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Entry version 197 (08 May 2019)
Sequence version 3 (20 Feb 2007)
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Protein

Proto-oncogene tyrosine-protein kinase ROS

Gene

ROS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by dephosphorylation by PTPN6.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1980ATPCurated1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2079Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1951 – 1959ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.10.1 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P08922

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08922

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proto-oncogene tyrosine-protein kinase ROS (EC:2.7.10.1)
Alternative name(s):
Proto-oncogene c-Ros
Proto-oncogene c-Ros-1
Receptor tyrosine kinase c-ros oncogene 1
c-Ros receptor tyrosine kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROS1
Synonyms:MCF3, ROS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10261 ROS1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
165020 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08922

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1859ExtracellularSequence analysisAdd BLAST1832
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1860 – 1882HelicalSequence analysisAdd BLAST23
Topological domaini1883 – 2347CytoplasmicSequence analysisAdd BLAST465

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1980K → M: Loss of kinase activity. 1 Publication1
Mutagenesisi2274Y → F: Loss of phosphorylation at Y-2274 and loss of interaction with PTPN11. 1 Publication1
Mutagenesisi2334Y → F: Loss of phosphorylation at Y-2334 and loss of interaction with PTPN11. 1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1852 – 1853Breakpoint for translocation to form SLC34A2-ROS1 and CD74-ROS1 fusion proteins2
Sitei1880 – 1881Breakpoint for translocation to form GOPC-ROS1 fusion protein2

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
6098

Open Targets

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OpenTargetsi
ENSG00000047936

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34633

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5568

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1840

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ROS1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
126302596

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001672228 – 2347Proto-oncogene tyrosine-protein kinase ROSAdd BLAST2320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi352N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi471N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi706N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi714N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi732N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi961N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1015N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1087N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1090N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1095N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1211N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1499N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1669N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1715N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1808N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2274Phosphotyrosine; by autocatalysis1 Publication1
Modified residuei2334Phosphotyrosine; by autocatalysis1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.By similarity1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P08922

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08922

PeptideAtlas

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PeptideAtlasi
P08922

PRoteomics IDEntifications database

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PRIDEi
P08922

ProteomicsDB human proteome resource

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ProteomicsDBi
52177

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P08922

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P08922

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain. Expression is increased in primary gliomas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000047936 Expressed in 49 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08922 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08922 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049098
HPA072424

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112025, 6 interactors

Protein interaction database and analysis system

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IntActi
P08922, 4 interactors

Molecular INTeraction database

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MINTi
P08922

STRING: functional protein association networks

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STRINGi
9606.ENSP00000357494

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P08922

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08922

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 196Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini197 – 285Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini557 – 671Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST115
Domaini947 – 1042Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST96
Domaini1043 – 1150Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST108
Domaini1450 – 1556Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST107
Domaini1557 – 1656Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST100
Domaini1658 – 1751Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST94
Domaini1752 – 1854Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST103
Domaini1945 – 2222Protein kinasePROSITE-ProRule annotationAdd BLAST278

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IQAA Eukaryota
ENOG410XSTC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160831

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000137937

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08922

KEGG Orthology (KO)

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KOi
K05088

Identification of Orthologs from Complete Genome Data

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OMAi
YVWLLNG

Database of Orthologous Groups

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OrthoDBi
203310at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P08922

TreeFam database of animal gene trees

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TreeFami
TF351636

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.120.10.30, 3 hits
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS

