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Entry version 206 (16 Oct 2019)
Sequence version 2 (01 Feb 1991)
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Protein

Pro-opiomelanocortin

Gene

POMC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Corticotropin: Stimulates the adrenal glands to release cortisol.
Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin: Endogenous orexigenic opiate.
Met-enkephalin: Endogenous opiate.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndorphin, Hormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111885 Opioid Signalling
R-HSA-193048 Androgen biosynthesis
R-HSA-194002 Glucocorticoid biosynthesis
R-HSA-202040 G-protein activation
R-HSA-209952 Peptide hormone biosynthesis
R-HSA-211976 Endogenous sterols
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01189

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pro-opiomelanocortin
Short name:
POMC
Alternative name(s):
Corticotropin-lipotropin
Cleaved into the following 11 chains:
Alternative name(s):
Gamma-MSH
Alternative name(s):
Adrenocorticotropic hormone
Short name:
ACTH
Alternative name(s):
Melanotropin alpha
Alternative name(s):
Beta-LPH
Alternative name(s):
Gamma-LPH
Alternative name(s):
Melanotropin beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POMC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9201 POMC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176830 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01189

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Obesity (OBESITY)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Related information in OMIM
Obesity, early-onset, with adrenal insufficiency and red hair (OBAIRH)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by early-onset obesity due to severe hyperphagia, pigmentary abnormalities, mainly pale skin and red hair, and secondary hypocortisolism.
Related information in OMIM

Keywords - Diseasei

Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
5443

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
POMC

MalaCards human disease database

More...
MalaCardsi
POMC
MIMi601665 phenotype
609734 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115138

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
71526 Obesity due to pro-opiomelanocortin deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33526

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P01189

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01565 Dihydromorphine
DB01497 Etorphine
DB00836 Loperamide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
POMC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116880

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 263 PublicationsAdd BLAST26
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000002496627 – 102NPPAdd BLAST76
PeptideiPRO_000002496777 – 87Melanotropin gamma1 PublicationAdd BLAST11
PeptideiPRO_0000024968105 – 134Potential peptideAdd BLAST30
PeptideiPRO_0000024969138 – 176CorticotropinAdd BLAST39
PeptideiPRO_0000024970138 – 150Melanocyte-stimulating hormone alphaAdd BLAST13
PeptideiPRO_0000024971156 – 176Corticotropin-like intermediary peptideAdd BLAST21
PeptideiPRO_0000024972179 – 267Lipotropin betaAdd BLAST89
PeptideiPRO_0000024973179 – 234Lipotropin gammaAdd BLAST56
PeptideiPRO_0000024974217 – 234Melanocyte-stimulating hormone betaAdd BLAST18
PeptideiPRO_0000024975237 – 267Beta-endorphinAdd BLAST31
PeptideiPRO_0000024976237 – 241Met-enkephalin5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 50By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71O-linked (HexNAc...) threonine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87Phenylalanine amideBy similarity1
Glycosylationi91N-linked (GlcNAc...) asparagine1
Modified residuei134Glutamic acid 1-amide1 Publication1
Modified residuei138N-acetylserine; in CorticotropinBy similarity1
Modified residuei150Valine amideBy similarity1
Modified residuei168PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages at paired basic residues yield the different active peptides.1 Publication
O-glycosylated; reducing sugar is probably N-acetylgalactosamine.

Keywords - PTMi

Acetylation, Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01189

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01189

PeptideAtlas

More...
PeptideAtlasi
P01189

PRoteomics IDEntifications database

More...
PRIDEi
P01189

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51343

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01189

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01189

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01189

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

ACTH and MSH are produced by the pituitary gland.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115138 Expressed in 93 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01189 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01189 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002762
HPA046135
HPA063644

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
HSF2BPO750314EBI-12219503,EBI-7116203

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111439, 21 interactors

Protein interaction database and analysis system

More...
IntActi
P01189, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384092

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01189

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the POMC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKR5 Eukaryota
ENOG410Z5R4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000016811

