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UniProtKB - O88576 (S6A18_MOUSE)

Entry version 135 (16 Oct 2019)
Sequence version 1 (01 Nov 1998)
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Protein

Sodium-dependent neutral amino acid transporter B(0)AT3

Gene

Slc6a18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a sodium and chloride-dependent neutral amino acid transporter in kidneys (PubMed:26240152, PubMed:19478081). Required CLTRN for cell surface expression and for its amino acid transporter activity (PubMed:26240152).2 Publications

Caution

Human SLC6A18 has been shown to be an inactive protein.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.79 mM for L-alanine (in the presence of CLTRN)1 Publication
  2. KM=0.14 mM for L-alanine (in the presence of ACE2)1 Publication
  3. KM=0.99 mM for L-glycine (in the presence of CLTRN)1 Publication
  4. KM=0.27 mM for L-glycine (in the presence of ACE2)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-MMU-352230 Amino acid transport across the plasma membrane
    R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Sodium-dependent neutral amino acid transporter B(0)AT31 Publication
    Alternative name(s):
    Sodium- and chloride-dependent transporter XTRP2
    Solute carrier family 6 member 18
    System B(0) neutral amino acid transporter AT3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Slc6a18
    Synonyms:Xt21 Publication, Xtrp2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...    MGIi    		MGI:1336892 Slc6a18

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
    Topological domaini48 – 52ExtracellularSequence analysis5
    Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
    Topological domaini74 – 105CytoplasmicSequence analysisAdd BLAST32
    Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
    Topological domaini127 – 177ExtracellularSequence analysisAdd BLAST51
    Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
    Topological domaini199 – 206CytoplasmicSequence analysis8
    Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
    Topological domaini228 – 255ExtracellularSequence analysisAdd BLAST28
    Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
    Topological domaini277 – 288CytoplasmicSequence analysisAdd BLAST12
    Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
    Topological domaini310 – 397ExtracellularSequence analysisAdd BLAST88
    Transmembranei398 – 418Helical; Name=8Sequence analysisAdd BLAST21
    Topological domaini419 – 441CytoplasmicSequence analysisAdd BLAST23
    Transmembranei442 – 462Helical; Name=9Sequence analysisAdd BLAST21
    Topological domaini463 – 472ExtracellularSequence analysis10
    Transmembranei473 – 493Helical; Name=10Sequence analysisAdd BLAST21
    Topological domaini494 – 520CytoplasmicSequence analysisAdd BLAST27
    Transmembranei521 – 541Helical; Name=11Sequence analysisAdd BLAST21
    Topological domaini542 – 570ExtracellularSequence analysisAdd BLAST29
    Transmembranei571 – 591Helical; Name=12Sequence analysisAdd BLAST21
    Topological domaini592 – 615CytoplasmicSequence analysisAdd BLAST24

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Animals lacking this protein exhibit no gross abnormalities and grow to adulthood, although they do exhibit hypertension. The elevated blood pressure appears to be attributable to a decreased level of renal glycine. High-affinity renal reabsorption of glycine is eliminated and intrarenal glycine concentration is reduced.1 Publication

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi21D → N: No effect on protein abundance. Increases localization to the cell membrane. Increases alanine uptake activity. 1 Publication1
    Mutagenesisi25Q → D: No effect on protein abundance. Almost complete loss of cell surface localization. Decreases alanine uptake activity. 1 Publication1
    Mutagenesisi25Q → V: No effect on protein abundance. Strong decrease of cell surface localization. Decreases alanine uptake. 1 Publication1
    Mutagenesisi50H → Y: No effect on protein abundance. No effect on cell surface localization. Increases alanine uptake activity. 1 Publication1
    Mutagenesisi72Y → H: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi78G → S: No effect on protein abundance. No effect on cell surface expression. Decreases alanine uptake activity. 1 Publication1
    Mutagenesisi90K → T: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi158S → D: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi213L → W: No effect on protein abundance. No effect on cell surface localization. Decreases alanine uptake activity. 1 Publication1
    Mutagenesisi225R → T: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake. 1 Publication1
    Mutagenesisi283N → D: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake. 1 Publication1
    Mutagenesisi287D → K: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake. 1 Publication1
    Mutagenesisi287D → N: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity. 1 Publication1
    Mutagenesisi296S → R: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity. 1 Publication1
    Mutagenesisi297M → C: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi297M → S: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi456I → T: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi464G → N: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi477L → P: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1
    Mutagenesisi495G → R: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity. 1 Publication1
    Mutagenesisi502D → N: Decreases protein abundance. Strong decreases of cell surface localization. Strong decreases on alanine uptake activity. 1 Publication1
    Mutagenesisi568Q → R: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002148071 – 615Sodium-dependent neutral amino acid transporter B(0)AT3Add BLAST615

