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Entry version 221 (13 Nov 2019)
Sequence version 4 (05 Feb 2008)
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Protein

Complement C5

Gene

C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MOUSE:MONOMER-12977

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.43 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166665 Terminal pathway of complement
R-HSA-174577 Activation of C3 and C5
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-977606 Regulation of Complement cascade

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01031

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement C5
Alternative name(s):
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
Cleaved into the following 4 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C5
Synonyms:CPAMD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1331 C5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120900 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01031

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Complement component 5 deficiency (C5D)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
Related information in OMIM
An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
727

MalaCards human disease database

More...
MalaCardsi
C5
MIMi609536 phenotype
615749 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000106804

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
169150 Immunodeficiency due to a late component of complement deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25911

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P01031

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2364163

Drug and drug target database

More...
DrugBanki
DB09130 Copper
DB01257 Eculizumab
DB00028 Immune Globulin Human
DB11580 Ravulizumab
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

DrugCentral

More...
DrugCentrali
P01031

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166900096

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000598519 – 673Complement C5 beta chainAdd BLAST655
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000005986674 – 6771 Publication4
ChainiPRO_0000005987678 – 1676Complement C5 alpha chainAdd BLAST999
ChainiPRO_0000005988678 – 751C5a anaphylatoxinAdd BLAST74
ChainiPRO_0000005989752 – 1676Complement C5 alpha' chainAdd BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi567 ↔ 810
Disulfide bondi634 ↔ 669
Disulfide bondi698 ↔ 724
Disulfide bondi699 ↔ 731
Disulfide bondi711 ↔ 732
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi741N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi856 ↔ 883
Disulfide bondi866 ↔ 1527
Glycosylationi911N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi1101 ↔ 1159
Glycosylationi1115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1375 ↔ 1505
Disulfide bondi1405 ↔ 1474
Disulfide bondi1520 ↔ 1525
Disulfide bondi1532 ↔ 1606
Disulfide bondi1553 ↔ 1676
Glycosylationi1630N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1654 ↔ 1657

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-1108
non-CPTAC-1109

Encyclopedia of Proteome Dynamics

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EPDi
P01031

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01031

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P01031

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P01031

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01031

PeptideAtlas

More...
PeptideAtlasi
P01031

PRoteomics IDEntifications database

More...
PRIDEi
P01031

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
12624
51309

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P01031

GlyConnect protein glycosylation platform

More...
GlyConnecti
1147

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P01031

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01031

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01031

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000106804 Expressed in 179 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01031 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA029339

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). The C5a anaphylatoxin interacts with C5AR1.

Interacts with tick complement inhibitor.

4 Publications

(Microbial infection) Interacts with Staphylococcus aureus protein SSL5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107188, 9 interactors

Protein interaction database and analysis system

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IntActi
P01031, 11 interactors

Molecular INTeraction database

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MINTi
P01031

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000223642

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11676
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01031

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01031

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini698 – 732Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35
Domaini1532 – 1676NTRPROSITE-ProRule annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni692 – 721Involved in C5AR1 binding1 PublicationAdd BLAST30

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366 Eukaryota
ENOG410XRED LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155670

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231860

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01031

KEGG Orthology (KO)

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KOi
K03994

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHVTTVV

Database of Orthologous Groups

More...
OrthoDBi
20179at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01031

