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Entry version 207 (13 Nov 2019)
Sequence version 2 (02 Nov 2010)
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Protein

Macrophage colony-stimulating factor 1

Gene

CSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Growth factor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-8957275 Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P09603

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P09603

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Macrophage colony-stimulating factor 1
Short name:
CSF-1
Short name:
M-CSF
Short name:
MCSF
Alternative name(s):
Lanimostim
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2432 CSF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120420 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P09603

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini33 – 496LumenalSequence analysisAdd BLAST464
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 554CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers.
Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi489 – 554Missing : Produces biologically active protein which is secreted. 1 PublicationAdd BLAST66

Organism-specific databases

DisGeNET

More...
DisGeNETi
1435

Open Targets

More...
OpenTargetsi
ENSG00000184371

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26935

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P09603

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3989382

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033367

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 321 PublicationAdd BLAST32
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000585733 – 554Macrophage colony-stimulating factor 1Add BLAST522
ChainiPRO_000029623133 – 450Processed macrophage colony-stimulating factor 1By similarityAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 1221 Publication
Disulfide bondi63Interchain1 Publication
Disulfide bondi80 ↔ 1711 Publication
Disulfide bondi134 ↔ 1781 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi189Interchain1 Publication
Disulfide bondi191Interchain1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei266Phosphothreonine; by FAM20C1 Publication1
Glycosylationi363O-linked (GalNAc...) threonine1 Publication1
Glycosylationi365O-linked (GalNAc...) threonine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P09603

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P09603

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P09603

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P09603

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P09603

PeptideAtlas

More...
PeptideAtlasi
P09603

PRoteomics IDEntifications database

More...
PRIDEi
P09603

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52250 [P09603-1]
52251 [P09603-2]
52252 [P09603-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P09603

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P09603

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P09603

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184371 Expressed in 184 organ(s), highest expression level in esophagus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P09603 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P09603 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer; disulfide-linked.

Interacts with CSF1R.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107822, 10 interactors

Database of interacting proteins

More...
DIPi
DIP-41860N

Protein interaction database and analysis system

More...
IntActi
P09603, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000327513

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1554
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P09603

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P09603

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni406 – 426O-glycosylated at one siteAdd BLAST21

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II8R Eukaryota
ENOG410Z5Q9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015805

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P09603

KEGG Orthology (KO)

More...
KOi
K05453

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCSSQDV

Database of Orthologous Groups

More...
OrthoDBi
715874at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P09603

TreeFam database of animal gene trees

More...
TreeFami
TF337718

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR008001 MCSF-1

The PANTHER Classification System

More...
PANTHERi
PTHR10058 PTHR10058, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05337 CSF-1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001948 MCSF-1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P09603-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS
60 70 80 90 100
LQRLIDSQME TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR
110 120 130 140 150
DNTPNAIAIV QLQELSLRLK SCFTKDYEEH DKACVRTFYE TPLQLLEKVK
160 170 180 190 200
NVFNETKNLL DKDWNIFSKN CNNSFAECSS QDVVTKPDCN CLYPKAIPSS
210 220 230 240 250
DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP LHTVDPGSAK
260 270 280 290 300
QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG
310 320 330 340 350
TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL
360 370 380 390 400
PASAKGQQPA DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP
410 420 430 440 450
GSPRISSLRP QGLSNPSTLS AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR
460 470 480 490 500
SPAEPEGGPA SEGAARPLPR FNSVPLTDTG HERQSEGSFS PQLQESVFHL
510 520 530 540 550
LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG SPLTQDDRQV

ELPV
Length:554
Mass (Da):60,179
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i656B0894F9255AED
GO
Isoform 2 (identifier: P09603-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-480: Missing.

Show »
Length:438
Mass (Da):47,903
Checksum:i1B6A3CDBE1C06775
GO
Isoform 3 (identifier: P09603-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-479: Missing.

