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Entry version 231 (18 Sep 2019)
Sequence version 2 (01 Feb 1991)
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Protein

Plasma protease C1 inhibitor

Gene

SERPING1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei465 – 466Reactive bond for chymotrypsin2
Sitei466 – 467Reactive bond2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Complement pathway, Fibrinolysis, Hemostasis, Immunity, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-977606 Regulation of Complement cascade

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I04.024

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plasma protease C1 inhibitor
Short name:
C1 Inh
Short name:
C1Inh
Alternative name(s):
C1 esterase inhibitor
C1-inhibiting factor
Serpin G1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPING1
Synonyms:C1IN, C1NH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1228 SERPING1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606860 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P05155

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Hereditary angioedema (HAE)17 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. Hereditary angioedema due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In hereditary angioedema type 1, serum levels of C1 esterase inhibitor are decreased, while in type 2, the levels are normal or elevated, but the protein is non-functional.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07170111L → R in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_04620284 – 138Missing in HAE; phenotype consistent with hereditary angioedema type 2. 1 PublicationAdd BLAST55
Natural variantiVAR_068832118T → A in HAE. 1 PublicationCorresponds to variant dbSNP:rs200534715EnsemblClinVar.1
Natural variantiVAR_027379130C → Y in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_068833154Y → C in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875168EnsemblClinVar.1
Natural variantiVAR_068834170S → F in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875169EnsemblClinVar.1
Natural variantiVAR_068835184G → R in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875170EnsemblClinVar.1
Natural variantiVAR_068836230L → P in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875171EnsemblClinVar.1
Natural variantiVAR_068837232I → K in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875172EnsemblClinVar.1
Natural variantiVAR_071702265W → R in HAE. 1 Publication1
Natural variantiVAR_068838272Missing in HAE. 1 Publication1
Natural variantiVAR_007012273Missing in HAE; phenotype consistent with hereditary angioedema type 2; creates a new glycosylation site. 1 Publication1
Natural variantiVAR_071703274I → V in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_068839299W → R in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875173EnsemblClinVar.1
Natural variantiVAR_027376345G → R in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_027380394T → P in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_027381408D → V in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_007013429G → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_068840430L → Q in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875174EnsemblClinVar.1
Natural variantiVAR_068841441M → T in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875175EnsemblClinVar.1
Natural variantiVAR_068842447L → P in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875176EnsemblClinVar.1
Natural variantiVAR_007014454V → E in HAE; phenotype consistent with hereditary angioedema type 2. 1 PublicationCorresponds to variant dbSNP:rs121907949EnsemblClinVar.1
Natural variantiVAR_007015456A → E in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007016458A → T in HAE; phenotype consistent with hereditary angioedema type 2. 3 PublicationsCorresponds to variant dbSNP:rs121907947EnsemblClinVar.1
Natural variantiVAR_007017458A → V in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007018465A → V in HAE; phenotype consistent with hereditary angioedema type 2. 1 PublicationCorresponds to variant dbSNP:rs121907950EnsemblClinVar.1
Natural variantiVAR_007019466R → C in HAE; phenotype consistent with hereditary angioedema type 2. 3 PublicationsCorresponds to variant dbSNP:rs28940870EnsemblClinVar.1
Natural variantiVAR_007020466R → H in HAE; phenotype consistent with hereditary angioedema type 2. 2 PublicationsCorresponds to variant dbSNP:rs121907948EnsemblClinVar.1
Natural variantiVAR_007021466R → L in HAE; phenotype consistent with hereditary angioedema type 2. 2 PublicationsCorresponds to variant dbSNP:rs121907948EnsemblClinVar.1
Natural variantiVAR_007022466R → S in HAE; phenotype consistent with hereditary angioedema type 2. 2 PublicationsCorresponds to variant dbSNP:rs28940870EnsemblClinVar.1
Natural variantiVAR_007023467T → P in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_027382473V → E in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_068843473V → G in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875177EnsemblClinVar.1
Natural variantiVAR_007024473V → M in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007026477F → S in HAE; phenotype consistent with hereditary angioedema type 2. 1
Natural variantiVAR_007028481L → P in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007029481L → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007030489P → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_027383493G → E in HAE; phenotype consistent with hereditary angioedema type 1. 2 Publications1
Natural variantiVAR_071704493G → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_068844497D → G in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875178EnsemblClinVar.1
Natural variantiVAR_027384498P → R in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_007031498P → S in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
710