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01189

KEGG Orthology (KO)

More...
KOi
K05228

Identification of Orthologs from Complete Genome Data

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OMAi
FRWNKFG

Database of Orthologous Groups

More...
OrthoDBi
1168862at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01189

TreeFam database of animal gene trees

More...
TreeFami
TF333215

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR013593 Melanocortin_N
IPR013532 Opioid_neuropept
IPR001941 PMOC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00976 ACTH_domain, 3 hits
PF08384 NPP, 1 hit
PF08035 Op_neuropeptide, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00383 MELANOCORTIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01363 ACTH_domain, 2 hits
SM01364 NPP, 1 hit
SM01365 Op_neuropeptide, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01189-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSCCSRSG ALLLALLLQA SMEVRGWCLE SSQCQDLTTE SNLLECIRAC
60 70 80 90 100
KPDLSAETPM FPGNGDEQPL TENPRKYVMG HFRWDRFGRR NSSSSGSSGA
110 120 130 140 150
GQKREDVSAG EDCGPLPEGG PEPRSDGAKP GPREGKRSYS MEHFRWGKPV
160 170 180 190 200
GKKRRPVKVY PNGAEDESAE AFPLEFKREL TGQRLREGDG PDGPADDGAG
210 220 230 240 250
AQADLEHSLL VAAEKKDEGP YRMEHFRWGS PPKDKRYGGF MTSEKSQTPL
260
VTLFKNAIIK NAYKKGE
Length:267
Mass (Da):29,424
Last modified:February 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB927323474A67536
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHK5E9PHK5_HUMAN
Pro-opiomelanocortin
POMC
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48R → G (PubMed:6254047).Curated1
Sequence conflicti115P → T (PubMed:6299668).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0106997S → T1 Publication1
Natural variantiVAR_0107009S → L1 PublicationCorresponds to variant dbSNP:rs139750421Ensembl.1
Natural variantiVAR_02976262P → L. Corresponds to variant dbSNP:rs28932471Ensembl.1
Natural variantiVAR_01071497 – 99Missing 3 Publications3
Natural variantiVAR_010715106D → N1 PublicationCorresponds to variant dbSNP:rs750136455Ensembl.1
Natural variantiVAR_029314132P → A. Corresponds to variant dbSNP:rs8192606Ensembl.1
Natural variantiVAR_010716214E → G1 PublicationCorresponds to variant dbSNP:rs80326661EnsemblClinVar.1
Natural variantiVAR_010701236R → G May confer susceptibility to obesity; reduces the ability to activate melanocortin receptor 4. 2 PublicationsCorresponds to variant dbSNP:rs28932472EnsemblClinVar.1
Natural variantiVAR_012201236R → Q1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M38297 mRNA Translation: AAA60140.1
J00292, J00291 Genomic DNA Translation: AAB59621.1
V01510 Genomic DNA Translation: CAA24754.1
AC012457 Genomic DNA Translation: AAY24354.1
CH471053 Genomic DNA Translation: EAX00729.1
CH471053 Genomic DNA Translation: EAX00730.1
BC065832 mRNA Translation: AAH65832.1
M25896 mRNA Translation: AAA35799.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1717.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A17229 CTHUP

NCBI Reference Sequences

More...
RefSeqi
NP_000930.1, NM_000939.3
NP_001030333.1, NM_001035256.2
NP_001306133.1, NM_001319204.1
NP_001306134.1, NM_001319205.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264708; ENSP00000264708; ENSG00000115138
ENST00000380794; ENSP00000370171; ENSG00000115138
ENST00000395826; ENSP00000379170; ENSG00000115138
ENST00000405623; ENSP00000384092; ENSG00000115138

