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Entry version 142 (16 Oct 2019)
Sequence version 1 (01 May 1999)
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Protein

Tumor necrosis factor alpha-induced protein 8

Gene

TNFAIP8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB

GO - Biological processi

  • negative regulation of apoptotic process Source: ProtInc
  • positive regulation of apoptotic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483255 PI Metabolism

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O95379

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 8
Short name:
TNF alpha-induced protein 8
Alternative name(s):
Head and neck tumor and metastasis-related protein
MDC-3.13
NF-kappa-B-inducible DED-containing protein
Short name:
NDED
SCC-S2
TNF-induced protein GG2-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFAIP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17260 TNFAIP8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612111 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O95379

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25816

Open Targets

More...
OpenTargetsi
ENSG00000145779

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134957136

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O95379

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFAIP8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002857181 – 198Tumor necrosis factor alpha-induced protein 8Add BLAST198

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O95379

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O95379

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O95379

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O95379

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O95379

PeptideAtlas

More...
PeptideAtlasi
O95379

PRoteomics IDEntifications database

More...
PRIDEi
O95379

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
50831 [O95379-1]
50832 [O95379-2]
50833 [O95379-3]
6823

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O95379

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O95379

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at high levels in the fetal liver, lung and kidney.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145779 Expressed in 202 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O95379 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O95379 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054434
HPA057089

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117344, 23 interactors

Protein interaction database and analysis system

More...
IntActi
O95379, 11 interactors

Molecular INTeraction database

More...
MINTi
O95379

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O95379

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili49 – 83Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TNFAIP8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003488

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007708

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O95379

Identification of Orthologs from Complete Genome Data

More...
OMAi
LYNPFGT

Database of Orthologous Groups

More...
OrthoDBi
1284744at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O95379

TreeFam database of animal gene trees

More...
TreeFami
TF323415

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1440.160, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12757 PTHR12757, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05527 DUF758, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O95379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHSEAEESKE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV
60 70 80 90 100
LDELYRVTRE YTQNKKEAEK IIKNLIKTVI KLAILYRNNQ FNQDELALME
110 120 130 140 150
KFKKKVHQLA MTVVSFHQVD YTFDRNVLSR LLNECREMLH QIIQRHLTAK
160 170 180 190
SHGRVNNVFD HFSDCEFLAA LYNPFGNFKP HLQKLCDGIN KMLDEENI
Length:198
Mass (Da):23,003
Last modified:May 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9B8F6FCF9AFC2C3
GO
Isoform 2 (identifier: O95379-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MA

Show »
Length:190
Mass (Da):22,048
Checksum:i0DCD250217A1209C
GO
Isoform 3 (identifier: O95379-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: MHSEAEESKEV → M

Show »
Length:188
Mass (Da):21,877
Checksum:i60452EC0A684F535
GO
Isoform 4 (identifier: O95379-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MHSEAEESKE → MTLPRYCEVVLLIAHGEKMLKL

Note: No experimental confirmation available.
Show »
Length:210
Mass (Da):24,385
Checksum:i44DE8FBED9290476
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCM8D6RCM8_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP8
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIJ3E5RIJ3_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP8
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQT8J3KQT8_HUMAN
Tumor necrosis factor alpha-induced...
TNFAIP8
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032047151S → C. Corresponds to variant dbSNP:rs3203922Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0248981 – 11MHSEAEESKEV → M in isoform 3. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_0248991 – 10MHSEAEESKE → MA in isoform 2. 2 Publications10
Alternative sequenceiVSP_0548271 – 10MHSEAEESKE → MTLPRYCEVVLLIAHGEKML KL in isoform 4. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF070671 mRNA Translation: AAC83229.1
AF099935 mRNA Translation: AAC72975.1
AF099936 mRNA Translation: AAC72976.1
CR457137 mRNA Translation: CAG33418.1
AK001850 mRNA Translation: BAG50983.1
AK001931 mRNA Translation: BAG50994.1
AK301281 mRNA Translation: BAH13449.1
AC008475 Genomic DNA No translation available.
AC027320 Genomic DNA No translation available.
AC035144 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48914.1
BC005352 mRNA Translation: AAH05352.1
BC007014 mRNA Translation: AAH07014.1
AF098933 mRNA Translation: AAF29435.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47257.1 [O95379-3]
CCDS47258.1 [O95379-1]
CCDS68933.1 [O95379-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001071122.1, NM_001077654.2 [O95379-3]
NP_001273742.1, NM_001286813.1 [O95379-1]
NP_001273743.1, NM_001286814.1 [O95379-4]
NP_001273744.1, NM_001286815.1
NP_001273746.1, NM_001286817.1
NP_055165.2, NM_014350.3 [O95379-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000274456; ENSP00000274456; ENSG00000145779 [O95379-3]
ENST00000503646; ENSP00000421848; ENSG00000145779 [O95379-1]
ENST00000504771; ENSP00000422245; ENSG00000145779 [O95379-1]
ENST00000513374; ENSP00000427424; ENSG00000145779 [O95379-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25816

