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Entry version 175 (18 Sep 2019)
Sequence version 2 (07 Mar 2006)
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Protein

Zinc finger protein 189

Gene

ZNF189

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri148 – 170C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 189
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF189
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12980 ZNF189

Online Mendelian Inheritance in Man (OMIM)

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MIMi
603132 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O75820

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7743

Open Targets

More...
OpenTargetsi
ENSG00000136870

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37561

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF189

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000474441 – 626Zinc finger protein 189Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki67Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki88Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki160Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki434Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O75820

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O75820

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O75820

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O75820

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O75820

PeptideAtlas

More...
PeptideAtlasi
O75820

PRoteomics IDEntifications database

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PRIDEi
O75820

ProteomicsDB human proteome resource

More...
ProteomicsDBi
50210 [O75820-1]
50211 [O75820-2]
50212 [O75820-3]
50213 [O75820-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O75820

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O75820

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000136870 Expressed in 236 organ(s), highest expression level in caput epididymis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O75820 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O75820 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034814

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113528, 11 interactors

Protein interaction database and analysis system

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IntActi
O75820, 22 interactors

Molecular INTeraction database

More...
MINTi
O75820

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000342019

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O75820

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 89KRABPROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri148 – 170C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri176 – 198C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri204 – 226C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri232 – 254C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri260 – 282C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri288 – 310C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri316 – 338C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri344 – 366C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri372 – 394C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri400 – 422C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri456 – 478C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri484 – 506C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri512 – 534C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri540 – 562C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri568 – 590C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri599 – 621C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161823

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O75820

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLHTTWM

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O75820

TreeFam database of animal gene trees

More...
TreeFami
TF336942

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O75820-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPSPPPES KGLLTFEDVA VFFTQEEWDY LDPAQRSLYK DVMMENYGNL
60 70 80 90 100
VSLDVLNRDK DEEPTVKQEI EEIEEEVEPQ GVIVTRIKSE IDQDPMGRET
110 120 130 140 150
FELVGRLDKQ RGIFLWEIPR ESLTQEQRMF RENTNIIRKR PNSEEKCHKC
160 170 180 190 200
EECGKGFVRK AHFIQHQRVH TGEKPFQCNE CGKSFSRSSF VIEHQRIHTG
210 220 230 240 250
ERPYECNYCG KTFSVSSTLI RHQRIHTGER PYQCNQCKQS FSQRRSLVKH
260 270 280 290 300
QRIHTGEKPH KCSDCGKAFS WKSHLIEHQR THTGEKPYHC TKCKKSFSRN
310 320 330 340 350
SLLVEHQRIH TGERPHKCGE CGKAFRLSTY LIQHQKIHTG EKPFLCIECG
360 370 380 390 400
KSFSRSSFLI EHQRIHTGER PYQCKECGKS FSQLCNLTRH QRIHTGDKPH
410 420 430 440 450
KCEECGKAFS RSSGLIQHQR IHTREKTYPY NETKESFDPN CSLVIQQEVY
460 470 480 490 500
PKEKSYKCDE CGKTFSVSAH LVQHQRIHTG EKPYLCTVCG KSFSRSSFLI
510 520 530 540 550
EHQRIHTGER PYLCRQCGKS FSQLCNLIRH QGVHTGNKPH KCDECGKAFS
560 570 580 590 600
RNSGLIQHQR IHTGEKPYKC EKCDKSFSQQ RSLVNHQKIH AEVKTQETHE
610 620
CDACGEAFNC RISLIQHQKL HTAWMQ
Length:626
Mass (Da):72,976
Last modified:March 7, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF6E0F9943F15E4C
GO
Isoform 2 (identifier: O75820-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-25: Missing.

Show »
Length:612
Mass (Da):71,407
Checksum:i37BB52F79CA7643C
GO
Isoform 3 (identifier: O75820-3) [UniParc]FASTAAdd to basket
Also known as: B2

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:531
Mass (Da):62,061
Checksum:iF0DDE4B367716666
GO
Isoform 4 (identifier: O75820-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.

