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Entry version 182 (03 Jul 2019)
Sequence version 1 (01 Jun 1998)
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Protein

5'-AMP-activated protein kinase subunit beta-2

Gene

PRKAB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1632852 Macroautophagy
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-9619483 Activation of AMPK downstream of NMDARs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
O43741

SIGNOR Signaling Network Open Resource

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SIGNORi
O43741

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM48 Carbohydrate-Binding Module Family 48

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-AMP-activated protein kinase subunit beta-2
Short name:
AMPK subunit beta-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRKAB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:9379 PRKAB2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602741 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O43741

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi235H → A: Results in an AMPK enzyme that is activable by phosphorylation but has significantly increased rate of dephosphorylation in phosphatase assays. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5565

Open Targets

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OpenTargetsi
ENSG00000131791

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33747

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2117

Drug and drug target database

More...
DrugBanki
DB00945 Acetylsalicylic acid
DB00131 Adenosine monophosphate

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1544

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PRKAB2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002043681 – 2725'-AMP-activated protein kinase subunit beta-2Add BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei39PhosphoserineBy similarity1
Modified residuei40PhosphothreonineBy similarity1
Modified residuei69Phosphoserine; by ULK1By similarity1
Modified residuei95PhosphoserineCombined sources1
Modified residuei108PhosphoserineCombined sources1
Modified residuei148PhosphothreonineCombined sources1
Modified residuei158PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei174PhosphoserineBy similarity1
Modified residuei184PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O43741

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O43741

MaxQB - The MaxQuant DataBase

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MaxQBi
O43741

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O43741

PeptideAtlas

More...
PeptideAtlasi
O43741

PRoteomics IDEntifications database

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PRIDEi
O43741

ProteomicsDB human proteome resource

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ProteomicsDBi
49144

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O43741

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O43741

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000131791 Expressed in 207 organ(s), highest expression level in biceps brachii

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O43741 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA044342

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1053424,EBI-1053424
ADAMTSL4Q6UY14-33EBI-1053424,EBI-10173507
AESQ08117-24EBI-1053424,EBI-11741437
BANPQ8N9N53EBI-1053424,EBI-744695
BANPQ8N9N5-23EBI-1053424,EBI-11524452
BEND5Q7L4P64EBI-1053424,EBI-724373
BLZF1Q9H2G97EBI-1053424,EBI-2548012
CCDC36Q8IYA86EBI-1053424,EBI-8638439
CDX4O146274EBI-1053424,EBI-10181162
CREB3L1Q96BA84EBI-1053424,EBI-6942903
CRXO431866EBI-1053424,EBI-748171
DAOP149205EBI-1053424,EBI-3908043
FAM208BQ5VWN6-23EBI-1053424,EBI-10172380
GATA1P159763EBI-1053424,EBI-3909284
GATA1P15976-25EBI-1053424,EBI-9090198
GATAD2BQ8WXI94EBI-1053424,EBI-923440
GET4Q7L5D67EBI-1053424,EBI-711823
GOLGA2Q083798EBI-1053424,EBI-618309
IKZF1Q134223EBI-1053424,EBI-745305
IKZF3Q9UKT99EBI-1053424,EBI-747204
KLF15Q9UIH96EBI-1053424,EBI-2796400
KRT40Q6A1625EBI-1053424,EBI-10171697
KRTAP10-5P603703EBI-1053424,EBI-10172150
KRTAP10-7P604093EBI-1053424,EBI-10172290
KRTAP10-8P604105EBI-1053424,EBI-10171774
KRTAP10-9P604115EBI-1053424,EBI-10172052
KRTAP4-12Q9BQ663EBI-1053424,EBI-739863
KRTAP4-2Q9BYR53EBI-1053424,EBI-10172511
KRTAP5-9P263715EBI-1053424,EBI-3958099
KRTAP9-2Q9BYQ47EBI-1053424,EBI-1044640
KRTAP9-4Q9BYQ23EBI-1053424,EBI-10185730
KRTAP9-8Q9BYQ04EBI-1053424,EBI-11958364
LZTS2Q9BRK44EBI-1053424,EBI-741037
MAGED1Q9Y5V34EBI-1053424,EBI-716006
MDFIQ997508EBI-1053424,EBI-724076
MEOX2P502223EBI-1053424,EBI-748397
PIAS2O759283EBI-1053424,EBI-348555
PRDM14Q9GZV83EBI-1053424,EBI-3957793
PRKAA1Q1313114EBI-1053424,EBI-1181405
PRKAA2P5464612EBI-1053424,EBI-1383852
PRKAG1P5461911EBI-1053424,EBI-1181439
PSME3P612898EBI-1053424,EBI-355546
PYGMP112176EBI-1053424,EBI-357469
RBPMSQ93062-33EBI-1053424,EBI-740343
RELQ04864-23EBI-1053424,EBI-10829018
RHEBL1Q8TAI76EBI-1053424,EBI-746555
RIMBP3Q9UFD94EBI-1053424,EBI-10182375
SPRY2O435974EBI-1053424,EBI-742487
STX11O755584EBI-1053424,EBI-714135
STX19Q8N4C74EBI-1053424,EBI-8484990
TRAF2Q129337EBI-1053424,EBI-355744
UBXN11Q5T1243EBI-1053424,EBI-746004

