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Entry version 212 (13 Nov 2019)
Sequence version 3 (07 Mar 2006)
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Protein

Apolipoprotein A-IV

Gene

APOA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8963888 Chylomicron assembly
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Apolipoprotein A-IV
Short name:
Apo-AIV
Short name:
ApoA-IV
Alternative name(s):
Apolipoprotein A4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APOA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:602 APOA4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
107690 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06727

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
337

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P06727

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB09130 Copper
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
APOA4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
93163358

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 201 PublicationAdd BLAST20
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000197521 – 396Apolipoprotein A-IVAdd BLAST376

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-1077
non-CPTAC-1078
non-CPTAC-1079

Encyclopedia of Proteome Dynamics

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EPDi
P06727

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P06727

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P06727

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P06727

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06727

PeptideAtlas

More...
PeptideAtlasi
P06727

PRoteomics IDEntifications database

More...
PRIDEi
P06727

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51912

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P06727

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00304273

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P06727

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P06727

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06727

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P06727

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Synthesized primarily in the intestine and secreted in plasma.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110244 Expressed in 154 organ(s), highest expression level in jejunal mucosa

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P06727 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068250
CAB068251
CAB068252
HPA001352
HPA002549

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-38333N

Protein interaction database and analysis system

More...
IntActi
P06727, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350425

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06727

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati33 – 541Add BLAST22
Repeati60 – 812Add BLAST22
Repeati82 – 1033Add BLAST22
Repeati115 – 1364Add BLAST22
Repeati137 – 1585Add BLAST22
Repeati159 – 1806Add BLAST22
Repeati181 – 2027Add BLAST22
Repeati203 – 2248Add BLAST22
Repeati225 – 2469Add BLAST22
Repeati247 – 26810Add BLAST22
Repeati269 – 28611Add BLAST18
Repeati287 – 30812Add BLAST22
Repeati309 – 33013Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 33013 X 22 AA approximate tandem repeatsAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi372 – 389Gln/Glu-richAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKU1 Eukaryota
ENOG41119VI LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000037942

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06727

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06727

TreeFam database of animal gene trees

More...
TreeFami
TF334458

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000074 ApoA_E

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01442 Apolipoprotein, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P06727-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLKAVVLTL ALVAVAGARA EVSADQVATV MWDYFSQLSN NAKEAVEHLQ
60 70 80 90 100
KSELTQQLNA LFQDKLGEVN TYAGDLQKKL VPFATELHER LAKDSEKLKE
110 120 130 140 150
EIGKELEELR ARLLPHANEV SQKIGDNLRE LQQRLEPYAD QLRTQVNTQA
160 170 180 190 200
EQLRRQLTPY AQRMERVLRE NADSLQASLR PHADELKAKI DQNVEELKGR
210 220 230 240 250
LTPYADEFKV KIDQTVEELR RSLAPYAQDT QEKLNHQLEG LTFQMKKNAE
260 270 280 290 300
ELKARISASA EELRQRLAPL AEDVRGNLRG NTEGLQKSLA ELGGHLDQQV
310 320 330 340 350
EEFRRRVEPY GENFNKALVQ QMEQLRQKLG PHAGDVEGHL SFLEKDLRDK
360 370 380 390
VNSFFSTFKE KESQDKTLSL PELEQQQEQQ QEQQQEQVQM LAPLES
Length:396
Mass (Da):45,399
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i193753196CA2FA4A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158 – 160TPY → DPL in AAA51744 (PubMed:3755616).Curated3
Sequence conflicti158 – 160TPY → DPL in AAA51745 (PubMed:3095836).Curated3
Sequence conflicti327Q → T in AAA96731 (PubMed:3036793).Curated1
Sequence conflicti327Q → T in AAA51748 (PubMed:3080432).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Eight alleles have been characterized (APOA-IV*0 to APOA-IV*7). APOA-IV*1 is the major allele (90%), APOA-IV*2 is also common (8%), the others are rare alleles. The sequence shown represents allele APOA-IV*1.6 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00062613V → M in allele APOA-IV*1D. 2 PublicationsCorresponds to variant dbSNP:rs12721041Ensembl.1
Natural variantiVAR_00062744E → K in Budapest-2. 1 Publication1
Natural variantiVAR_01461074G → S. Corresponds to variant dbSNP:rs5102Ensembl.1
Natural variantiVAR_02544477Q → H1 PublicationCorresponds to variant dbSNP:rs12721042Ensembl.1
Natural variantiVAR_000628147N → S in allele APOA-IV*1B. Combined sources3 PublicationsCorresponds to variant dbSNP:rs5104Ensembl.1
Natural variantiVAR_000629161A → S in Seattle-3. 2 PublicationsCorresponds to variant dbSNP:rs12721043Ensembl.1
Natural variantiVAR_000630178S → L in Seattle-1; may contribute to the development of familial combined hyperlipidemia. 1 PublicationCorresponds to variant dbSNP:rs1181852696Ensembl.1
Natural variantiVAR_000631185E → K in allele APOA-IV*3. 1 PublicationCorresponds to variant dbSNP:rs201861136Ensembl.1
Natural variantiVAR_000632187K → E in allele APOA-IV*0A; associated with H-380. 1 PublicationCorresponds to variant dbSNP:rs773492545Ensembl.1
Natural variantiVAR_000633250E → K in allele APOA-IV*3A. 1 PublicationCorresponds to variant dbSNP:rs121909576EnsemblClinVar.1
Natural variantiVAR_000634264R → Q in Seattle-2; may contribute to the development of familial combined hyperlipidemia. 1 PublicationCorresponds to variant dbSNP:rs2238008Ensembl.1
Natural variantiVAR_025443279R → K2 PublicationsCorresponds to variant dbSNP:rs1042372Ensembl.1
Natural variantiVAR_000635305R → C in Budapest-1. 1 PublicationCorresponds to variant dbSNP:rs150264487Ensembl.1
Natural variantiVAR_014611307V → L. Corresponds to variant dbSNP:rs5108Ensembl.1
Natural variantiVAR_000636367T → S in allele APOA-IV*1A and allele Budapest-1. 3 PublicationsCorresponds to variant dbSNP:rs675Ensembl.1
Natural variantiVAR_000637380Q → H in allele APOA-IV*2 and allele APOA-IV*0A; associated with E-187 in allele APOA-IV*0A. 7 PublicationsCorresponds to variant dbSNP:rs5110EnsemblClinVar.1
Natural variantiVAR_000638381Q → QEQQQ in allele APOA-IV*0 and allele APOA-IV*5; allele APOA-IV*5 is further defined by a silent nucleotide substitution. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13654 mRNA Translation: AAA51744.1
M14642 Genomic DNA Translation: AAA51745.1
J02758 Genomic DNA Translation: AAA96731.1
X13629 mRNA Translation: CAA31955.1
AY422950 Genomic DNA Translation: AAQ91809.1
AY555191 Genomic DNA Translation: AAS68228.1
AP006216 Genomic DNA No translation available.
BC074764 mRNA Translation: AAH74764.1
BC113594 mRNA Translation: AAI13595.1
BC113596 mRNA Translation: AAI13597.1
M14566 mRNA Translation: AAA51748.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31681.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A94137 LPHUA4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357780; ENSP00000350425; ENSG00000110244