Show »
Length:584
Mass (Da):68,188
Checksum:iB5F6A7FA667E212C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0K2A0A087X0K2_HUMAN
Zinc finger protein 189
ZNF189
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti588K → M in AAC25910 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC25909 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC39798 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC39799 (PubMed:9653648).Curated1
Sequence conflicti588K → M in AAC39800 (PubMed:9653648).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025403221R → K. Corresponds to variant dbSNP:rs10989492Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0069011 – 95Missing in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0068991 – 42Missing in isoform 4. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_00690012 – 25Missing in isoform 2. 2 PublicationsAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U95992 mRNA Translation: AAC25910.1
U95991 mRNA Translation: AAC25909.1
U75454 mRNA Translation: AAC39798.1
AF025770 mRNA Translation: AAC39799.1
AF025771 mRNA Translation: AAC39800.1
AF025772 Genomic DNA Translation: AAD50527.1
AF025772 Genomic DNA Translation: AAD50528.1
AK290163 mRNA Translation: BAF82852.1
AL353621 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58949.1
BC092425 mRNA Translation: AAH92425.1
BC126120 mRNA Translation: AAI26121.1
BC143876 mRNA Translation: AAI43877.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS65096.1 [O75820-2]
CCDS6754.1 [O75820-1]
CCDS6755.1 [O75820-4]

NCBI Reference Sequences

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RefSeqi
NP_001265160.1, NM_001278231.1 [O75820-2]
NP_001265161.1, NM_001278232.1
NP_001265169.1, NM_001278240.1
NP_003443.2, NM_003452.3 [O75820-1]
NP_932094.1, NM_197977.2 [O75820-4]
XP_006717343.1, XM_006717280.3 [O75820-4]
XP_006717344.1, XM_006717281.3 [O75820-4]
XP_011517300.1, XM_011518998.2 [O75820-4]
XP_016870610.1, XM_017015121.1 [O75820-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259395; ENSP00000259395; ENSG00000136870 [O75820-4]
ENST00000339664; ENSP00000342019; ENSG00000136870 [O75820-1]
ENST00000374861; ENSP00000363995; ENSG00000136870 [O75820-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7743

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7743

UCSC genome browser

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UCSCi
uc004bbg.3 human [O75820-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95992 mRNA Translation: AAC25910.1
U95991 mRNA Translation: AAC25909.1
U75454 mRNA Translation: AAC39798.1
AF025770 mRNA Translation: AAC39799.1
AF025771 mRNA Translation: AAC39800.1
AF025772 Genomic DNA Translation: AAD50527.1
AF025772 Genomic DNA Translation: AAD50528.1
AK290163 mRNA Translation: BAF82852.1
AL353621 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58949.1
BC092425 mRNA Translation: AAH92425.1
BC126120 mRNA Translation: AAI26121.1
BC143876 mRNA Translation: AAI43877.1
CCDSiCCDS65096.1 [O75820-2]
CCDS6754.1 [O75820-1]
CCDS6755.1 [O75820-4]
RefSeqiNP_001265160.1, NM_001278231.1 [O75820-2]
NP_001265161.1, NM_001278232.1
NP_001265169.1, NM_001278240.1
NP_003443.2, NM_003452.3 [O75820-1]
NP_932094.1, NM_197977.2 [O75820-4]
XP_006717343.1, XM_006717280.3 [O75820-4]
XP_006717344.1, XM_006717281.3 [O75820-4]
XP_011517300.1, XM_011518998.2 [O75820-4]
XP_016870610.1, XM_017015121.1 [O75820-4]

3D structure databases

SMRiO75820
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113528, 11 interactors
IntActiO75820, 22 interactors
MINTiO75820
STRINGi9606.ENSP00000342019

PTM databases

iPTMnetiO75820
PhosphoSitePlusiO75820

Polymorphism and mutation databases

BioMutaiZNF189

Proteomic databases

EPDiO75820
jPOSTiO75820
MassIVEiO75820
MaxQBiO75820
PaxDbiO75820
PeptideAtlasiO75820
PRIDEiO75820
ProteomicsDBi50210 [O75820-1]
50211 [O75820-2]
50212 [O75820-3]
50213 [O75820-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259395; ENSP00000259395; ENSG00000136870 [O75820-4]
ENST00000339664; ENSP00000342019; ENSG00000136870 [O75820-1]
ENST00000374861; ENSP00000363995; ENSG00000136870 [O75820-2]
GeneIDi7743
KEGGihsa:7743
UCSCiuc004bbg.3 human [O75820-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7743
DisGeNETi7743

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF189
HGNCiHGNC:12980 ZNF189
HPAiHPA034814
MIMi603132 gene
neXtProtiNX_O75820
OpenTargetsiENSG00000136870
PharmGKBiPA37561

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161823
InParanoidiO75820
KOiK09228
OMAiKLHTTWM
OrthoDBi1318335at2759
PhylomeDBiO75820
TreeFamiTF336942

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7743

Pharos

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Pharosi
O75820

Protein Ontology

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PROi
PR:O75820

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136870 Expressed in 236 organ(s), highest expression level in caput epididymis
ExpressionAtlasiO75820 baseline and differential
GenevisibleiO75820 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 15 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 16 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN189_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O75820
Secondary accession number(s): O75802
, Q5T7D7, Q5T7D8, Q5T7D9, Q9UBL4, Q9UPE9, Q9UPF0, Q9UPF1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 7, 2006
Last modified: September 18, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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