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		O88576

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		O88576

    PRoteomics IDEntifications database

    More...    PRIDEi    		O88576

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		O88576

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		O88576

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed predominantly in kidney.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSMUSG00000021612 Expressed in 69 organ(s), highest expression level in adult mammalian kidney

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		O88576 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		O88576 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with CLTRN; this interaction regulates the trafficking of SLC6A18 to the cell membrane and its activity.

    2 Publications

    Protein-protein interaction databases

    Database of interacting proteins

    More...    DIPi    		DIP-60421N

    Protein interaction database and analysis system

    More...    IntActi    		O88576, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		10090.ENSMUSP00000022105

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG3659 Eukaryota
    COG0733 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000158906

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		O88576

    KEGG Orthology (KO)

    More...    KOi    		K05048

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		VAWVLWY

    Database of Orthologous Groups

    More...    OrthoDBi    		547281at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		O88576

    TreeFam database of animal gene trees

    More...    TreeFami    		TF343812

    Family and domain databases

    Conserved Domains Database

    More...    CDDi    		cd11517 SLC6sbd_B0AT3, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR042701 B0AT3_SLC6sbd
    IPR000175 Na/ntran_symport
    IPR002438 Neutral_aa_SLC6
    IPR037272 SNS_sf

    The PANTHER Classification System

    More...    PANTHERi    		PTHR11616 PTHR11616, 1 hit

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF00209 SNF, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...    PRINTSi    		PR00176 NANEUSMPORT
    PR01206 ORPHTRNSPORT

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF161070 SSF161070, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
    PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
    PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: O88576-1) [UniParc]FASTAAdd to basket
    Also known as: A12

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCQTH 
            60         70         80         90        100
    GGGAFLIPYF IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG 
           110        120        130        140        150
    LGCFSVSFLV SLYYNTVLLW VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE 
           160        170        180        190        200
    CQSSGTVSYF WYRQTLNITS DISNTGTIQW KLFLCLVACW STVYLCVIRG 
           210        220        230        240        250
    IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLIYLF TPNMKTLQNP 
           260        270        280        290        300
    RVWLDAATQI FFSLSLAFGG HIAFASYNPP RNNCEKDAVI IALVNSMTSL 
           310        320        330        340        350
    YASIAIFSVM GFKASNDYGR CLDRNILSLI NEFDLPELSI SRDEYPSVLM 
           360        370        380        390        400
    YLNATQTARV AQLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV 
           410        420        430        440        450
    WSVLFFGMLF TLGLSSMFGN MEGVITPLLD MGILPKGIPK EVMTGVICFA 
           460        470        480        490        500
    CFLSAICFTL QSGGYWLEIF DSFAASLNLI IFAFMEVVGV IHIYGMKRFC 
           510        520        530        540        550
    DDIEWMTGRR PGLYWQVTWR VVSPMLLFGI FLSYIVLLIQ TPPSYKAWNP 
           560        570        580        590        600
    QYEHFPSREE KFYPGWVQVT CVLLSFLPSL WVPGVALAQL LSQYKQRWKA 
           610 
    THLESGLKLQ ESRGC
    Length:615
    Mass (Da):69,229
    Last modified:November 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7925C0397FC63F8
    GO
    Isoform 2 (identifier: O88576-2) [UniParc]FASTAAdd to basket
    Also known as: A11

    The sequence of this isoform differs from the canonical sequence as follows:
         445-454: Missing.

    Show »
    Length:605
    Mass (Da):68,188
    Checksum:iE86342EE242445BF
    GO
    Isoform 3 (identifier: O88576-3) [UniParc]FASTAAdd to basket
    Also known as: B11

    The sequence of this isoform differs from the canonical sequence as follows:
         377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP

    Show »
    Length:577
    Mass (Da):65,254
    Checksum:i5F84F7C5CF1B14E3
    GO
    Isoform 4 (identifier: O88576-4) [UniParc]FASTAAdd to basket
    Also known as: A10

    The sequence of this isoform differs from the canonical sequence as follows:
         499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
         553-615: Missing.

