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Entry version 184 (16 Oct 2019)
Sequence version 4 (17 Apr 2007)
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Protein

Slit homolog 1 protein

Gene

SLIT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • heparin binding Source: GO_Central
  • Roundabout binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-8985801 Regulation of cortical dendrite branching
R-HSA-9010553 Regulation of expression of SLITs and ROBOs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O75093

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Slit homolog 1 protein
Short name:
Slit-1
Alternative name(s):
Multiple epidermal growth factor-like domains protein 4
Short name:
Multiple EGF-like domains protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLIT1
Synonyms:KIAA0813, MEGF4, SLIL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11085 SLIT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603742 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75093

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6585

Open Targets

More...
OpenTargetsi
ENSG00000187122

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35938

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O75093

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLIT1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 33Sequence analysisAdd BLAST33
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000772234 – 1534Slit homolog 1 proteinAdd BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi286 ↔ 295By similarity
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi443 ↔ 466By similarity
Disulfide bondi445 ↔ 487By similarity
Disulfide bondi513 ↔ 519By similarity
Disulfide bondi517 ↔ 526By similarity
Glycosylationi571N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi630N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi675 ↔ 698By similarity
Disulfide bondi677 ↔ 719By similarity
Glycosylationi762N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi806N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi929 ↔ 940By similarity
Disulfide bondi934 ↔ 950By similarity
Disulfide bondi952 ↔ 961By similarity
Disulfide bondi968 ↔ 979By similarity
Disulfide bondi973 ↔ 991By similarity
Disulfide bondi993 ↔ 1002By similarity
Disulfide bondi1009 ↔ 1020By similarity
Disulfide bondi1014 ↔ 1029By similarity
Glycosylationi1026N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1031 ↔ 1040By similarity
Disulfide bondi1047 ↔ 1060By similarity
Disulfide bondi1054 ↔ 1069By similarity
Disulfide bondi1071 ↔ 1080By similarity
Glycosylationi1079N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1087 ↔ 1098By similarity
Disulfide bondi1092 ↔ 1107By similarity
Disulfide bondi1109 ↔ 1118By similarity
Disulfide bondi1131 ↔ 1142By similarity
Disulfide bondi1136 ↔ 1151By similarity
Disulfide bondi1153 ↔ 1162By similarity
Glycosylationi1189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1306N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1313 ↔ 1339By similarity
Disulfide bondi1342 ↔ 1352By similarity
Disulfide bondi1347 ↔ 1362By similarity
Disulfide bondi1364 ↔ 1373By similarity
Disulfide bondi1381 ↔ 1391By similarity
Disulfide bondi1386 ↔ 1401By similarity
Disulfide bondi1403 ↔ 1412By similarity
Disulfide bondi1422 ↔ 1432By similarity
Disulfide bondi1427 ↔ 1442By similarity
Disulfide bondi1444 ↔ 1453By similarity
Disulfide bondi1459 ↔ 1498By similarity
Disulfide bondi1477 ↔ 1512By similarity
Disulfide bondi1488 ↔ 1528By similarity
Disulfide bondi1492 ↔ 1530By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O75093

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75093

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75093

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75093

PeptideAtlas

More...
PeptideAtlasi
O75093

PRoteomics IDEntifications database

More...
PRIDEi
O75093

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
49753 [O75093-1]
49754 [O75093-2]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
O75093

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O75093

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O75093

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000187122 Expressed in 122 organ(s), highest expression level in Brodmann (1909) area 23

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75093 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75093 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA006879

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ROBO1 and GREM1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112472, 2 interactors

Protein interaction database and analysis system

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IntActi
O75093, 18 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000266058

