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Entry version 228 (03 Jul 2019)
Sequence version 1 (23 Oct 1986)
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Protein

Vitronectin

Gene

VTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-977606 Regulation of Complement cascade

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P04004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitronectin
Short name:
VN
Alternative name(s):
S-protein
Serum-spreading factor
V75
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VTN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12724 VTN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
193190 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P04004

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69T → A: Abolishes phosphorylation by CK2 and inhibits adhesion and spreading; when associated with A-76. 1 Publication1
Mutagenesisi69T → E: Abolishes phosphorylation by CK2 and enhances adhesion and spreading; when associated with E-76. 1 Publication1
Mutagenesisi76T → A: Abolishes phosphorylation by CK2 and inhibits adhesion and spreading; when associated with A-69. 1 Publication1
Mutagenesisi76T → E: Abolishes phosphorylation by CK2 and enhances adhesion and spreading; when associated with E-69. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7448

Open Targets

More...
OpenTargetsi
ENSG00000109072

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37335

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1075314

Drug and drug target database

More...
DrugBanki
DB00054 Abciximab

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
VTN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
139653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 192 PublicationsAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003639420 – 478VitronectinAdd BLAST459
ChainiPRO_000003639520 – 398Vitronectin V65 subunitAdd BLAST379
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000003639620 – 63Somatomedin-BAdd BLAST44
ChainiPRO_0000036397399 – 478Vitronectin V10 subunitAdd BLAST80

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 40PROSITE-ProRule annotation
Disulfide bondi24 ↔ 28PROSITE-ProRule annotation1 Publication
Disulfide bondi28 ↔ 58PROSITE-ProRule annotation
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi38 ↔ 40PROSITE-ProRule annotation1 Publication
Disulfide bondi44 ↔ 50PROSITE-ProRule annotation1 Publication
Disulfide bondi51 ↔ 58PROSITE-ProRule annotation1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei69Phosphothreonine; by CK2; in vitro1 Publication1
Modified residuei75Sulfotyrosine1 Publication1
Modified residuei76Phosphothreonine; by CK2; in vitro1 Publication1
Modified residuei78Sulfotyrosine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) (complex) asparagine5 Publications1
Modified residuei130PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Glycosylationi169N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi242N-linked (GlcNAc...) (complex) asparagine4 Publications1
Modified residuei282SulfotyrosineSequence analysis1
Disulfide bondi293 ↔ 430PROSITE-ProRule annotation1 Publication
Modified residuei312PhosphoserineCombined sources1 Publication1
Modified residuei397Phosphoserine; by PKA2 Publications1
Modified residuei417SulfotyrosineSequence analysis1
Modified residuei420SulfotyrosineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sulfated on 2 tyrosine residues.2 Publications
N- and O-glycosylated.By similarity
Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.1 Publication
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Phosphorylation sites are present in the extracellular medium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei398 – 399Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P04004

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P04004

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P04004

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P04004

PeptideAtlas

More...
PeptideAtlasi
P04004

PRoteomics IDEntifications database

More...
PRIDEi
P04004

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51633

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P04004

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P04004

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
625

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P04004

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P04004

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P04004

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P04004

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109072 Expressed in 87 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P04004 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P04004 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016695
CAB016765
HPA060933

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond.

Interacts with SERPINE1/PAI1, insulin and C1QBP.

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113287, 124 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-475 Vitronectin-PAI-1 complex
CPX-501 uPA-uPAR-vitronectin complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P04004

Database of interacting proteins

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DIPi
DIP-36566N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P04004

Protein interaction database and analysis system

More...
IntActi
P04004, 62 interactors

Molecular INTeraction database

More...
MINTi
P04004

STRING: functional protein association networks

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STRINGi
9606.ENSP00000226218

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1478
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P04004

