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Entry version 8 (16 Oct 2019)
Sequence version 1 (13 Feb 2019)
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Protein

Internalin B

Gene

inlB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the entry of L.monocytogenes into normally non-phagocytic mammalian host cells (PubMed:19900460). Its host receptor is hepatocyte growth factor receptor (HGF receptor, a tyrosine kinase, MET) which is tyrosine-phosphorylated in response to InlB. Downstream targets MAPK1/MAPK3 (Erk1/2) and AKT are phosphorylated in response to InlB, which also causes cell colony scattering (PubMed:19900460, PubMed:21345802, PubMed:22887347, PubMed:27789707). Complement component 1 Q subcomponent-binding protein (gC1q-R, C1QBP) has been suggested to also act an InlB receptor, but this is less certain. Stimulation of Tyr-phosphorylation of MET by InlB is potentiated by the InlB GW domains and glycosaminoglycans such as heparin (By similarity).By similarity4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processVirulence
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Internalin B
Short name:
InlB
Alternative name(s):
Invasion protein InlB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:inlB
Ordered Locus Names:lmo0434
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri169963 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000817 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion of inlB alone decreases host cell entry; the reduction varies from 99% to 37% depending on the cell line tested.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi95Q → EYLPNLDQLILNNNSIASIV G: Adds LRRb repeat, N-terminal fragment (36-321) binds MET, wild-type phosphorylation of downstream effectors MAPK1/MAPK3, full-length protein induces wild-type cell scattering. 1 Publication1
Mutagenesisi95Q → YLPNLTSLNLSNNQITDISP I: Adds LRRa repeat, N-terminal fragment (36-321) binds MET, slightly reduced phosphorylation of downstream effectors MAPK1/MAPK3. 1 Publication1
Mutagenesisi199 – 227SDIVP…LRALA → RRIVPLARLTKLQNLYLSKN HISDLRALR: A 4 Arg mutant, in vitro wild-type binding of host MET, severely reduced activation of MET and downstream targets. 1 PublicationAdd BLAST29
Mutagenesisi200 – 227DIVPL…LRALA → RIVPLARLTKLQNLYLSKNH ISDLRALR: A 3 Arg mutant, in vitro about 100-fold reduced activation of host MET and downstream targets, reduced host cell scattering upon incubation with mutant protein. 1 PublicationAdd BLAST28
Mutagenesisi206 – 227GLTKL…LRALA → CLTKLQNLYLSKNHISDLRA LC: A 2 Cys mutant, forms 2 intermolecular disulfide bonds, about 100-fold more potent activator of MET, increased downstream effector phosphorylation. 1 PublicationAdd BLAST22
Mutagenesisi332T → E: The B-repeat fragment (residues 31-392) no longer scatters host cell colonies, full-length protein reduces MET phosphorylation and downstream activity about 10-fold. 1 Publication1
Mutagenesisi334 – 336IKT → KKL: The B-repeat fragment (residues 31-392) no longer scatters host cell colonies. 1 Publication3
Mutagenesisi336T → Y: No effect on cell scattering by the B-repeat fragment (residues 31-392). 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002151431 – 630Internalin BAdd BLAST600

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P25147

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts via its LRR repeats plus the Ig-like region with the extracellular portion (residues 25-741) of its receptor MET; MET can bind HGF, its endogenous ligand, and InlB simultaneously (PubMed:17662939). Probably forms a dimer upon interaction with host MET, which subsequently allows dimerization of the host MET and subsequent host signaling; dimerization probably occurs via the convex surface of InlB (PubMed:19900460) (Probable). Prevention of dimerization does not block interaction with MET but prevents downstream action (PubMed:19900460).

