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Entry version 141 (18 Sep 2019)
Sequence version 3 (12 Apr 2005)
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Protein

Transmembrane and coiled-coil domains protein 2

Gene

TMCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane and coiled-coil domains protein 21 Publication
Alternative name(s):
Cerebral protein 111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMCC21 Publication
Synonyms:KIAA04811 Publication
ORF Names:hucep-111 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:24239 TMCC2

neXtProt; the human protein knowledge platform

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neXtProti
NX_O75069

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei649 – 669HelicalSequence analysisAdd BLAST21
Transmembranei682 – 702HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9911

Open Targets

More...
OpenTargetsi
ENSG00000133069

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134963344

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75069

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMCC2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001845971 – 709Transmembrane and coiled-coil domains protein 2Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei6PhosphoserineBy similarity1
Modified residuei163Omega-N-methylarginineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei464PhosphoserineCombined sources1
Modified residuei470PhosphoserineBy similarity1
Modified residuei503PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75069

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75069

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75069

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75069

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75069

PeptideAtlas

More...
PeptideAtlasi
O75069

PRoteomics IDEntifications database

More...
PRIDEi
O75069

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49736 [O75069-1]
6357

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75069

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75069

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000133069 Expressed in 182 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75069 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75069 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014254

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimers and heterodimers with TMCC2 or TMCC3 via the coiled-coil domains (PubMed:24454821).

Interacts with ribosomal proteins RPL4 and RPS6 (PubMed:24454821).

Interacts with APOE and proteolytic processed C-terminal fragment C99 of the amyloid precursor protein (APP C99) (PubMed:21593558).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115240, 40 interactors

Protein interaction database and analysis system

More...
IntActi
O75069, 40 interactors

Molecular INTeraction database

More...
MINTi
O75069

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350718

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75069

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili333 – 368Sequence analysisAdd BLAST36
Coiled coili514 – 633Sequence analysisAdd BLAST120

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TEX28 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3850 Eukaryota
ENOG410Y9KV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158314

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000294160

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75069

Database of Orthologous Groups

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OrthoDBi
1175041at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75069

TreeFam database of animal gene trees

More...
TreeFami
TF316292

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019394 TEX28/TMCC

The PANTHER Classification System

More...
PANTHERi
PTHR17613 PTHR17613, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10267 Tmemb_cc2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75069-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRCRSDELQ QQQGEEDGAG LEDAASHLPG ADLRPGETTG ANSAGGPTSD
60 70 80 90 100
AGAAAAPNPG PRSKPPDLKK IQQLSEGSMF GHGLKHLFHS RRRSREREHQ
110 120 130 140 150
TSQDSQQHQQ QQGMSDHDSP DEKERSPEMH RVSYAMSLHD LPARPTAFNR
160 170 180 190 200
VLQQIRSRPS IKRGASLHSS SGGGSSGSSS RRTKSSSLEP QRGSPHLLRK
210 220 230 240 250
APQDSSLAAI LHQHQCRPRS SSTTDTALLL ADGSNVYLLA EEAEGIGDKV
260 270 280 290 300
DKGDLVALSL PAGHGDTDGP ISLDVPDGAP DPQRTKAAID HLHQKILKIT
310 320 330 340 350
EQIKIEQEAR DDNVAEYLKL ANNADKQQVS RIKQVFEKKN QKSAQTIAQL
360 370 380 390 400
HKKLEHYRRR LKEIEQNGPS RQPKDVLRDM QQGLKDVGAN VRAGISGFGG
410 420 430 440 450
GVVEGVKGSL SGLSQATHTA VVSKPREFAS LIRNKFGSAD NIAHLKDPLE
460 470 480 490 500
DGPPEEAARA LSGSATLVSS PKYGSDDECS SASASSAGAG SNSGAGPGGA
510 520 530 540 550
LGSPKSNALY GAPGNLDALL EELREIKEGQ SHLEDSMEDL KTQLQRDYTY
560 570 580 590 600
MTQCLQEERY RYERLEEQLN DLTELHQNEM TNLKQELASM EEKVAYQSYE
610 620 630 640 650
RARDIQEAVE SCLTRVTKLE LQQQQQQVVQ LEGVENANAR ALLGKFINVI
660 670 680 690 700
LALMAVLLVF VSTIANFITP LMKTRLRITS TTLLVLVLFL LWKHWDSLTY

LLEHVLLPS
Length:709
Mass (Da):77,449
Last modified:April 12, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i002993EA6B0E4546
GO
Isoform 2 (identifier: O75069-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Note: No experimental confirmation available.
Show »
Length:631
Mass (Da):69,586
Checksum:iB8F8F066BDBB8AFA
GO
Isoform 3 (identifier: O75069-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: MKRCRSDELQ...AEEAEGIGDK → MKSKEEETA

Show »
Length:469
Mass (Da):51,658
Checksum:iC6A2FC63518C3C4E
GO
Isoform 4 (identifier: O75069-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-389: MKRCRSDELQ...MQQGLKDVGA → MEEKVAYQSY...NARALLGKFI
     589-643: SMEEKVAYQS...VENANARALL → TLLQEGPLDF...GSLECSPTWR
     644-709: Missing.

