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Entry version 190 (31 Jul 2019)
Sequence version 4 (23 Jan 2007)
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Protein

WD repeat-containing protein 1

Gene

WDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O75083

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 1
Alternative name(s):
Actin-interacting protein 1
Short name:
AIP1
NORI-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12754 WDR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604734 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75083

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9948

Open Targets

More...
OpenTargetsi
ENSG00000071127

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37358

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513411 – 606WD repeat-containing protein 1Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei28N6-acetyllysineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei115N6-acetyllysineCombined sources1
Modified residuei238PhosphotyrosineCombined sources1
Modified residuei480N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75083

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O75083

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75083

PeptideAtlas

More...
PeptideAtlasi
O75083

PRoteomics IDEntifications database

More...
PRIDEi
O75083

ProteomicsDB human proteome resource

More...
ProteomicsDBi
49749 [O75083-1]
49750 [O75083-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O75083-1 [O75083-1]

2D gel databases

USC-OGP 2-DE database

More...
OGPi
O75083

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00746165
O75083

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
O75083

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75083

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75083

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O75083

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000071127 Expressed in 233 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75083 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O75083 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB020804
HPA036434
HPA070293

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115273, 106 interactors

Protein interaction database and analysis system

More...
IntActi
O75083, 36 interactors

Molecular INTeraction database

More...
MINTi
O75083

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427687

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O75083

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati4 – 45WD 1Add BLAST42
Repeati48 – 87WD 2Add BLAST40
Repeati93 – 135WD 3Add BLAST43
Repeati138 – 176WD 4Add BLAST39
Repeati180 – 218WD 5Add BLAST39
Repeati224 – 263WD 6Add BLAST40
Repeati270 – 306WD 7Add BLAST37
Repeati311 – 351WD 8Add BLAST41
Repeati358 – 408WD 9Add BLAST51
Repeati432 – 474WD 10Add BLAST43
Repeati480 – 518WD 11Add BLAST39
Repeati523 – 561WD 12Add BLAST39
Repeati566 – 604WD 13Add BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat AIP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0318 Eukaryota
ENOG410XQN1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009416

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75083

Identification of Orthologs from Complete Genome Data

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OMAi
WDVNVNS

Database of Orthologous Groups

More...
OrthoDBi
325552at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75083

TreeFam database of animal gene trees

More...
TreeFami
TF300821

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 4 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00320 WD40, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50974 SSF50974, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75083-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL
60 70 80 90 100
ADIYTEHAHQ VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP
110 120 130 140 150
FAGKIKDIAW TEDSKRIAVV GEGREKFGAV FLWDSGSSVG EITGHNKVIN
160 170 180 190 200
SVDIKQSRPY RLATGSDDNC AAFFEGPPFK FKFTIGDHSR FVNCVRFSPD
210 220 230 240 250
GNRFATASAD GQIYIYDGKT GEKVCALGGS KAHDGGIYAI SWSPDSTHLL
260 270 280 290 300
SASGDKTSKI WDVSVNSVVS TFPMGSTVLD QQLGCLWQKD HLLSVSLSGY
310 320 330 340 350
INYLDRNNPS KPLHVIKGHS KSIQCLTVHK NGGKSYIYSG SHDGHINYWD
360 370 380 390 400
SETGENDSFA GKGHTNQVSR MTVDESGQLI SCSMDDTVRY TSLMLRDYSG
410 420 430 440 450
QGVVKLDVQP KCVAVGPGGY AVVVCIGQIV LLKDQRKCFS IDNPGYEPEV
460 470 480 490 500
VAVHPGGDTV AIGGVDGNVR LYSILGTTLK DEGKLLEAKG PVTDVAYSHD
510 520 530 540 550
GAFLAVCDAS KVVTVFSVAD GYSENNVFYG HHAKIVCLAW SPDNEHFASG
560 570 580 590 600
GMDMMVYVWT LSDPETRVKI QDAHRLHHVS SLAWLDEHTL VTTSHDASVK

EWTITY
Length:606
Mass (Da):66,194
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C08C31D5CD097F1
GO
Isoform 2 (identifier: O75083-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-186: Missing.