1 Publication2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P0DQD2, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P0DQD2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P25147

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 76LRRNTAdd BLAST46
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati75 – 97LRR 1Sequence analysisAdd BLAST23
Repeati98 – 121LRR 2Sequence analysisAdd BLAST24
Repeati123 – 141LRR 3Sequence analysisAdd BLAST19
Repeati142 – 163LRR 4Sequence analysisAdd BLAST22
Repeati164 – 187LRR 5Sequence analysisAdd BLAST24
Repeati189 – 207LRR 6Sequence analysisAdd BLAST19
Repeati208 – 231LRR 7Sequence analysisAdd BLAST24
Domaini241 – 330LRRCTAdd BLAST90
Domaini393 – 467GW 1PROSITE-ProRule annotationAdd BLAST75
Domaini472 – 550GW 2PROSITE-ProRule annotationAdd BLAST79
Domaini553 – 630GW 3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni241 – 319Ig-like region3 PublicationsAdd BLAST79
Regioni320 – 392B repeat region1 PublicationAdd BLAST73
Regioni399 – 630GW repeat region, necessary and sufficient for cell surface attachment, interacts with host C1QBP and with heparinBy similarityAdd BLAST232

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus (36-79) resembles a truncated EF hand, the LRR region (80-240) has a curved form, while residues 241-321 form an Ig-like region; the whole region forms a curved tube (PubMed:11575932, PubMed:17662939, PubMed:19900460). The LRR domain alone (31-241) binds mammalian MET and stimulates its Tyr-phosphorylation; the LRR plus Ig-like region (36-321) are required for receptor dimerization; adding the B-repeat allows the protein to scatter host cell colonies, and the GW domains, especially GW2 and GW3, potentiate MET activation (PubMed:17662939, PubMed:21345802). The cap, LRR and Ig-like regions all interact with residues 25-656 of host MET (the Sema, PSI and Ig1 domains) via the interior (concave surface) of the curved tube (PubMed:17662939). Dimerizes via the exterior (convex surface) of the curved tube which probably induces host receptor dimerization; preventing dimerization prevents host downstream signaling (PubMed:19900460) (Probable). The B repeat region crystallizes in a SUMO-like fold. The B repeat region interacts synergistically with N-terminus of InlB, conferring on it the ability to stimulate cell motility; the B repeat does not bind to MET (PubMed:21345802). Deletion of the B-repeat (exact residues are not given) slightly decreased protein activity in host; the authors suggest the B-repeat probably contributes to homodimerization rather than binding another host cell receptor (PubMed:27789707).1 Publication5 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the internalin family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K13731

Identification of Orthologs from Complete Genome Data

More...
OMAi
KYCLISG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P25147

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.170, 3 hits
3.10.20.660, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025987 GW_dom
IPR038200 GW_dom_sf
IPR014756 Ig_E-set
IPR024634 Internalin_N
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR013378 Listeria/Bacterioides_rpt
IPR042229 Listeria/Bacterioides_rpt_sf
IPR012569 LRR-contain_adjacent_dom
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09479 Flg_new, 1 hit
PF13457 GW, 3 hits
PF12354 Internalin_N, 1 hit
PF12799 LRR_4, 1 hit
PF08191 LRR_adjacent, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81296 SSF81296, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02543 List_Bact_rpt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51780 GW, 3 hits
PS51450 LRR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P0DQD2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEKHNPRRK YCLISGLAII FSLWIIIGNG AKVQAETITV PTPIKQIFSD
60 70 80 90 100
DAFAETIKDN LKKKSVTDAV TQNELNSIDQ IIANNSDIKS VQGIQYLPNV
110 120 130 140 150
TKLFLNGNKL TDIKPLANLK NLGWLFLDEN KVKDLSSLKD LKKLKSLSLE
160 170 180 190 200
HNGISDINGL VHLPQLESLY LGNNKITDIT VLSRLTKLDT LSLEDNQISD
210 220 230 240 250
IVPLAGLTKL QNLYLSKNHI SDLRALAGLK NLDVLELFSQ ECLNKPINHQ
260 270 280 290 300
SNLVVPNTVK NTDGSLVTPE IISDDGDYEK PNVKWHLPEF TNEVSFIFYQ
310 320 330 340 350
PVTIGKAKAR FHGRVTQPLK EVYTVSYDVD GTVIKTKVEA GTRITAPKPP
360 370 380 390 400
TKQGYVFKGW YTEKNGGHEW NFNTDYMSGN DFTLYAVFKA ETTEKAVNLT
410 420 430 440 450
RYVKYIRGNA GIYKLPREDN SLKQGTLASH RCKALTVDRE ARNGGKLWYR
460 470 480 490 500
LKNIGWTKAE NLSLDRYDKM EYDKGVTAYA RVRNASGNSV WTKPYNTAGA
510 520 530 540 550
KHVNKLSVYQ GKNMRILREA KTPITTWYQF SIGGKVIGWV DTRALNTFYK
560 570 580 590 600
QSMEKPTRLT RYVSANKAGE SYYKVPVADN PVKRGTLAKY KNQKLIVDCQ
610 620 630
ATIEGQLWYR IRTSSTFIGW TKAANLRAQK
Length:630
Mass (Da):71,147
Last modified:February 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA05F31BEFE9748C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL591975 Genomic DNA Translation: CAC98513.1

