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Entry version 168 (03 Jul 2019)
Sequence version 4 (07 Nov 2018)
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Protein

Protein transport protein Sec16A

Gene

SEC16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:17192411, PubMed:17005010, PubMed:17428803, PubMed:21768384, PubMed:22355596). Mediates the recruitment of MIA3/TANGO to ERES (PubMed:28442536). Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane (PubMed:28067262). Positively regulates the protein stability of E3 ubiquitin-protein ligases RNF152 and RNF183 and the ER localization of RNF183 (PubMed:29300766). Acts as a RAB10 effector in the regulation of insulin-induced SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the cell membrane in adipocytes (By similarity).By similarity8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-204005 COPII-mediated vesicle transport

SIGNOR Signaling Network Open Resource

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SIGNORi
O15027

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein transport protein Sec16A
Alternative name(s):
SEC16 homolog A
Short name:
p2501 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC16A
Synonyms:KIAA0310, SEC16, SEC16L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29006 SEC16A

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612854 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15027

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9919

Open Targets

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OpenTargetsi
ENSG00000148396

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162402611

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SEC16A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507461 – 2357Protein transport protein Sec16AAdd BLAST2357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei296PhosphoserineCombined sources1
Modified residuei314PhosphoserineCombined sources1
Modified residuei331PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei593PhosphothreonineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1207PhosphoserineCombined sources1
Modified residuei1229PhosphoserineCombined sources1
Modified residuei1305PhosphoserineCombined sources1
Modified residuei1325PhosphothreonineCombined sources1
Modified residuei1327PhosphoserineCombined sources1
Modified residuei1347PhosphoserineCombined sources1
Modified residuei1350PhosphoserineCombined sources1
Modified residuei1356PhosphoserineCombined sources1
Modified residuei1359PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1369PhosphoserineCombined sources1
Modified residuei1573PhosphoserineCombined sources1
Modified residuei1601PhosphoserineCombined sources1
Modified residuei1907PhosphothreonineCombined sources1
Modified residuei1939PhosphoserineCombined sources1
Modified residuei1964PhosphoserineCombined sources1
Modified residuei2022PhosphoserineCombined sources1
Modified residuei2042PhosphoserineCombined sources1
Modified residuei2054PhosphothreonineCombined sources1
Modified residuei2056PhosphoserineCombined sources1
Modified residuei2073PhosphoserineCombined sources1
Modified residuei2083PhosphoserineCombined sources1
Modified residuei2271PhosphoserineCombined sources1
Modified residuei2291PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15027

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15027

MaxQB - The MaxQuant DataBase

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MaxQBi
O15027

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O15027

PeptideAtlas

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PeptideAtlasi
O15027

PRoteomics IDEntifications database

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PRIDEi
O15027

ProteomicsDB human proteome resource

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ProteomicsDBi
48383
48384 [O15027-2]
48385 [O15027-3]
48386 [O15027-4]
48387 [O15027-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15027

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15027

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at higher levels in the pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000148396 Expressed in 229 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15027 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15027 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA005684

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

SEC16A and SEC16B are each present in multiple copies in a heteromeric complex (PubMed:17192411, PubMed:22355596).

Interacts with SEC23A (PubMed:17192411, PubMed:17428803).

Interacts with RNF183 and RNF152 (PubMed:29300766).

Interacts with LRRK2 (via ROC domain) (PubMed:25201882).

Interacts with SEC13 (PubMed:25201882, PubMed:19638414, PubMed:17428803).

Interacts with RAB10 (By similarity).

Interacts with MIA3 (PubMed:28442536).

Interacts with GORASP2 in response to ER stress (PubMed:28067262).

By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115247, 197 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O15027

Database of interacting proteins

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DIPi
DIP-27588N

Protein interaction database and analysis system

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IntActi
O15027, 187 interactors

Molecular INTeraction database

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MINTi
O15027

STRING: functional protein association networks

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STRINGi
9606.ENSP00000325827

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15027

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1019 – 1890Required for localization to endoplasmic reticulum exit sites1 PublicationAdd BLAST872
Regioni1101 – 1400Interaction with MIA31 PublicationAdd BLAST300
Regioni1102 – 1405Required for endoplasmic reticulum localization1 PublicationAdd BLAST304
Regioni1434 – 1890Central conserved domain (CCD); mediates interaction with RNF183, LRRK2 and SEC133 PublicationsAdd BLAST457
Regioni2106 – 2357Required for interaction with SEC23A1 PublicationAdd BLAST252

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1113 – 1181Pro-richAdd BLAST69
Compositional biasi1159 – 1162Poly-Tyr4
Compositional biasi1591 – 1594Poly-Glu4
Compositional biasi1931 – 2285Pro-richAdd BLAST355

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC16 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1913 Eukaryota
ENOG4111J6D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159324