    Show »
    Length:552
    Mass (Da):61,513
    Checksum:i8DEE83992276B575
    GO
    Isoform 5 (identifier: O88576-5) [UniParc]FASTAAdd to basket
    Also known as: B9

    The sequence of this isoform differs from the canonical sequence as follows:
         377-444: SASGPGLAFI...PKGIPKEVMT → PTWKQISGARVLGEGCARLTSRVCEASVLP
         499-552: FCDDIEWMTG...PSYKAWNPQY → NIFPQERRSS...GGRLRIWKVV
         553-615: Missing.

    Show »
    Length:514
    Mass (Da):57,538
    Checksum:i3743C2342ECE0610
    GO
    Isoform 6 (identifier: O88576-6) [UniParc]FASTAAdd to basket
    Also known as: A8

    The sequence of this isoform differs from the canonical sequence as follows:
         377-422: SASGPGLAFI...GLSSMFGNME → VLLCGLCSSL...SYPKVYPRRS
         423-615: Missing.

    Show »
    Length:422
    Mass (Da):47,619
    Checksum:i6A794BDE016C00C3
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A0A217FL56A0A217FL56_MOUSE
    Transporter
    Slc6a18 mCG_20942
    		542Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1Y7VJ53A0A1Y7VJ53_MOUSE
    Transporter
    Slc6a18
    		109Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1Y7VJY3A0A1Y7VJY3_MOUSE
    Transporter
    Slc6a18
    		211Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A1Y7VMA5A0A1Y7VMA5_MOUSE
    Sodium-dependent neutral amino acid...
    Slc6a18
    		26Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050364377 – 444SASGP…KEVMT → PTWKQISGARVLGEGCARLT SRVCEASVLP in isoform 3 and isoform 5. 2 PublicationsAdd BLAST68
    Alternative sequenceiVSP_050363377 – 422SASGP…FGNME → VLLCGLCSSLGCCLPWVCPP CLGTWRVSLHHYWTWGSYPK VYPRRS in isoform 6. 1 PublicationAdd BLAST46
    Alternative sequenceiVSP_050697423 – 615Missing in isoform 6. 1 PublicationAdd BLAST193
    Alternative sequenceiVSP_050365445 – 454Missing in isoform 2. 1 Publication10
    Alternative sequenceiVSP_050366499 – 552FCDDI…WNPQY → NIFPQERRSSTQAGCRSPVC SCPSCPHCGSLELLWLSYCP STNRGGRLRIWKVV in isoform 4 and isoform 5. 1 PublicationAdd BLAST54
    Alternative sequenceiVSP_050367553 – 615Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST63

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF075262 mRNA Translation: AAC27757.1
    AF075263 mRNA Translation: AAC27758.1
    AF075264 mRNA Translation: AAC27759.1
    AF075265 mRNA Translation: AAC27760.1
    AF075266 mRNA Translation: AAC27761.1
    AF075267 mRNA Translation: AAC27762.1
    BC010748 mRNA Translation: AAH10748.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS36727.1 [O88576-1]
    CCDS49311.1 [O88576-3]
    CCDS49312.1 [O88576-4]

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001035782.1, NM_001040692.3 [O88576-1]
    NP_001129559.1, NM_001136087.2 [O88576-3]
    NP_001162115.1, NM_001168644.1 [O88576-4]
    NP_001162116.1, NM_001168645.1 [O88576-5]
    NP_001162117.1, NM_001168646.1 [O88576-2]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENSMUST00000109679; ENSMUSP00000105301; ENSMUSG00000021612 [O88576-4]
    ENSMUST00000109680; ENSMUSP00000105302; ENSMUSG00000021612 [O88576-3]
    ENSMUST00000220650; ENSMUSP00000152403; ENSMUSG00000021612 [O88576-5]
    ENSMUST00000222029; ENSMUSP00000152525; ENSMUSG00000021612 [O88576-1]
    ENSMUST00000223026; ENSMUSP00000152516; ENSMUSG00000021612 [O88576-6]
    ENSMUST00000223074; ENSMUSP00000152146; ENSMUSG00000021612 [O88576-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		22598