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111552, 109 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O43741

Database of interacting proteins

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DIPi
DIP-39763N

Protein interaction database and analysis system

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IntActi
O43741, 173 interactors

Molecular INTeraction database

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MINTi
O43741

STRING: functional protein association networks

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STRINGi
9606.ENSP00000254101

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O43741

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O43741

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1616 Eukaryota
ENOG410XRB3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159284

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230597

KEGG Orthology (KO)

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KOi
K07199

Identification of Orthologs from Complete Genome Data

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OMAi
QMGTINN

Database of Orthologous Groups

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OrthoDBi
702827at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O43741

TreeFam database of animal gene trees

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TreeFami
TF313827

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR032640 AMPK1_CBM
IPR039160 AMPKB
IPR006828 ASC_dom
IPR037256 ASC_dom_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set

The PANTHER Classification System

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PANTHERi
PTHR10343:SF83 PTHR10343:SF83, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF16561 AMPK1_CBM, 1 hit
PF04739 AMPKBI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01010 AMPKBI, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF160219 SSF160219, 1 hit
SSF81296 SSF81296, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O43741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNTTSDRVS GERHGAKAAR SEGAGGHAPG KEHKIMVGST DDPSVFSLPD
60 70 80 90 100
SKLPGDKEFV SWQQDLEDSV KPTQQARPTV IRWSEGGKEV FISGSFNNWS
110 120 130 140 150
TKIPLIKSHN DFVAILDLPE GEHQYKFFVD GQWVHDPSEP VVTSQLGTIN
160 170 180 190 200
NLIHVKKSDF EVFDALKLDS MESSETSCRD LSSSPPGPYG QEMYAFRSEE
210 220 230 240 250
RFKSPPILPP HLLQVILNKD TNISCDPALL PEPNHVMLNH LYALSIKDSV
260 270
MVLSATHRYK KKYVTTLLYK PI
Length:272
Mass (Da):30,302
Last modified:June 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42B23BD70B92519C
GO
Isoform 2 (identifier: O43741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MGNTTSDRVSGERHGAKAARSEGAG → MPRGRSTRSWWGVRTTPACSASLTP
     26-107: Missing.

Note: No experimental confirmation available.
Show »
Length:190
Mass (Da):21,485
Checksum:iBB41913AB4FDEB54
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0558201 – 25MGNTT…SEGAG → MPRGRSTRSWWGVRTTPACS ASLTP in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_05582126 – 107Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ224538 mRNA Translation: CAA12030.1
AF504543
, AF504538, AF504539, AF504540, AF504541, AF504542 Genomic DNA Translation: AAM74153.1
AK292820 mRNA Translation: BAF85509.1
AK294863 mRNA Translation: BAG57967.1
AK316005 mRNA Translation: BAH14376.1
AL356378 Genomic DNA Translation: CAH72644.1
CH471223 Genomic DNA Translation: EAW50945.1
BC053610 mRNA Translation: AAH53610.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS925.1 [O43741-1]

