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Entry version 190 (31 Jul 2019)
Sequence version 3 (01 Mar 2005)
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Protein

Synaptojanin-2

Gene

SYNJ2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, RNA-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS01279-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptojanin-2 (EC:3.1.3.36By similarity)
Alternative name(s):
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNJ2
Synonyms:KIAA0348
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:11504 SYNJ2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609410 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15056

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8871

Open Targets

More...
OpenTargetsi
ENSG00000078269

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36286

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SYNJ2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002097331 – 1496Synaptojanin-2Add BLAST1496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1124PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15056

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O15056

MaxQB - The MaxQuant DataBase

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MaxQBi
O15056

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15056

PeptideAtlas

More...
PeptideAtlasi
O15056

PRoteomics IDEntifications database

More...
PRIDEi
O15056

ProteomicsDB human proteome resource

More...
ProteomicsDBi
48407 [O15056-1]
48408 [O15056-2]
48409 [O15056-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
O15056

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O15056

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O15056

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000078269 Expressed in 236 organ(s), highest expression level in inferior vagus X ganglion

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15056 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15056 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031575

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114391, 10 interactors

Protein interaction database and analysis system

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IntActi
O15056, 15 interactors

Molecular INTeraction database

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MINTi
O15056

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347792

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11496
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15056

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O15056

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 444SACPROSITE-ProRule annotationAdd BLAST325
Domaini889 – 968RRMPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni450 – ?CatalyticBy similarity

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1099 – 1114Pro-richAdd BLAST16
Compositional biasi1209 – 1334Pro-richAdd BLAST126

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptojanin family.Curated
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0566 Eukaryota
COG5329 LUCA
COG5411 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160715

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O15056

KEGG Orthology (KO)

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KOi
K20279

Identification of Orthologs from Complete Genome Data

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OMAi
KHYQVNC

Database of Orthologous Groups

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OrthoDBi
359616at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O15056