Pfam protein domain database

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Pfami
View protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00109 TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P08922-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNIYCLIPK LVNFATLGCL WISVVQCTVL NSCLKSCVTN LGQQLDLGTP
60 70 80 90 100
HNLSEPCIQG CHFWNSVDQK NCALKCRESC EVGCSSAEGA YEEEVLENAD
110 120 130 140 150
LPTAPFASSI GSHNMTLRWK SANFSGVKYI IQWKYAQLLG SWTYTKTVSR
160 170 180 190 200
PSYVVKPLHP FTEYIFRVVW IFTAQLQLYS PPSPSYRTHP HGVPETAPLI
210 220 230 240 250
RNIESSSPDT VEVSWDPPQF PGGPILGYNL RLISKNQKLD AGTQRTSFQF
260 270 280 290 300
YSTLPNTIYR FSIAAVNEVG EGPEAESSIT TSSSAVQQEE QWLFLSRKTS
310 320 330 340 350
LRKRSLKHLV DEAHCLRLDA IYHNITGISV DVHQQIVYFS EGTLIWAKKA
360 370 380 390 400
ANMSDVSDLR IFYRGSGLIS SISIDWLYQR MYFIMDELVC VCDLENCSNI
410 420 430 440 450
EEITPPSISA PQKIVADSYN GYVFYLLRDG IYRADLPVPS GRCAEAVRIV
460 470 480 490 500
ESCTLKDFAI KPQAKRIIYF NDTAQVFMST FLDGSASHLI LPRIPFADVK
510 520 530 540 550
SFACENNDFL VTDGKVIFQQ DALSFNEFIV GCDLSHIEEF GFGNLVIFGS
560 570 580 590 600
SSQLHPLPGR PQELSVLFGS HQALVQWKPP ALAIGANVIL ISDIIELFEL
610 620 630 640 650
GPSAWQNWTY EVKVSTQDPP EVTHIFLNIS GTMLNVPELQ SAMKYKVSVR
660 670 680 690 700
ASSPKRPGPW SEPSVGTTLV PASEPPFIMA VKEDGLWSKP LNSFGPGEFL
710 720 730 740 750
SSDIGNVSDM DWYNNSLYYS DTKGDVFVWL LNGTDISENY HLPSIAGAGA
760 770 780 790 800
LAFEWLGHFL YWAGKTYVIQ RQSVLTGHTD IVTHVKLLVN DMVVDSVGGY
810 820 830 840 850
LYWTTLYSVE STRLNGESSL VLQTQPWFSG KKVIALTLDL SDGLLYWLVQ
860 870 880 890 900
DSQCIHLYTA VLRGQSTGDT TITEFAAWST SEISQNALMY YSGRLFWING
910 920 930 940 950
FRIITTQEIG QKTSVSVLEP ARFNQFTIIQ TSLKPLPGNF SFTPKVIPDS
960 970 980 990 1000
VQESSFRIEG NASSFQILWN GPPAVDWGVV FYSVEFSAHS KFLASEQHSL
1010 1020 1030 1040 1050
PVFTVEGLEP YALFNLSVTP YTYWGKGPKT SLSLRAPETV PSAPENPRIF
1060 1070 1080 1090 1100
ILPSGKCCNK NEVVVEFRWN KPKHENGVLT KFEIFYNISN QSITNKTCED
1110 1120 1130 1140 1150
WIAVNVTPSV MSFQLEGMSP RCFIAFQVRA FTSKGPGPYA DVVKSTTSEI
1160 1170 1180 1190 1200
NPFPHLITLL GNKIVFLDMD QNQVVWTFSA ERVISAVCYT ADNEMGYYAE
1210 1220 1230 1240 1250
GDSLFLLHLH NRSSSELFQD SLVFDITVIT IDWISRHLYF ALKESQNGMQ
1260 1270 1280 1290 1300
VFDVDLEHKV KYPREVKIHN RNSTIISFSV YPLLSRLYWT EVSNFGYQMF
1310 1320 1330 1340 1350
YYSIISHTLH RILQPTATNQ QNKRNQCSCN VTEFELSGAM AIDTSNLEKP
1360 1370 1380 1390 1400
LIYFAKAQEI WAMDLEGCQC WRVITVPAML AGKTLVSLTV DGDLIYWIIT
1410 1420 1430 1440 1450
AKDSTQIYQA KKGNGAIVSQ VKALRSRHIL AYSSVMQPFP DKAFLSLASD
1460 1470 1480 1490 1500
TVEPTILNAT NTSLTIRLPL AKTNLTWYGI TSPTPTYLVY YAEVNDRKNS
1510 1520 1530 1540 1550
SDLKYRILEF QDSIALIEDL QPFSTYMIQI AVKNYYSDPL EHLPPGKEIW
1560 1570 1580 1590 1600
GKTKNGVPEA VQLINTTVRS DTSLIISWRE SHKPNGPKES VRYQLAISHL
1610 1620 1630 1640 1650
ALIPETPLRQ SEFPNGRLTL LVTRLSGGNI YVLKVLACHS EEMWCTESHP
1660 1670 1680 1690 1700
VTVEMFNTPE KPYSLVPENT SLQFNWKAPL NVNLIRFWVE LQKWKYNEFY
1710 1720 1730 1740 1750
HVKTSCSQGP AYVCNITNLQ PYTSYNVRVV VVYKTGENST SLPESFKTKA
1760 1770 1780 1790 1800
GVPNKPGIPK LLEGSKNSIQ WEKAEDNGCR ITYYILEIRK STSNNLQNQN
1810 1820 1830 1840 1850
LRWKMTFNGS CSSVCTWKSK NLKGIFQFRV VAANNLGFGE YSGISENIIL
1860 1870 1880 1890 1900
VGDDFWIPET SFILTIIVGI FLVVTIPLTF VWHRRLKNQK SAKEGVTVLI
1910 1920 1930 1940 1950
NEDKELAELR GLAAGVGLAN ACYAIHTLPT QEEIENLPAF PREKLTLRLL
1960 1970 1980 1990 2000
LGSGAFGEVY EGTAVDILGV GSGEIKVAVK TLKKGSTDQE KIEFLKEAHL
2010 2020 2030 2040 2050
MSKFNHPNIL KQLGVCLLNE PQYIILELME GGDLLTYLRK ARMATFYGPL
2060 2070 2080 2090 2100
LTLVDLVDLC VDISKGCVYL ERMHFIHRDL AARNCLVSVK DYTSPRIVKI
2110 2120 2130 2140 2150
GDFGLARDIY KNDYYRKRGE GLLPVRWMAP ESLMDGIFTT QSDVWSFGIL
2160 2170 2180 2190 2200
IWEILTLGHQ PYPAHSNLDV LNYVQTGGRL EPPRNCPDDL WNLMTQCWAQ
2210 2220 2230 2240 2250
EPDQRPTFHR IQDQLQLFRN FFLNSIYKSR DEANNSGVIN ESFEGEDGDV
2260 2270 2280 2290 2300
ICLNSDDIMP VALMETKNRE GLNYMVLATE CGQGEEKSEG PLGSQESESC
2310 2320 2330 2340
GLRKEEKEPH ADKDFCQEKQ VAYCPSGKPE GLNYACLTHS GYGDGSD
Length:2,347
