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Entry version 171 (08 May 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Intermediate conductance calcium-activated potassium channel protein 4

Gene

KCNN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The channel is inhibited by clotrimazole and charybdotoxin but is insensitive to apamin.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Ion channel
Biological processImmunity, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1296052 Ca2+ activated K+ channels

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O15554

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.16.2 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intermediate conductance calcium-activated potassium channel protein 4
Short name:
SK4
Short name:
SKCa 4
Short name:
SKCa4
Alternative name(s):
IKCa1
Short name:
IK1
KCa3.1
KCa4
Putative Gardos channel
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNN4
Synonyms:IK1, IKCA1, KCA4, SK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6293 KCNN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602754 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O15554

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49Helical; Name=Segment S1Sequence analysisAdd BLAST21
Transmembranei59 – 79Helical; Name=Segment S2Sequence analysisAdd BLAST21
Transmembranei108 – 128Helical; Name=Segment S3Sequence analysisAdd BLAST21
Transmembranei143 – 163Helical; Name=Segment S4Sequence analysisAdd BLAST21
Transmembranei207 – 227Helical; Name=Segment S5Sequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei241 – 261Pore-forming; Name=Segment H5Sequence analysisAdd BLAST21
Transmembranei265 – 285Helical; Name=Segment S6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Dehydrated hereditary stomatocytosis 2 (DHS2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. Erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. Affected individuals typically manifest mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Their red cells exhibit a panel of various shape abnormalities such as elliptocytes, hemighosts, schizocytes, and very rare stomatocytic cells. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_074485282V → E in DHS2. 1 PublicationCorresponds to variant dbSNP:rs1057519077EnsemblClinVar.1
Natural variantiVAR_074486282V → M in DHS2. 2 PublicationsCorresponds to variant dbSNP:rs1057519076EnsemblClinVar.1
Natural variantiVAR_074487352R → H in DHS2; no effect on plasma membrane localization; increases calcium-activated potassium channel activity. 2 PublicationsCorresponds to variant dbSNP:rs774455945EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi250T → S: Loss of sensitivity to triarylmethanes. 1 Publication1
Mutagenesisi275V → A: Loss of sensitivity to triarylmethanes. 1 Publication1

Keywords - Diseasei

Disease mutation, Hereditary hemolytic anemia

Organism-specific databases

DisGeNET

More...
DisGeNETi
3783

MalaCards human disease database

More...
MalaCardsi
KCNN4
MIMi616689 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000104783

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3202 Dehydrated hereditary stomatocytosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA222

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4305

Drug and drug target database

More...
DrugBanki
DB00257 Clotrimazole
DB00228 Enflurane
DB01159 Halothane
DB01110 Miconazole
DB00721 Procaine
DB00468 Quinine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
384

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNN4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001550171 – 427Intermediate conductance calcium-activated potassium channel protein 4Add BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei358Phosphohistidine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O15554

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O15554

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O15554

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O15554

PeptideAtlas

More...
PeptideAtlasi
O15554

PRoteomics IDEntifications database

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PRIDEi
O15554

ProteomicsDB human proteome resource

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ProteomicsDBi
48757

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O15554

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O15554

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O15554

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in non-excitable tissues.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by phorbol myristate acetate (PMA) and phytohemagglutinin (PHA) in T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104783 Expressed in 151 organ(s), highest expression level in minor salivary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O15554 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O15554 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053841
HPA059622

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of potassium channel proteins (Probable).

Interacts with MTMR6.

Curated2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109984, 7 interactors

Database of interacting proteins

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DIPi
DIP-48598N

Protein interaction database and analysis system

More...
IntActi
O15554, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262888

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O15554

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O15554

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni286 – 347Calmodulin-bindingAdd BLAST62

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3684 Eukaryota
ENOG410XT9D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182904

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000276908

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O15554

KEGG Orthology (KO)

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KOi
K04945

Identification of Orthologs from Complete Genome Data

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OMAi
AEMLWFG

Database of Orthologous Groups

More...
OrthoDBi
1179130at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O15554

TreeFam database of animal gene trees

More...
TreeFami
TF315015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10153 PTHR10153, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01053 CaMBD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81327 SSF81327, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

O15554-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGDLVLGLG ALRRRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG
60 70 80 90 100
GCSWALYLFL VKCTISISTF LLLCLIVAFH AKEVQLFMTD NGLRDWRVAL
110 120 130 140 150
TGRQAAQIVL ELVVCGLHPA PVRGPPCVQD LGAPLTSPQP WPGFLGQGEA
160 170 180 190 200
LLSLAMLLRL YLVPRAVLLR SGVLLNASYR SIGALNQVRF RHWFVAKLYM
210 220 230 240 250
NTHPGRLLLG LTLGLWLTTA WVLSVAERQA VNATGHLSDT LWLIPITFLT
260 270 280 290 300
IGYGDVVPGT MWGKIVCLCT GVMGVCCTAL LVAVVARKLE FNKAEKHVHN
310 320 330 340 350
FMMDIQYTKE MKESAARVLQ EAWMFYKHTR RKESHAARRH QRKLLAAINA
360 370 380 390 400
FRQVRLKHRK LREQVNSMVD ISKMHMILYD LQQNLSSSHR ALEKQIDTLA
410 420
GKLDALTELL STALGPRQLP EPSQQSK
Length:427
Mass (Da):47,696
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23F9AF66609B410F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D1MQ08D1MQ08_HUMAN
Intermediate conductance calcium-ac...
KCNN4
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2E8M0R2E8_HUMAN
Intermediate conductance calcium-ac...
KCNN4
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1J0M0R1J0_HUMAN
Intermediate conductance calcium-ac...
KCNN4
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZ70M0QZ70_HUMAN
Intermediate conductance calcium-ac...
KCNN4
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2F1M0R2F1_HUMAN
Intermediate conductance calcium-ac...
KCNN4
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66S → G in AAK81862 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074485282V → E in DHS2. 1 PublicationCorresponds to variant dbSNP:rs1057519077EnsemblClinVar.1
Natural variantiVAR_074486282V → M in DHS2. 2 PublicationsCorresponds to variant dbSNP:rs1057519076EnsemblClinVar.1
Natural variantiVAR_074487352R → H in DHS2; no effect on plasma membrane localization; increases calcium-activated potassium channel activity. 2 PublicationsCorresponds to variant dbSNP:rs774455945EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF000972 mRNA Translation: AAB82739.1
AF022150 mRNA Translation: AAC23541.1
AF022797 mRNA Translation: AAC51913.1
AF033021 mRNA Translation: AAC36804.1
AF305735
, AF305731, AF305732, AF305733, AF305734 Genomic DNA Translation: AAG26917.1
AF395661 mRNA Translation: AAK81862.1
BT007426 mRNA Translation: AAP36094.1
CH471126 Genomic DNA Translation: EAW57230.1
BC015337 mRNA Translation: AAH15337.1
AF053403 mRNA Translation: AAC35281.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12630.1