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 61LRRNTAdd BLAST28
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati62 – 83LRR 1Add BLAST22
Repeati86 – 107LRR 2Add BLAST22
Repeati110 – 131LRR 3Add BLAST22
Repeati134 – 155LRR 4Add BLAST22
Repeati158 – 179LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
Domaini215 – 265LRRCT 1Add BLAST51
Domaini273 – 309LRRNT 2Add BLAST37
Repeati310 – 331LRR 7Add BLAST22
Repeati334 – 355LRR 8Add BLAST22
Repeati358 – 379LRR 9Add BLAST22
Repeati382 – 403LRR 10Add BLAST22
Repeati406 – 427LRR 11Add BLAST22
Domaini439 – 489LRRCT 2Add BLAST51
Domaini504 – 540LRRNT 3Add BLAST37
Repeati541 – 562LRR 12Add BLAST22
Repeati566 – 587LRR 13Add BLAST22
Repeati590 – 611LRR 14Add BLAST22
Repeati614 – 635LRR 15Add BLAST22
Repeati638 – 659LRR 16Add BLAST22
Domaini671 – 721LRRCT 3Add BLAST51
Domaini725 – 761LRRNT 4Add BLAST37
Repeati762 – 783LRR 17Add BLAST22
Repeati785 – 806LRR 18Add BLAST22
Repeati809 – 830LRR 19Add BLAST22
Repeati833 – 854LRR 20Add BLAST22
Domaini866 – 916LRRCT 4Add BLAST51
Domaini927 – 962EGF-like 1PROSITE-ProRule annotationAdd BLAST36
Domaini964 – 1003EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini1005 – 1041EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini1043 – 1081EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1083 – 1119EGF-like 5PROSITE-ProRule annotationAdd BLAST37
Domaini1127 – 1163EGF-like 6PROSITE-ProRule annotationAdd BLAST37
Domaini1166 – 1339Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1340 – 1374EGF-like 7PROSITE-ProRule annotationAdd BLAST35
Domaini1377 – 1413EGF-like 8PROSITE-ProRule annotationAdd BLAST37
Domaini1418 – 1454EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini1459 – 1534CTCKPROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4237 Eukaryota
COG4886 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116120

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75093

KEGG Orthology (KO)

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KOi
K06838

Identification of Orthologs from Complete Genome Data

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OMAi
QYAGRAC

Database of Orthologous Groups

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OrthoDBi
28488at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O75093

