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Entry version 191 (03 Jul 2019)
Sequence version 4 (16 Mar 2016)
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Protein

Neuronal migration protein doublecortin

Gene

DCX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-447043 Neurofascin interactions

SIGNOR Signaling Network Open Resource

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SIGNORi
O43602

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neuronal migration protein doublecortin
Alternative name(s):
Doublin
Lissencephalin-X
Short name:
Lis-X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCX
Synonyms:DBCN, LISX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:2714 DCX

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300121 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43602

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lissencephaly, X-linked 1 (LISX1)7 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02602242T → I in LISX1. 1 Publication1
Natural variantiVAR_00781943L → S in LISX1. 1 PublicationCorresponds to variant dbSNP:rs587783521EnsemblClinVar.1
Natural variantiVAR_00782047S → R in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894783EnsemblClinVar.1
Natural variantiVAR_00782159R → L in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs122457137EnsemblClinVar.1
Natural variantiVAR_02602460N → D in LISX1. 1 Publication1
Natural variantiVAR_00782362D → N in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs104894779EnsemblClinVar.1
Natural variantiVAR_02602671A → S in LISX1. 1 PublicationCorresponds to variant dbSNP:rs104894786EnsemblClinVar.1
Natural variantiVAR_007826100G → A in LISX1 and SBHX. 2 Publications1
Natural variantiVAR_007827102R → S in LISX1. 1 Publication1
Natural variantiVAR_007828125Y → H in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs104894781EnsemblClinVar.1
Natural variantiVAR_007833192R → W in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894780EnsemblClinVar.1
Natural variantiVAR_026031196R → H in LISX1. 2 PublicationsCorresponds to variant dbSNP:rs56030372EnsemblClinVar.1
Natural variantiVAR_007835203T → R in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894782EnsemblClinVar.1
Natural variantiVAR_026036243F → L in LISX1. 1 Publication1
Natural variantiVAR_077482262D → G in LISX1 and SBHX; decreased tubulin binding. 1 PublicationCorresponds to variant dbSNP:rs398124557EnsemblClinVar.1
Subcortical band heterotopia X-linked (SBHX)8 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSBHX is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00782047S → R in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894783EnsemblClinVar.1
Natural variantiVAR_02602350K → N in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783523EnsemblClinVar.1
Natural variantiVAR_00782259R → H in SBHX. 1 PublicationCorresponds to variant dbSNP:rs122457137EnsemblClinVar.1
Natural variantiVAR_00782159R → L in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs122457137EnsemblClinVar.1
Natural variantiVAR_00782362D → N in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs104894779EnsemblClinVar.1
Natural variantiVAR_02602567G → E in SBHX. 1 Publication1
Natural variantiVAR_00782478R → L in SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894784EnsemblClinVar.1
Natural variantiVAR_00782586D → H in SBHX. 1 Publication1
Natural variantiVAR_01053689R → G in SBHX; mild. 2 PublicationsCorresponds to variant dbSNP:rs104894785EnsemblClinVar.1
Natural variantiVAR_02602797L → R in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783537EnsemblClinVar.1
Natural variantiVAR_007826100G → A in LISX1 and SBHX. 2 Publications1
Natural variantiVAR_026028104I → T in SBHX. 1 Publication1
Natural variantiVAR_007829125Y → D in SBHX. 1 Publication1
Natural variantiVAR_007828125Y → H in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs104894781EnsemblClinVar.1
Natural variantiVAR_026029178R → C in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783558EnsemblClinVar.1
Natural variantiVAR_007830178R → L in SBHX. Corresponds to variant dbSNP:rs587783559EnsemblClinVar.1
Natural variantiVAR_007831186R → C in SBHX. 3 PublicationsCorresponds to variant dbSNP:rs587783562EnsemblClinVar.1
Natural variantiVAR_026030191P → L in SBHX. 1
Natural variantiVAR_007832191P → R in SBHX. Corresponds to variant dbSNP:rs587783566EnsemblClinVar.1
Natural variantiVAR_007833192R → W in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894780EnsemblClinVar.1
Natural variantiVAR_026033200N → I in SBHX. 1 Publication1
Natural variantiVAR_007834200N → K in SBHX. 2 Publications1
Natural variantiVAR_026034203T → A in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783570EnsemblClinVar.1
Natural variantiVAR_007835203T → R in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894782EnsemblClinVar.1
Natural variantiVAR_007836214I → T in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783574EnsemblClinVar.1
Natural variantiVAR_007837222T → I in SBHX. 1
Natural variantiVAR_007838223G → E in SBHX. 1 Publication1
Natural variantiVAR_026035223G → V in SBHX. 1 Publication1
Natural variantiVAR_007839236V → I in SBHX. Corresponds to variant dbSNP:rs1324159050Ensembl.1
Natural variantiVAR_007840250I → N in SBHX. 1
Natural variantiVAR_007841250I → T in SBHX. 1 Publication1
Natural variantiVAR_026037251A → S in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783585EnsemblClinVar.1
Natural variantiVAR_026038251A → V in SBHX. 1 Publication1
Natural variantiVAR_007842253G → D in SBHX. 1
Natural variantiVAR_077482262D → G in LISX1 and SBHX; decreased tubulin binding. 1 PublicationCorresponds to variant dbSNP:rs398124557EnsemblClinVar.1
A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1).