MalaCards human disease database

More...
MalaCardsi
SERPING1
MIMi106100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000149131

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
459353 C1 inhibitor deficiency
100050 Hereditary angioedema type 1
100051 Hereditary angioedema type 2

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35029

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P05155

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09130 Copper
DB05961 PPL-100

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERPING1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124096

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003251423 – 500Plasma protease C1 inhibitor1 PublicationAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) (complex) asparagine5 Publications1
Glycosylationi47O-linked (GalNAc...) threonine2 Publications1
Glycosylationi48O-linked (GalNAc...) threonine3 Publications1
Glycosylationi64O-linked (GalNAc...) serine1 Publication1
Glycosylationi69N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi71O-linked (GalNAc...) threonine1 Publication1
Glycosylationi81N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi83O-linked (GalNAc...) threonine1 Publication1
Glycosylationi88O-linked (GalNAc...) threonine1 Publication1
Glycosylationi92O-linked (GalNAc...) threonine1 Publication1
Glycosylationi96O-linked (GalNAc...) threonine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi123 ↔ 4282 Publications
Disulfide bondi130 ↔ 2052 Publications
Glycosylationi238N-linked (GlcNAc...) (complex) asparagine6 Publications1
Glycosylationi253N-linked (GlcNAc...) (complex) asparagine6 Publications1
Glycosylationi272N-linked (GlcNAc...) asparagine; in variant TA1
Glycosylationi352N-linked (GlcNAc...) (complex) asparagine6 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).11 Publications
Can be proteolytically cleaved by E.coli stcE.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-1305
CPTAC-684
non-CPTAC-1147
non-CPTAC-1148

Encyclopedia of Proteome Dynamics

More...
EPDi
P05155

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P05155

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P05155

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P05155

PeptideAtlas

More...
PeptideAtlasi
P05155

PRoteomics IDEntifications database

More...
PRIDEi
P05155

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51806 [P05155-1]
5752
5757

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P05155-1 [P05155-1]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
749

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P05155

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P05155

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P05155

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P05155

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149131 Expressed in 232 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P05155 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P05155 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026161
HPA048738

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis.

Interacts with MASP1.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107171, 19 interactors

Database of interacting proteins

More...
DIPi
DIP-45635N

Protein interaction database and analysis system

More...
IntActi
P05155, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278407

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1500
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P05155

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P05155

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati85 – 8814
Repeati89 – 9224
Repeati93 – 9634
Repeati97 – 10044
Repeati101 – 10454
Repeati105 – 10864
Repeati116 – 11974

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 1197 X 4 AA tandem repeats of [QE]-P-T-[TQ]Add BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2392 Eukaryota
COG4826 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159681

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231936

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P05155

KEGG Orthology (KO)

More...
KOi
K04001

Database of Orthologous Groups

More...
OrthoDBi
1124079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P05155

TreeFam database of animal gene trees

More...
TreeFami
TF317350

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015553 C1-inh
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2

The PANTHER Classification System

More...
PANTHERi
PTHR11461 PTHR11461, 1 hit
PTHR11461:SF159 PTHR11461:SF159, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00079 Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00093 SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56574 SSF56574, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00284 SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P05155-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI
60 70 80 90 100
SKMLFVEPIL EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI
110 120 130 140 150
QPTQPTTQLP TDSPTQPTTG SFCPGPVTLC SDLESHSTEA VLGDALVDFS
160 170 180 190 200
LKLYHAFSAM KKVETNMAFS PFSIASLLTQ VLLGAGENTK TNLESILSYP
210 220 230 240 250
KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS RTLYSSSPRV
260 270 280 290 300
LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK
310 320 330 340 350
TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS
360 370 380 390 400
HNLSLVILVP QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR
410 420 430 440 450
IKVTTSQDML SIMEKLEFFD FSYDLNLCGL TEDPDLQVSA MQHQTVLELT
460 470 480 490 500
ETGVEAAAAS AISVARTLLV FEVQQPFLFV LWDQQHKFPV FMGRVYDPRA
Length:500
Mass (Da):55,154
Last modified:February 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B5E874833EA6C05
GO
Isoform 2 (identifier: P05155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Note: No experimental confirmation available.
Show »
Length:448
Mass (Da):49,757
Checksum:iC3BA362232FA47AB
GO
Isoform 3 (identifier: P05155-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-17: G → GFLEPQ