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25816

UCSC genome browser

More...
UCSCi
uc003ksg.5 human [O95379-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070671 mRNA Translation: AAC83229.1
AF099935 mRNA Translation: AAC72975.1
AF099936 mRNA Translation: AAC72976.1
CR457137 mRNA Translation: CAG33418.1
AK001850 mRNA Translation: BAG50983.1
AK001931 mRNA Translation: BAG50994.1
AK301281 mRNA Translation: BAH13449.1
AC008475 Genomic DNA No translation available.
AC027320 Genomic DNA No translation available.
AC035144 Genomic DNA No translation available.
CH471086 Genomic DNA Translation: EAW48914.1
BC005352 mRNA Translation: AAH05352.1
BC007014 mRNA Translation: AAH07014.1
AF098933 mRNA Translation: AAF29435.1
CCDSiCCDS47257.1 [O95379-3]
CCDS47258.1 [O95379-1]
CCDS68933.1 [O95379-4]
RefSeqiNP_001071122.1, NM_001077654.2 [O95379-3]
NP_001273742.1, NM_001286813.1 [O95379-1]
NP_001273743.1, NM_001286814.1 [O95379-4]
NP_001273744.1, NM_001286815.1
NP_001273746.1, NM_001286817.1
NP_055165.2, NM_014350.3 [O95379-1]

3D structure databases

SMRiO95379
ModBaseiSearch...

Protein-protein interaction databases

BioGridi117344, 23 interactors
IntActiO95379, 11 interactors
MINTiO95379
STRINGi9606.ENSP00000427424

PTM databases

iPTMnetiO95379
PhosphoSitePlusiO95379

Polymorphism and mutation databases

BioMutaiTNFAIP8

Proteomic databases

EPDiO95379
jPOSTiO95379
MassIVEiO95379
MaxQBiO95379
PaxDbiO95379
PeptideAtlasiO95379
PRIDEiO95379
ProteomicsDBi50831 [O95379-1]
50832 [O95379-2]
50833 [O95379-3]
6823

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25816

Genome annotation databases

EnsembliENST00000274456; ENSP00000274456; ENSG00000145779 [O95379-3]
ENST00000503646; ENSP00000421848; ENSG00000145779 [O95379-1]
ENST00000504771; ENSP00000422245; ENSG00000145779 [O95379-1]
ENST00000513374; ENSP00000427424; ENSG00000145779 [O95379-4]
GeneIDi25816
KEGGihsa:25816
UCSCiuc003ksg.5 human [O95379-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25816
DisGeNETi25816

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TNFAIP8
HGNCiHGNC:17260 TNFAIP8
HPAiHPA054434
HPA057089
MIMi612111 gene
neXtProtiNX_O95379
OpenTargetsiENSG00000145779
PharmGKBiPA134957136

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IEG9 Eukaryota
ENOG4111KN4 LUCA
GeneTreeiENSGT00390000003488
HOGENOMiHOG000007708
InParanoidiO95379
OMAiLYNPFGT
OrthoDBi1284744at2759
PhylomeDBiO95379
TreeFamiTF323415

Enzyme and pathway databases

ReactomeiR-HSA-1483255 PI Metabolism
SIGNORiO95379

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TNFAIP8 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNFAIP8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
25816
PharosiO95379

Protein Ontology

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PROi
PR:O95379

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000145779 Expressed in 202 organ(s), highest expression level in bone marrow
ExpressionAtlasiO95379 baseline and differential
GenevisibleiO95379 HS

Family and domain databases

Gene3Di1.20.1440.160, 1 hit
InterProiView protein in InterPro
IPR008477 TNFAIP8-like
IPR038355 TNFAIP8_sf
PANTHERiPTHR12757 PTHR12757, 1 hit
PfamiView protein in Pfam
PF05527 DUF758, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFIP8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O95379
Secondary accession number(s): B3KMH1
, B3KMI2, B7Z713, Q9P1Q1, Q9UER5, Q9UP47
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 1999
Last modified: October 16, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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