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Entry version 44 (05 Jun 2019)
Sequence version 1 (05 Sep 2012)
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Protein

Internalin A

Gene

inlA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells (PubMed:1905979, PubMed:8601315, PubMed:10406800). Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin-2 function as receptors (PubMed:8601315). Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA (PubMed:10406800).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Bacterial uptake is inhibited by EDTA and by anti-E-cadherin antibodies.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
LMON169963:LMO0433-MONOMER

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.43.1.12 the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Internalin A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:inlA1 Publication
Ordered Locus Names:lmo0433
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri169963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000817 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion of both inlA and inlB prevents bacterial uptake by human enterocyte-like cell line Caco-2 (PubMed:1905979). Deletion of inlA alone decreases host cell entry; the reduction varies from 98% to none depending on the cell line tested (PubMed:11929538, PubMed:8601315, PubMed:10406800).4 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi150F → A: No longer binds human cadherin-1 (CDH1) domain 1. 1 Publication1
Mutagenesisi192S → N: 40-fold increased affinity for human CDH1 domain 1. 6700-fold increased affinity for CDH1, better adhesion to human Caco cells, 1000-fold more virulent in mice; when associated with S-369. 2 Publications1
Mutagenesisi194G → SS: Increased affinity for human CDH1 domain 1. 1 Publication1
Mutagenesisi343Y → A: No longer binds human CDH1 domain 1. 1 Publication1
Mutagenesisi347Y → A: Decreased affinity for human CDH1 domain 1. 1 Publication1
Mutagenesisi367F → A: No longer binds human CDH1 domain 1. 1 Publication1
Mutagenesisi369Y → A: Increased affinity for human CDH1 domain 1. 2 Publications1
Mutagenesisi369Y → S: 170-fold increased affinity for human CDH1 domain 1. 6700-fold increased affinity for CDH1, better adhesion to human Caco cells, 1000-fold more virulent in mice; when associated with N-192. 2 Publications1
Mutagenesisi387W → A: No longer binds human CDH1 domain 1. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 351 PublicationAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000560936 – 770Internalin AAdd BLAST735
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000005610771 – 800Removed by sortase APROSITE-ProRule annotation3 Publications1 PublicationAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei770Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1 Publication1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P0DJM0

PRoteomics IDEntifications database

More...
PRIDEi
P0DJM0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

More prevalent in stationary than exponential phase (at protein level) (PubMed:16247833, PubMed:21725001). Levels maybe post-transcriptionally decreased by InlH; disruption of inlH in some strains (EGD-e and EGD-2) leads to increased levels of InlA (at protein level) (PubMed:20176794).3 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with host (human) cadherin-1 (CDH1) (PubMed:12526809, PubMed:17540170, PubMed:17715295). The formation of the complex between inlA and cadherin-1 is calcium-dependent (PubMed:12526809). Mutagenesis studies show it is possible to increase the affinity of InlA for CDH1 by rational engineering of InlA residues (PubMed:17715295).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CDH1P128303EBI-1035388,EBI-727477From Homo sapiens.

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P0DJM0, 1 interactor

STRING: functional protein association networks

More...
STRINGi
169963.lmo0433

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1800
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P0DJM0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 76LRRNTAdd BLAST41
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 98LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati121 – 142LRR 3Add BLAST22
Repeati143 – 164LRR 4Add BLAST22
Repeati165 – 186LRR 5Add BLAST22
Repeati187 – 207LRR 6Add BLAST21
Repeati208 – 229LRR 7Add BLAST22
Repeati230 – 251LRR 8Add BLAST22
Repeati252 – 273LRR 9Add BLAST22
Repeati274 – 295LRR 10Add BLAST22
Repeati296 – 317LRR 11Add BLAST22
Repeati318 – 339LRR 12Add BLAST22
Repeati340 – 361LRR 13Add BLAST22
Repeati362 – 383LRR 14Add BLAST22
Repeati384 – 405LRR 15Add BLAST22
Domaini416 – 505LRRCTAdd BLAST90
Repeati518 – 587B-1Add BLAST70
Repeati588 – 657B-2Add BLAST70
Repeati658 – 706B-3Add BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni518 – 7063 X approximate tandem repeats, type BAdd BLAST189

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi767 – 771LPXTG sorting signalPROSITE-ProRule annotation1 Publication5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of an N-terminal cap, a leucine-rich repeat domain (LRR), and an Ig-like interrepeat domain.3 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the internalin family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4108NJY Bacteria
COG4886 LUCA

KEGG Orthology (KO)

