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1 to 25 of 43  Show
  1. 1
    "A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells."
    Leytus S.P., Loeb K.R., Hagen F.S., Kurachi K., Davie E.W.
    Biochemistry 27:1067-1074(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Category: Sequences.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Tissue: Mammary gland.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 12927 other entries.

  3. 3
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Category: Sequences.
    Tissue: Pancreas and Spleen.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50448 other entries.

  4. 4
    "Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization."
    Tsuji A., Torres-Rosado A., Arai T., le Beau M.M., Lemons R.S., Chou S.H., Kurachi K.
    J. Biol. Chem. 266:16948-16953(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Category: Subcellular Location.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 3 other entries.

  5. 5
    "Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth."
    Torres-Rosado A., O'Shea K.S., Tsuji A., Chou S.-H., Kurachi K.
    Proc. Natl. Acad. Sci. U.S.A. 90:7181-7185(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 11 other entries.

  6. 6
    "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112.
    Category: PTM / Processing.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 478 other entries.

  7. 7
    Cited for: FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
    Category: Function, Expression.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 and mapped to 19 other entries.

  8. 8
    "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Category: Sequences.
    Tissue: Liver.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 11551 other entries.

  9. 9
    "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."
    Heurich A., Hofmann-Winkler H., Gierer S., Liepold T., Jahn O., Poehlmann S.
    J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 6 and mapped to 14 other entries.

  10. 10
    "The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin."
    Brunati M., Perucca S., Han L., Cattaneo A., Consolato F., Andolfo A., Schaeffer C., Olinger E., Peng J., Santambrogio S., Perrier R., Li S., Bokhove M., Bachi A., Hummler E., Devuyst O., Wu Q., Jovine L., Rampoldi L.
    Elife 4:0-0(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION.
    Category: Function, Subcellular Location.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 20 other entries.

  11. 11
    "The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain."
    Somoza J.R., Ho J.D., Luong C., Ghate M., Sprengeler P.A., Mortara K., Shrader W.D., Sperandio D., Chan H., McGrath M.E., Katz B.A.
    Structure 11:1123-1131(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 46-417, DISULFIDE BONDS, ACTIVE SITE, DOMAIN.
    Category: Function, PTM / Processing, Structure, Family & Domains.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is mapped to 3 other entries.

  12. 12
    "Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers."
    Herter S., Piper D.E., Aaron W., Gabriele T., Cutler G., Cao P., Bhatt A.S., Choe Y., Craik C.S., Walker N., Meininger D., Hoey T., Austin R.J.
    Biochem. J. 390:125-136(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 46-417, DISULFIDE BONDS, FUNCTION, CATALYTIC ACTIVITY, ACTIVE SITE.
    Category: Function, PTM / Processing, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  13. 13
    "Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer."
    Chen Z., Fan Z., McNeal J.E., Nolley R., Caldwell M.C., Mahadevappa M., Zhang Z., Warrington J.A., Stamey T.A.
    J. Urol. 169:1316-1319(2003) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer.
    Source: GeneRIF:3249.

    This publication is mapped to 7 other entries.

  14. 14
    "A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis."
    Hartmann G., Naldini L., Weidner K.M., Sachs M., Vigna E., Comoglio P.M., Birchmeier W.
    Proc. Natl. Acad. Sci. U.S.A. 89:11574-11578(1992) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-6800195, Reactome:R-HSA-8849219.

    This publication is mapped to 2 other entries.

  15. 15
    Category: Function.
    Annotation: Pathway.
    Source: Reactome:R-HSA-6800195, Reactome:R-HSA-8849219.

    This publication is mapped to 11 other entries.

  16. 16
    "Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA)."
    Katz B.A., Luong C., Ho J.D., Somoza J.R., Gjerstad E., Tang J., Williams S.R., Verner E., Mackman R.L., Young W.B., Sprengeler P.A., Chan H., Mortara K., Janc J.W., McGrath M.E.
    J. Mol. Biol. 344:527-547(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:1O5E, PDB:1O5F.

    This publication is mapped to 5 other entries.

