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1 to 25 of 155  Show
  1. 1
    Category: Function, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "The genomic organization and polymorphism analysis of the human Niemann-Pick C1 gene."
    Morris J.A., Zhang D., Coleman K.G., Nagle J., Pentchev P.G., Carstea E.D.
    Biochem. Biophys. Res. Commun. 261:493-498(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS.
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  3. 3
    "NPC1: complete genomic sequence, mutation analysis, and characterization of haplotypes."
    Bauer P., Knoblich R., Bauer C., Finckh U., Hufen A., Kropp J., Braun S., Kustermann-Kuhn B., Schmidt D., Harzer K., Rolfs A.
    Hum. Mutat. 19:30-38(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS NPC1 ARG-512; TRP-670; CYS-825; ILE-849; VAL-874; TYR-948; LEU-954; LEU-958; ALA-1007 AND THR-1061, VARIANTS ARG-215; ILE-642; VAL-858; GLY-971 AND VAL-1049.
    Category: Pathology & Biotech, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 5 other entries.

  4. 4
    "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Category: Sequences.
    Tissue: Cerebellum.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 12927 other entries.

  5. 5
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1173 other entries.

  6. 6
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS GLY-151 AND ILE-642.
    Category: Sequences.
    Tissue: Placenta.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50462 other entries.

  7. 7
    "Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization."
    Watari H., Blanchette-Mackie E.J., Dwyer N.K., Glick J.M., Patel S., Neufeld E.B., Brady R.O., Pentchev P.G., Strauss J.F. III
    Proc. Natl. Acad. Sci. U.S.A. 96:805-810(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DOMAIN, MUTAGENESIS OF CYS-63; 74-CYS-CYS-75; CYS-97 AND 1275-LEU--PHE-1278.
    Category: Function, Subcellular Location, Pathology & Biotech, Family & Domains.
    Source: UniProtKB/Swiss-Prot (reviewed).
  8. 8
    "Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein."
    Davies J.P., Ioannou Y.A.
    J. Biol. Chem. 275:24367-24374(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TOPOLOGY, GLYCOSYLATION.
    Category: Function, Subcellular Location, PTM / Processing.
    Source: UniProtKB/Swiss-Prot (reviewed).
  9. 9
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Category: Subcellular Location.
    Tissue: Placenta.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 37 other entries.

  10. 10
    "NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes."
    Infante R.E., Wang M.L., Radhakrishnan A., Kwon H.J., Brown M.S., Goldstein J.L.
    Proc. Natl. Acad. Sci. U.S.A. 105:15287-15292(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NPC2.
    Category: Function, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  11. 11
    "Identification of cholesterol-regulating genes by targeted RNAi screening."
    Bartz F., Kern L., Erz D., Zhu M., Gilbert D., Meinhof T., Wirkner U., Erfle H., Muckenthaler M., Pepperkok R., Runz H.
    Cell Metab. 10:63-75(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TMEM97.
    Category: Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  12. 12
    "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-135 AND ASN-524.
    Category: PTM / Processing.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 483 other entries.

  13. 13
    "NPC1/NPC2 function as a tag team duo to mobilize cholesterol."
    Subramanian K., Balch W.E.
    Proc. Natl. Acad. Sci. U.S.A. 105:15223-15224(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  14. 14
    "Transfer of cholesterol by the NPC team."
    Vance J.E.
    Cell Metab. 12:105-106(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  15. 15
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 18287 other entries.

  16. 16
    "Function of the Niemann-Pick type C proteins and their bypass by cyclodextrin."
    Vance J.E., Peake K.B.
    Curr. Opin. Lipidol. 22:204-209(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 other entries.

  17. 17
    Cited for: FUNCTION (MICROBIAL INFECTION), INTERACTION WITH EBOLAVIRUS GLYCOPROTEIN.
    Category: Function, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 9 other entries.

  18. 18
    "Interaction between TIM-1 and NPC1 Is Important for Cellular Entry of Ebola Virus."
    Kuroda M., Fujikura D., Nanbo A., Marzi A., Noyori O., Kajihara M., Maruyama J., Matsuno K., Miyamoto H., Yoshida R., Feldmann H., Takada A.
    J. Virol. 89:6481-6493(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIM1, FUNCTION (MICROBIAL INFECTION).
    Category: Function, Interaction.
    Source: UniProtKB/Swiss-Prot (reviewed).
  19. 19
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 6430 other entries.

