Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 176 (16 Oct 2019)
Sequence version 1 (01 May 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

Gene

NDUFB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1268020 Mitochondrial protein import
R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Alternative name(s):
Complex I-ASHI
Short name:
CI-ASHI
NADH-ubiquinone oxidoreductase ASHI subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NDUFB8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7703 NDUFB8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602140 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95169

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei133 – 153HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mitochondrial complex I deficiency, nuclear type 32 (MC1DN32)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN32 transmission pattern is consistent with autosomal recessive inheritance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08146662Y → H in MC1DN32. 1 PublicationCorresponds to variant dbSNP:rs1554843434EnsemblClinVar.1
Natural variantiVAR_08146776P → Q in MC1DN32. 1 PublicationCorresponds to variant dbSNP:rs1239013578EnsemblClinVar.1
Natural variantiVAR_081468105 – 156Missing in MC1DN32; due to a nucleotide substitution that results in exon 4 skipping or in missense variant W-144; patient cells contain both type of transcripts; transcript lacking exon 4 is the most abundant. 1 PublicationAdd BLAST52
Natural variantiVAR_081469144C → W in MC1DN32; due to a nucleotide substitution that results in exon 4 skipping or missense variant W-144; patient cells contain both type of transcripts; transcript with the missense variant is the less abundant. 1 PublicationCorresponds to variant dbSNP:rs1554843251EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
4714

MalaCards human disease database

More...
MalaCardsi
NDUFB8
MIMi618252 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000166136

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
70474 Leigh syndrome with cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31514

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95169

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2363065

Drug and drug target database

More...
DrugBanki
DB00157 NADH

DrugCentral

More...
DrugCentrali
O95169

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NDUFB8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 28MitochondrionBy similarityAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002004629 – 186NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialAdd BLAST158

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95169

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95169

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95169

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95169

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95169

PeptideAtlas

More...
PeptideAtlasi
O95169

PRoteomics IDEntifications database

More...
PRIDEi
O95169

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50683 [O95169-1]
65796
65797

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O95169-1 [O95169-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95169

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95169

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O95169

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166136 Expressed in 238 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95169 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95169 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003886

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Complex I is composed of 45 different subunits.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110794, 76 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-577 Mitochondrial respiratory chain complex I

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
O95169

Protein interaction database and analysis system

More...
IntActi
O95169, 43 interactors

Molecular INTeraction database

More...
MINTi
O95169

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299166

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95169

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I NDUFB8 subunit family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4040 Eukaryota
ENOG4111WEY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000628

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012999

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95169

KEGG Orthology (KO)

More...
KOi
K03964

Identification of Orthologs from Complete Genome Data

More...
OMAi
KLCAANP

Database of Orthologous Groups

More...
OrthoDBi
1427659at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95169

TreeFam database of animal gene trees

More...
TreeFami
TF317319

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008699 NDUFB8
IPR016551 Ndufb8_metazoa

The PANTHER Classification System

More...
PANTHERi
PTHR12840 PTHR12840, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05821 NDUF_B8, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF009288 NDUB8, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95169-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVARAGVLG VQWLQRASRN VMPLGARTAS HMTKDMFPGP YPRTPEERAA
60 70 80 90 100
AAKKYNMRVE DYEPYPDDGM GYGDYPKLPD RSQHERDPWY SWDQPGLRLN
110 120 130 140 150
WGEPMHWHLD MYNRNRVDTS PTPVSWHVMC MQLFGFLAFM IFMCWVGDVY
160 170 180
PVYQPVGPKQ YPYNNLYLER GGDPSKEPER VVHYEI
Length:186
Mass (Da):21,766
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i518459D44965D202
GO
Isoform 2 (identifier: O95169-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     157-172: GPKQYPYNNLYLERGG → CRHHFSYNLGFLSALG
     173-186: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):20,039
Checksum:iD11BE3F6BEDD1658
GO
Isoform 3 (identifier: O95169-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:155
Mass (Da):18,479
Checksum:iB409F622289FC308
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQ68E9PQ68_HUMAN
Uncharacterized protein
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIZ8E9PIZ8_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB8
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K9J7I2K9J7I2_HUMAN
Uncharacterized protein
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44T → I in CAB45691 (PubMed:11230166).Curated1
Sequence conflicti44T → I in CAG38521 (Ref. 5) Curated1
Sequence conflicti171G → S in AAD27761 (PubMed:11042152).Curated1
Sequence conflicti184Y → N in CAB45691 (PubMed:11230166).Curated1
Sequence conflicti184Y → N in CAG38521 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08146662Y → H in MC1DN32. 1 PublicationCorresponds to variant dbSNP:rs1554843434EnsemblClinVar.1
Natural variantiVAR_08146776P → Q in MC1DN32. 1 PublicationCorresponds to variant dbSNP:rs1239013578EnsemblClinVar.1
Natural variantiVAR_081468105 – 156Missing in MC1DN32; due to a nucleotide substitution that results in exon 4 skipping or in missense variant W-144; patient cells contain both type of transcripts; transcript lacking exon 4 is the most abundant. 1 PublicationAdd BLAST52
Natural variantiVAR_081469144C → W in MC1DN32; due to a nucleotide substitution that results in exon 4 skipping or missense variant W-144; patient cells contain both type of transcripts; transcript with the missense variant is the less abundant. 1 PublicationCorresponds to variant dbSNP:rs1554843251EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0548421 – 31Missing in isoform 3. 1 PublicationAdd BLAST31
Alternative sequenceiVSP_054843157 – 172GPKQY…LERGG → CRHHFSYNLGFLSALG in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_054844173 – 186Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF044958 mRNA Translation: AAD05422.1
AF115968 mRNA Translation: AAP97239.1
AF077028 mRNA Translation: AAD27761.1
AL080056 mRNA Translation: CAB45691.1
CR533490 mRNA Translation: CAG38521.1
AK289579 mRNA Translation: BAF82268.1
AK295867 mRNA Translation: BAG58666.1
AL133352 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49819.1
CH471066 Genomic DNA Translation: EAW49820.1
BC000466 mRNA Translation: AAH00466.1
BC019276 mRNA Translation: AAH19276.1
BI602529 mRNA No translation available.
Y18944 Genomic DNA Translation: CAB46274.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS65916.1 [O95169-3]
CCDS65917.1 [O95169-2]
CCDS7497.1 [O95169-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JE0382

