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Entry version 180 (16 Oct 2019)
Sequence version 1 (01 Nov 1998)
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Protein
Submitted name:

GEO01111p1

Gene

SkpA

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathwaySAAS annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-68949 Orc1 removal from chromatin
R-DME-69231 Cyclin D associated events in G1
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8951664 Neddylation
R-DME-9020702 Interleukin-1 signaling
R-DME-917937 Iron uptake and transport
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GEO01111p1Imported
Submitted name:
HL01263pImported
Submitted name:
RH26825pImported
Submitted name:
SKP1-related A, isoform AImported
Submitted name:
SKP1-related A, isoform BImported
Submitted name:
SKP1-related A, isoform CImported
Submitted name:
SKP1-related A, isoform EImported
Submitted name:
SKP1-related A, isoform FImported
Submitted name:
SKP1-related A, isoform GImported
Submitted name:
SKPAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SkpAImported
Synonyms:anon-WO03040301.234Imported, anon-WO03040301.236Imported, anon-WO03040301.238Imported, Dmel\CG16983Imported, DreddImported, dSkip-1Imported, dSkp-1Imported, dSKP1Imported, dSkpAImported, dskpAImported, EG:115C2.4Imported, l(1)G0037Imported, l(1)G0058Imported, l(1)G0109Imported, l(1)G0389Imported, SkpImported, SKP1Imported, Skp1Imported, SKPAImported, skpAImported, skpA-RCImported, skpA-RHImported, spkAImported
ORF Names:CG16983Imported, Dmel_CG16983Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025637 SkpA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025637 Expressed in 31 organ(s), highest expression level in cleaving embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-18869N

Protein interaction database and analysis system

More...
IntActi
O77430, 57 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070118

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 66Skp1_POZInterPro annotationAdd BLAST65
Domaini112 – 159Skp1InterPro annotationAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKP1 family.SAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1724 Eukaryota
COG5201 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012652

KEGG Orthology (KO)

More...
KOi
K03094

Identification of Orthologs from Complete Genome Data

More...
OMAi
SDNEQFT

Database of Orthologous Groups

More...
OrthoDBi
1412723at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00512 Skp1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O77430-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSIKLQSSD EEIFDTDIQI AKCSGTIKTM LEDCGMEDDE NAIVPLPNVN
60 70 80 90 100
STILRKVLTW AHYHKDDPQP TEDDESKEKR TDDIISWDAD FLKVDQGTLF
110 120 130 140 150
ELILAANYLD IKGLLELTCK TVANMIKGKT PEEIRKTFNI KKDFSPAEEE
160
QVRKENEWCE EK
Length:162
Mass (Da):18,597
Last modified:November 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD218D30AC98CA0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45538.1
AE014298 Genomic DNA Translation: AAF45539.1
AE014298 Genomic DNA Translation: AAF45540.1
AF220066 Genomic DNA Translation: AAF64674.1
AE014298 Genomic DNA Translation: AAG22362.1
AY069297 mRNA Translation: AAL39442.1
AE014298 Genomic DNA Translation: AAN09024.1
AE014298 Genomic DNA Translation: AAN09025.1
AE014298 Genomic DNA Translation: AAN09026.1
AE014298 Genomic DNA Translation: ABC67161.1
BT099582 mRNA Translation: ACU43544.1
BT099610 mRNA Translation: ACU51754.1
AE014298 Genomic DNA Translation: AHN59226.1
KX532038 mRNA Translation: ANY27848.1
AL031581 Genomic DNA Translation: CAA20889.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13390