TreeFam database of animal gene trees

More...
TreeFami
TF332887

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 5 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 6 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 4 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 21 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O75093-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALTPGWGSS AGPVRPELWL LLWAAAWRLG ASACPALCTC TGTTVDCHGT
60 70 80 90 100
GLQAIPKNIP RNTERLELNG NNITRIHKND FAGLKQLRVL QLMENQIGAV
110 120 130 140 150
ERGAFDDMKE LERLRLNRNQ LHMLPELLFQ NNQALSRLDL SENAIQAIPR
160 170 180 190 200
KAFRGATDLK NLQLDKNQIS CIEEGAFRAL RGLEVLTLNN NNITTIPVSS
210 220 230 240 250
FNHMPKLRTF RLHSNHLFCD CHLAWLSQWL RQRPTIGLFT QCSGPASLRG
260 270 280 290 300
LNVAEVQKSE FSCSGQGEAG RVPTCTLSSG SCPAMCTCSN GIVDCRGKGL
310 320 330 340 350
TAIPANLPET MTEIRLELNG IKSIPPGAFS PYRKLRRIDL SNNQIAEIAP
360 370 380 390 400
DAFQGLRSLN SLVLYGNKIT DLPRGVFGGL YTLQLLLLNA NKINCIRPDA
410 420 430 440 450
FQDLQNLSLL SLYDNKIQSL AKGTFTSLRA IQTLHLAQNP FICDCNLKWL
460 470 480 490 500
ADFLRTNPIE TSGARCASPR RLANKRIGQI KSKKFRCSAK EQYFIPGTED
510 520 530 540 550
YQLNSECNSD VVCPHKCRCE ANVVECSSLK LTKIPERIPQ STAELRLNNN
560 570 580 590 600
EISILEATGM FKKLTHLKKI NLSNNKVSEI EDGAFEGAAS VSELHLTANQ
610 620 630 640 650
LESIRSGMFR GLDGLRTLML RNNRISCIHN DSFTGLRNVR LLSLYDNQIT
660 670 680 690 700
TVSPGAFDTL QSLSTLNLLA NPFNCNCQLA WLGGWLRKRK IVTGNPRCQN
710 720 730 740 750
PDFLRQIPLQ DVAFPDFRCE EGQEEGGCLP RPQCPQECAC LDTVVRCSNK
760 770 780 790 800
HLRALPKGIP KNVTELYLDG NQFTLVPGQL STFKYLQLVD LSNNKISSLS
810 820 830 840 850
NSSFTNMSQL TTLILSYNAL QCIPPLAFQG LRSLRLLSLH GNDISTLQEG
860 870 880 890 900
IFADVTSLSH LAIGANPLYC DCHLRWLSSW VKTGYKEPGI ARCAGPQDME
910 920 930 940 950
GKLLLTTPAK KFECQGPPTL AVQAKCDLCL SSPCQNQGTC HNDPLEVYRC
960 970 980 990 1000
ACPSGYKGRD CEVSLDSCSS GPCENGGTCH AQEGEDAPFT CSCPTGFEGP
1010 1020 1030 1040 1050
TCGVNTDDCV DHACANGGVC VDGVGNYTCQ CPLQYEGKAC EQLVDLCSPD
1060 1070 1080 1090 1100
LNPCQHEAQC VGTPDGPRCE CMPGYAGDNC SENQDDCRDH RCQNGAQCMD
1110 1120 1130 1140 1150
EVNSYSCLCA EGYSGQLCEI PPHLPAPKSP CEGTECQNGA NCVDQGNRPV
1160 1170 1180 1190 1200
CQCLPGFGGP ECEKLLSVNF VDRDTYLQFT DLQNWPRANI TLQVSTAEDN
1210 1220 1230 1240 1250
GILLYNGDND HIAVELYQGH VRVSYDPGSY PSSAIYSAET INDGQFHTVE
1260 1270 1280 1290 1300
LVAFDQMVNL SIDGGSPMTM DNFGKHYTLN SEAPLYVGGM PVDVNSAAFR
1310 1320 1330 1340 1350
LWQILNGTGF HGCIRNLYIN NELQDFTKTQ MKPGVVPGCE PCRKLYCLHG
1360 1370 1380 1390 1400
ICQPNATPGP MCHCEAGWVG LHCDQPADGP CHGHKCVHGQ CVPLDALSYS
1410 1420 1430 1440 1450
CQCQDGYSGA LCNQAGALAE PCRGLQCLHG HCQASGTKGA HCVCDPGFSG
1460 1470 1480 1490 1500
ELCEQESECR GDPVRDFHQV QRGYAICQTT RPLSWVECRG SCPGQGCCQG
1510 1520 1530
LRLKRRKFTF ECSDGTSFAE EVEKPTKCGC ALCA
Length:1,534
Mass (Da):167,926
Last modified:April 17, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47B11CE6704A3E1D
GO
Isoform 2 (identifier: O75093-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     338-338: I → IRPLSFCSPCR
     790-813: Missing.
     830-1534: Missing.

Show »
Length:815
Mass (Da):90,633
Checksum:i4E435E97AD79F37C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T0V0Q5T0V0_HUMAN
Slit homolog 1 protein
SLIT1
1,461Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0V2Q5T0V2_HUMAN
Slit homolog 1 protein
SLIT1
409Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T0V4Q5T0V4_HUMAN
Slit homolog 1 protein
SLIT1
781Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32465 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti99A → V in BAA32465 (PubMed:9693030).Curated1
Sequence conflicti163Q → R in BAA35184 (PubMed:9813312).Curated1
Sequence conflicti829Q → P in AAK31796 (PubMed:12141424).Curated1
Sequence conflicti966D → N in BAA35184 (PubMed:9813312).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049003824P → L. Corresponds to variant dbSNP:rs2817673Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009706338I → IRPLSFCSPCR in isoform 2. 1 Publication1
Alternative sequenceiVSP_009707790 – 813Missing in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_009708830 – 1534Missing in isoform 2. 1 PublicationAdd BLAST705