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P04004

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 63SMBPROSITE-ProRule annotationAdd BLAST44
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati158 – 202Hemopexin 1Add BLAST45
Repeati203 – 250Hemopexin 2Add BLAST48
Repeati251 – 305Hemopexin 3Add BLAST55
Repeati419 – 472Hemopexin 4Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni362 – 395Heparin-bindingAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi64 – 66Cell attachment site3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1565 Eukaryota
ENOG410XQ5D LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063751

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000133161

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P04004

KEGG Orthology (KO)

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KOi
K06251

Identification of Orthologs from Complete Genome Data

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OMAi
QPSQEEC

Database of Orthologous Groups

More...
OrthoDBi
419397at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P04004

TreeFam database of animal gene trees

More...
TreeFami
TF332780

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00094 HX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.110.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00045 Hemopexin, 4 hits
PF01033 Somatomedin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00022 SOMATOMEDINB

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00120 HX, 4 hits
SM00201 SO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50923 SSF50923, 1 hit
SSF90188 SSF90188, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 4 hits
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P04004-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPLRPLLIL ALLAWVALAD QESCKGRCTE GFNVDKKCQC DELCSYYQSC
60 70 80 90 100
CTDYTAECKP QVTRGDVFTM PEDEYTVYDD GEEKNNATVH EQVGGPSLTS
110 120 130 140 150
DLQAQSKGNP EQTPVLKPEE EAPAPEVGAS KPEGIDSRPE TLHPGRPQPP
160 170 180 190 200
AEEELCSGKP FDAFTDLKNG SLFAFRGQYC YELDEKAVRP GYPKLIRDVW
210 220 230 240 250
GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGVLDPDYP RNISDGFDGI
260 270 280 290 300
PDNVDAALAL PAHSYSGRER VYFFKGKQYW EYQFQHQPSQ EECEGSSLSA
310 320 330 340 350
VFEHFAMMQR DSWEDIFELL FWGRTSAGTR QPQFISRDWH GVPGQVDAAM
360 370 380 390 400
AGRIYISGMA PRPSLAKKQR FRHRNRKGYR SQRGHSRGRN QNSRRPSRAT
410 420 430 440 450
WLSLFSSEES NLGANNYDDY RMDWLVPATC EPIQSVFFFS GDKYYRVNLR
460 470
TRRVDTVDPP YPRSIAQYWL GCPAPGHL
Length:478
Mass (Da):54,306
Last modified:October 23, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D6DB5591CBFEF45
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GX75F5GX75_HUMAN
Vitronectin
VTN
118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50C → N AA sequence (PubMed:631332).Curated1
Sequence conflicti225S → N (PubMed:3004934).Curated1
Sequence conflicti225S → N (PubMed:2447940).Curated1
Sequence conflicti366A → T in CAA26933 (PubMed:3004934).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012983122A → S1 PublicationCorresponds to variant dbSNP:rs2227741Ensembl.1
Natural variantiVAR_012984268R → Q1 PublicationCorresponds to variant dbSNP:rs2227723Ensembl.1
Natural variantiVAR_012985400T → M2 PublicationsCorresponds to variant dbSNP:rs704Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X03168 mRNA Translation: CAA26933.1 Sequence problems.
X05006 Genomic DNA Translation: CAA28659.1 Sequence problems.
AK312968 mRNA Translation: BAG35807.1
AF382388 Genomic DNA Translation: AAK60270.1
BC005046 mRNA Translation: AAH05046.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11229.1

Protein sequence database of the Protein Information Resource

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PIRi
A29744 SGHU1V

NCBI Reference Sequences

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RefSeqi
NP_000629.3, NM_000638.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000226218; ENSP00000226218; ENSG00000109072

Database of genes from NCBI RefSeq genomes

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GeneIDi
7448

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7448

UCSC genome browser

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UCSCi
uc002hbc.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03168 mRNA Translation: CAA26933.1 Sequence problems.
X05006 Genomic DNA Translation: CAA28659.1 Sequence problems.
AK312968 mRNA Translation: BAG35807.1
AF382388 Genomic DNA Translation: AAK60270.1
BC005046 mRNA Translation: AAH05046.1
CCDSiCCDS11229.1
PIRiA29744 SGHU1V
RefSeqiNP_000629.3, NM_000638.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OC0X-ray2.28B20-70[»]
1S4GNMR-A20-70[»]
1SSUNMR-A20-70[»]
2JQ8NMR-A20-66[»]
3BT1X-ray2.80B21-60[»]
3BT2X-ray2.50B21-60[»]
4K24X-ray4.50B21-60[»]
SMRiP04004
ModBaseiSearch...