Mass (Da):263,915
Last modified:February 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i98902B9A59ACB8F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5H8Y1Q5H8Y1_HUMAN
Tyrosine-protein kinase receptor
ROS1
2,341Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y3T9H0Y3T9_HUMAN
Proto-oncogene tyrosine-protein kin...
ROS1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2246 – 2260EDGDV…DDIMP → KFDSSEFSSFRCTVN in AAA60277 (PubMed:3023956).CuratedAdd BLAST15
Sequence conflicti2262A → V in AAA60278 (PubMed:2352949).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04144213N → S1 PublicationCorresponds to variant dbSNP:rs45606237Ensembl.1
Natural variantiVAR_041443126G → V1 PublicationCorresponds to variant dbSNP:rs34245787Ensembl.1
Natural variantiVAR_030648145T → P1 PublicationCorresponds to variant dbSNP:rs1998206Ensembl.1
Natural variantiVAR_030649167R → Q1 PublicationCorresponds to variant dbSNP:rs2243380Ensembl.1
Natural variantiVAR_041444224P → S1 PublicationCorresponds to variant dbSNP:rs55959124Ensembl.1
Natural variantiVAR_041445338Y → C1 PublicationCorresponds to variant dbSNP:rs55707658Ensembl.1
Natural variantiVAR_041446370S → P1 PublicationCorresponds to variant dbSNP:rs56274823Ensembl.1
Natural variantiVAR_041447419Y → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1444274116Ensembl.1
Natural variantiVAR_041448537I → M1 PublicationCorresponds to variant dbSNP:rs28639589Ensembl.1
Natural variantiVAR_041449653S → F1 PublicationCorresponds to variant dbSNP:rs34203286Ensembl.1
Natural variantiVAR_049712790N → S. Corresponds to variant dbSNP:rs34582164Ensembl.1
Natural variantiVAR_041450865Q → H in a lung large cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0306501109S → L1 PublicationCorresponds to variant dbSNP:rs2229079Ensembl.1
Natural variantiVAR_0414511239Y → F1 PublicationCorresponds to variant dbSNP:rs56192249Ensembl.1
Natural variantiVAR_0414521353Y → S1 PublicationCorresponds to variant dbSNP:rs35269727Ensembl.1
Natural variantiVAR_0414531370C → R1 PublicationCorresponds to variant dbSNP:rs36106063Ensembl.1
Natural variantiVAR_0306511439F → S. Corresponds to variant dbSNP:rs17079086Ensembl.1
Natural variantiVAR_0414541506R → G1 PublicationCorresponds to variant dbSNP:rs35841892Ensembl.1
Natural variantiVAR_0306521776D → H1 PublicationCorresponds to variant dbSNP:rs12664076Ensembl.1
Natural variantiVAR_0306531902E → K1 PublicationCorresponds to variant dbSNP:rs9489124Ensembl.1
Natural variantiVAR_0414551999H → N1 PublicationCorresponds to variant dbSNP:rs45569132Ensembl.1
Natural variantiVAR_0414562003K → R in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0306542039R → H. Corresponds to variant dbSNP:rs3752566Ensembl.1
Natural variantiVAR_0414572138F → S in a gastric adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0414582203D → N1 PublicationCorresponds to variant dbSNP:rs556427413Ensembl.1
Natural variantiVAR_0414592213D → E1 PublicationCorresponds to variant dbSNP:rs75510639Ensembl.1
Natural variantiVAR_0306552213D → N2 PublicationsCorresponds to variant dbSNP:rs529038Ensembl.1
Natural variantiVAR_0414602228K → Q2 PublicationsCorresponds to variant dbSNP:rs529156Ensembl.1
Natural variantiVAR_0306562229S → C2 PublicationsCorresponds to variant dbSNP:rs619203Ensembl.1
Natural variantiVAR_0306572240N → K1 PublicationCorresponds to variant dbSNP:rs210968Ensembl.1
Natural variantiVAR_0497132328K → R. Corresponds to variant dbSNP:rs35932630Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34353 mRNA Translation: AAA60278.1
Z98880 Genomic DNA No translation available.
AL132671 Genomic DNA No translation available.
M13599
, M13368, M13591, M13592, M13593, M13594, M13595, M13596, M13597, M13598 Genomic DNA Translation: AAA60277.1
M13880 mRNA Translation: AAA36580.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5116.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A35512 TVHURS