Keywords - Diseasei

Disease mutation, Epilepsy, Lissencephaly

Organism-specific databases

DisGeNET

More...
DisGeNETi
1641

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
DCX

MalaCards human disease database

More...
MalaCardsi
DCX
MIMi300067 phenotype

Open Targets

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OpenTargetsi
ENSG00000077279

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
2148 Lissencephaly type 1 due to doublecortin gene mutation
99796 Subcortical band heterotopia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27184

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCX

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000798331 – 365Neuronal migration protein doublecortinAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14Phosphothreonine; by PKCSequence analysis1
Modified residuei28Phosphoserine; by CDK5By similarity1
Modified residuei47Phosphoserine; by MARK1 and PKABy similarity1
Modified residuei70Phosphotyrosine; by ABLSequence analysis1
Modified residuei74Phosphoserine; by PKCSequence analysis1
Modified residuei90Phosphoserine; by CK2Sequence analysis1
Modified residuei110Phosphoserine; by PKCSequence analysis1
Modified residuei115Phosphoserine; by CK2, MARK1 and PKABy similarity1
Modified residuei265Phosphoserine; by CK2By similarity1
Modified residuei287Phosphoserine; by CDK5By similarity1
Modified residuei289Phosphothreonine; by CDK5By similarity1
Modified residuei294Phosphoserine; by PKCSequence analysis1
Modified residuei297Phosphoserine; by CDK5By similarity1
Modified residuei306Phosphoserine; by CK2Sequence analysisBy similarity1
Modified residuei306Phosphoserine; by DYRK21 Publication1
Modified residuei326Phosphothreonine; by CDK5By similarity1
Modified residuei326Phosphothreonine; by PKC and MAPKSequence analysis1
Modified residuei332Phosphoserine; by CDK5By similarity1
Modified residuei332Phosphoserine; by MAPKSequence analysis1
Modified residuei336Phosphothreonine; by MAPKSequence analysis1
Modified residuei339Phosphoserine; by CDK5By similarity1
Modified residuei339Phosphoserine; by MAPKSequence analysis1
Modified residuei342Phosphoserine; by PKCSequence analysis1
Modified residuei354Phosphoserine; by CK2Sequence analysis1
Modified residuei360Phosphoserine; by CK2Sequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (By similarity).By similarity
Ubiquitinated by MDM2, leading to its degradation by the proteasome. Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43602

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43602

PeptideAtlas

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PeptideAtlasi
O43602

PRoteomics IDEntifications database

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PRIDEi
O43602

ProteomicsDB human proteome resource

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ProteomicsDBi
49072
49073 [O43602-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43602

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43602

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000077279 Expressed in 88 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O43602 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43602 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA036121

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tubulin (PubMed:27292316).

Interacts with USP9X (PubMed:24607389).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108008, 45 interactors

Protein interaction database and analysis system

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IntActi
O43602, 26 interactors

Molecular INTeraction database

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MINTi
O43602

STRING: functional protein association networks

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STRINGi
9606.ENSP00000337697

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43602

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O43602

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 139Doublecortin 1PROSITE-ProRule annotationAdd BLAST87
Domaini180 – 263Doublecortin 2PROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi287 – 365Pro/Ser-richAdd BLAST79

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3757 Eukaryota
ENOG410ZE6Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161570

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O43602

KEGG Orthology (KO)

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KOi
K16579

Database of Orthologous Groups

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OrthoDBi
330091at2759

TreeFam database of animal gene trees

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TreeFami
TF318770

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01617 DCX, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.20.230, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017302 Doublecortin_chordata
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR040163 RP1/RP1L1/DCX