Note: No experimental confirmation available.
Show »
Length:466
Mass (Da):50,694
Checksum:i4CC6C543EB6F365D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RD66D6RD66_HUMAN
WD repeat-containing protein 1
WDR1
245Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD05045 differs from that shown. Aberrant splicing.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013445185I → V1 PublicationCorresponds to variant dbSNP:rs13441Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01292647 – 186Missing in isoform 2. 1 PublicationAdd BLAST140

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF020056 mRNA Translation: AAD05044.1
AF020260 mRNA Translation: AAD05045.1 Sequence problems.
AB010427 mRNA Translation: BAA31855.2
AK291614 mRNA Translation: BAF84303.1
AC005674 Genomic DNA No translation available.
AC093664 Genomic DNA No translation available.
BC000201 mRNA Translation: AAH00201.1
BC002489 mRNA Translation: AAH02489.1
BC030541 mRNA Translation: AAH30541.1
AL050108 mRNA Translation: CAB43276.1
AL110208 mRNA Translation: CAB53674.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54739.1 [O75083-3]
CCDS54740.1 [O75083-1]

Protein sequence database of the Protein Information Resource

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PIRi
T13152

NCBI Reference Sequences

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RefSeqi
NP_005103.2, NM_005112.4 [O75083-3]
NP_059830.1, NM_017491.3 [O75083-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382451; ENSP00000371889; ENSG00000071127 [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127 [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127 [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127 [O75083-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9948

UCSC genome browser

More...
UCSCi
uc032tcf.2 human [O75083-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020056 mRNA Translation: AAD05044.1
AF020260 mRNA Translation: AAD05045.1 Sequence problems.
AB010427 mRNA Translation: BAA31855.2
AK291614 mRNA Translation: BAF84303.1
AC005674 Genomic DNA No translation available.
AC093664 Genomic DNA No translation available.
BC000201 mRNA Translation: AAH00201.1
BC002489 mRNA Translation: AAH02489.1
BC030541 mRNA Translation: AAH30541.1
AL050108 mRNA Translation: CAB43276.1
AL110208 mRNA Translation: CAB53674.2
CCDSiCCDS54739.1 [O75083-3]
CCDS54740.1 [O75083-1]
PIRiT13152
RefSeqiNP_005103.2, NM_005112.4 [O75083-3]
NP_059830.1, NM_017491.3 [O75083-1]

3D structure databases

SMRiO75083
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115273, 106 interactors
IntActiO75083, 36 interactors
MINTiO75083
STRINGi9606.ENSP00000427687

PTM databases

iPTMnetiO75083
PhosphoSitePlusiO75083
SwissPalmiO75083

Polymorphism and mutation databases

BioMutaiWDR1

2D gel databases

OGPiO75083
REPRODUCTION-2DPAGEiIPI00746165
O75083
UCD-2DPAGEiO75083

Proteomic databases

EPDiO75083
jPOSTiO75083
PaxDbiO75083
PeptideAtlasiO75083
PRIDEiO75083
ProteomicsDBi49749 [O75083-1]
49750 [O75083-3]
TopDownProteomicsiO75083-1 [O75083-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382451; ENSP00000371889; ENSG00000071127 [O75083-3]
ENST00000382452; ENSP00000371890; ENSG00000071127 [O75083-1]
ENST00000499869; ENSP00000427687; ENSG00000071127 [O75083-1]
ENST00000502702; ENSP00000426725; ENSG00000071127 [O75083-3]
GeneIDi9948
KEGGihsa:9948
UCSCiuc032tcf.2 human [O75083-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9948
DisGeNETi9948

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR1
HGNCiHGNC:12754 WDR1
HPAiCAB020804
HPA036434
HPA070293
MIMi604734 gene
neXtProtiNX_O75083
OpenTargetsiENSG00000071127
PharmGKBiPA37358

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0318 Eukaryota
ENOG410XQN1 LUCA
GeneTreeiENSGT00390000009416
InParanoidiO75083
OMAiWDVNVNS
OrthoDBi325552at2759
PhylomeDBiO75083
TreeFamiTF300821

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
SignaLinkiO75083

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
WDR1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
WDR1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9948

Protein Ontology

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PROi
PR:O75083

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000071127 Expressed in 233 organ(s), highest expression level in testis
ExpressionAtlasiO75083 baseline and differential
GenevisibleiO75083 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50974 SSF50974, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75083
Secondary accession number(s): A8K6E9
, A8MPU4, O75313, Q8N6E5, Q9UG05, Q9UG78, Q9UQE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 23, 2007
Last modified: July 31, 2019
This is version 190 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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