Note: No experimental confirmation available.
Show »
Length:505
Mass (Da):55,769
Checksum:i6AAEEB52FEE89B80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H9KV48H9KV48_HUMAN
Plasma protease C1 inhibitor
SERPING1
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MCB9B5MCB9_HUMAN
Plasma protease C1 inhibitor
SERPING1
160Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGN7E9PGN7_HUMAN
Plasma protease C1 inhibitor
SERPING1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCA1H0YCA1_HUMAN
Plasma protease C1 inhibitor
SERPING1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WUD9A0A087WUD9_HUMAN
Plasma protease C1 inhibitor
SERPING1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PK97E9PK97_HUMAN
Plasma protease C1 inhibitor
SERPING1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZJ9C9JZJ9_HUMAN
Plasma protease C1 inhibitor
SERPING1
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA53096 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103T → S in BAF85743 (PubMed:14702039).Curated1
Sequence conflicti187E → Q in AAB59387 (PubMed:3756141).Curated1
Sequence conflicti306K → R in AAA35613 (PubMed:3488058).Curated1
Sequence conflicti314 – 320HFKNSVI → QLQKLSY AA sequence (PubMed:3458172).Curated7
Sequence conflicti322V → M AA sequence (PubMed:3458172).Curated1
Sequence conflicti332V → L AA sequence (PubMed:3458172).Curated1
Sequence conflicti370 – 375MEQALS → TGTGSQ AA sequence (PubMed:3458172).Curated6
Sequence conflicti417E → V AA sequence (PubMed:3458172).Curated1
Sequence conflicti439S → F AA sequence (PubMed:3458172).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Chymotrypsin uses Ala-465 as its reactive site in normal plasma protease C1 inhibitor, and His-466 as its reactive site in the variant His-466.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07170111L → R in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_02737439D → E. Corresponds to variant dbSNP:rs11229062EnsemblClinVar.1
Natural variantiVAR_02737556V → A2 PublicationsCorresponds to variant dbSNP:rs11546660EnsemblClinVar.1
Natural variantiVAR_04620284 – 138Missing in HAE; phenotype consistent with hereditary angioedema type 2. 1 PublicationAdd BLAST55
Natural variantiVAR_068832118T → A in HAE. 1 PublicationCorresponds to variant dbSNP:rs200534715EnsemblClinVar.1
Natural variantiVAR_027379130C → Y in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_068833154Y → C in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875168EnsemblClinVar.1
Natural variantiVAR_068834170S → F in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875169EnsemblClinVar.1
Natural variantiVAR_068835184G → R in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875170EnsemblClinVar.1
Natural variantiVAR_068836230L → P in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875171EnsemblClinVar.1
Natural variantiVAR_068837232I → K in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875172EnsemblClinVar.1
Natural variantiVAR_071702265W → R in HAE. 1 Publication1
Natural variantiVAR_068838272Missing in HAE. 1 Publication1
Natural variantiVAR_007012273Missing in HAE; phenotype consistent with hereditary angioedema type 2; creates a new glycosylation site. 1 Publication1
Natural variantiVAR_071703274I → V in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_068839299W → R in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875173EnsemblClinVar.1
Natural variantiVAR_011751308T → S. Corresponds to variant dbSNP:rs1803212Ensembl.1
Natural variantiVAR_027376345G → R in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_027380394T → P in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_027381408D → V in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_007013429G → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_068840430L → Q in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875174EnsemblClinVar.1
Natural variantiVAR_068841441M → T in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875175EnsemblClinVar.1