NCBI Reference Sequences

More...
RefSeqi
NP_001033818.1, NM_001038729.3
NP_001284755.1, NM_001297826.1
NP_477390.1, NM_058042.5
NP_726690.1, NM_166856.3
NP_726691.1, NM_166857.3
NP_726692.1, NM_166858.3
NP_726693.1, NM_166859.3
NP_726694.1, NM_166860.3
NP_726695.1, NM_166861.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070123; FBpp0070118; FBgn0025637
FBtr0070124; FBpp0070119; FBgn0025637
FBtr0070125; FBpp0070120; FBgn0025637
FBtr0070126; FBpp0070121; FBgn0025637
FBtr0070127; FBpp0070122; FBgn0025637
FBtr0070128; FBpp0070123; FBgn0025637
FBtr0070129; FBpp0070124; FBgn0025637
FBtr0100530; FBpp0099971; FBgn0025637
FBtr0345314; FBpp0311474; FBgn0025637

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31016

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG16983

UCSC genome browser

More...
UCSCi
CG16983-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45538.1
AE014298 Genomic DNA Translation: AAF45539.1
AE014298 Genomic DNA Translation: AAF45540.1
AF220066 Genomic DNA Translation: AAF64674.1
AE014298 Genomic DNA Translation: AAG22362.1
AY069297 mRNA Translation: AAL39442.1
AE014298 Genomic DNA Translation: AAN09024.1
AE014298 Genomic DNA Translation: AAN09025.1
AE014298 Genomic DNA Translation: AAN09026.1
AE014298 Genomic DNA Translation: ABC67161.1
BT099582 mRNA Translation: ACU43544.1
BT099610 mRNA Translation: ACU51754.1
AE014298 Genomic DNA Translation: AHN59226.1
KX532038 mRNA Translation: ANY27848.1
AL031581 Genomic DNA Translation: CAA20889.1
PIRiT13390
RefSeqiNP_001033818.1, NM_001038729.3
NP_001284755.1, NM_001297826.1
NP_477390.1, NM_058042.5
NP_726690.1, NM_166856.3
NP_726691.1, NM_166857.3
NP_726692.1, NM_166858.3
NP_726693.1, NM_166859.3
NP_726694.1, NM_166860.3
NP_726695.1, NM_166861.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-18869N
IntActiO77430, 57 interactors
STRINGi7227.FBpp0070118

Genome annotation databases

EnsemblMetazoaiFBtr0070123; FBpp0070118; FBgn0025637
FBtr0070124; FBpp0070119; FBgn0025637
FBtr0070125; FBpp0070120; FBgn0025637
FBtr0070126; FBpp0070121; FBgn0025637
FBtr0070127; FBpp0070122; FBgn0025637
FBtr0070128; FBpp0070123; FBgn0025637
FBtr0070129; FBpp0070124; FBgn0025637
FBtr0100530; FBpp0099971; FBgn0025637
FBtr0345314; FBpp0311474; FBgn0025637
GeneIDi31016
KEGGidme:Dmel_CG16983
UCSCiCG16983-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31016
FlyBaseiFBgn0025637 SkpA

Phylogenomic databases

eggNOGiKOG1724 Eukaryota
COG5201 LUCA
GeneTreeiENSGT00390000012652
KOiK03094
OMAiSDNEQFT
OrthoDBi1412723at2759

Enzyme and pathway databases

ReactomeiR-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-68949 Orc1 removal from chromatin
R-DME-69231 Cyclin D associated events in G1
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8951664 Neddylation
R-DME-9020702 Interleukin-1 signaling
R-DME-917937 Iron uptake and transport
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31016

Gene expression databases

BgeeiFBgn0025637 Expressed in 31 organ(s), highest expression level in cleaving embryo

Family and domain databases

InterProiView protein in InterPro
IPR016897 SKP1
IPR001232 SKP1-like
IPR036296 SKP1-like_dim_sf
IPR011333 SKP1/BTB/POZ_sf
IPR016072 Skp1_comp_dimer
IPR016073 Skp1_comp_POZ
PfamiView protein in Pfam
PF01466 Skp1, 1 hit
PF03931 Skp1_POZ, 1 hit
PIRSFiPIRSF028729 E3_ubiquit_lig_SCF_Skp, 1 hit
SMARTiView protein in SMART
SM00512 Skp1, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF81382 SSF81382, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO77430_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O77430
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 16, 2019
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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