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15027

KEGG Orthology (KO)

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KOi
K20353

Identification of Orthologs from Complete Genome Data

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OMAi
LKKWVNK

Database of Orthologous Groups

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OrthoDBi
235062at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15027

TreeFam database of animal gene trees

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TreeFami
TF316276

Family and domain databases

Conserved Domains Database

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CDDi
cd09233 ACE1-Sec16-like, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O15027-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPPPQTVPS GMAGPPPAGN PRSVFWASSP YRRRANNNAA VAPTTCPLQP
60 70 80 90 100
VTDPFAFSRQ ALQSTPLGSS SKSSPPVLQG PAPAGFSQHP GLLVPHTHAR
110 120 130 140 150
DSSQGPCEPL PGPLTQPRAH ASPFSGALTP SAPPGPEMNR SAEVGPSSEP
160 170 180 190 200
EVQTLPYLPH YIPGVDPETS HGGHPHGNMP GLDRPLSRQN PHDGVVTPAA
210 220 230 240 250
SPSLPQPGLQ MPGQWGPVQG GPQPSGQHRS PCPEGPVPSG VPCATSVPHF
260 270 280 290 300
PTPSILHQGP GHEQHSPLVA PPAALPSDGR DEVSHLQSGS HLANNSDPES
310 320 330 340 350
TFRQNPRIVN HWASPELRQN PGVKNEHRPA SALVNPLARG DSPENRTHHP
360 370 380 390 400
LGAGAGSGCA PLEADSGASG ALAMFFQGGE TENEENLSSE KAGLSGQADF
410 420 430 440 450
DDFCSSPGLG RPPAPTHVGA GSLCQALLPG PSNEAAGDVW GDTASTGVPD
460 470 480 490 500
ASGSQYENVE NLEFVQNQEV LPSEPLNLDP SSPSDQFRYG PLPGPAVPRH
510 520 530 540 550
GAVCHTGAPD ATLHTVHPDS VSSSYSSRSH GRLSGSARPQ ELVGTFIQQE
560 570 580 590 600
VGKPEDEASG SFFKQIDSSP VGGETDETTV SQNYRGSVSQ PSTPSPPKPT
610 620 630 640 650
GIFQTSANSS FEPVKSHLVG VKPFEADRAN VVGEVRETCV RQKQCRPAAA
660 670 680 690 700
LPDASPGNLE QPPDNMETLC APQVCPLPLN STTEAVHMLP HAGAPPLDTV
710 720 730 740 750
YPAPEKRPSA RTQGPVKCES PATTLWAQSE LPDFGGNVLL APAAPALYVC
760 770 780 790 800
AKPQPPVVQP PEEAMSGQQS RNPSSAAPVQ SRGGIGASEN LENPPKMGEE
810 820 830 840 850
EALQSQASSG YASLLSSPPT ESLQNPPVLI AQPDHSYNLA QPINFSVSLS
860 870 880 890 900
NSHEKNQSWR EALVGDRPAV SSWALGGDSG ENTSLSGIPT SSVLSLSLPS
910 920 930 940 950
SVAQSNFPQG SGASEMVSNQ PANLLVQPPS QPVPENLVPE SQKDRKAGSA
960 970 980 990 1000
LPGFANSPAG STSVVLVPPA HGTLVPDGNK ANHSSHQEDT YGALDFTLSR
1010 1020 1030 1040 1050
TLENPVNVYN PSHSDSLASQ QSVASHPRQS GPGAPNLDRF YQQVTKDAQG
1060 1070 1080 1090 1100
QPGLERAQQE LVPPQQQASP PQLPKAMFSE LSNPESLPAQ GQAQNSAQSP
1110 1120 1130 1140 1150
ASLVLVDAGQ QLPPRPPQSS SVSLVSSGSG QAAVPSEQPW PQPVPALAPG
1160 1170 1180 1190 1200
PPPQDLAAYY YYRPLYDAYQ PQYSLPYPPE PGAASLYYQD VYSLYEPRYR
1210 1220 1230 1240 1250
PYDGAASAYA QNYRYPEPER PSSRASHSSE RPPPRQGYPE GYYSSKSGWS
1260 1270 1280 1290 1300
SQSDYYASYY SSQYDYGDPG HWDRYHYSAR VRDPRTYDRR YWCDAEYDAY
1310 1320 1330 1340 1350
RREHSAFGDR PEKRDNNWRY DPRFTGSFDD DPDPHRDPYG EEVDRRSVHS
1360 1370 1380 1390 1400
EHSARSLHSA HSLASRRSSL SSHSHQSQIY RSHNVAAGSY EAPLPPGSFH
1410 1420 1430 1440 1450
GDFAYGTYRS NFSSGPGFPE YGYPADTVWP AMEQVSSRPT SPEKFSVPHV
1460 1470 1480 1490 1500
CARFGPGGQL IKVIPNLPSE GQPALVEVHS MEALLQHTSE QEEMRAFPGP
1510 1520 1530 1540 1550
LAKDDTHKVD VINFAQNKAM KCLQNENLID KESASLLWNF IVLLCRQNGT
1560 1570 1580 1590 1600
VVGTDIAELL LRDHRTVWLP GKSPNEANLI DFTNEAVEQV EEEESGEAQL
1610 1620 1630 1640 1650
SFLTGGPAAA ASSLERETER FRELLLYGRK KDALESAMKN GLWGHALLLA
1660 1670 1680 1690 1700
SKMDSRTHAR VMTRFANSLP INDPLQTVYQ LMSGRMPAAS TCCGDEKWGD
1710 1720 1730 1740 1750
WRPHLAMVLS NLNNNMDVES RTMATMGDTL ASRGLLDAAH FCYLMAQAGF
1760 1770 1780 1790 1800
GVYTKKTTKL VLIGSNHSLP FLKFATNEAI QRTEAYEYAQ SLGAETCPLP
1810 1820 1830 1840 1850
SFQVFKFIYS CRLAEMGLAT QAFHYCEAIA KSILTQPHLY SPVLISQLVQ
1860 1870 1880 1890 1900
MASQLRLFDP QLKEKPEEES LAAPTWLVHL QQVERQIKEG AGVWHQDGAL
1910 1920 1930 1940 1950
PQQCPGTPSS EMEQLDRPGL SQPGALGIAN PLLAVPAPSP EHSSPSVRLL
1960 1970 1980 1990 2000
PSAPQTLPDG PLASPARVPM FPVPLPPGPL EPGPGCVTPG PALGFLEPSG
2010 2020 2030 2040 2050
PGLPPGVPPL QERRHLLQEA RSPDPGIVPQ EAPVGNSLSE LSEENFDGKF
2060 2070 2080 2090 2100
ANLTPSRTVP DSEAPPGWDR ADSGPTQPPL SLSPAPETKR PGQAAKKETK
2110 2120 2130 2140 2150
EPKKGESWFF RWLPGKKKTE AYLPDDKNKS IVWDEKKNQW VNLNEPEEEK
2160 2170 2180 2190 2200
KAPPPPPTSM PKTVQAAPPA LPGPPGAPVN MYSRRAAGTR ARYVDVLNPS
2210 2220 2230 2240 2250
GTQRSEPALA PADFVAPLAP LPIPSNLFVP TPDAEEPQLP DGTGREGPAA
2260 2270 2280 2290 2300
ARGLANPEPA PEPKVLSSAA SLPGSELPSS RPEGSQGGEL SRCSSMSSLS
2310 2320 2330 2340 2350
REVSQHFNQA PGDLPAAGGP PSGAMPFYNP AQLAQACATS GSSRLGRIGQ