Natural variantiVAR_068842447L → P in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875176EnsemblClinVar.1
Natural variantiVAR_007014454V → E in HAE; phenotype consistent with hereditary angioedema type 2. 1 PublicationCorresponds to variant dbSNP:rs121907949EnsemblClinVar.1
Natural variantiVAR_007015456A → E in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007016458A → T in HAE; phenotype consistent with hereditary angioedema type 2. 3 PublicationsCorresponds to variant dbSNP:rs121907947EnsemblClinVar.1
Natural variantiVAR_007017458A → V in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007018465A → V in HAE; phenotype consistent with hereditary angioedema type 2. 1 PublicationCorresponds to variant dbSNP:rs121907950EnsemblClinVar.1
Natural variantiVAR_007019466R → C in HAE; phenotype consistent with hereditary angioedema type 2. 3 PublicationsCorresponds to variant dbSNP:rs28940870EnsemblClinVar.1
Natural variantiVAR_007020466R → H in HAE; phenotype consistent with hereditary angioedema type 2. 2 PublicationsCorresponds to variant dbSNP:rs121907948EnsemblClinVar.1
Natural variantiVAR_007021466R → L in HAE; phenotype consistent with hereditary angioedema type 2. 2 PublicationsCorresponds to variant dbSNP:rs121907948EnsemblClinVar.1
Natural variantiVAR_007022466R → S in HAE; phenotype consistent with hereditary angioedema type 2. 2 PublicationsCorresponds to variant dbSNP:rs28940870EnsemblClinVar.1
Natural variantiVAR_007023467T → P in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_027382473V → E in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_068843473V → G in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875177EnsemblClinVar.1
Natural variantiVAR_007024473V → M in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007025474Q → E. 1
Natural variantiVAR_007026477F → S in HAE; phenotype consistent with hereditary angioedema type 2. 1
Natural variantiVAR_007027480V → M6 PublicationsCorresponds to variant dbSNP:rs4926EnsemblClinVar.1
Natural variantiVAR_007028481L → P in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007029481L → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_007030489P → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_027383493G → E in HAE; phenotype consistent with hereditary angioedema type 1. 2 Publications1
Natural variantiVAR_071704493G → R in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1
Natural variantiVAR_068844497D → G in HAE. 1 PublicationCorresponds to variant dbSNP:rs281875178EnsemblClinVar.1
Natural variantiVAR_027384498P → R in HAE; phenotype consistent with hereditary angioedema type 1. 1 Publication1
Natural variantiVAR_007031498P → S in HAE; phenotype consistent with hereditary angioedema type 2. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0566621 – 52Missing in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_05666317G → GFLEPQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13690 mRNA Translation: AAA35613.1
M13656 mRNA Translation: AAB59387.1
X07427
, X07428, X07429, X07430, X07431, X07432, X07433 Genomic DNA Translation: CAA30314.1
X07577 mRNA Translation: CAA30469.1
X54486 Genomic DNA Translation: CAA38358.1
AF435921 Genomic DNA Translation: AAM21515.1
AK293054 mRNA Translation: BAF85743.1
AK303809 mRNA Translation: BAG64762.1
AK303840 mRNA Translation: BAG64784.1
AK312626 mRNA Translation: BAG35512.1
BT006966 mRNA Translation: AAP35612.1
AB209826 mRNA Translation: BAD93063.1
AY904027 Genomic DNA Translation: AAW69393.1
AP000662 Genomic DNA No translation available.
AP002893 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73764.1
BC011171 mRNA Translation: AAH11171.1
AY291075 Genomic DNA Translation: AAQ19269.1
M30688 Genomic DNA Translation: AAA53096.1 Sequence problems.
M14036 mRNA Translation: AAA51848.1
M13203 mRNA Translation: AAA51849.1
S76944 Genomic DNA Translation: AAB33044.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7962.1 [P05155-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
S15386 ITHUC1

