YSICTSKLRV KPGDVAVHGE AVVCVTPREN SKSSMYYVLQ FLKEDLPKVV
1210 1220 1230 1240 1250
VQGIPEVSRA VIHIDEQSGK EKYKLLVEGD NLRAVMATHG VKGTRTTSNN
1260 1270 1280 1290 1300
TYEVEKTLGI EAARTTIINE IQYTMVNHGM SIDRRHVMLL SDLMTYKGEV
1310 1320 1330 1340 1350
LGITRFGLAK MKESVLMLAS FEKTADHLFD AAYFGQKDSV CGVSECIIMG
1360 1370 1380 1390
IPMNIGTGLF KLLHKADRDP NPPKRPLIFD TNEFHIPLVT
Length:1,390
Mass (Da):155,641
Last modified:September 23, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56F30900848E3DB9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GMX2R4GMX2_HUMAN
DNA-directed RNA polymerase III sub...
POLR3A
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7Z755Q7Z755_HUMAN
DNA-directed RNA polymerase III sub...
POLR3A
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15I → T in AAB86536 (PubMed:9331371).Curated1
Sequence conflicti262I → F in AAB86536 (PubMed:9331371).Curated1
Sequence conflicti283L → P in AAM12029 (PubMed:12384934).Curated1
Sequence conflicti1056A → G in AAB86536 (PubMed:9331371).Curated1
Sequence conflicti1275M → MV in AAB86536 (PubMed:9331371).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07233891P → L in HLD7. 1 PublicationCorresponds to variant dbSNP:rs1375717376Ensembl.1
Natural variantiVAR_081999254 – 1390Missing in WDRTS. 2 PublicationsAdd BLAST1137
Natural variantiVAR_072339310W → C in HLD7. 1 PublicationCorresponds to variant dbSNP:rs1217230904Ensembl.1
Natural variantiVAR_066516372D → N in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608673EnsemblClinVar.1
Natural variantiVAR_072340387A → G in HLD7. 1 PublicationCorresponds to variant dbSNP:rs1307896663Ensembl.1
Natural variantiVAR_066517558F → L in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608668EnsemblClinVar.1
Natural variantiVAR_051873582R → L. Corresponds to variant dbSNP:rs34588967EnsemblClinVar.1
Natural variantiVAR_072341602S → R in HLD7. 1 PublicationCorresponds to variant dbSNP:rs762708292Ensembl.1
Natural variantiVAR_066518636S → Y in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608676EnsemblClinVar.1
Natural variantiVAR_082000669 – 1390Missing in WDRTS. 1 PublicationAdd BLAST722
Natural variantiVAR_066519672G → E in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608670EnsemblClinVar.1
Natural variantiVAR_051874713K → N. Corresponds to variant dbSNP:rs35354908Ensembl.1
Natural variantiVAR_066520724C → Y in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608679EnsemblClinVar.1
Natural variantiVAR_066521775N → I in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608672EnsemblClinVar.1
Natural variantiVAR_072342804I → T in HLD7. 1 Publication1
Natural variantiVAR_082001825 – 1390Missing in WDRTS. 1 PublicationAdd BLAST566
Natural variantiVAR_066522852M → V in HLD7. 2 PublicationsCorresponds to variant dbSNP:rs267608671EnsemblClinVar.1
Natural variantiVAR_082002873 – 1390Missing in WDRTS. 1 PublicationAdd BLAST518
Natural variantiVAR_067004897I → N in HLD7. 1 PublicationCorresponds to variant dbSNP:rs267608681EnsemblClinVar.1
Natural variantiVAR_082003903G → R in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0665231005R → C in HLD7. 2 PublicationsCorresponds to variant dbSNP:rs267608682EnsemblClinVar.1
Natural variantiVAR_0820041069R → Q in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0820051131K → R in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0665241247T → TT in HLD7. 1 Publication1
Natural variantiVAR_0723431261E → K in HLD7. 1 PublicationCorresponds to variant dbSNP:rs371703979Ensembl.1
Natural variantiVAR_0820061292D → N in WDRTS; unknown pathological significance. 1 Publication1
Natural variantiVAR_0820071335G → R in WDRTS; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF021351 mRNA Translation: AAB86536.1
AL512628 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54617.1
BC041089 mRNA Translation: AAH41089.1
AY091459 mRNA Translation: AAM12029.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7354.1

NCBI Reference Sequences

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RefSeqi
NP_008986.2, NM_007055.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372371; ENSP00000361446; ENSG00000148606

Database of genes from NCBI RefSeq genomes

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GeneIDi
11128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11128

UCSC genome browser

More...
UCSCi
uc001jzn.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF021351 mRNA Translation: AAB86536.1
AL512628 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54617.1
BC041089 mRNA Translation: AAH41089.1
AY091459 mRNA Translation: AAM12029.1
CCDSiCCDS7354.1
RefSeqiNP_008986.2, NM_007055.3

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116301, 90 interactors
IntActiO14802, 35 interactors
STRINGi9606.ENSP00000361446

PTM databases

iPTMnetiO14802
PhosphoSitePlusiO14802
SwissPalmiO14802

Polymorphism and mutation databases

BioMutaiPOLR3A

Proteomic databases

EPDiO14802
jPOSTiO14802
MassIVEiO14802
MaxQBiO14802
PaxDbiO14802
PeptideAtlasiO14802
PRIDEiO14802
ProteomicsDBi48248

Genome annotation databases

EnsembliENST00000372371; ENSP00000361446; ENSG00000148606
GeneIDi11128
KEGGihsa:11128
UCSCiuc001jzn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11128
DisGeNETi11128

GeneCards: human genes, protein and diseases

More...
GeneCardsi
POLR3A
GeneReviewsiPOLR3A
HGNCiHGNC:30074 POLR3A
HPAiHPA037926
MalaCardsiPOLR3A
MIMi264090 phenotype
607694 phenotype
614258 gene
neXtProtiNX_O14802
OpenTargetsiENSG00000148606
Orphaneti137639 Hypomyelinating leukodystrophy-ataxia-hypodontia-hypomyelination syndrome
447893 Hypomyelination-cerebellar atrophy-hypoplasia of the corpus callosum syndrome
88637 Hypomyelination-hypogonadotropic hypogonadism-hypodontia syndrome
77295 Odontoleukodystrophy
447896 Tremor-ataxia-central hypomyelination syndrome
3455 Wiedemann-Rautenstrauch syndrome
PharmGKBiPA134900426

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0260 Eukaryota
COG0086 LUCA
GeneTreeiENSGT00930000151028
HOGENOMiHOG000222974
InParanoidiO14802
KOiK03018
OMAiAVCPPYN
OrthoDBi591636at2759
PhylomeDBiO14802
TreeFamiTF103054

Enzyme and pathway databases

ReactomeiR-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
POLR3A human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11128
PharosiO14802

Protein Ontology

More...
PROi
PR:O14802

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148606 Expressed in 201 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiO14802 baseline and differential
GenevisibleiO14802 HS

Family and domain databases

CDDicd02736 RNAP_III_Rpc1_C, 1 hit
cd02583 RNAP_III_RPC1_N, 1 hit
Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
InterProiView protein in InterPro
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR042102 RNA_pol_Rpb1_3_sf
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR035698 RNAP_III_Rpc1_C
IPR035697 RNAP_III_RPC1_N
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O14802
Secondary accession number(s): Q8IW34, Q8TCW5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: September 18, 2019
This is version 172 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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