NCBI Reference Sequences

More...
RefSeqi
NP_001271296.1, NM_001284367.1 [O95169-2]
NP_001271297.1, NM_001284368.1 [O95169-3]
NP_004995.1, NM_005004.3 [O95169-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299166; ENSP00000299166; ENSG00000166136 [O95169-1]
ENST00000370320; ENSP00000359344; ENSG00000166136 [O95169-2]
ENST00000370322; ENSP00000359346; ENSG00000166136 [O95169-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4714

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4714

UCSC genome browser

More...
UCSCi
uc001kri.3 human [O95169-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044958 mRNA Translation: AAD05422.1
AF115968 mRNA Translation: AAP97239.1
AF077028 mRNA Translation: AAD27761.1
AL080056 mRNA Translation: CAB45691.1
CR533490 mRNA Translation: CAG38521.1
AK289579 mRNA Translation: BAF82268.1
AK295867 mRNA Translation: BAG58666.1
AL133352 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49819.1
CH471066 Genomic DNA Translation: EAW49820.1
BC000466 mRNA Translation: AAH00466.1
BC019276 mRNA Translation: AAH19276.1
BI602529 mRNA No translation available.
Y18944 Genomic DNA Translation: CAB46274.1
CCDSiCCDS65916.1 [O95169-3]
CCDS65917.1 [O95169-2]
CCDS7497.1 [O95169-1]
PIRiJE0382
RefSeqiNP_001271296.1, NM_001284367.1 [O95169-2]
NP_001271297.1, NM_001284368.1 [O95169-3]
NP_004995.1, NM_005004.3 [O95169-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70c34-186[»]
5XTDelectron microscopy3.70c34-186[»]
5XTHelectron microscopy3.90c34-186[»]
5XTIelectron microscopy17.40Bc/c34-186[»]
SMRiO95169
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110794, 76 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiO95169
IntActiO95169, 43 interactors
MINTiO95169
STRINGi9606.ENSP00000299166

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH
DrugCentraliO95169

PTM databases

iPTMnetiO95169
PhosphoSitePlusiO95169
SwissPalmiO95169

Polymorphism and mutation databases

BioMutaiNDUFB8

Proteomic databases

EPDiO95169
jPOSTiO95169
MassIVEiO95169
MaxQBiO95169
PaxDbiO95169
PeptideAtlasiO95169
PRIDEiO95169
ProteomicsDBi50683 [O95169-1]
65796
65797
TopDownProteomicsiO95169-1 [O95169-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4714

Genome annotation databases

EnsembliENST00000299166; ENSP00000299166; ENSG00000166136 [O95169-1]
ENST00000370320; ENSP00000359344; ENSG00000166136 [O95169-2]
ENST00000370322; ENSP00000359346; ENSG00000166136 [O95169-3]
GeneIDi4714
KEGGihsa:4714
UCSCiuc001kri.3 human [O95169-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4714
DisGeNETi4714

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NDUFB8
HGNCiHGNC:7703 NDUFB8
HPAiHPA003886
MalaCardsiNDUFB8
MIMi602140 gene
618252 phenotype
neXtProtiNX_O95169
OpenTargetsiENSG00000166136
Orphaneti70474 Leigh syndrome with cardiomyopathy
PharmGKBiPA31514

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4040 Eukaryota
ENOG4111WEY LUCA
GeneTreeiENSGT00390000000628
HOGENOMiHOG000012999
InParanoidiO95169
KOiK03964
OMAiKLCAANP
OrthoDBi1427659at2759
PhylomeDBiO95169
TreeFamiTF317319

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NDUFB8 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
NDUFB8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4714
PharosiO95169

Protein Ontology

More...
PROi
PR:O95169

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166136 Expressed in 238 organ(s), highest expression level in endothelial cell
ExpressionAtlasiO95169 baseline and differential
GenevisibleiO95169 HS

Family and domain databases

InterProiView protein in InterPro
IPR008699 NDUFB8
IPR016551 Ndufb8_metazoa
PANTHERiPTHR12840 PTHR12840, 1 hit
PfamiView protein in Pfam
PF05821 NDUF_B8, 1 hit
PIRSFiPIRSF009288 NDUB8, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNDUB8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95169
Secondary accession number(s): A8K0L4
, Q5W143, Q5W144, Q5W145, Q9UG53, Q9UJR4, Q9UQF3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: October 16, 2019
This is version 176 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again