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KOi
K13730

Identification of Orthologs from Complete Genome Data

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OMAi
FGSGVWI

Database for complete collections of gene phylogenies

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PhylomeDBi
P0DJM0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.20.660, 3 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019948 Gram-positive_anchor
IPR014756 Ig_E-set
IPR024634 Internalin_N
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR013378 Listeria/Bacterioides_rpt
IPR042229 Listeria/Bacterioides_rpt_sf
IPR019931 LPXTG_anchor
IPR012569 LRR-contain_adjacent_dom
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09479 Flg_new, 3 hits
PF00746 Gram_pos_anchor, 1 hit
PF12354 Internalin_N, 1 hit
PF12799 LRR_4, 5 hits
PF08191 LRR_adjacent, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00369 LRR_TYP, 12 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF81296 SSF81296, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR02543 List_Bact_rpt, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
PS51450 LRR, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0DJM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKKRYVWLK SILVAILVFG SGVWINTSNG TNAQAATITQ DTPINQIFTD
60 70 80 90 100
TALAEKMKTV LGKTNVTDTV SQTDLDQVTT LQADRLGIKS IDGVEYLNNL
110 120 130 140 150
TQINFSNNQL TDITPLKNLT KLVDILMNNN QIADITPLAN LTNLTGLTLF
160 170 180 190 200
NNQITDIDPL KNLTNLNRLE LSSNTISDIS ALSGLTSLQQ LSFGNQVTDL
210 220 230 240 250
KPLANLTTLE RLDISSNKVS DISVLAKLTN LESLIATNNQ ISDITPLGIL
260 270 280 290 300
TNLDELSLNG NQLKDIGTLA SLTNLTDLDL ANNQISNLAP LSGLTKLTEL
310 320 330 340 350
KLGANQISNI SPLAGLTALT NLELNENQLE DISPISNLKN LTYLTLYFNN
360 370 380 390 400
ISDISPVSSL TKLQRLFFYN NKVSDVSSLA NLTNINWLSA GHNQISDLTP
410 420 430 440 450
LANLTRITQL GLNDQAWTNA PVNYKANVSI PNTVKNVTGA LIAPATISDG
460 470 480 490 500
GSYTEPDITW NLPSYTNEVS YTFSQPVTIG KGTTTFSGTV TQPLKAIFNV
510 520 530 540 550
KFHVDGKETT KEVEAGNLLT EPAKPVKEGH TFVGWFDAQT GGTKWNFSTD
560 570 580 590 600
KMPTNDINLY AQFSINSYTA TFDNDGVTTS QTVDYQGLLQ EPTAPTKEGY
610 620 630 640 650
TFKGWYDAKT GGDKWDFATS KMPAKNITLY AQYSANSYTA TFDVDGKSTT
660 670 680 690 700
QAVDYQGLLK EPKAPTKAGY TFKGWYDEKT DGKKWDFATD KMPANDITLY
710 720 730 740 750
AQFTKNPVAP PTTGGNTPPT TNNGGNTTPP SANIPGSDTS NTSTGNSAST
760 770 780 790 800
TSTMNAYDPY NSKEASLPTT GDSDNALYLL LGLLAVGTAM ALTKKARASK
Length:800
Mass (Da):86,493
Last modified:September 5, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D1B03A5CF7CCDE3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA25289 differs from that shown. Reason: Frameshift at position 56.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti3K → R in strain: H4. 1
Natural varianti19F → L in strain: H4. 1
Natural varianti51T → A in strain: EGD-SmR / Serovar 1/2a. 1
Natural varianti94V → L in strain: EGD-SmR / Serovar 1/2a, F4233 / Serotype 1/2b, F6789 / Serotype 1/2b, F5782 / Serotype 4b and H4. 1
Natural varianti118N → D in strain: EGD-SmR / Serovar 1/2a, F4233 / Serotype 1/2b, F6789 / Serotype 1/2b, F5782 / Serotype 4b and H4. 1
Natural varianti142T → S in strain: F5782 / Serotype 4b and H4. 1
Natural varianti187S → N in strain: EGD-SmR / Serovar 1/2a, F4233 / Serotype 1/2b, F6789 / Serotype 1/2b and H4. 1
Natural varianti193F → L in strain: F5782 / Serotype 4b, F4233 / Serotype 1/2b and F6789 / Serotype 1/2b. 1
Natural varianti253L → W in strain: F4233 / Serotype 1/2b and F6789 / Serotype 1/2b. 1
Natural varianti292S → P in strain: F4233 / Serotype 1/2b and F5782 / Serotype 4b. 1
Natural varianti292S → R in strain: F6789 / Serotype 1/2b. 1
Natural varianti321N → S in strain: H4. 1
Natural varianti381N → S in strain: H4. 1
Natural varianti416A → E in strain: F4233 / Serotype 1/2b, F6789 / Serotype 1/2b and F5782 / Serotype 4b. 1
Natural varianti454T → A in strain: EGD-SmR / Serovar 1/2a and H4. 1
Natural varianti474S → N in strain: H4. 1
Natural varianti476P → S in strain: H4. 1
Natural varianti500V → A in strain: EGD-SmR / Serovar 1/2a and H4. 1
Natural varianti530H → Y in strain: H4. 1
Natural varianti558N → D in strain: H4. 1
Natural varianti573D → E in strain: EGD-SmR / Serovar 1/2a. 1
Natural varianti594A → P in strain: EGD-SmR / Serovar 1/2a. 1
Natural varianti648S → T in strain: H4. 1
Natural varianti664A → T in strain: H4. 1
Natural varianti729P → S in strain: H4. 1
Natural varianti738D → N in strain: H4. 1
Natural varianti781L → I in strain: H4. 1
Natural varianti790M → V in strain: H4. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M67471 Genomic DNA Translation: AAA25289.1 Frameshift.
AJ012346 Genomic DNA Translation: CAC20628.1
DQ132794 Genomic DNA Translation: AAZ53235.1
AL591975 Genomic DNA Translation: CAC98512.1
U25448 Genomic DNA Translation: AAA69530.1
U25451 Genomic DNA Translation: AAA69533.1
U25454 Genomic DNA Translation: AAA69536.1