RKHLVLN
Length:2,357
Mass (Da):251,894
Last modified:November 7, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAE9570BD5CD434B
GO
Isoform 2 (identifier: O15027-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2265-2309: Missing.

Note: No experimental confirmation available.
Show »
Length:2,312
Mass (Da):247,247
Checksum:i21A238D7B48C0C85
GO
Isoform 3 (identifier: O15027-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2290-2309: Missing.

Note: No experimental confirmation available.
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Length:2,337
Mass (Da):249,628
Checksum:iDFDABDD30C5D717D
GO
Isoform 4 (identifier: O15027-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2265-2289: Missing.

Show »
Length:2,332
Mass (Da):249,512
Checksum:i321487A041AC7D9F
GO
Isoform 5 (identifier: O15027-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2231-2231: T → TPVSSVRPQGRSGRNDGLLALSS

Note: No experimental confirmation available.
Show »
Length:2,379
Mass (Da):254,129
Checksum:i89093DD547B2FAA6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1T0I1F1T0I1_HUMAN
Protein transport protein sec16
SEC16A
2,334Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGP5X6RGP5_HUMAN
Protein transport protein sec16
SEC16A
1,059Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3F2YNX0A0A3F2YNX0_HUMAN
Protein transport protein sec16
SEC16A
2,134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3F2YNZ0A0A3F2YNZ0_HUMAN
Protein transport protein sec16
SEC16A
2,154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH09A0A0C4DH09_HUMAN
Protein transport protein Sec16A
SEC16A
751Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N9G1Q8N9G1_HUMAN
Protein transport protein Sec16A
SEC16A
385Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA20769 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1277Y → A in AAH28183 (PubMed:15489334).Curated1
Sequence conflicti2279S → P in AAH28183 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0233321039R → C. Corresponds to variant dbSNP:rs3812594Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0360292231T → TPVSSVRPQGRSGRNDGLLA LSS in isoform 5. 1 Publication1
Alternative sequenceiVSP_0152522265 – 2309Missing in isoform 2. CuratedAdd BLAST45
Alternative sequenceiVSP_0343702265 – 2289Missing in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0152532290 – 2309Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB002308 mRNA Translation: BAA20769.4 Different initiation.
AL592301 Genomic DNA No translation available.
DQ903855 mRNA Translation: ABI78944.1
BC008332 mRNA Translation: AAH08332.1
BC028183 mRNA Translation: AAH28183.1
BC098454 mRNA Translation: AAH98454.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS55351.1 [O15027-1]