The PANTHER Classification System

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PANTHERi
PTHR23005 PTHR23005, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF03607 DCX, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF037870 Doublin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00537 DCX, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF89837 SSF89837, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50309 DC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O43602-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MELDFGHFDE RDKTSRNMRG SRMNGLPSPT HSAHCSFYRT RTLQALSNEK
60 70 80 90 100
KAKKVRFYRN GDRYFKGIVY AVSSDRFRSF DALLADLTRS LSDNINLPQG
110 120 130 140 150
VRYIYTIDGS RKIGSMDELE EGESYVCSSD NFFKKVEYTK NVNPNWSVNV
160 170 180 190 200
KTSANMKAPQ SLASSNSAQA RENKDFVRPK LVTIIRSGVK PRKAVRVLLN
210 220 230 240 250
KKTAHSFEQV LTDITEAIKL ETGVVKKLYT LDGKQVTCLH DFFGDDDVFI
260 270 280 290 300
ACGPEKFRYA QDDFSLDENE CRVMKGNPSA TAGPKASPTP QKTSAKSPGP
310 320 330 340 350
MRRSKSPADS GNDQDANGTS SSQLSTPKSK QSPISTPTSP GSLRKHKDLY
360
LPLSLDDSDS LGDSM
Length:365
Mass (Da):40,574
Last modified:March 16, 2016 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E859F2114CC3BB1
GO
Isoform 2 (identifier: O43602-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-315: SGNDQD → S