Protein sequence database of the Protein Information Resource

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PIRi
AB1129

NCBI Reference Sequences

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RefSeqi
NP_463962.1, NC_003210.1
WP_010989462.1, NC_003210.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

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EnsemblBacteriai
CAC98512; CAC98512; CAC98512

Database of genes from NCBI RefSeq genomes

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GeneIDi
985151

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
lmo:lmo0433

Pathosystems Resource Integration Center (PATRIC)

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PATRICi
fig|169963.11.peg.446

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67471 Genomic DNA Translation: AAA25289.1 Frameshift.
AJ012346 Genomic DNA Translation: CAC20628.1
DQ132794 Genomic DNA Translation: AAZ53235.1
AL591975 Genomic DNA Translation: CAC98512.1
U25448 Genomic DNA Translation: AAA69530.1
U25451 Genomic DNA Translation: AAA69533.1
U25454 Genomic DNA Translation: AAA69536.1
PIRiAB1129
RefSeqiNP_463962.1, NC_003210.1
WP_010989462.1, NC_003210.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O6SX-ray1.80A36-496[»]
1O6TX-ray1.60A36-496[»]
1O6VX-ray1.50A/B36-496[»]
2OMTX-ray2.00A36-496[»]
2OMUX-ray1.80A36-496[»]
2OMVX-ray1.90A36-495[»]
2OMWX-ray1.85A36-496[»]
2OMXX-ray1.70A36-496[»]
2OMYX-ray1.70A36-495[»]
2OMZX-ray1.60A36-495[»]
SMRiP0DJM0
ModBaseiSearch...

Protein-protein interaction databases

IntActiP0DJM0, 1 interactor
STRINGi169963.lmo0433

Protein family/group databases

TCDBi8.A.43.1.12 the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

Proteomic databases

PaxDbiP0DJM0
PRIDEiP0DJM0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC98512; CAC98512; CAC98512
GeneIDi985151
KEGGilmo:lmo0433
PATRICifig|169963.11.peg.446

Phylogenomic databases

eggNOGiENOG4108NJY Bacteria
COG4886 LUCA
KOiK13730
OMAiFGSGVWI
PhylomeDBiP0DJM0

Enzyme and pathway databases

BioCyciLMON169963:LMO0433-MONOMER
ReactomeiR-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells

Family and domain databases

Gene3Di3.10.20.660, 3 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR019948 Gram-positive_anchor
IPR014756 Ig_E-set
IPR024634 Internalin_N
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR013378 Listeria/Bacterioides_rpt
IPR042229 Listeria/Bacterioides_rpt_sf
IPR019931 LPXTG_anchor
IPR012569 LRR-contain_adjacent_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF09479 Flg_new, 3 hits
PF00746 Gram_pos_anchor, 1 hit
PF12354 Internalin_N, 1 hit
PF12799 LRR_4, 5 hits
PF08191 LRR_adjacent, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
SUPFAMiSSF81296 SSF81296, 1 hit
TIGRFAMsiTIGR02543 List_Bact_rpt, 3 hits
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
PS51450 LRR, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINLA_LISMO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DJM0
Secondary accession number(s): P25146
, Q45GD5, Q45GD6, Q48748, Q48749, Q48750, Q48752, Q9EXG2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: September 5, 2012
Last modified: June 5, 2019
This is version 44 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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