NCBI Reference Sequences

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RefSeqi
NP_005390.1, NM_005399.4 [O43741-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000254101; ENSP00000254101; ENSG00000131791 [O43741-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5565

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5565

UCSC genome browser

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UCSCi
uc001epe.5 human [O43741-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224538 mRNA Translation: CAA12030.1
AF504543
, AF504538, AF504539, AF504540, AF504541, AF504542 Genomic DNA Translation: AAM74153.1
AK292820 mRNA Translation: BAF85509.1
AK294863 mRNA Translation: BAG57967.1
AK316005 mRNA Translation: BAH14376.1
AL356378 Genomic DNA Translation: CAH72644.1
CH471223 Genomic DNA Translation: EAW50945.1
BC053610 mRNA Translation: AAH53610.1
CCDSiCCDS925.1 [O43741-1]
RefSeqiNP_005390.1, NM_005399.4 [O43741-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F15X-ray2.00A69-163[»]
2V8QX-ray2.10B187-272[»]
2V92X-ray2.40B187-272[»]
2V9JX-ray2.53B187-272[»]
2Y8LX-ray2.50B187-272[»]
2Y8QX-ray2.80B187-270[»]
2YA3X-ray2.51B187-272[»]
4CFHX-ray3.24B187-272[»]
4EAIX-ray2.28B189-272[»]
4EAJX-ray2.61B189-272[»]
4RERX-ray4.05B76-272[»]
4REWX-ray4.58B76-272[»]
6B2EX-ray3.80B1-272[»]
SMRiO43741
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111552, 109 interactors
CORUMiO43741
DIPiDIP-39763N
IntActiO43741, 173 interactors
MINTiO43741
STRINGi9606.ENSP00000254101

Chemistry databases

ChEMBLiCHEMBL2117
DrugBankiDB00945 Acetylsalicylic acid
DB00131 Adenosine monophosphate
GuidetoPHARMACOLOGYi1544

Protein family/group databases

CAZyiCBM48 Carbohydrate-Binding Module Family 48

PTM databases

iPTMnetiO43741
PhosphoSitePlusiO43741

Polymorphism and mutation databases

BioMutaiPRKAB2

Proteomic databases

EPDiO43741
jPOSTiO43741
MaxQBiO43741
PaxDbiO43741
PeptideAtlasiO43741
PRIDEiO43741
ProteomicsDBi49144

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5565
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254101; ENSP00000254101; ENSG00000131791 [O43741-1]
GeneIDi5565
KEGGihsa:5565
UCSCiuc001epe.5 human [O43741-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5565
DisGeNETi5565

GeneCards: human genes, protein and diseases

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GeneCardsi
PRKAB2
HGNCiHGNC:9379 PRKAB2
HPAiHPA044342
MIMi602741 gene
neXtProtiNX_O43741
OpenTargetsiENSG00000131791
PharmGKBiPA33747

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1616 Eukaryota
ENOG410XRB3 LUCA
GeneTreeiENSGT00940000159284
HOGENOMiHOG000230597
KOiK07199
OMAiQMGTINN
OrthoDBi702827at2759
PhylomeDBiO43741
TreeFamiTF313827

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-1632852 Macroautophagy
R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity
R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix
R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-9619483 Activation of AMPK downstream of NMDARs
SignaLinkiO43741
SIGNORiO43741

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PRKAB2 human
EvolutionaryTraceiO43741

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PRKAB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5565

Protein Ontology

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PROi
PR:O43741

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131791 Expressed in 207 organ(s), highest expression level in biceps brachii
GenevisibleiO43741 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR032640 AMPK1_CBM
IPR039160 AMPKB
IPR006828 ASC_dom
IPR037256 ASC_dom_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
PANTHERiPTHR10343:SF83 PTHR10343:SF83, 1 hit
PfamiView protein in Pfam
PF16561 AMPK1_CBM, 1 hit
PF04739 AMPKBI, 1 hit
SMARTiView protein in SMART
SM01010 AMPKBI, 1 hit
SUPFAMiSSF160219 SSF160219, 1 hit
SSF81296 SSF81296, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAKB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O43741
Secondary accession number(s): A8K9V5, B4DH06, Q5VXY0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 1, 1998
Last modified: July 3, 2019
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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