Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 192 (16 Oct 2019)
Sequence version 4 (13 Nov 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Laminin subunit beta-1

Gene

LanB1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (By similarity). Required for Ndg localization to the basement membrane (PubMed:30260959).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-3000157 Laminin interactions
R-DME-373752 Netrin-1 signaling
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-446107 Type I hemidesmosome assembly
R-DME-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Laminin subunit beta-1
Alternative name(s):
Laminin B1 chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LanB1
Synonyms:lamB1
ORF Names:CG7123
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261800 LanB1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Results in strong reduction of Ndg accumulation at the basement membrane in the gut, muscles and ventral nerve cord (PubMed:30260959). RNAi-mediated knockdown in the larvae reduces Ndg accumulation and created holes in the basal membrane of fat bodies (PubMed:30260959).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001707325 – 1788Laminin subunit beta-1Add BLAST1764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi288 ↔ 297PROSITE-ProRule annotation
Disulfide bondi290 ↔ 318PROSITE-ProRule annotation
Disulfide bondi320 ↔ 329PROSITE-ProRule annotation
Disulfide bondi332 ↔ 352PROSITE-ProRule annotation
Disulfide bondi355 ↔ 364PROSITE-ProRule annotation
Disulfide bondi357 ↔ 382PROSITE-ProRule annotation
Disulfide bondi385 ↔ 394PROSITE-ProRule annotation
Disulfide bondi397 ↔ 415PROSITE-ProRule annotation
Disulfide bondi418 ↔ 431PROSITE-ProRule annotation
Disulfide bondi420 ↔ 446PROSITE-ProRule annotation
Disulfide bondi448 ↔ 457PROSITE-ProRule annotation
Disulfide bondi460 ↔ 475PROSITE-ProRule annotation
Disulfide bondi478 ↔ 491PROSITE-ProRule annotation
Disulfide bondi480 ↔ 498PROSITE-ProRule annotation
Glycosylationi487N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi500 ↔ 509PROSITE-ProRule annotation
Disulfide bondi512 ↔ 526PROSITE-ProRule annotation
Disulfide bondi529 ↔ 541PROSITE-ProRule annotation
Disulfide bondi531 ↔ 548PROSITE-ProRule annotation
Disulfide bondi550 ↔ 559PROSITE-ProRule annotation
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi789 ↔ 801PROSITE-ProRule annotation
Disulfide bondi791 ↔ 808PROSITE-ProRule annotation
Disulfide bondi810 ↔ 819PROSITE-ProRule annotation
Disulfide bondi822 ↔ 834PROSITE-ProRule annotation
Disulfide bondi837 ↔ 849PROSITE-ProRule annotation
Disulfide bondi839 ↔ 856PROSITE-ProRule annotation
Disulfide bondi858 ↔ 867PROSITE-ProRule annotation
Disulfide bondi870 ↔ 880PROSITE-ProRule annotation
Disulfide bondi883 ↔ 892PROSITE-ProRule annotation
Disulfide bondi885 ↔ 899PROSITE-ProRule annotation
Disulfide bondi902 ↔ 911PROSITE-ProRule annotation
Disulfide bondi914 ↔ 930PROSITE-ProRule annotation
Disulfide bondi933 ↔ 949PROSITE-ProRule annotation
Disulfide bondi935 ↔ 960PROSITE-ProRule annotation
Disulfide bondi962 ↔ 971PROSITE-ProRule annotation
Disulfide bondi974 ↔ 988PROSITE-ProRule annotation
Disulfide bondi991 ↔ 1005PROSITE-ProRule annotation
Disulfide bondi993 ↔ 1012PROSITE-ProRule annotation
Disulfide bondi1015 ↔ 1024PROSITE-ProRule annotation
Disulfide bondi1027 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1043 ↔ 1057PROSITE-ProRule annotation
Disulfide bondi1045 ↔ 1064PROSITE-ProRule annotation
Glycosylationi1051N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1066 ↔ 1075PROSITE-ProRule annotation
Disulfide bondi1078 ↔ 1091PROSITE-ProRule annotation
Disulfide bondi1094 ↔ 1106PROSITE-ProRule annotation
Disulfide bondi1096 ↔ 1113PROSITE-ProRule annotation
Disulfide bondi1115 ↔ 1124PROSITE-ProRule annotation
Disulfide bondi1127 ↔ 1139PROSITE-ProRule annotation
Disulfide bondi1142 ↔ 1154PROSITE-ProRule annotation
Disulfide bondi1144 ↔ 1161PROSITE-ProRule annotation
Disulfide bondi1163 ↔ 1172PROSITE-ProRule annotation
Disulfide bondi1175 ↔ 1186PROSITE-ProRule annotation
Disulfide bondi1189InterchainCurated
Disulfide bondi1192InterchainCurated
Glycosylationi1246N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1301N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1330N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1493N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1644N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1703N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1786InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P11046