TreeFam database of animal gene trees

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TreeFami
TF354311

Family and domain databases

Conserved Domains Database

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CDDi
cd12720 RRM_SYNJ2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015047 DUF1866
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR002013 SAC_dom
IPR034974 SYNJ2
IPR034973 SYNJ2_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR11200:SF148 PTHR11200:SF148, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08952 DUF1866, 1 hit
PF03372 Exo_endo_phos, 1 hit
PF02383 Syja_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01165 DUF1866, 1 hit
SM00128 IPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit
SSF56219 SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit
PS50275 SAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2B2 (identifier: O15056-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSKGLRLL GRLGAEGDCS VLLEARGRDD CLLFEAGTVA TLAPEEKEVI
60 70 80 90 100
KGQYGKLTDA YGCLGELRLK SGGTSLSFLV LVTGCTSVGR IPDAEIYKIT
110 120 130 140 150
ATDFYPLQEE AKEEERLIAL KKILSSGVFY FSWPNDGSRF DLTVRTQKQG
160 170 180 190 200
DDSSEWGNSF FWNQLLHVPL RQHQVSCCDW LLKIICGVVT IRTVYASHKQ
210 220 230 240 250
AKACLVSRVS CERTGTRFHT RGVNDDGHVS NFVETEQMIY MDDGVSSFVQ
260 270 280 290 300
IRGSVPLFWE QPGLQVGSHH LRLHRGLEAN APAFDRHMVL LKEQYGQQVV
310 320 330 340 350
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQF AKGGKLEKLE
360 370 380 390 400
TLLRPQLKLH WEDFDVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI
410 420 430 440 450
ALEVLHLQLK TLGLSSKPIV DRFVESFKAM WSLNGHSLSK VFTGSRALEG
460 470 480 490 500
KAKVGKLKDG ARSMSRTIQS NFFDGVKQEA IKLLLVGDVY GEEVADKGGM
510 520 530 540 550
LLDSTALLVT PRILKAMTER QSEFTNFKRI RIAMGTWNVN GGKQFRSNVL
560 570 580 590 600
RTAELTDWLL DSPQLSGATD SQDDSSPADI FAVGFEEMVE LSAGNIVNAS
610 620 630 640 650
TTNKKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA
660 670 680 690 700
IDTVKTGMGG KAGNKGAVGI RFQFHSTSFC FICSHLTAGQ SQVKERNEDY
710 720 730 740 750
KEITQKLCFP MGRNVFSHDY VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL
760 770 780 790 800
LEFDQLQLQK SSGKIFKDFH EGAINFGPTY KYDVGSAAYD TSDKCRTPAW
810 820 830 840 850
TDRVLWWRKK HPFDKTAGEL NLLDSDLDVD TKVRHTWSPG ALQYYGRAEL
860 870 880 890 900
QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVVVNLQSPT
910 920 930 940 950
LEEKNEFPED LRTELMQTLG SYGTIVLVRI NQGQMLVTFA DSHSALSVLD
960 970 980 990 1000
VDGMKVKGRA VKIRPKTKDW LKGLREEIIR KRDSMAPVSP TANSCLLEEN
1010 1020 1030 1040 1050
FDFTSLDYES EGDILEDDED YLVDEFNQPG VSDSELGGDD LSDVPGPTAL
1060 1070 1080 1090 1100
APPSKSPALT KKKQHPTYKD DADLVELKRE LEAVGEFRHR SPSRSLSVPN
1110 1120 1130 1140 1150
RPRPPQPPQR PPPPTGLMVK KSASDASISS GTHGQYSILQ TARLLPGAPQ
1160 1170 1180 1190 1200
QPPKARTGIS KPYNVKQIKT TNAQEAEAAI RCLLEARGGA SEEALSAVAP
1210 1220 1230 1240 1250
RDLEASSEPE PTPGAAKPET PQAPPLLPRR PPPRVPAIKK PTLRRTGKPL
1260 1270 1280 1290 1300
SPEEQFEQQT VHFTIGPPET SVEAPPVVTA PRVPPVPKPR TFQPGKAAER
1310 1320 1330 1340 1350
PSHRKPASDE APPGAGASVP PPLEAPPLVP KVPPRRKKSA PAAFHLQVLQ
1360 1370 1380 1390 1400
SNSQLLQGLT YNSSDSPSGH PPAAGTVFPQ GDFLSTSSAT SPDSDGTKAM
1410 1420 1430 1440 1450
KPEAAPLLGD YQDPFWNLLH HPKLLNNTWL SKSSDPLDSG TRSPKRDPID
1460 1470 1480 1490
PVSAGASAAK AELPPDHEHK TLGHWVTISD QEKRTALQVF DPLAKT
Length:1,496
Mass (Da):165,538
Last modified:March 1, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CC9E368585ACF21
GO
Isoform 2B1 (identifier: O15056-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1070-1114: Missing.

Note: No experimental confirmation available.
Show »
Length:1,451
Mass (Da):160,434
Checksum:i42E19A35A791EA6A
GO
Isoform 2A (identifier: O15056-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1249-1288: PLSPEEQFEQ...TAPRVPPVPK → IVFCSRSQAS...ASVDTSGSSV
     1289-1496: Missing.

Show »
Length:1,288
Mass (Da):143,445
Checksum:i9A4EAA3AA9AE2451
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2PR85A0A1W2PR85_HUMAN
Synaptojanin-2
SYNJ2
1,259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER60E7ER60_HUMAN
Synaptojanin-2
SYNJ2
839Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEV8H0YEV8_HUMAN
Synaptojanin-2
SYNJ2
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY56H7BY56_HUMAN
Synaptojanin-2
SYNJ2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TA15Q5TA15_HUMAN
Synaptojanin-2
SYNJ2
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH43277 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0245071468E → G1 PublicationCorresponds to variant dbSNP:rs2502601Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0129111070 – 1114Missing in isoform 2B1. CuratedAdd BLAST45
Alternative sequenceiVSP_0129121249 – 1288PLSPE…PPVPK → IVFCSRSQASQPCLLLQRHE FVRTVAAQRLASVDTSGSSV in isoform 2A. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_0129131289 – 1496Missing in isoform 2A. 1 PublicationAdd BLAST208