Show »
Length:312
Mass (Da):33,776
Checksum:iF689253EAB9508AD
GO
Isoform 5 (identifier: O75069-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-249: MKRCRSDELQ...AEEAEGIGDK → MNQVVQPLMSRHSACRGSQAHLSW

Show »
Length:484
Mass (Da):53,330
Checksum:i3059EB939B553243
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DFR1A0A0C4DFR1_HUMAN
Transmembrane and coiled-coil domai...
TMCC2
514Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32326 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti466T → A in BAG53139 (PubMed:14702039).Curated1
Sequence conflicti470S → I in BAG37022 (PubMed:14702039).Curated1
Sequence conflicti492N → Y in BAG37022 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0589381 – 389MKRCR…KDVGA → MEEKVAYQSYERARDIQEAV ESCLTRVTKLELQQQQQQVV QLEGVENANARALLGKFI in isoform 4. Add BLAST389
Alternative sequenceiVSP_0589391 – 249MKRCR…GIGDK → MKSKEEETA in isoform 3. Add BLAST249
Alternative sequenceiVSP_0589401 – 249MKRCR…GIGDK → MNQVVQPLMSRHSACRGSQA HLSW in isoform 5. Add BLAST249
Alternative sequenceiVSP_0462451 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_058941589 – 643SMEEK…ARALL → TLLQEGPLDFFVCPVWPPAQ TVHSSSSCPLLCTCFCLTPS PCWPEGSLECSPTWR in isoform 4. Add BLAST55
Alternative sequenceiVSP_058942644 – 709Missing in isoform 4. Add BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007950 mRNA Translation: BAA32326.3 Different initiation.
AB001596 mRNA Translation: BAB46924.1
AK095816 mRNA Translation: BAG53139.1
AK131419 mRNA Translation: BAD18566.1
AK293734 mRNA Translation: BAH11583.1
AK314398 mRNA Translation: BAG37022.1
AC093422 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91548.1
BC053876 mRNA Translation: AAH53876.1
BC131629 mRNA Translation: AAI31630.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30984.1 [O75069-1]
CCDS55676.1 [O75069-2]
CCDS73010.1 [O75069-3]
CCDS76257.1 [O75069-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001229854.1, NM_001242925.1 [O75069-2]
NP_001284540.1, NM_001297611.1 [O75069-5]
NP_001284542.1, NM_001297613.1 [O75069-3]
NP_055673.2, NM_014858.3 [O75069-1]
XP_005245741.1, XM_005245684.1 [O75069-2]
XP_005245742.1, XM_005245685.4 [O75069-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329800; ENSP00000329436; ENSG00000133069 [O75069-3]
ENST00000358024; ENSP00000350718; ENSG00000133069 [O75069-1]
ENST00000545499; ENSP00000437943; ENSG00000133069 [O75069-2]
ENST00000637895; ENSP00000490308; ENSG00000133069 [O75069-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9911

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9911

UCSC genome browser

More...
UCSCi
uc001hca.4 human [O75069-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007950 mRNA Translation: BAA32326.3 Different initiation.
AB001596 mRNA Translation: BAB46924.1
AK095816 mRNA Translation: BAG53139.1
AK131419 mRNA Translation: BAD18566.1
AK293734 mRNA Translation: BAH11583.1
AK314398 mRNA Translation: BAG37022.1
AC093422 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91548.1
BC053876 mRNA Translation: AAH53876.1
BC131629 mRNA Translation: AAI31630.1
CCDSiCCDS30984.1 [O75069-1]
CCDS55676.1 [O75069-2]
CCDS73010.1 [O75069-3]
CCDS76257.1 [O75069-5]
RefSeqiNP_001229854.1, NM_001242925.1 [O75069-2]
NP_001284540.1, NM_001297611.1 [O75069-5]
NP_001284542.1, NM_001297613.1 [O75069-3]
NP_055673.2, NM_014858.3 [O75069-1]
XP_005245741.1, XM_005245684.1 [O75069-2]
XP_005245742.1, XM_005245685.4 [O75069-2]

3D structure databases

SMRiO75069
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115240, 40 interactors
IntActiO75069, 40 interactors
MINTiO75069
STRINGi9606.ENSP00000350718

PTM databases

iPTMnetiO75069
PhosphoSitePlusiO75069

Polymorphism and mutation databases

BioMutaiTMCC2

Proteomic databases

EPDiO75069
jPOSTiO75069
MassIVEiO75069
MaxQBiO75069
PaxDbiO75069
PeptideAtlasiO75069
PRIDEiO75069
ProteomicsDBi49736 [O75069-1]
6357

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9911

Genome annotation databases

EnsembliENST00000329800; ENSP00000329436; ENSG00000133069 [O75069-3]
ENST00000358024; ENSP00000350718; ENSG00000133069 [O75069-1]
ENST00000545499; ENSP00000437943; ENSG00000133069 [O75069-2]
ENST00000637895; ENSP00000490308; ENSG00000133069 [O75069-5]
GeneIDi9911
KEGGihsa:9911
UCSCiuc001hca.4 human [O75069-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9911
DisGeNETi9911

GeneCards: human genes, protein and diseases

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GeneCardsi
TMCC2
HGNCiHGNC:24239 TMCC2
HPAiHPA014254
neXtProtiNX_O75069
OpenTargetsiENSG00000133069
PharmGKBiPA134963344

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3850 Eukaryota
ENOG410Y9KV LUCA
GeneTreeiENSGT00940000158314
HOGENOMiHOG000294160
InParanoidiO75069
OrthoDBi1175041at2759
PhylomeDBiO75069
TreeFamiTF316292

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMCC2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9911
PharosiO75069

Protein Ontology

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PROi
PR:O75069

Gene expression databases

BgeeiENSG00000133069 Expressed in 182 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiO75069 baseline and differential
GenevisibleiO75069 HS

Family and domain databases

InterProiView protein in InterPro
IPR019394 TEX28/TMCC
PANTHERiPTHR17613 PTHR17613, 1 hit
PfamiView protein in Pfam
PF10267 Tmemb_cc2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMCC2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75069
Secondary accession number(s): A2RRH3
, B2RAX5, B3KTM7, B7Z1P7, Q6ZN09, Q7Z6C6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 12, 2005
Last modified: September 18, 2019
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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