Show »
Length:360
Mass (Da):40,044
Checksum:i91D0D89433AF52A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8K340A8K340_HUMAN
Neuronal migration protein doubleco...
DCX
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BLV5H3BLV5_HUMAN
Neuronal migration protein doubleco...
DCX
360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GWD1A0A1B0GWD1_HUMAN
Neuronal migration protein doubleco...
DCX
361Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU50E7EU50_HUMAN
Neuronal migration protein doubleco...
DCX
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUE1A0A1B0GUE1_HUMAN
Neuronal migration protein doubleco...
DCX
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAX02642 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAX02644 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAX02649 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02602242T → I in LISX1. 1 Publication1
Natural variantiVAR_00781943L → S in LISX1. 1 PublicationCorresponds to variant dbSNP:rs587783521EnsemblClinVar.1
Natural variantiVAR_00782047S → R in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894783EnsemblClinVar.1
Natural variantiVAR_02602350K → N in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783523EnsemblClinVar.1
Natural variantiVAR_00782259R → H in SBHX. 1 PublicationCorresponds to variant dbSNP:rs122457137EnsemblClinVar.1
Natural variantiVAR_00782159R → L in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs122457137EnsemblClinVar.1
Natural variantiVAR_02602460N → D in LISX1. 1 Publication1
Natural variantiVAR_00782362D → N in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs104894779EnsemblClinVar.1
Natural variantiVAR_02602567G → E in SBHX. 1 Publication1
Natural variantiVAR_02602671A → S in LISX1. 1 PublicationCorresponds to variant dbSNP:rs104894786EnsemblClinVar.1
Natural variantiVAR_01020278R → H in SBH. 1 PublicationCorresponds to variant dbSNP:rs104894784EnsemblClinVar.1
Natural variantiVAR_00782478R → L in SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894784EnsemblClinVar.1
Natural variantiVAR_00782586D → H in SBHX. 1 Publication1
Natural variantiVAR_01053689R → G in SBHX; mild. 2 PublicationsCorresponds to variant dbSNP:rs104894785EnsemblClinVar.1
Natural variantiVAR_02602797L → R in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783537EnsemblClinVar.1
Natural variantiVAR_007826100G → A in LISX1 and SBHX. 2 Publications1
Natural variantiVAR_007827102R → S in LISX1. 1 Publication1
Natural variantiVAR_026028104I → T in SBHX. 1 Publication1
Natural variantiVAR_007829125Y → D in SBHX. 1 Publication1
Natural variantiVAR_007828125Y → H in LISX1 and SBHX. 1 PublicationCorresponds to variant dbSNP:rs104894781EnsemblClinVar.1
Natural variantiVAR_026029178R → C in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783558EnsemblClinVar.1
Natural variantiVAR_007830178R → L in SBHX. Corresponds to variant dbSNP:rs587783559EnsemblClinVar.1
Natural variantiVAR_007831186R → C in SBHX. 3 PublicationsCorresponds to variant dbSNP:rs587783562EnsemblClinVar.1
Natural variantiVAR_026030191P → L in SBHX. 1
Natural variantiVAR_007832191P → R in SBHX. Corresponds to variant dbSNP:rs587783566EnsemblClinVar.1
Natural variantiVAR_007833192R → W in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894780EnsemblClinVar.1
Natural variantiVAR_026031196R → H in LISX1. 2 PublicationsCorresponds to variant dbSNP:rs56030372EnsemblClinVar.1
Natural variantiVAR_026032196R → S in epilepsy; resistant partial seizures; related to 'cryptogenic' epilepsy. 1 PublicationCorresponds to variant dbSNP:rs587783568EnsemblClinVar.1
Natural variantiVAR_026033200N → I in SBHX. 1 Publication1
Natural variantiVAR_007834200N → K in SBHX. 2 Publications1
Natural variantiVAR_026034203T → A in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783570EnsemblClinVar.1
Natural variantiVAR_007835203T → R in LISX1 and SBHX. 2 PublicationsCorresponds to variant dbSNP:rs104894782EnsemblClinVar.1
Natural variantiVAR_007836214I → T in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783574EnsemblClinVar.1
Natural variantiVAR_007837222T → I in SBHX. 1
Natural variantiVAR_007838223G → E in SBHX. 1 Publication1
Natural variantiVAR_026035223G → V in SBHX. 1 Publication1
Natural variantiVAR_007839236V → I in SBHX. Corresponds to variant dbSNP:rs1324159050Ensembl.1
Natural variantiVAR_026036243F → L in LISX1. 1 Publication1
Natural variantiVAR_007840250I → N in SBHX. 1
Natural variantiVAR_007841250I → T in SBHX. 1 Publication1
Natural variantiVAR_026037251A → S in SBHX. 1 PublicationCorresponds to variant dbSNP:rs587783585EnsemblClinVar.1
Natural variantiVAR_026038251A → V in SBHX. 1 Publication1
Natural variantiVAR_007842253G → D in SBHX. 1
Natural variantiVAR_077482262D → G in LISX1 and SBHX; decreased tubulin binding. 1 PublicationCorresponds to variant dbSNP:rs398124557EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058155310 – 315SGNDQD → S in isoform 2. 4 Publications6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ003112 mRNA Translation: CAA05867.1
AJ005592
, AJ005593, AJ005594, AJ005595, AJ005596, AJ005597 Genomic DNA Translation: CAA06617.1
AF034634 mRNA Translation: AAC52037.1
AF040254 mRNA Translation: AAC31797.1
AF040255 mRNA Translation: AAC31696.1
AL031117 Genomic DNA No translation available.
AL450490 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02644.1 Sequence problems.
CH471120 Genomic DNA Translation: EAX02645.1
CH471120 Genomic DNA Translation: EAX02642.1 Sequence problems.
CH471120 Genomic DNA Translation: EAX02643.1
CH471120 Genomic DNA Translation: EAX02646.1
CH471120 Genomic DNA Translation: EAX02647.1
CH471120 Genomic DNA Translation: EAX02649.1 Sequence problems.
BC027925 mRNA Translation: AAH27925.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14557.1 [O43602-2]
CCDS14558.1 [O43602-1]

NCBI Reference Sequences

More...
RefSeqi
NP_000546.2, NM_000555.3
NP_835364.1, NM_178151.2 [O43602-2]
NP_835365.1, NM_178152.2 [O43602-1]
NP_835366.1, NM_178153.2 [O43602-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358070; ENSP00000350776; ENSG00000077279 [O43602-2]
ENST00000371993; ENSP00000361061; ENSG00000077279 [O43602-2]
ENST00000488120; ENSP00000419861; ENSG00000077279 [O43602-2]
ENST00000496551; ENSP00000490448; ENSG00000077279 [O43602-1]
ENST00000635795; ENSP00000489635; ENSG00000077279 [O43602-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1641