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017167 mRNA Translation: BAA35184.1
AB011537 mRNA Translation: BAA32465.3 Different initiation.
AL442123 Genomic DNA No translation available.
AL512424 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49958.1
BC146851 mRNA Translation: AAI46852.1
AY029183 mRNA Translation: AAK31796.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7453.1 [O75093-1]

NCBI Reference Sequences

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RefSeqi
NP_003052.2, NM_003061.2 [O75093-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000266058; ENSP00000266058; ENSG00000187122 [O75093-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6585

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6585

UCSC genome browser

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UCSCi
uc001kmw.3 human [O75093-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017167 mRNA Translation: BAA35184.1
AB011537 mRNA Translation: BAA32465.3 Different initiation.
AL442123 Genomic DNA No translation available.
AL512424 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49958.1
BC146851 mRNA Translation: AAI46852.1
AY029183 mRNA Translation: AAK31796.1
CCDSiCCDS7453.1 [O75093-1]
RefSeqiNP_003052.2, NM_003061.2 [O75093-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112472, 2 interactors
IntActiO75093, 18 interactors
STRINGi9606.ENSP00000266058

PTM databases

CarbonylDBiO75093
iPTMnetiO75093
PhosphoSitePlusiO75093

Polymorphism and mutation databases

BioMutaiSLIT1

Proteomic databases

EPDiO75093
jPOSTiO75093
MassIVEiO75093
PaxDbiO75093
PeptideAtlasiO75093
PRIDEiO75093
ProteomicsDBi49753 [O75093-1]
49754 [O75093-2]

Genome annotation databases

EnsembliENST00000266058; ENSP00000266058; ENSG00000187122 [O75093-1]
GeneIDi6585
KEGGihsa:6585
UCSCiuc001kmw.3 human [O75093-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6585
DisGeNETi6585

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLIT1
HGNCiHGNC:11085 SLIT1
HPAiHPA006879
MIMi603742 gene
neXtProtiNX_O75093
OpenTargetsiENSG00000187122
PharmGKBiPA35938

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000157322
HOGENOMiHOG000116120
InParanoidiO75093
KOiK06838
OMAiQYAGRAC
OrthoDBi28488at2759
PhylomeDBiO75093
TreeFamiTF332887

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling
R-HSA-376176 Signaling by ROBO receptors
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
R-HSA-8985801 Regulation of cortical dendrite branching
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
SIGNORiO75093

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLIT1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLIT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6585
PharosiO75093

Protein Ontology

More...
PROi
PR:O75093

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187122 Expressed in 122 organ(s), highest expression level in Brodmann (1909) area 23
ExpressionAtlasiO75093 baseline and differential
GenevisibleiO75093 HS

Family and domain databases

Gene3Di3.80.10.10, 5 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000483 Cys-rich_flank_reg_C
IPR006207 Cys_knot_C
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR003645 Fol_N
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00008 EGF, 5 hits
PF12661 hEGF, 2 hits
PF02210 Laminin_G_2, 1 hit
PF13855 LRR_8, 6 hits
PF01463 LRRCT, 4 hits
PF01462 LRRNT, 4 hits
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00181 EGF, 9 hits
SM00179 EGF_CA, 7 hits
SM00274 FOLN, 4 hits
SM00282 LamG, 1 hit
SM00369 LRR_TYP, 18 hits
SM00082 LRRCT, 4 hits
SM00013 LRRNT, 4 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00022 EGF_1, 9 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 9 hits
PS01187 EGF_CA, 2 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS51450 LRR, 21 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75093
Secondary accession number(s): Q5T0V1, Q8WWZ2, Q9UIL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: April 17, 2007
Last modified: October 16, 2019
This is version 184 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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