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		mmu:22598

    UCSC genome browser

    More...    UCSCi    		uc007rds.2 mouse [O88576-1]
    uc007rdt.2 mouse [O88576-2]
    uc007rdu.2 mouse [O88576-3]
    uc007rdv.2 mouse [O88576-4]
    uc007rdw.2 mouse [O88576-5]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF075262 mRNA Translation: AAC27757.1
    AF075263 mRNA Translation: AAC27758.1
    AF075264 mRNA Translation: AAC27759.1
    AF075265 mRNA Translation: AAC27760.1
    AF075266 mRNA Translation: AAC27761.1
    AF075267 mRNA Translation: AAC27762.1
    BC010748 mRNA Translation: AAH10748.1
    CCDSiCCDS36727.1 [O88576-1]
    CCDS49311.1 [O88576-3]
    CCDS49312.1 [O88576-4]
    RefSeqiNP_001035782.1, NM_001040692.3 [O88576-1]
    NP_001129559.1, NM_001136087.2 [O88576-3]
    NP_001162115.1, NM_001168644.1 [O88576-4]
    NP_001162116.1, NM_001168645.1 [O88576-5]
    NP_001162117.1, NM_001168646.1 [O88576-2]

    3D structure databases

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    SWISS-MODEL Interactive Workspace

    More...    SWISS-MODEL-Workspacei    		Submit a new modelling project...

    Protein-protein interaction databases

    DIPiDIP-60421N
    IntActiO88576, 1 interactor
    STRINGi10090.ENSMUSP00000022105

    PTM databases

    iPTMnetiO88576
    PhosphoSitePlusiO88576

    Proteomic databases

    jPOSTiO88576
    PaxDbiO88576
    PRIDEiO88576

    Genome annotation databases

    EnsembliENSMUST00000109679; ENSMUSP00000105301; ENSMUSG00000021612 [O88576-4]
    ENSMUST00000109680; ENSMUSP00000105302; ENSMUSG00000021612 [O88576-3]
    ENSMUST00000220650; ENSMUSP00000152403; ENSMUSG00000021612 [O88576-5]
    ENSMUST00000222029; ENSMUSP00000152525; ENSMUSG00000021612 [O88576-1]
    ENSMUST00000223026; ENSMUSP00000152516; ENSMUSG00000021612 [O88576-6]
    ENSMUST00000223074; ENSMUSP00000152146; ENSMUSG00000021612 [O88576-2]
    GeneIDi22598
    KEGGimmu:22598
    UCSCiuc007rds.2 mouse [O88576-1]
    uc007rdt.2 mouse [O88576-2]
    uc007rdu.2 mouse [O88576-3]
    uc007rdv.2 mouse [O88576-4]
    uc007rdw.2 mouse [O88576-5]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		348932
    MGIiMGI:1336892 Slc6a18

    Phylogenomic databases

    eggNOGiKOG3659 Eukaryota
    COG0733 LUCA
    GeneTreeiENSGT00940000158906
    InParanoidiO88576
    KOiK05048
    OMAiVAWVLWY
    OrthoDBi547281at2759
    PhylomeDBiO88576
    TreeFamiTF343812

    Enzyme and pathway databases

    ReactomeiR-MMU-352230 Amino acid transport across the plasma membrane
    R-MMU-442660 Na+/Cl- dependent neurotransmitter transporters

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		Slc6a18 mouse

    Protein Ontology

    More...    PROi    		PR:O88576

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSMUSG00000021612 Expressed in 69 organ(s), highest expression level in adult mammalian kidney
    ExpressionAtlasiO88576 baseline and differential
    GenevisibleiO88576 MM

    Family and domain databases

    CDDicd11517 SLC6sbd_B0AT3, 1 hit
    InterProiView protein in InterPro
    IPR042701 B0AT3_SLC6sbd
    IPR000175 Na/ntran_symport
    IPR002438 Neutral_aa_SLC6
    IPR037272 SNS_sf
    PANTHERiPTHR11616 PTHR11616, 1 hit
    PfamiView protein in Pfam
    PF00209 SNF, 1 hit
    PRINTSiPR00176 NANEUSMPORT
    PR01206 ORPHTRNSPORT
    SUPFAMiSSF161070 SSF161070, 1 hit
    PROSITEiView protein in PROSITE
    PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
    PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
    PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS6A18_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O88576
    Secondary accession number(s): O88577
    , O88578, O88579, O88580, O88581, Q91XG6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: November 1, 1998
    Last modified: October 16, 2019
    This is version 135 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    UniProt is an ELIXIR core data resource
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