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1641

UCSC genome browser

More...
UCSCi
uc004epd.4 human [O43602-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003112 mRNA Translation: CAA05867.1
AJ005592
, AJ005593, AJ005594, AJ005595, AJ005596, AJ005597 Genomic DNA Translation: CAA06617.1
AF034634 mRNA Translation: AAC52037.1
AF040254 mRNA Translation: AAC31797.1
AF040255 mRNA Translation: AAC31696.1
AL031117 Genomic DNA No translation available.
AL450490 Genomic DNA No translation available.
CH471120 Genomic DNA Translation: EAX02644.1 Sequence problems.
CH471120 Genomic DNA Translation: EAX02645.1
CH471120 Genomic DNA Translation: EAX02642.1 Sequence problems.
CH471120 Genomic DNA Translation: EAX02643.1
CH471120 Genomic DNA Translation: EAX02646.1
CH471120 Genomic DNA Translation: EAX02647.1
CH471120 Genomic DNA Translation: EAX02649.1 Sequence problems.
BC027925 mRNA Translation: AAH27925.1
CCDSiCCDS14557.1 [O43602-2]
CCDS14558.1 [O43602-1]
RefSeqiNP_000546.2, NM_000555.3
NP_835364.1, NM_178151.2 [O43602-2]
NP_835365.1, NM_178152.2 [O43602-1]
NP_835366.1, NM_178153.2 [O43602-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MJDNMR-A45-150[»]
2BQQX-ray2.20A45-150[»]
2XRPelectron microscopy8.20I46-140[»]
4ATUelectron microscopy8.30I2-365[»]
5IKCX-ray2.06M/N52-140[»]
5IN7X-ray2.48A/B46-150[»]
5IO9X-ray1.30A/B52-149[»]
5IOIX-ray2.40A/B/C/D/E/F52-150[»]
5IP4X-ray1.81D/E170-260[»]
6FNZX-ray2.23A/B/C/D174-254[»]
SMRiO43602
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108008, 45 interactors
IntActiO43602, 26 interactors
MINTiO43602
STRINGi9606.ENSP00000337697

PTM databases

iPTMnetiO43602
PhosphoSitePlusiO43602

Polymorphism and mutation databases

BioMutaiDCX

Proteomic databases

jPOSTiO43602
PaxDbiO43602
PeptideAtlasiO43602
PRIDEiO43602
ProteomicsDBi49072
49073 [O43602-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
O43602

The DNASU plasmid repository

More...
DNASUi
1641
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358070; ENSP00000350776; ENSG00000077279 [O43602-2]
ENST00000371993; ENSP00000361061; ENSG00000077279 [O43602-2]
ENST00000488120; ENSP00000419861; ENSG00000077279 [O43602-2]
ENST00000496551; ENSP00000490448; ENSG00000077279 [O43602-1]
ENST00000635795; ENSP00000489635; ENSG00000077279 [O43602-1]
GeneIDi1641
KEGGihsa:1641
UCSCiuc004epd.4 human [O43602-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1641
DisGeNETi1641

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCX
GeneReviewsiDCX
HGNCiHGNC:2714 DCX
HPAiHPA036121
MalaCardsiDCX
MIMi300067 phenotype
300121 gene
neXtProtiNX_O43602
OpenTargetsiENSG00000077279
Orphaneti2148 Lissencephaly type 1 due to doublecortin gene mutation
99796 Subcortical band heterotopia
PharmGKBiPA27184

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3757 Eukaryota
ENOG410ZE6Q LUCA
GeneTreeiENSGT00940000161570
InParanoidiO43602
KOiK16579
OrthoDBi330091at2759
TreeFamiTF318770

Enzyme and pathway databases

ReactomeiR-HSA-447043 Neurofascin interactions
SIGNORiO43602

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DCX human
EvolutionaryTraceiO43602

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Doublecortin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1641

Protein Ontology

More...
PROi
PR:O43602

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077279 Expressed in 88 organ(s), highest expression level in frontal cortex
ExpressionAtlasiO43602 baseline and differential
GenevisibleiO43602 HS

Family and domain databases

CDDicd01617 DCX, 2 hits
Gene3Di3.10.20.230, 2 hits
InterProiView protein in InterPro
IPR017302 Doublecortin_chordata
IPR003533 Doublecortin_dom
IPR036572 Doublecortin_dom_sf
IPR040163 RP1/RP1L1/DCX
PANTHERiPTHR23005 PTHR23005, 2 hits
PfamiView protein in Pfam
PF03607 DCX, 2 hits
PIRSFiPIRSF037870 Doublin, 1 hit
SMARTiView protein in SMART
SM00537 DCX, 2 hits
SUPFAMiSSF89837 SSF89837, 2 hits
PROSITEiView protein in PROSITE
PS50309 DC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43602
Secondary accession number(s): A6NFY6
, A9Z1V8, D3DUY8, D3DUY9, D3DUZ0, O43911, Q5JYZ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: March 16, 2016
Last modified: July 3, 2019
This is version 191 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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