Protein-protein interaction databases

BioGridi113287, 124 interactors
ComplexPortaliCPX-475 Vitronectin-PAI-1 complex
CPX-501 uPA-uPAR-vitronectin complex
CORUMiP04004
DIPiDIP-36566N
ELMiP04004
IntActiP04004, 62 interactors
MINTiP04004
STRINGi9606.ENSP00000226218

Chemistry databases

ChEMBLiCHEMBL1075314
DrugBankiDB00054 Abciximab

PTM databases

GlyConnecti625
iPTMnetiP04004
PhosphoSitePlusiP04004
UniCarbKBiP04004

Polymorphism and mutation databases

BioMutaiVTN
DMDMi139653

2D gel databases

DOSAC-COBS-2DPAGEiP04004
SWISS-2DPAGEiP04004

Proteomic databases

EPDiP04004
jPOSTiP04004
MaxQBiP04004
PaxDbiP04004
PeptideAtlasiP04004
PRIDEiP04004
ProteomicsDBi51633

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7448
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226218; ENSP00000226218; ENSG00000109072
GeneIDi7448
KEGGihsa:7448
UCSCiuc002hbc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7448
DisGeNETi7448

GeneCards: human genes, protein and diseases

More...
GeneCardsi
VTN
HGNCiHGNC:12724 VTN
HPAiCAB016695
CAB016765
HPA060933
MIMi193190 gene
neXtProtiNX_P04004
OpenTargetsiENSG00000109072
PharmGKBiPA37335

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00530000063751
HOGENOMiHOG000133161
InParanoidiP04004
KOiK06251
OMAiQPSQEEC
OrthoDBi419397at2759
PhylomeDBiP04004
TreeFamiTF332780

Enzyme and pathway databases

ReactomeiR-HSA-2129379 Molecules associated with elastic fibres
R-HSA-216083 Integrin cell surface interactions
R-HSA-3000170 Syndecan interactions
R-HSA-3000178 ECM proteoglycans
R-HSA-977606 Regulation of Complement cascade
SIGNORiP04004

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
VTN human
EvolutionaryTraceiP04004

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Vitronectin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7448
PMAP-CutDBiP04004

Protein Ontology

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PROi
PR:P04004

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109072 Expressed in 87 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP04004 baseline and differential
GenevisibleiP04004 HS

Family and domain databases

CDDicd00094 HX, 1 hit
Gene3Di2.110.10.10, 2 hits
InterProiView protein in InterPro
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR036024 Somatomedin_B-like_dom_sf
IPR020436 Somatomedin_B_chordata
IPR001212 Somatomedin_B_dom
PfamiView protein in Pfam
PF00045 Hemopexin, 4 hits
PF01033 Somatomedin_B, 1 hit
PRINTSiPR00022 SOMATOMEDINB
SMARTiView protein in SMART
SM00120 HX, 4 hits
SM00201 SO, 1 hit
SUPFAMiSSF50923 SSF50923, 1 hit
SSF90188 SSF90188, 1 hit
PROSITEiView protein in PROSITE
PS00024 HEMOPEXIN, 2 hits
PS51642 HEMOPEXIN_2, 4 hits
PS00524 SMB_1, 1 hit
PS50958 SMB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVTNC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P04004
Secondary accession number(s): B2R7G0, P01141, Q9BSH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 1986
Last sequence update: October 23, 1986
Last modified: July 3, 2019
This is version 228 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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