NCBI Reference Sequences

More...
RefSeqi
NP_002935.2, NM_002944.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368508; ENSP00000357494; ENSG00000047936

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6098

UCSC genome browser

More...
UCSCi
uc003pxp.2 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34353 mRNA Translation: AAA60278.1
Z98880 Genomic DNA No translation available.
AL132671 Genomic DNA No translation available.
M13599
, M13368, M13591, M13592, M13593, M13594, M13595, M13596, M13597, M13598 Genomic DNA Translation: AAA60277.1
M13880 mRNA Translation: AAA36580.1
CCDSiCCDS5116.1
PIRiA35512 TVHURS
RefSeqiNP_002935.2, NM_002944.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZBFX-ray2.20A1934-2232[»]
4UXLX-ray2.40A1934-2232[»]
SMRiP08922
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112025, 6 interactors
IntActiP08922, 4 interactors
MINTiP08922
STRINGi9606.ENSP00000357494

Chemistry databases

BindingDBiP08922
ChEMBLiCHEMBL5568
GuidetoPHARMACOLOGYi1840

PTM databases

iPTMnetiP08922
PhosphoSitePlusiP08922

Polymorphism and mutation databases

BioMutaiROS1
DMDMi126302596

Proteomic databases

EPDiP08922
PaxDbiP08922
PeptideAtlasiP08922
PRIDEiP08922
ProteomicsDBi52177

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6098
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368508; ENSP00000357494; ENSG00000047936
GeneIDi6098
KEGGihsa:6098
UCSCiuc003pxp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6098
DisGeNETi6098

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ROS1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0207391
HGNCiHGNC:10261 ROS1
HPAiHPA049098
HPA072424
MIMi165020 gene
neXtProtiNX_P08922
OpenTargetsiENSG00000047936
PharmGKBiPA34633

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQAA Eukaryota
ENOG410XSTC LUCA
GeneTreeiENSGT00940000160831
HOGENOMiHOG000137937
InParanoidiP08922
KOiK05088
OMAiYVWLLNG
OrthoDBi203310at2759
PhylomeDBiP08922
TreeFamiTF351636

Enzyme and pathway databases

BRENDAi2.7.10.1 2681
SignaLinkiP08922
SIGNORiP08922

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ROS1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ROS1_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6098

Protein Ontology

More...
PROi
PR:P08922

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000047936 Expressed in 49 organ(s), highest expression level in lung
ExpressionAtlasiP08922 baseline and differential
GenevisibleiP08922 HS

Family and domain databases

CDDicd00063 FN3, 7 hits
Gene3Di2.120.10.30, 3 hits
2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000033 LDLR_classB_rpt
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR002011 Tyr_kinase_rcpt_2_CS
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SM00135 LY, 4 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS00239 RECEPTOR_TYR_KIN_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiROS1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08922
Secondary accession number(s): Q15368, Q5TDB5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 20, 2007
Last modified: May 8, 2019
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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