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017 ANATO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR041425 C3/4/5_MG1
IPR037562 Complement_C5
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF83 PTHR11412:SF83, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF17790 MG1, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00004 ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01031-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF
60 70 80 90 100
DATISIKSYP DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS
110 120 130 140 150
YVYLEVVSKH FSKSKRMPIT YDNGFLFIHT DKPVYTPDQS VKVRVYSLND
160 170 180 190 200
DLKPAKRETV LTFIDPEGSE VDMVEEIDHI GIISFPDFKI PSNPRYGMWT
210 220 230 240 250
IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY KNFKNFEITI
260 270 280 290 300
KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT
310 320 330 340 350
FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS
360 370 380 390 400
PYKLNLVATP LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE
410 420 430 440 450
TSDLDPSKSV TRVDDGVASF VLNLPSGVTV LEFNVKTDAP DLPEENQARE
460 470 480 490 500
GYRAIAYSSL SQSYLYIDWT DNHKALLVGE HLNIIVTPKS PYIDKITHYN
510 520 530 540 550
YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL LVYYIVTGEQ
560 570 580 590 600
TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV
610 620 630 640 650
ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG
660 670 680 690 700
LTFLTNANAD DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY
710 720 730 740 750
DGACVNNDET CEQRAARISL GPRCIKAFTE CCVVASQLRA NISHKDMQLG
760 770 780 790 800
RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV PRRKQLQFAL PDSLTTWEIQ
810 820 830 840 850
GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ LKGTVYNYRT
860 870 880 890 900
SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV
910 920 930 940 950
LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY
960 970 980 990 1000
GTISRRKEFP YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL
1010 1020 1030 1040 1050
THLPKGSAEA ELMSVVPVFY VFHYLETGNH WNIFHSDPLI EKQKLKKKLK
1060 1070 1080 1090 1100
EGMLSIMSYR NADYSYSVWK GGSASTWLTA FALRVLGQVN KYVEQNQNSI
1110 1120 1130 1140 1150
CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN SLYLTAFTVI
1160 1170 1180 1190 1200
GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK
1210 1220 1230 1240 1250
THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET
1260 1270 1280 1290 1300
TAYALLTSLN LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY
1310 1320 1330 1340 1350
SLLVKQLRLS MDIDVSYKHK GALHNYKMTD KNFLGRPVEV LLNDDLIVST
1360 1370 1380 1390 1400
GFGSGLATVH VTTVVHKTST SEEVCSFYLK IDTQDIEASH YRGYGNSDYK
1410 1420 1430 1440 1450
RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK ALVEGVDQLF
1460 1470 1480 1490 1500
TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR
1510 1520 1530 1540 1550
PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ
1560 1570 1580 1590 1600
TACKPEIAYA YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF
1610 1620 1630 1640 1650
IKKVTCTNAE LVKGRQYLIM GKEALQIKYN FSFRYIYPLD SLTWIEYWPR
1660 1670
DTTCSSCQAF LANLDEFAED IFLNGC
Length:1,676
Mass (Da):188,305
Last modified:February 5, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7589E352F74672A
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

C5 variants are responsible for poor response to eculizumab [MIMi:615749]. Eculizumab is a monoclonal antibody highly effective in reducing intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria. It specifically binds to the terminal complement protein C5, inhibits its cleavage into C5a and C5b, and prevents the formations of the cytolytic complement pore (PubMed:24521109).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038735145V → I1 PublicationCorresponds to variant dbSNP:rs17216529Ensembl.1
Natural variantiVAR_048822354L → M. Corresponds to variant dbSNP:rs34552775Ensembl.1
Natural variantiVAR_023946389T → I2 Publications1
Natural variantiVAR_038736449R → G1 PublicationCorresponds to variant dbSNP:rs2230213Ensembl.1
Natural variantiVAR_001996518F → S. 1
Natural variantiVAR_014574802V → I7 PublicationsCorresponds to variant dbSNP:rs17611Ensembl.1
Natural variantiVAR_071067885R → C Polymorphism associated with poor response to eculizumab in PNH patients. 1 PublicationCorresponds to variant dbSNP:rs373359894EnsemblClinVar.1
Natural variantiVAR_071068885R → H Polymorphism associated with poor response to eculizumab in PNH patients. 1 PublicationCorresponds to variant dbSNP:rs56040400EnsemblClinVar.1
Natural variantiVAR_038737928R → Q1 PublicationCorresponds to variant dbSNP:rs41309892Ensembl.1
Natural variantiVAR_038738933G → V1 PublicationCorresponds to variant dbSNP:rs41309902Ensembl.1
Natural variantiVAR_048823966D → Y Polymorphism; confirmed at protein level. 1 PublicationCorresponds to variant dbSNP:rs2230212Ensembl.1
Natural variantiVAR_0387391033I → T1 PublicationCorresponds to variant dbSNP:rs41311881Ensembl.1
Natural variantiVAR_0387401037D → N1 PublicationCorresponds to variant dbSNP:rs41311883Ensembl.1
Natural variantiVAR_0387411043Q → K1 PublicationCorresponds to variant dbSNP:rs41311887Ensembl.1
Natural variantiVAR_0145751053M → L. Corresponds to variant dbSNP:rs17609Ensembl.1
Natural variantiVAR_0145761310S → N1 PublicationCorresponds to variant dbSNP:rs17610Ensembl.1
Natural variantiVAR_0488241365V → A. Corresponds to variant dbSNP:rs16910245Ensembl.1
Natural variantiVAR_0145771437E → D1 PublicationCorresponds to variant dbSNP:rs17612Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M57729 mRNA Translation: AAA51925.1
DQ400449 Genomic DNA Translation: ABD48959.1
CH471090 Genomic DNA Translation: EAW87480.1
BC113738 mRNA Translation: AAI13739.1
BC113740 mRNA Translation: AAI13741.1
M65134 mRNA Translation: AAA51856.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6826.1

Protein sequence database of the Protein Information Resource

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PIRi
A40075 C5HU

NCBI Reference Sequences

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RefSeqi
NP_001304092.1, NM_001317163.1
NP_001726.2, NM_001735.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000223642; ENSP00000223642; ENSG00000106804