NCBI Reference Sequences

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RefSeqi
NP_001263347.1, NM_001276418.1
NP_055681.1, NM_014866.1 [O15027-1]
XP_005266191.1, XM_005266134.2 [O15027-5]
XP_011517548.1, XM_011519246.2 [O15027-5]
XP_011517549.1, XM_011519247.1 [O15027-5]
XP_011517550.1, XM_011519248.2 [O15027-5]
XP_011517554.1, XM_011519252.2 [O15027-1]
XP_011517557.1, XM_011519255.2 [O15027-3]
XP_011517559.1, XM_011519257.1 [O15027-4]
XP_011517561.1, XM_011519259.1 [O15027-2]
XP_011517562.1, XM_011519260.2 [O15027-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000313050; ENSP00000325827; ENSG00000148396 [O15027-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9919

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9919

UCSC genome browser

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UCSCi
uc064xch.1 human [O15027-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002308 mRNA Translation: BAA20769.4 Different initiation.
AL592301 Genomic DNA No translation available.
DQ903855 mRNA Translation: ABI78944.1
BC008332 mRNA Translation: AAH08332.1
BC028183 mRNA Translation: AAH28183.1
BC098454 mRNA Translation: AAH98454.1
CCDSiCCDS55351.1 [O15027-1]
RefSeqiNP_001263347.1, NM_001276418.1
NP_055681.1, NM_014866.1 [O15027-1]
XP_005266191.1, XM_005266134.2 [O15027-5]
XP_011517548.1, XM_011519246.2 [O15027-5]
XP_011517549.1, XM_011519247.1 [O15027-5]
XP_011517550.1, XM_011519248.2 [O15027-5]
XP_011517554.1, XM_011519252.2 [O15027-1]
XP_011517557.1, XM_011519255.2 [O15027-3]
XP_011517559.1, XM_011519257.1 [O15027-4]
XP_011517561.1, XM_011519259.1 [O15027-2]
XP_011517562.1, XM_011519260.2 [O15027-5]

3D structure databases

SMRiO15027
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115247, 197 interactors
CORUMiO15027
DIPiDIP-27588N
IntActiO15027, 187 interactors
MINTiO15027
STRINGi9606.ENSP00000325827

PTM databases

iPTMnetiO15027
PhosphoSitePlusiO15027

Polymorphism and mutation databases

BioMutaiSEC16A

Proteomic databases

EPDiO15027
jPOSTiO15027
MaxQBiO15027
PaxDbiO15027
PeptideAtlasiO15027
PRIDEiO15027
ProteomicsDBi48383
48384 [O15027-2]
48385 [O15027-3]
48386 [O15027-4]
48387 [O15027-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313050; ENSP00000325827; ENSG00000148396 [O15027-1]
GeneIDi9919
KEGGihsa:9919
UCSCiuc064xch.1 human [O15027-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9919
DisGeNETi9919

GeneCards: human genes, protein and diseases

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GeneCardsi
SEC16A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0169092
HGNCiHGNC:29006 SEC16A
HPAiHPA005684
MIMi612854 gene
neXtProtiNX_O15027
OpenTargetsiENSG00000148396
PharmGKBiPA162402611

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1913 Eukaryota
ENOG4111J6D LUCA
GeneTreeiENSGT00940000159324
InParanoidiO15027
KOiK20353
OMAiLKKWVNK
OrthoDBi235062at2759
PhylomeDBiO15027
TreeFamiTF316276

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
SIGNORiO15027

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SEC16A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SEC16A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9919

Protein Ontology

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PROi
PR:O15027

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148396 Expressed in 229 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiO15027 baseline and differential
GenevisibleiO15027 HS

Family and domain databases

CDDicd09233 ACE1-Sec16-like, 1 hit
InterProiView protein in InterPro
IPR024298 ACE1_Sec16_Sec31
IPR024880 Sec16
IPR024340 Sec16_CCD
PfamiView protein in Pfam
PF12932 Sec16, 1 hit
PF12931 Sec16_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC16A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15027
Secondary accession number(s): A1YCA4
, J3KNL6, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 7, 2018
Last modified: July 3, 2019
This is version 168 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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