  20. 20
    "Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol."
    Kwon H.J., Abi-Mosleh L., Wang M.L., Deisenhofer J., Goldstein J.L., Brown M.S., Infante R.E.
    Cell 137:1213-1224(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 23-252 OF MUTANT GLN-70; GLN-122 AND GLN-185 IN COMPLEX WITH CHOLESTEROL, FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-158 AND ASN-222, MUTAGENESIS OF 26-VAL-TRP-27; 39-ARG--ASN-41; ASN-41; ASN-70; 82-THR-LEU-83; 101-PHE-TYR-102; 106-ASN--PHE-108; 110-GLU--THR-112; ASN-122; 144-LEU-GLN-145; 146-TYR-TYR-147; 175-LEU-LEU-176; 180-ASP--ASP-182; ASN-185; 187-TYR-ASN-188; 191-GLU-TYR-192; 195-ASN-LYS-196; 197-ASP-ASN-198; 199-GLY-GLN-200; 202-PRO-PHE-203; 204-THR-ILE-205 AND GLY-660.
    Category: Function, Pathology & Biotech, PTM / Processing, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 7 other entries.

  21. 21
    "Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1."
    Wang H., Shi Y., Song J., Qi J., Lu G., Yan J., Gao G.F.
    Cell 164:258-268(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 374-620 IN COMPLEX WITH EBOLAVIRUS GLYCOPROTEIN GP, INTERACTION WITH EBOLAVIRUS GLYCOPROTEIN GP (MICROBIAL INFECTION), MUTAGENESIS OF 423-TYR-PRO-424; PHE-503; PHE-504 AND TYR-506, DISULFIDE BONDS.
    Category: Pathology & Biotech, PTM / Processing, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 6 other entries.

  22. 22
    "Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection."
    Gong X., Qian H., Zhou X., Wu J., Wan T., Cao P., Huang W., Zhao X., Wang X., Wang P., Shi Y., Gao G.F., Zhou Q., Yan N.
    Cell 165:1467-1478(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.43 ANGSTROMS), FUNCTION, INTERACTION WITH NPC2 AND WITH EBOLAVIRUS GLYCOPROTEIN GP, TOPOLOGY, GLYCOSYLATION AT ASN-122; ASN-135; ASN-158; ASN-185; ASN-222; ASN-524; ASN-572; ASN-598 AND ASN-1064, DISULFIDE BONDS, CHARACTERIZATION OF VARIANT NPC1 TRP-518, MUTAGENESIS OF 25-CYS--PRO-257; 175-LEU-LEU-176; 202-PRO-PHE-203 AND 249-PRO--PRO-257.
    Category: Function, Subcellular Location, Pathology & Biotech, PTM / Processing, Interaction, Structure, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  23. 23
    "Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions."
    Zhao Y., Ren J., Harlos K., Stuart D.I.
    FEBS Lett. 590:605-612(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 387-618, GLYCOSYLATION AT ASN-478; ASN-524; ASN-557; ASN-572 AND ASN-598, DISULFIDE BONDS.
    Category: PTM / Processing, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 5 other entries.

  24. 24
    "Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2."
    Li X., Saha P., Li J., Blobel G., Pfeffer S.R.
    Proc. Natl. Acad. Sci. U.S.A. 113:10079-10084(2016) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 374-620 IN COMPLEX WITH NPC2, DISULFIDE BONDS.
    Category: PTM / Processing, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 10 other entries.

  25. 25
    "3.3 A structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport."
    Li X., Lu F., Trinh M.N., Schmiege P., Seemann J., Wang J., Blobel G.
    Proc. Natl. Acad. Sci. U.S.A. 114:9116-9121(2017) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.33 ANGSTROMS) OF 334-1278, FUNCTION, TOPOLOGY, GLYCOSYLATION AT ASN-452; ASN-459; ASN-478; ASN-524; ASN-557; ASN-598; ASN-916; ASN-931; ASN-961; ASN-968 AND ASN-1064, MUTAGENESIS OF 230-SER--VAL-234; PRO-691 AND 909-CYS--ASP-917, DISULFIDE BONDS.
    Category: Function, Subcellular Location, Pathology & Biotech, PTM / Processing, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 5 other entries.

1 to 25 of 155  Show
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