  17. 17
    Category: Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:3249.

    This publication is mapped to 55 other entries.

  18. 18
    "Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2."
    Kirchhofer D., Peek M., Lipari M.T., Billeci K., Fan B., Moran P.
    FEBS Lett. 579:1945-1950(2005) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Hepsin is functionally linked to hepatocyte growth factor/MET pathway which may contribute to prostate cancer progression. [GeneRIF:3249]. Pathway. [Reactome:R-HSA-6800195, Reactome:R-HSA-8849219].
    Source: Reactome:R-HSA-6800195, Reactome:R-HSA-8849219, GeneRIF:3249.

    This publication is mapped to 8 other entries.

  19. 19
    "Variants in the HEPSIN gene are associated with prostate cancer in men of European origin."
    Pal P., Xi H., Kaushal R., Sun G., Jin C.H., Jin L., Suarez B.K., Catalona W.J., Deka R.
    Hum. Genet. 120:187-192(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech, Expression, Sequences.
    Annotation: Associated with CANCER: prostate cancer. [GAD:149122]. Observational study of gene-disease association. (HuGE Navigator); A major 11-locus haplotype is significantly associated with prostate cancer which provides further support that HPN is a potentially important candidate gene involved in prostate cancer susceptibility. [GeneRIF:3249].
    Source: GAD:149122, GeneRIF:3249.

    This publication is mapped to 4 other entries.

  20. 20
    "Pro-urokinase-type plasminogen activator is a substrate for hepsin."
    Moran P., Li W., Fan B., Vij R., Eigenbrot C., Kirchhofer D.
    J. Biol. Chem. 281:30439-30446(2006) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: the ability of hepsin to efficiently activate pro-uPA suggests that it may initiate plasmin-mediated proteolytic pathways at the tumor/stroma interface that lead to basement membrane disruption and tumor progression.
    Source: GeneRIF:3249.

    This publication is mapped to 19 other entries.

  21. 21
    "Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma."
    Betsunoh H., Mukai S., Akiyama Y., Fukushima T., Minamiguchi N., Hasui Y., Osada Y., Kataoka H.
    Cancer Sci. 98:491-498(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Our findings suggest that the balance between hepsin and its inhibitor HAI-2 may have prognostic value in RCC.
    Source: GeneRIF:3249.

    This publication is mapped to 4 other entries.

  22. 22
    "Genes involved in the transforming growth factor beta signalling pathway and the risk of intracranial aneurysms."
    Ruigrok Y.M., Tan S., Medic J., Rinkel G.J., Wijmenga C.
    J. Neurol. Neurosurg. Psychiatry 79:722-724(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: We analyzed all the common variations using tag SNP in the HPN and LTBP4 genes for association with IA in 390 patients and 642 controls in the Dutch population; Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:3249.

    This publication is mapped to 27 other entries.

  23. 23
    "Hepsin inhibits the cell growth of endometrial cancer."
    Nakamura K., Takamoto N., Abarzua F., Hongo A., Kodama J., Nasu Y., Kumon H., Hiramatsu Y.
    Int. J. Mol. Med. 22:389-397(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Hepsin showed potential inhibitory effects mediated by the induction of 14-3-3sigma expression which leads to both cell cycle arrest at the G2/M phase.
    Source: GeneRIF:3249.

    This publication is mapped to 4 other entries.

  24. 24
    "Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression."
    Tripathi M., Nandana S., Yamashita H., Ganesan R., Kirchhofer D., Quaranta V.
    J. Biol. Chem. 283:30576-30584(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Ln-332 may be one mechanism by which hepsin promotes prostate tumor progression and metastasis possibly by up-regulating prostate cancer cell motility.
    Source: GeneRIF:3249.

    This publication is mapped to 9 other entries.

  25. 25
    "Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor."
    Chen M., Chen L.M., Lin C.Y., Chai K.X.
    Mol. Cell. Biochem. 337:259-266(2010) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.
    Source: GeneRIF:3249.

    This publication is mapped to 47 other entries.

1 to 25 of 43  Show
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