PRoteomics IDEntifications database

More...
PRIDEi
P11046

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P11046

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in the basement membranes (major component).

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the larva, expressed mainly by fat body adipocytes and blood cells and secreted in the basal membranes that surround the fat body, imaginal disks, tracheae, salivary glands, midgut, mature muscles and heart (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261800 Expressed in 35 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P11046 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
60207, 27 interactors

Protein interaction database and analysis system

More...
IntActi
P11046, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0079113

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P11046

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 287Laminin N-terminalPROSITE-ProRule annotationAdd BLAST238
Domaini288 – 354Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST67
Domaini355 – 417Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini418 – 477Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini478 – 528Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST51
Domaini529 – 559Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini567 – 783Laminin IV type BPROSITE-ProRule annotationAdd BLAST217
Domaini789 – 836Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini837 – 882Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini883 – 932Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini933 – 990Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST58
Domaini991 – 1042Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1043 – 1093Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST51
Domaini1094 – 1141Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1142 – 1188Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1189 – 1405Domain IIAdd BLAST217
Regioni1406 – 1432Domain alphaAdd BLAST27
Regioni1433 – 1788Domain IAdd BLAST356

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1255 – 1405Sequence analysisAdd BLAST151
Coiled coili1453 – 1505Sequence analysisAdd BLAST53
Coiled coili1540 – 1561Sequence analysisAdd BLAST22
Coiled coili1608 – 1762Sequence analysisAdd BLAST155

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi641 – 643Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0994 Eukaryota
ENOG410XPEG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167171

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P11046

KEGG Orthology (KO)

More...
KOi
K05636

Identification of Orthologs from Complete Genome Data

More...
OMAi
LSCEHGA

Database of Orthologous Groups

More...
OrthoDBi
65841at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P11046