NCBI Reference Sequences

More...
RefSeqi
NP_000053.2, NM_000062.2 [P05155-1]
NP_001027466.1, NM_001032295.1 [P05155-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278407; ENSP00000278407; ENSG00000149131 [P05155-1]
ENST00000378323; ENSP00000367574; ENSG00000149131 [P05155-3]
ENST00000378324; ENSP00000367575; ENSG00000149131 [P05155-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
710

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:710

UCSC genome browser

More...
UCSCi
uc001nkp.2 human [P05155-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

C1-inhibitor entry

SERPING1base

SERPING1 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13690 mRNA Translation: AAA35613.1
M13656 mRNA Translation: AAB59387.1
X07427
, X07428, X07429, X07430, X07431, X07432, X07433 Genomic DNA Translation: CAA30314.1
X07577 mRNA Translation: CAA30469.1
X54486 Genomic DNA Translation: CAA38358.1
AF435921 Genomic DNA Translation: AAM21515.1
AK293054 mRNA Translation: BAF85743.1
AK303809 mRNA Translation: BAG64762.1
AK303840 mRNA Translation: BAG64784.1
AK312626 mRNA Translation: BAG35512.1
BT006966 mRNA Translation: AAP35612.1
AB209826 mRNA Translation: BAD93063.1
AY904027 Genomic DNA Translation: AAW69393.1
AP000662 Genomic DNA No translation available.
AP002893 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73764.1
BC011171 mRNA Translation: AAH11171.1
AY291075 Genomic DNA Translation: AAQ19269.1
M30688 Genomic DNA Translation: AAA53096.1 Sequence problems.
M14036 mRNA Translation: AAA51848.1
M13203 mRNA Translation: AAA51849.1
S76944 Genomic DNA Translation: AAB33044.2
CCDSiCCDS7962.1 [P05155-1]
PIRiS15386 ITHUC1
RefSeqiNP_000053.2, NM_000062.2 [P05155-1]
NP_001027466.1, NM_001032295.1 [P05155-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M6Qmodel-A138-500[»]
2OAYX-ray2.35A119-500[»]
5DU3X-ray2.10A/B119-500[»]
5DUQX-ray2.90A/B118-500[»]
SMRiP05155
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107171, 19 interactors
DIPiDIP-45635N
IntActiP05155, 13 interactors
STRINGi9606.ENSP00000278407

Chemistry databases

DrugBankiDB09130 Copper
DB05961 PPL-100

Protein family/group databases

MEROPSiI04.024

PTM databases

GlyConnecti749
iPTMnetiP05155
PhosphoSitePlusiP05155
UniCarbKBiP05155

Polymorphism and mutation databases

BioMutaiSERPING1
DMDMi124096

Proteomic databases

CPTACiCPTAC-1305
CPTAC-684
non-CPTAC-1147
non-CPTAC-1148
EPDiP05155
jPOSTiP05155
MassIVEiP05155
PaxDbiP05155
PeptideAtlasiP05155
PRIDEiP05155
ProteomicsDBi51806 [P05155-1]
5752
5757
TopDownProteomicsiP05155-1 [P05155-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
710

Genome annotation databases

EnsembliENST00000278407; ENSP00000278407; ENSG00000149131 [P05155-1]
ENST00000378323; ENSP00000367574; ENSG00000149131 [P05155-3]
ENST00000378324; ENSP00000367575; ENSG00000149131 [P05155-2]
GeneIDi710
KEGGihsa:710
UCSCiuc001nkp.2 human [P05155-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
710
DisGeNETi710

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SERPING1
HGNCiHGNC:1228 SERPING1
HPAiCAB026161
HPA048738
MalaCardsiSERPING1
MIMi106100 phenotype
606860 gene
neXtProtiNX_P05155
OpenTargetsiENSG00000149131
Orphaneti459353 C1 inhibitor deficiency
100050 Hereditary angioedema type 1
100051 Hereditary angioedema type 2
PharmGKBiPA35029

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00940000159681
HOGENOMiHOG000231936
InParanoidiP05155
KOiK04001
OrthoDBi1124079at2759
PhylomeDBiP05155
TreeFamiTF317350

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SERPING1 human
EvolutionaryTraceiP05155

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C1-inhibitor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
710
PharosiP05155
PMAP-CutDBiP05155

Protein Ontology

More...
PROi
PR:P05155

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149131 Expressed in 232 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP05155 baseline and differential
GenevisibleiP05155 HS

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR015553 C1-inh
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF159 PTHR11461:SF159, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P05155
Secondary accession number(s): A6NMU0
, A8KAI9, B2R6L5, B4E1F0, B4E1H2, Q16304, Q547W3, Q59EI5, Q7Z455, Q96FE0, Q9UC49, Q9UCF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: February 1, 1991
Last modified: September 18, 2019
This is version 231 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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