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY152396 mRNA Translation: AAN73051.1
AF318616 mRNA Translation: AAG46036.1
AL139330 Genomic DNA No translation available.
AF039945 mRNA Translation: AAD02178.1
AB002346 mRNA Translation: BAA20805.2
BC043277 mRNA Translation: AAH43277.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS5254.1 [O15056-1]

NCBI Reference Sequences

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RefSeqi
NP_001171559.1, NM_001178088.1
NP_003889.1, NM_003898.3 [O15056-1]
XP_006715655.1, XM_006715592.3 [O15056-3]
XP_011534527.1, XM_011536225.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000355585; ENSP00000347792; ENSG00000078269 [O15056-1]
ENST00000640338; ENSP00000492532; ENSG00000078269 [O15056-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8871

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:8871

UCSC genome browser

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UCSCi
uc003qqx.3 human [O15056-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY152396 mRNA Translation: AAN73051.1
AF318616 mRNA Translation: AAG46036.1
AL139330 Genomic DNA No translation available.
AF039945 mRNA Translation: AAD02178.1
AB002346 mRNA Translation: BAA20805.2
BC043277 mRNA Translation: AAH43277.1 Different initiation.
CCDSiCCDS5254.1 [O15056-1]
RefSeqiNP_001171559.1, NM_001178088.1
NP_003889.1, NM_003898.3 [O15056-1]
XP_006715655.1, XM_006715592.3 [O15056-3]
XP_011534527.1, XM_011536225.1

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UFWNMR-A882-963[»]
SMRiO15056
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114391, 10 interactors
IntActiO15056, 15 interactors
MINTiO15056
STRINGi9606.ENSP00000347792

PTM databases

DEPODiO15056
iPTMnetiO15056
PhosphoSitePlusiO15056

Polymorphism and mutation databases

BioMutaiSYNJ2

Proteomic databases

EPDiO15056
jPOSTiO15056
MaxQBiO15056
PaxDbiO15056
PeptideAtlasiO15056
PRIDEiO15056
ProteomicsDBi48407 [O15056-1]
48408 [O15056-2]
48409 [O15056-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355585; ENSP00000347792; ENSG00000078269 [O15056-1]
ENST00000640338; ENSP00000492532; ENSG00000078269 [O15056-3]
GeneIDi8871
KEGGihsa:8871
UCSCiuc003qqx.3 human [O15056-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8871
DisGeNETi8871

GeneCards: human genes, protein and diseases

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GeneCardsi
SYNJ2
HGNCiHGNC:11504 SYNJ2
HPAiHPA031575
MIMi609410 gene
neXtProtiNX_O15056
OpenTargetsiENSG00000078269
PharmGKBiPA36286

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0566 Eukaryota
COG5329 LUCA
COG5411 LUCA
GeneTreeiENSGT00940000160715
InParanoidiO15056
KOiK20279
OMAiKHYQVNC
OrthoDBi359616at2759
PhylomeDBiO15056
TreeFamiTF354311

Enzyme and pathway databases

BioCyciMetaCyc:HS01279-MONOMER
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SYNJ2 human
EvolutionaryTraceiO15056

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8871

Protein Ontology

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PROi
PR:O15056

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000078269 Expressed in 236 organ(s), highest expression level in inferior vagus X ganglion
ExpressionAtlasiO15056 baseline and differential
GenevisibleiO15056 HS

Family and domain databases

CDDicd12720 RRM_SYNJ2, 1 hit
Gene3Di3.30.70.330, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR015047 DUF1866
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR002013 SAC_dom
IPR034974 SYNJ2
IPR034973 SYNJ2_RRM
PANTHERiPTHR11200:SF148 PTHR11200:SF148, 1 hit
PfamiView protein in Pfam
PF08952 DUF1866, 1 hit
PF03372 Exo_endo_phos, 1 hit
PF02383 Syja_N, 1 hit
SMARTiView protein in SMART
SM01165 DUF1866, 1 hit
SM00128 IPPc, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50275 SAC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYNJ2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15056
Secondary accession number(s): Q5TA13
, Q5TA16, Q5TA19, Q86XK0, Q8IZA8, Q9H226
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 1, 2005
Last modified: July 31, 2019
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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