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P11046-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLELRLIVVI VLALLSWQWD PVDSQRPPQH GRRDRPKYPP NKFIKTHPCE
60 70 80 90 100
RSSCYPATGN LLIGRENRLT ASSTCGLHSP ERFCILSHLQ DKKCFLCDTR
110 120 130 140 150
EETKHDPYKN HRIGQIIYKT KPGTNIPTWW QSENGKENAT IQLDLEAEFH
160 170 180 190 200
FTHLIITFTT FRPAAMYIER SFDFGQTWHI YRYFAYDCKE SFPGVPTVLE
210 220 230 240 250
NITDVMCTSR YSNVEPSRNG EVIFRVLPPN INVTDPYAEH VQNQLKMTNL
260 270 280 290 300
RIQMTKLHKL GDNLLDSRLE NEEKYYYGIS NMVVRGSCSC YGHASQCLPL
310 320 330 340 350
DPAFSQADNE DGMVHGRCEC THNTKGMNCE ECEDFFNDLP WKPAFGKKTN
360 370 380 390 400
ACKKCECNDH AVSCHFDEAV FTASGFVSGG VCDNCLHNTR GQHCEECMPY
410 420 430 440 450
FYRDPEQDIT SERVCQPCDC DPQGSSDDGI CDSLNELEEG AVAGACHCKA
460 470 480 490 500
FVTGRRCNQC KDGYWNLQSD NPEGCEPCTC NPLGTLNNSG CVMRTGECKC
510 520 530 540 550
KKYVTGKDCN QCMPETYGLS ESPEGCSLCN CDAGGSYDNY CDVISGQCRC
560 570 580 590 600
RPHMTGRSCS QPKQNYFIPL LPEVHEAEVV DECISYGANG NCSLVAETPD
610 620 630 640 650
GSFTGIGFTR VPENSELVFT VGDIPRSMPY DAVIRYQSTS RGDWENAFIT
660 670 680 690 700
LVRPDQVDPE GGCGELAAAT SSETRIPFSL PDRSRQVVAL NEVCLEAGKV
710 720 730 740 750
YKFRIYFERK RHDVDSPTAT ILVDSLTLIP RIDVTPIFQG SVLADIRKKD
760 770 780 790 800
YEKYNCKSSL YDMNYKSDPK CQNLDNILSV FVHDGASMCN CNPTGSLSKV
810 820 830 840 850
CESNGGYCQC KPNVVGRQCD QCAPGTYGFG PEGCKACDCN SIGSKDKYCD
860 870 880 890 900
LITGQCQCVP NTYGRECNQC QPGYWNFPEC RVCQCNGHAA TCDPIQGTCI
910 920 930 940 950
DCQDSTTGYS CDSCLDGYYG NPLFGSEIGC RPCRCPETVA SGLAHADGCS
960 970 980 990 1000
LDTRNNNMLC HCQEGYSGSR CEICADNFFG NPDNGGTCSK CECSNNVDLY
1010 1020 1030 1040 1050
DTGNCDRQTG ACLKCLYQTT GDHCELCKDG FFGDALQQNC QQCECDFLGT
1060 1070 1080 1090 1100
NNTIAHCDRF TGQCPCLPNV QGVRCDQCAE NHWKIASGEG CESCNCDPIG
1110 1120 1130 1140 1150
ALHEQCNSYT GQCQCKPGFG GRACNQCQAH YWGNPNEKCQ PCECDQFGAA
1160 1170 1180 1190 1200
DFQCDRETGN CVCHEGIGGY KCNECARGYI GQFPHCSPCG ECFNNWDLIL
1210 1220 1230 1240 1250
SALEDATTAT ILRAKEIKQV GATGAYTSEF SELDKKLQHI RNLLQNTSVS
1260 1270 1280 1290 1300
LVDIEKLDYE TQSLRDQLQA SHGRLSETEQ NLDDIYNSLS LSGVELESLQ
1310 1320 1330 1340 1350
NHSRLVQQLS KELKENGIQL QESNIEGALN LTRHAYERVS NLSTLKDEAN
1360 1370 1380 1390 1400
ELASNTDRNC KRVENLSNKI QAEADDLANN NKLIEDYRAE LTSLTSQIPE
1410 1420 1430 1440 1450
LNNQVCGKPG DPCDSLCGGA GCGHCGGFLS CEHGAKTHSE EALKVAKDAE
1460 1470 1480 1490 1500
TAITSKKDQA DQTIRALTQA KLNASEAYEK AKRGFEQSER YLNQTNANIK
1510 1520 1530 1540 1550
LAENLFIALN NFQENKTASP SESKELAQKT LDLDLKLEPE EIETLGDQIN
1560 1570 1580 1590 1600
RAVSSLKNVE AIIYRTKPDL DRVNNLQSIA NATKEKADKI LDSANSVVES
1610 1620 1630 1640 1650
LAAADESQGK AKDAIQQANS NIELAGQDLE KIDEETYSAE APANNTAQQV
1660 1670 1680 1690 1700
EKLAKKVQKL QNNIMKNDRD AKEITKEAGS VKLEAMRARG EANNLQSATS
1710 1720 1730 1740 1750
ATNQTLTDRA SRSENARERA KQLLQRASKL TVDTNAKLKD LNDLQTVYLN
1760 1770 1780
KNQQLLRLQA EIGPLNKELN EHLIHIKERG SHYRQCYT
Length:1,788
Mass (Da):198,333
Last modified:November 13, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CB99C9608452085
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM11329 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAT94451 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12L → LAL in AAD19752 (PubMed:8397815).Curated1
Sequence conflicti12L → LAL in AAA28663 (PubMed:3365769).Curated1
Sequence conflicti666L → H in AAD19752 (PubMed:8397815).Curated1
Sequence conflicti724 – 725DS → VT in AAA28663 (PubMed:3365769).Curated2
Sequence conflicti766 – 767KS → NA in AAD19752 (PubMed:8397815).Curated2
Sequence conflicti766 – 767KS → NA in AAA28663 (PubMed:3365769).Curated2
Sequence conflicti939V → I in AAT94451 (Ref. 5) Curated1
Sequence conflicti946 – 947Missing in AAD19752 (PubMed:8397815).Curated2
Sequence conflicti946 – 947Missing in AAA28663 (PubMed:3365769).Curated2
Sequence conflicti1356 – 1373TDRNC…KIQAE → SDRIAREWKICLIRFRPN in AAD19752 (PubMed:8397815).CuratedAdd BLAST18
Sequence conflicti1356 – 1373TDRNC…KIQAE → SDRIAREWKICLIRFRPN in AAA28663 (PubMed:3365769).CuratedAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M95811 Genomic DNA Translation: AAD19752.1
M19525 mRNA Translation: AAA28663.1
AE014134 Genomic DNA Translation: AAF52563.1
AE014134 Genomic DNA Translation: AAN10647.1
BT015222 mRNA Translation: AAT94451.1 Frameshift.
AY095001 mRNA Translation: AAM11329.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
A28783 MMFFB1

