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Entry version 83 (18 Sep 2019)
Sequence version 1 (22 Jul 2008)
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Protein

Coiled-coil domain-containing protein 172

Gene

CCDC172

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 172
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC172
Synonyms:C10orf96
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30524 CCDC172

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P0C7W6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000182645

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134867240

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC172

Domain mapping of disease mutations (DMDM)

More...
DMDMi
206557852

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003445131 – 258Coiled-coil domain-containing protein 172Add BLAST258

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P0C7W6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P0C7W6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P0C7W6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0C7W6

PeptideAtlas

More...
PeptideAtlasi
P0C7W6

PRoteomics IDEntifications database

More...
PRIDEi
P0C7W6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52381

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P0C7W6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P0C7W6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182645 Expressed in 24 organ(s), highest expression level in testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P0C7W6 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with TEKT2.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131893, 19 interactors

Protein interaction database and analysis system

More...
IntActi
P0C7W6, 32 interactors

Molecular INTeraction database

More...
MINTi
P0C7W6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000329860

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0C7W6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili13 – 90Sequence analysisAdd BLAST78
Coiled coili123 – 191Sequence analysisAdd BLAST69
Coiled coili226 – 256Sequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CCDC172 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWRG Eukaryota
ENOG4112A44 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111699

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P0C7W6

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIIFSEH

Database of Orthologous Groups

More...
OrthoDBi
1399070at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P0C7W6

TreeFam database of animal gene trees

More...
TreeFami
TF333231

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029618 CCDC172

The PANTHER Classification System

More...
PANTHERi
PTHR22419 PTHR22419, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P0C7W6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLESLFQHI IFTEHQAEES RRLMREVRSE ITRCREKIKK ATEELNEEKI
60 70 80 90 100
KLESKVQQFF EKSFFLQLLK AHENALEKQY SEITNHRNML LQTFEAIKKQ
110 120 130 140 150
MIEEEDKFIK EITDFNNDYE ITKKRELLMK ENVKIEISDL ENQANMLKSE
160 170 180 190 200
MKSMEHDSSQ LNELQKQKSE LIQELFTLQR KLKVFEDEEN ESICTTKYLE
210 220 230 240 250
AEKIKISEKP QNDTECLRLK KELELYKEDD MESVYEALQT EIEFLELTLA

QKDLQESK
Length:258
Mass (Da):31,035
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CFC9C42B13486B3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011328 Genomic DNA No translation available.
BC044830 mRNA Translation: AAH44830.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31291.1

NCBI Reference Sequences

More...
RefSeqi
NP_940917.1, NM_198515.2
XP_016871695.1, XM_017016206.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333254; ENSP00000329860; ENSG00000182645

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
374355

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374355

UCSC genome browser

More...
UCSCi
uc001lck.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011328 Genomic DNA No translation available.
BC044830 mRNA Translation: AAH44830.1
CCDSiCCDS31291.1
RefSeqiNP_940917.1, NM_198515.2
XP_016871695.1, XM_017016206.1

3D structure databases

SMRiP0C7W6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131893, 19 interactors
IntActiP0C7W6, 32 interactors
MINTiP0C7W6
STRINGi9606.ENSP00000329860

PTM databases

iPTMnetiP0C7W6
PhosphoSitePlusiP0C7W6

Polymorphism and mutation databases

BioMutaiCCDC172
DMDMi206557852

Proteomic databases

EPDiP0C7W6
MassIVEiP0C7W6
MaxQBiP0C7W6
PaxDbiP0C7W6
PeptideAtlasiP0C7W6
PRIDEiP0C7W6
ProteomicsDBi52381

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
374355
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333254; ENSP00000329860; ENSG00000182645
GeneIDi374355
KEGGihsa:374355
UCSCiuc001lck.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
374355

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC172
HGNCiHGNC:30524 CCDC172
neXtProtiNX_P0C7W6
OpenTargetsiENSG00000182645
PharmGKBiPA134867240

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWRG Eukaryota
ENOG4112A44 LUCA
GeneTreeiENSGT00390000005203
HOGENOMiHOG000111699
InParanoidiP0C7W6
OMAiHIIFSEH
OrthoDBi1399070at2759
PhylomeDBiP0C7W6
TreeFamiTF333231

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
374355

Pharos

More...
Pharosi
P0C7W6

Protein Ontology

More...
PROi
PR:P0C7W6

Gene expression databases

BgeeiENSG00000182645 Expressed in 24 organ(s), highest expression level in testis
GenevisibleiP0C7W6 HS

Family and domain databases

InterProiView protein in InterPro
IPR029618 CCDC172
PANTHERiPTHR22419 PTHR22419, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC172_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0C7W6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 18, 2019
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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