Database of genes from NCBI RefSeq genomes

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GeneIDi
727

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:727

UCSC genome browser

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UCSCi
uc004bkv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

C5base

C5 mutation db

Wikipedia

Complement C5 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57729 mRNA Translation: AAA51925.1
DQ400449 Genomic DNA Translation: ABD48959.1
CH471090 Genomic DNA Translation: EAW87480.1
BC113738 mRNA Translation: AAI13739.1
BC113740 mRNA Translation: AAI13741.1
M65134 mRNA Translation: AAA51856.1
CCDSiCCDS6826.1
PIRiA40075 C5HU
RefSeqiNP_001304092.1, NM_001317163.1
NP_001726.2, NM_001735.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CFANMR-A679-747[»]
1KJSNMR-A679-751[»]
1XWENMR-A1530-1676[»]
3CU7X-ray3.10A/B1-1676[»]
3HQAX-ray2.59A/B679-750[»]
3HQBX-ray3.30A/B679-750[»]
3KLSX-ray3.60A/B1-1676[»]
3KM9X-ray4.20A/B1-1676[»]
3PRXX-ray4.30A/C1-1676[»]
3PVMX-ray4.30A/C1-1676[»]
4A5WX-ray3.50A19-1676[»]
4E0SX-ray4.21A1-1676[»]
4P39X-ray2.40A/B/C/D678-747[»]
4UU9X-ray2.12C/D678-751[»]
5B4PX-ray2.40B/D678-751[»]
5B71X-ray2.11E/F20-124[»]
5HCCX-ray2.59A679-1676[»]
B19-674[»]
5HCDX-ray2.98A679-1676[»]
B19-674[»]
5HCEX-ray3.12A679-1676[»]
B19-674[»]
5I5KX-ray4.20A/B1-1676[»]
6H03electron microscopy5.60A19-1676[»]
6H04electron microscopy5.60A19-1676[»]
SMRiP01031
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107188, 9 interactors
IntActiP01031, 11 interactors
MINTiP01031
STRINGi9606.ENSP00000223642

Chemistry databases

ChEMBLiCHEMBL2364163
DrugBankiDB09130 Copper
DB01257 Eculizumab
DB00028 Immune Globulin Human
DB11580 Ravulizumab
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride
DrugCentraliP01031

Protein family/group databases

MEROPSiI39.952

PTM databases

CarbonylDBiP01031
GlyConnecti1147
iPTMnetiP01031
PhosphoSitePlusiP01031

Polymorphism and mutation databases

BioMutaiC5
DMDMi166900096

Proteomic databases

CPTACinon-CPTAC-1108
non-CPTAC-1109
EPDiP01031
jPOSTiP01031
MassIVEiP01031
MaxQBiP01031
PaxDbiP01031
PeptideAtlasiP01031
PRIDEiP01031
ProteomicsDBi12624
51309

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01031

Genome annotation databases

EnsembliENST00000223642; ENSP00000223642; ENSG00000106804
GeneIDi727
KEGGihsa:727
UCSCiuc004bkv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
727
DisGeNETi727

GeneCards: human genes, protein and diseases

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GeneCardsi
C5
HGNCiHGNC:1331 C5
HPAiHPA029339
MalaCardsiC5
MIMi120900 gene
609536 phenotype
615749 phenotype
neXtProtiNX_P01031
OpenTargetsiENSG00000106804
Orphaneti169150 Immunodeficiency due to a late component of complement deficiency
PharmGKBiPA25911

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00940000155670
HOGENOMiHOG000231860
InParanoidiP01031
KOiK03994
OMAiVHVTTVV
OrthoDBi20179at2759
PhylomeDBiP01031
TreeFamiTF313285

Enzyme and pathway databases

BioCyciMOUSE:MONOMER-12977
BRENDAi3.4.21.43 2681
ReactomeiR-HSA-166665 Terminal pathway of complement
R-HSA-174577 Activation of C3 and C5
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-977606 Regulation of Complement cascade
SIGNORiP01031

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C5 human
EvolutionaryTraceiP01031

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Complement_component_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
727
PharosiP01031
PMAP-CutDBiP01031

Protein Ontology

More...
PROi
PR:P01031

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106804 Expressed in 179 organ(s), highest expression level in liver
GenevisibleiP01031 HS

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR041425 C3/4/5_MG1
IPR037562 Complement_C5
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR002890 MG2
IPR041555 MG3
IPR040839 MG4
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF83 PTHR11412:SF83, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF17790 MG1, 1 hit
PF01835 MG2, 1 hit
PF17791 MG3, 1 hit
PF17789 MG4, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit
PRINTSiPR00004 ANAPHYLATOXN
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01031
Secondary accession number(s): Q14CJ0, Q27I61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 5, 2008
Last modified: November 13, 2019
This is version 221 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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