Protein sequence database of the Protein Information Resource

More...
PIRi
AC1129

NCBI Reference Sequences

More...
RefSeqi
NP_463963.1, NC_003210.1
WP_010989463.1, NC_003210.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
986892

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lmo:lmo0434

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|169963.11.peg.447

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591975 Genomic DNA Translation: CAC98513.1
PIRiAC1129
RefSeqiNP_463963.1, NC_003210.1
WP_010989463.1, NC_003210.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H6TX-ray1.60A36-321[»]
2UZXX-ray2.80A/C36-321[»]
2UZYX-ray4.00A/C36-321[»]
2WQUX-ray2.60A/B/C/D/E/F36-321[»]
2WQVX-ray2.80A/B36-321[»]
2WQWX-ray2.24A/B36-321[»]
2WQXX-ray2.03A/B36-321[»]
2Y5PX-ray1.30A/B/C/D322-392[»]
2Y5QX-ray3.20A36-392[»]
4AW4X-ray1.93A/B/C36-321[»]
4CILX-ray1.50A93-321[»]
6DBFX-ray1.55A36-248[»]
6DBGX-ray1.51A/B36-321[»]
SMRiP0DQD2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP0DQD2, 2 interactors

Proteomic databases

PaxDbiP25147

Genome annotation databases

GeneIDi986892
KEGGilmo:lmo0434
PATRICifig|169963.11.peg.447

Phylogenomic databases

KOiK13731
OMAiKYCLISG
PhylomeDBiP25147

Enzyme and pathway databases

ReactomeiR-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell

Miscellaneous databases

EvolutionaryTraceiP25147

Family and domain databases

Gene3Di2.30.30.170, 3 hits
3.10.20.660, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR025987 GW_dom
IPR038200 GW_dom_sf
IPR014756 Ig_E-set
IPR024634 Internalin_N
IPR001611 Leu-rich_rpt
IPR025875 Leu-rich_rpt_4
IPR003591 Leu-rich_rpt_typical-subtyp
IPR013378 Listeria/Bacterioides_rpt
IPR042229 Listeria/Bacterioides_rpt_sf
IPR012569 LRR-contain_adjacent_dom
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF09479 Flg_new, 1 hit
PF13457 GW, 3 hits
PF12354 Internalin_N, 1 hit
PF12799 LRR_4, 1 hit
PF08191 LRR_adjacent, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 5 hits
SUPFAMiSSF81296 SSF81296, 1 hit
TIGRFAMsiTIGR02543 List_Bact_rpt, 1 hit
PROSITEiView protein in PROSITE
PS51780 GW, 3 hits
PS51450 LRR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINLB_LISMO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P0DQD2
Secondary accession number(s): P25147, Q9EXG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 13, 2019
Last sequence update: February 13, 2019
Last modified: October 16, 2019
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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