NCBI Reference Sequences

More...
RefSeqi
NP_476618.1, NM_057270.5
NP_723319.1, NM_164773.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079490; FBpp0079113; FBgn0261800
FBtr0079491; FBpp0079114; FBgn0261800

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
34068

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7123

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95811 Genomic DNA Translation: AAD19752.1
M19525 mRNA Translation: AAA28663.1
AE014134 Genomic DNA Translation: AAF52563.1
AE014134 Genomic DNA Translation: AAN10647.1
BT015222 mRNA Translation: AAT94451.1 Frameshift.
AY095001 mRNA Translation: AAM11329.1 Different initiation.
PIRiA28783 MMFFB1
RefSeqiNP_476618.1, NM_057270.5
NP_723319.1, NM_164773.3

3D structure databases

SMRiP11046
ModBaseiSearch...

Protein-protein interaction databases

BioGridi60207, 27 interactors
IntActiP11046, 9 interactors
STRINGi7227.FBpp0079113

PTM databases

iPTMnetiP11046

Proteomic databases

PaxDbiP11046
PRIDEiP11046

Genome annotation databases

EnsemblMetazoaiFBtr0079490; FBpp0079113; FBgn0261800
FBtr0079491; FBpp0079114; FBgn0261800
GeneIDi34068
KEGGidme:Dmel_CG7123

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
34068
FlyBaseiFBgn0261800 LanB1

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00940000167171
InParanoidiP11046
KOiK05636
OMAiLSCEHGA
OrthoDBi65841at2759
PhylomeDBiP11046

Enzyme and pathway databases

ReactomeiR-DME-3000157 Laminin interactions
R-DME-373752 Netrin-1 signaling
R-DME-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-DME-446107 Type I hemidesmosome assembly
R-DME-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LanB1 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
34068

Protein Ontology

More...
PROi
PR:P11046

Gene expression databases

BgeeiFBgn0261800 Expressed in 35 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)
GenevisibleiP11046 DM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P11046
Secondary accession number(s): A4V0D8
, Q26328, Q6AWM6, Q8SWY0, Q9VLW6, Q9XZT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1989
Last sequence update: November 13, 2007
Last modified: October 16, 2019
This is version 192 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again