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Entry version 119 (13 Nov 2019)
Sequence version 1 (21 Jul 1986)
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Protein

ATP synthase gamma chain

Gene

atpG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF0 complex.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:ATPG-MONOMER
ECOL316407:JW3711-MONOMER
MetaCyc:ATPG-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.2.1.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase gamma chain
Alternative name(s):
ATP synthase F1 sector gamma subunit
F-ATPase gamma subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atpG
Synonyms:papC, uncG
Ordered Locus Names:b3733, JW3711
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(1), Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000732821 – 287ATP synthase gamma chainAdd BLAST287

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0ABA6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P0ABA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0ABA6

PRoteomics IDEntifications database

More...
PRIDEi
P0ABA6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P0A6E65EBI-544306,EBI-544362

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
852545, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4022 ATP synthase complex

Database of interacting proteins

More...
DIPi
DIP-35938N

Protein interaction database and analysis system

More...
IntActi
P0ABA6, 15 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3733

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0ABA6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P0ABA6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase gamma chain family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105J80 Bacteria
COG0224 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000215912

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0ABA6

KEGG Orthology (KO)

More...
KOi
K02115

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0ABA6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12151 F1-ATPase_gamma, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00815 ATP_synth_gamma_bact, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035968 ATP_synth_F1_ATPase_gsu
IPR000131 ATP_synth_F1_gsu
IPR023632 ATP_synth_F1_gsu_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11693 PTHR11693, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00231 ATP-synt, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00126 ATPASEGAMMA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52943 SSF52943, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01146 ATPsyn_F1gamma, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00153 ATPASE_GAMMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0ABA6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAKEIRSK IASVQNTQKI TKAMEMVAAS KMRKSQDRMA ASRPYAETMR
60 70 80 90 100
KVIGHLAHGN LEYKHPYLED RDVKRVGYLV VSTDRGLCGG LNINLFKKLL
110 120 130 140 150
AEMKTWTDKG VQCDLAMIGS KGVSFFNSVG GNVVAQVTGM GDNPSLSELI
160 170 180 190 200
GPVKVMLQAY DEGRLDKLYI VSNKFINTMS QVPTISQLLP LPASDDDDLK
210 220 230 240 250
HKSWDYLYEP DPKALLDTLL RRYVESQVYQ GVVENLASEQ AARMVAMKAA
260 270 280
TDNGGSLIKE LQLVYNKARQ ASITQELTEI VSGAAAV
Length:287
Mass (Da):31,577
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2417A4B8FBDB8EF8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA23597 differs from that shown. Sequencing errors.Curated
The sequence CAA23597 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X01631 Genomic DNA Translation: CAA25781.1
V00267 Genomic DNA Translation: CAA23526.1
J01594 Genomic DNA Translation: AAA24736.1 Frameshift.
V00312 Genomic DNA Translation: CAA23597.1 Sequence problems.
M25464 Genomic DNA Translation: AAA83874.1
L10328 Genomic DNA Translation: AAA62085.1
U00096 Genomic DNA Translation: AAC76756.1
AP009048 Genomic DNA Translation: BAE77555.1
M34095 Genomic DNA Translation: AAA24742.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A01038 PWECG

NCBI Reference Sequences

More...
RefSeqi
NP_418189.1, NC_000913.3
WP_000896498.1, NZ_STEB01000015.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76756; AAC76756; b3733
BAE77555; BAE77555; BAE77555

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3711
eco:b3733

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2967

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01631 Genomic DNA Translation: CAA25781.1
V00267 Genomic DNA Translation: CAA23526.1
J01594 Genomic DNA Translation: AAA24736.1 Frameshift.
V00312 Genomic DNA Translation: CAA23597.1 Sequence problems.
M25464 Genomic DNA Translation: AAA83874.1
L10328 Genomic DNA Translation: AAA62085.1
U00096 Genomic DNA Translation: AAC76756.1
AP009048 Genomic DNA Translation: BAE77555.1
M34095 Genomic DNA Translation: AAA24742.1
PIRiA01038 PWECG
RefSeqiNP_418189.1, NC_000913.3
WP_000896498.1, NZ_STEB01000015.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D8SX-ray4.40G1-287[»]
1FS0X-ray2.10G19-248[»]
3OAAX-ray3.26G/O/W/e2-287[»]
5T4Oelectron microscopy6.90G1-287[»]
5T4Pelectron microscopy7.77G1-287[»]
5T4Qelectron microscopy8.53G1-287[»]
SMRiP0ABA6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi852545, 6 interactors
ComplexPortaliCPX-4022 ATP synthase complex
DIPiDIP-35938N
IntActiP0ABA6, 15 interactors
STRINGi511145.b3733

Protein family/group databases

TCDBi3.A.2.1.1 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Proteomic databases

EPDiP0ABA6
jPOSTiP0ABA6
PaxDbiP0ABA6
PRIDEiP0ABA6

Genome annotation databases

EnsemblBacteriaiAAC76756; AAC76756; b3733
BAE77555; BAE77555; BAE77555
GeneIDi948243
KEGGiecj:JW3711
eco:b3733
PATRICifig|1411691.4.peg.2967

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0102

Phylogenomic databases

eggNOGiENOG4105J80 Bacteria
COG0224 LUCA
HOGENOMiHOG000215912
InParanoidiP0ABA6
KOiK02115
PhylomeDBiP0ABA6

Enzyme and pathway databases

BioCyciEcoCyc:ATPG-MONOMER
ECOL316407:JW3711-MONOMER
MetaCyc:ATPG-MONOMER

Miscellaneous databases

EvolutionaryTraceiP0ABA6

Protein Ontology

More...
PROi
PR:P0ABA6

Family and domain databases

CDDicd12151 F1-ATPase_gamma, 1 hit
HAMAPiMF_00815 ATP_synth_gamma_bact, 1 hit
InterProiView protein in InterPro
IPR035968 ATP_synth_F1_ATPase_gsu
IPR000131 ATP_synth_F1_gsu
IPR023632 ATP_synth_F1_gsu_CS
PANTHERiPTHR11693 PTHR11693, 1 hit
PfamiView protein in Pfam
PF00231 ATP-synt, 1 hit
PRINTSiPR00126 ATPASEGAMMA
SUPFAMiSSF52943 SSF52943, 1 hit
TIGRFAMsiTIGR01146 ATPsyn_F1gamma, 1 hit
PROSITEiView protein in PROSITE
PS00153 ATPASE_GAMMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATPG_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0ABA6
Secondary accession number(s): P00837, P00838, Q2M851
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 13, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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