Show »
Length:256
Mass (Da):29,215
Checksum:i0656D858DE1A4086
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BY18H7BY18_HUMAN
Macrophage colony-stimulating facto...
CSF1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJA2E9PJA2_HUMAN
Macrophage colony-stimulating facto...
CSF1
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKP4E9PKP4_HUMAN
Macrophage colony-stimulating facto...
CSF1
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ08E9PQ08_HUMAN
Macrophage colony-stimulating facto...
CSF1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69F → S AA sequence (PubMed:3498652).Curated1
Sequence conflicti91D → Y in AAB59527 (PubMed:2996129).Curated1
Sequence conflicti91D → Y in AAA59572 (PubMed:2460758).Curated1
Sequence conflicti91D → Y in AAA64849 (PubMed:2460758).Curated1
Sequence conflicti91D → Y in AAA52120 (PubMed:1791839).Curated1
Sequence conflicti104 – 106PNA → ANP in AAA52117 (PubMed:3493529).Curated3
Sequence conflicti364G → A in AAA52117 (PubMed:3493529).Curated1
Sequence conflicti374R → M in AAA52117 (PubMed:3493529).Curated1
Sequence conflicti412G → A in AAA52117 (PubMed:3493529).Curated1
Sequence conflicti450R → T in AAA52117 (PubMed:3493529).Curated1
Sequence conflicti457 – 458GG → AA in AAA52117 (PubMed:3493529).Curated2
Sequence conflicti480Missing in AAA59573 (PubMed:2660794).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048810341S → N. Corresponds to variant dbSNP:rs12565736Ensembl.1
Natural variantiVAR_020454408L → P1 PublicationCorresponds to variant dbSNP:rs1058885Ensembl.1
Natural variantiVAR_029320438G → R. Corresponds to variant dbSNP:rs2229165Ensembl.1
Natural variantiVAR_048811489F → S9 PublicationsCorresponds to variant dbSNP:rs333971Ensembl.1
Natural variantiVAR_020455496S → F. Corresponds to variant dbSNP:rs12721516Ensembl.1
Natural variantiVAR_022146531A → V. Corresponds to variant dbSNP:rs2229167Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001187182 – 479Missing in isoform 3. 1 PublicationAdd BLAST298
Alternative sequenceiVSP_001188365 – 480Missing in isoform 2. CuratedAdd BLAST116

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M11296, M11038, M11295 Genomic DNA Translation: AAB59527.1
M37435 mRNA Translation: AAA52117.1
M64592 mRNA Translation: AAA59572.1
U22386 mRNA Translation: AAA64849.1
M27087 mRNA Translation: AAA59573.1
AK291660 mRNA Translation: BAF84349.1
AL450468 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56416.1
BC021117 mRNA Translation: AAH21117.1
X05825 mRNA Translation: CAA29265.1
X06106 Genomic DNA Translation: CAA29479.1
M76453 mRNA Translation: AAA52120.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS30797.1 [P09603-3]
CCDS816.1 [P09603-1]
CCDS817.1 [P09603-2]

Protein sequence database of the Protein Information Resource

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PIRi
A47583 FQHUMP

NCBI Reference Sequences

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RefSeqi
NP_000748.3, NM_000757.5 [P09603-1]
NP_757349.1, NM_172210.2 [P09603-2]
NP_757350.1, NM_172211.3 [P09603-3]
NP_757351.1, NM_172212.2 [P09603-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000329608; ENSP00000327513; ENSG00000184371 [P09603-1]
ENST00000369801; ENSP00000358816; ENSG00000184371 [P09603-2]
ENST00000369802; ENSP00000358817; ENSG00000184371 [P09603-1]
ENST00000420111; ENSP00000407317; ENSG00000184371 [P09603-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1435