Database of genes from NCBI RefSeq genomes

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GeneIDi
5443

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5443

UCSC genome browser

More...
UCSCi
uc002rfy.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Melanocyte-stimulating hormone entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M38297 mRNA Translation: AAA60140.1
J00292, J00291 Genomic DNA Translation: AAB59621.1
V01510 Genomic DNA Translation: CAA24754.1
AC012457 Genomic DNA Translation: AAY24354.1
CH471053 Genomic DNA Translation: EAX00729.1
CH471053 Genomic DNA Translation: EAX00730.1
BC065832 mRNA Translation: AAH65832.1
M25896 mRNA Translation: AAA35799.1
CCDSiCCDS1717.1
PIRiA17229 CTHUP
RefSeqiNP_000930.1, NM_000939.3
NP_001030333.1, NM_001035256.2
NP_001306133.1, NM_001319204.1
NP_001306134.1, NM_001319205.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XNHX-ray2.10F138-145[»]
4XPDX-ray2.81F138-145[»]
4Y49X-ray3.95E/K/Q138-145[»]
SMRiP01189
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111439, 21 interactors
IntActiP01189, 22 interactors
STRINGi9606.ENSP00000384092

Chemistry databases

DrugBankiDB01565 Dihydromorphine
DB01497 Etorphine
DB00836 Loperamide

PTM databases

iPTMnetiP01189
PhosphoSitePlusiP01189

Polymorphism and mutation databases

BioMutaiPOMC
DMDMi116880

Proteomic databases

MassIVEiP01189
PaxDbiP01189
PeptideAtlasiP01189
PRIDEiP01189
ProteomicsDBi51343

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5443

Genome annotation databases

EnsembliENST00000264708; ENSP00000264708; ENSG00000115138
ENST00000380794; ENSP00000370171; ENSG00000115138
ENST00000395826; ENSP00000379170; ENSG00000115138
ENST00000405623; ENSP00000384092; ENSG00000115138
GeneIDi5443
KEGGihsa:5443
UCSCiuc002rfy.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5443
DisGeNETi5443

GeneCards: human genes, protein and diseases

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GeneCardsi
POMC
GeneReviewsiPOMC
HGNCiHGNC:9201 POMC
HPAiCAB002762
HPA046135
HPA063644
MalaCardsiPOMC
MIMi176830 gene
601665 phenotype
609734 phenotype
neXtProtiNX_P01189
OpenTargetsiENSG00000115138
Orphaneti71526 Obesity due to pro-opiomelanocortin deficiency
PharmGKBiPA33526

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IKR5 Eukaryota
ENOG410Z5R4 LUCA
GeneTreeiENSGT00390000016811
InParanoidiP01189
KOiK05228
OMAiFRWNKFG
OrthoDBi1168862at2759
PhylomeDBiP01189
TreeFamiTF333215

Enzyme and pathway databases

ReactomeiR-HSA-111885 Opioid Signalling
R-HSA-193048 Androgen biosynthesis
R-HSA-194002 Glucocorticoid biosynthesis
R-HSA-202040 G-protein activation
R-HSA-209952 Peptide hormone biosynthesis
R-HSA-211976 Endogenous sterols
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
SIGNORiP01189

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
POMC human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Proopiomelanocortin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5443
PharosiP01189
PMAP-CutDBiP01189

Protein Ontology

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PROi
PR:P01189

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000115138 Expressed in 93 organ(s), highest expression level in pituitary gland
ExpressionAtlasiP01189 baseline and differential
GenevisibleiP01189 HS

Family and domain databases

InterProiView protein in InterPro
IPR013531 Mcrtin_ACTH_cent
IPR013593 Melanocortin_N
IPR013532 Opioid_neuropept
IPR001941 PMOC
PfamiView protein in Pfam
PF00976 ACTH_domain, 3 hits
PF08384 NPP, 1 hit
PF08035 Op_neuropeptide, 1 hit
PRINTSiPR00383 MELANOCORTIN
SMARTiView protein in SMART
SM01363 ACTH_domain, 2 hits
SM01364 NPP, 1 hit
SM01365 Op_neuropeptide, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOLI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01189
Secondary accession number(s): P78442
, Q53T23, Q9UD39, Q9UD40
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: October 16, 2019
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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