NCBI Reference Sequences

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RefSeqi
NP_002241.1, NM_002250.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262888; ENSP00000262888; ENSG00000104783
ENST00000648319; ENSP00000496939; ENSG00000104783

Database of genes from NCBI RefSeq genomes

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GeneIDi
3783

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3783

UCSC genome browser

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UCSCi
uc002oxl.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000972 mRNA Translation: AAB82739.1
AF022150 mRNA Translation: AAC23541.1
AF022797 mRNA Translation: AAC51913.1
AF033021 mRNA Translation: AAC36804.1
AF305735
, AF305731, AF305732, AF305733, AF305734 Genomic DNA Translation: AAG26917.1
AF395661 mRNA Translation: AAK81862.1
BT007426 mRNA Translation: AAP36094.1
CH471126 Genomic DNA Translation: EAW57230.1
BC015337 mRNA Translation: AAH15337.1
AF053403 mRNA Translation: AAC35281.1
CCDSiCCDS12630.1
RefSeqiNP_002241.1, NM_002250.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6CNMelectron microscopy3.40A/B/C/D1-427[»]
6CNNelectron microscopy3.50A/B/C/D1-427[»]
6CNOelectron microscopy4.70A/B/C/D1-427[»]
6D42X-ray1.75A/B376-415[»]
SMRiO15554
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109984, 7 interactors
DIPiDIP-48598N
IntActiO15554, 11 interactors
STRINGi9606.ENSP00000262888

Chemistry databases

BindingDBiO15554
ChEMBLiCHEMBL4305
DrugBankiDB00257 Clotrimazole
DB00228 Enflurane
DB01159 Halothane
DB01110 Miconazole
DB00721 Procaine
DB00468 Quinine
GuidetoPHARMACOLOGYi384

Protein family/group databases

TCDBi1.A.1.16.2 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiO15554
PhosphoSitePlusiO15554
SwissPalmiO15554

Polymorphism and mutation databases

BioMutaiKCNN4

Proteomic databases

EPDiO15554
jPOSTiO15554
MaxQBiO15554
PaxDbiO15554
PeptideAtlasiO15554
PRIDEiO15554
ProteomicsDBi48757

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3783
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262888; ENSP00000262888; ENSG00000104783
ENST00000648319; ENSP00000496939; ENSG00000104783
GeneIDi3783
KEGGihsa:3783
UCSCiuc002oxl.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3783
DisGeNETi3783

GeneCards: human genes, protein and diseases

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GeneCardsi
KCNN4
HGNCiHGNC:6293 KCNN4
HPAiHPA053841
HPA059622
MalaCardsiKCNN4
MIMi602754 gene
616689 phenotype
neXtProtiNX_O15554
OpenTargetsiENSG00000104783
Orphaneti3202 Dehydrated hereditary stomatocytosis
PharmGKBiPA222

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3684 Eukaryota
ENOG410XT9D LUCA
GeneTreeiENSGT00950000182904
HOGENOMiHOG000276908
InParanoidiO15554
KOiK04945
OMAiAEMLWFG
OrthoDBi1179130at2759
PhylomeDBiO15554
TreeFamiTF315015

Enzyme and pathway databases

ReactomeiR-HSA-1296052 Ca2+ activated K+ channels
SIGNORiO15554

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCNN4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KCNN4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3783

Protein Ontology

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PROi
PR:O15554

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104783 Expressed in 151 organ(s), highest expression level in minor salivary gland
ExpressionAtlasiO15554 baseline and differential
GenevisibleiO15554 HS

Family and domain databases

InterProiView protein in InterPro
IPR004178 CaM-bd_dom
IPR036122 CaM-bd_dom_sf
IPR015449 K_chnl_Ca-activ_SK
IPR013099 K_chnl_dom
PANTHERiPTHR10153 PTHR10153, 1 hit
PfamiView protein in Pfam
PF02888 CaMBD, 1 hit
PF07885 Ion_trans_2, 1 hit
PF03530 SK_channel, 1 hit
SMARTiView protein in SMART
SM01053 CaMBD, 1 hit
SUPFAMiSSF81327 SSF81327, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNN4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O15554
Secondary accession number(s): Q53XR4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: January 1, 1998
Last modified: May 8, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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