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1435

UCSC genome browser

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UCSCi
uc001dyt.3 human [P09603-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11296, M11038, M11295 Genomic DNA Translation: AAB59527.1
M37435 mRNA Translation: AAA52117.1
M64592 mRNA Translation: AAA59572.1
U22386 mRNA Translation: AAA64849.1
M27087 mRNA Translation: AAA59573.1
AK291660 mRNA Translation: BAF84349.1
AL450468 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56416.1
BC021117 mRNA Translation: AAH21117.1
X05825 mRNA Translation: CAA29265.1
X06106 Genomic DNA Translation: CAA29479.1
M76453 mRNA Translation: AAA52120.2
CCDSiCCDS30797.1 [P09603-3]
CCDS816.1 [P09603-1]
CCDS817.1 [P09603-2]
PIRiA47583 FQHUMP
RefSeqiNP_000748.3, NM_000757.5 [P09603-1]
NP_757349.1, NM_172210.2 [P09603-2]
NP_757350.1, NM_172211.3 [P09603-3]
NP_757351.1, NM_172212.2 [P09603-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HMCX-ray2.50A/B36-181[»]
3UEZX-ray3.41E/F/G/H33-181[»]
3UF2X-ray2.75A/B/C/D/E/F/G/H/I/J33-181[»]
4ADFX-ray4.40G/H/I/J/K/L/S/T/U/V/W/X33-181[»]
4FA8X-ray2.20E/F/G36-180[»]
4WRLX-ray2.80B/D33-181[»]
4WRMX-ray6.85B33-181[»]
5LXFX-ray2.00A/B33-181[»]
SMRiP09603
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107822, 10 interactors
DIPiDIP-41860N
IntActiP09603, 16 interactors
STRINGi9606.ENSP00000327513

Chemistry databases

ChEMBLiCHEMBL3989382

PTM databases

iPTMnetiP09603
PhosphoSitePlusiP09603

Polymorphism and mutation databases

BioMutaiCSF1
DMDMi311033367

Proteomic databases

EPDiP09603
jPOSTiP09603
MassIVEiP09603
MaxQBiP09603
PaxDbiP09603
PeptideAtlasiP09603
PRIDEiP09603
ProteomicsDBi52250 [P09603-1]
52251 [P09603-2]
52252 [P09603-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P09603

The DNASU plasmid repository

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DNASUi
1435

Genome annotation databases

EnsembliENST00000329608; ENSP00000327513; ENSG00000184371 [P09603-1]
ENST00000369801; ENSP00000358816; ENSG00000184371 [P09603-2]
ENST00000369802; ENSP00000358817; ENSG00000184371 [P09603-1]
ENST00000420111; ENSP00000407317; ENSG00000184371 [P09603-3]
GeneIDi1435
KEGGihsa:1435
UCSCiuc001dyt.3 human [P09603-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1435
DisGeNETi1435

GeneCards: human genes, protein and diseases

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GeneCardsi
CSF1
HGNCiHGNC:2432 CSF1
MIMi120420 gene
neXtProtiNX_P09603
OpenTargetsiENSG00000184371
PharmGKBiPA26935

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II8R Eukaryota
ENOG410Z5Q9 LUCA
GeneTreeiENSGT00390000015805
InParanoidiP09603
KOiK05453
OMAiKCSSQDV
OrthoDBi715874at2759
PhylomeDBiP09603
TreeFamiTF337718

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-449836 Other interleukin signaling
R-HSA-6783783 Interleukin-10 signaling
R-HSA-8957275 Post-translational protein phosphorylation
SignaLinkiP09603
SIGNORiP09603

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CSF1 human
EvolutionaryTraceiP09603

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Macrophage_colony-stimulating_factor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1435
PharosiP09603
PMAP-CutDBiP09603

Protein Ontology

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PROi
PR:P09603

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184371 Expressed in 184 organ(s), highest expression level in esophagus
ExpressionAtlasiP09603 baseline and differential
GenevisibleiP09603 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR008001 MCSF-1
PANTHERiPTHR10058 PTHR10058, 1 hit
PfamiView protein in Pfam
PF05337 CSF-1, 1 hit
PIRSFiPIRSF001948 MCSF-1, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P09603
Secondary accession number(s): A8K6J5
, Q13130, Q14086, Q14806, Q5VVF3, Q5VVF4, Q9UQR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 2, 2010
Last modified: November 13, 2019
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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