UCSC genome browser

More...
UCSCi
uc001pps.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13654 mRNA Translation: AAA51744.1
M14642 Genomic DNA Translation: AAA51745.1
J02758 Genomic DNA Translation: AAA96731.1
X13629 mRNA Translation: CAA31955.1
AY422950 Genomic DNA Translation: AAQ91809.1
AY555191 Genomic DNA Translation: AAS68228.1
AP006216 Genomic DNA No translation available.
BC074764 mRNA Translation: AAH74764.1
BC113594 mRNA Translation: AAI13595.1
BC113596 mRNA Translation: AAI13597.1
M14566 mRNA Translation: AAA51748.1
CCDSiCCDS31681.1
PIRiA94137 LPHUA4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S84X-ray2.40A/B84-355[»]
SMRiP06727
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-38333N
IntActiP06727, 10 interactors
STRINGi9606.ENSP00000350425

Chemistry databases

DrugBankiDB09130 Copper
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

PTM databases

CarbonylDBiP06727
iPTMnetiP06727
PhosphoSitePlusiP06727

Polymorphism and mutation databases

BioMutaiAPOA4
DMDMi93163358

2D gel databases

DOSAC-COBS-2DPAGEiP06727
REPRODUCTION-2DPAGEiIPI00304273
SWISS-2DPAGEiP06727

Proteomic databases

CPTACinon-CPTAC-1077
non-CPTAC-1078
non-CPTAC-1079
EPDiP06727
jPOSTiP06727
MassIVEiP06727
MaxQBiP06727
PaxDbiP06727
PeptideAtlasiP06727
PRIDEiP06727
ProteomicsDBi51912

Genome annotation databases

EnsembliENST00000357780; ENSP00000350425; ENSG00000110244
UCSCiuc001pps.2 human

Organism-specific databases

DisGeNETi337

GeneCards: human genes, protein and diseases

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GeneCardsi
APOA4
HGNCiHGNC:602 APOA4
HPAiCAB068250
CAB068251
CAB068252
HPA001352
HPA002549
MIMi107690 gene
neXtProtiNX_P06727

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IKU1 Eukaryota
ENOG41119VI LUCA
HOGENOMiHOG000037942
InParanoidiP06727
PhylomeDBiP06727
TreeFamiTF334458

Enzyme and pathway databases

ReactomeiR-HSA-8963888 Chylomicron assembly
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
R-HSA-8963901 Chylomicron remodeling
R-HSA-975634 Retinoid metabolism and transport
R-HSA-977225 Amyloid fiber formation

Miscellaneous databases

PharosiP06727

Protein Ontology

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PROi
PR:P06727

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110244 Expressed in 154 organ(s), highest expression level in jejunal mucosa
GenevisibleiP06727 HS

Family and domain databases

InterProiView protein in InterPro
IPR000074 ApoA_E
PfamiView protein in Pfam
PF01442 Apolipoprotein, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPOA4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06727
Secondary accession number(s): A8MSL6, Q14CW8, Q6Q787
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 7, 2006
Last modified: November 13, 2019
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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