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Entry version 186 (11 Dec 2019)
Sequence version 2 (25 Nov 2008)
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Protein

Homeobox protein Hox-B3

Gene

HOXB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi188 – 247HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P14651

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXB3
Synonyms:HOX2G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000120093.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5114 HOXB3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142966 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P14651

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3213

Open Targets

More...
OpenTargetsi
ENSG00000120093

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29390

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P14651 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HOXB3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274007

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002001171 – 431Homeobox protein Hox-B3Add BLAST431

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P14651

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P14651

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P14651

PeptideAtlas

More...
PeptideAtlasi
P14651

PRoteomics IDEntifications database

More...
PRIDEi
P14651

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53070 [P14651-1]
6705
7060

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1942

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P14651

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P14651

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120093 Expressed in 205 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P14651 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P14651 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009860
HPA064990

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109453, 2 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P14651

Protein interaction database and analysis system

More...
IntActi
P14651, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000417207

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P14651 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P14651

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi129 – 134Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi154 – 178Gly-richAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0489 Eukaryota
ENOG410ZTBY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159774

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252944

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P14651

KEGG Orthology (KO)

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KOi
K09303

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPPKCGA

Database of Orthologous Groups

More...
OrthoDBi
934469at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P14651

TreeFam database of animal gene trees

More...
TreeFami
TF315938

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00024 HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P14651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT
110 120 130 140 150
SNSSNGGGPS KSGPPKCGPG TNSTLTKQIF PWMKESRQTS KLKNNSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK SPPGSAASKR ARTAYTSAQL
210 220 230 240 250
VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR MKYKKDQKAK
260 270 280 290 300
GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
310 320 330 340 350
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP
360 370 380 390 400
VYVGGGGYAD PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP
410 420 430
CEPHPTYTDL SSHHAPPPQG RIQEAPKLTH L
Length:431
Mass (Da):44,340
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56D39C0C9496E65A
GO
Isoform 2 (identifier: P14651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:358
Mass (Da):36,698
Checksum:i8E6B18948B2AD02E
GO
Isoform 3 (identifier: P14651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Show »
Length:299
Mass (Da):30,989
Checksum:i6C0A22D64D10D5FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VXG0F8VXG0_HUMAN
Homeobox protein Hox-B3
HOXB3
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2I3C9J2I3_HUMAN
Homeobox protein Hox-B3
HOXB3
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1L2F8W1L2_HUMAN
Homeobox protein Hox-B3
HOXB3
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti100T → A in BAH12984 (PubMed:14702039).Curated1
Sequence conflicti199 – 200QL → HV in AAD10852 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04772982P → T4 PublicationsCorresponds to variant dbSNP:rs2229304Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0568151 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0564341 – 73Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X16667 mRNA Translation: CAA34657.1
U59298 mRNA Translation: AAD10852.1
AF287967 Genomic DNA Translation: AAG31555.1
AK291182 mRNA Translation: BAF83871.1
AK299226 mRNA Translation: BAH12974.1
AK299265 mRNA Translation: BAH12984.1
AK315102 mRNA Translation: BAG37563.1
AK316245 mRNA Translation: BAH14616.1
AC103702 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94739.1
CH471109 Genomic DNA Translation: EAW94740.1
CH471109 Genomic DNA Translation: EAW94741.1
X16175 Genomic DNA Translation: CAA34297.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11528.1 [P14651-1]
CCDS82153.1 [P14651-3]
CCDS82154.1 [P14651-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S07543 WJHU2G

NCBI Reference Sequences

More...
RefSeqi
NP_001317251.1, NM_001330322.1 [P14651-2]
NP_001317252.1, NM_001330323.1 [P14651-3]
NP_002137.4, NM_002146.4 [P14651-1]
XP_005257334.1, XM_005257277.3 [P14651-1]
XP_006721917.1, XM_006721854.2 [P14651-1]
XP_011523010.1, XM_011524708.2 [P14651-3]
XP_011523012.1, XM_011524710.1 [P14651-1]
XP_011523021.1, XM_011524719.1 [P14651-1]
XP_011523022.1, XM_011524720.2 [P14651-1]
XP_011523028.1, XM_011524726.2 [P14651-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311626; ENSP00000308252; ENSG00000120093 [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093 [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093 [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093 [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093 [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093 [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093 [P14651-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3213

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3213

UCSC genome browser

More...
UCSCi
uc002inn.4 human [P14651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16667 mRNA Translation: CAA34657.1
U59298 mRNA Translation: AAD10852.1
AF287967 Genomic DNA Translation: AAG31555.1
AK291182 mRNA Translation: BAF83871.1
AK299226 mRNA Translation: BAH12974.1
AK299265 mRNA Translation: BAH12984.1
AK315102 mRNA Translation: BAG37563.1
AK316245 mRNA Translation: BAH14616.1
AC103702 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94739.1
CH471109 Genomic DNA Translation: EAW94740.1
CH471109 Genomic DNA Translation: EAW94741.1
X16175 Genomic DNA Translation: CAA34297.1
CCDSiCCDS11528.1 [P14651-1]
CCDS82153.1 [P14651-3]
CCDS82154.1 [P14651-2]
PIRiS07543 WJHU2G
RefSeqiNP_001317251.1, NM_001330322.1 [P14651-2]
NP_001317252.1, NM_001330323.1 [P14651-3]
NP_002137.4, NM_002146.4 [P14651-1]
XP_005257334.1, XM_005257277.3 [P14651-1]
XP_006721917.1, XM_006721854.2 [P14651-1]
XP_011523010.1, XM_011524708.2 [P14651-3]
XP_011523012.1, XM_011524710.1 [P14651-1]
XP_011523021.1, XM_011524719.1 [P14651-1]
XP_011523022.1, XM_011524720.2 [P14651-1]
XP_011523028.1, XM_011524726.2 [P14651-2]

3D structure databases

SMRiP14651
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109453, 2 interactors
ELMiP14651
IntActiP14651, 1 interactor
STRINGi9606.ENSP00000417207

PTM databases

GlyConnecti1942
iPTMnetiP14651
PhosphoSitePlusiP14651

Polymorphism and mutation databases

BioMutaiHOXB3
DMDMi215274007

Proteomic databases

jPOSTiP14651
MassIVEiP14651
PaxDbiP14651
PeptideAtlasiP14651
PRIDEiP14651
ProteomicsDBi53070 [P14651-1]
6705
7060

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3213

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093 [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093 [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093 [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093 [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093 [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093 [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093 [P14651-1]
GeneIDi3213
KEGGihsa:3213
UCSCiuc002inn.4 human [P14651-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3213
DisGeNETi3213
EuPathDBiHostDB:ENSG00000120093.11

GeneCards: human genes, protein and diseases

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GeneCardsi
HOXB3
HGNCiHGNC:5114 HOXB3
HPAiCAB009860
HPA064990
MIMi142966 gene
neXtProtiNX_P14651
OpenTargetsiENSG00000120093
PharmGKBiPA29390

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00940000159774
HOGENOMiHOG000252944
InParanoidiP14651
KOiK09303
OMAiGPPKCGA
OrthoDBi934469at2759
PhylomeDBiP14651
TreeFamiTF315938

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
SIGNORiP14651

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HOXB3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HOXB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3213
PharosiP14651 Tbio

Protein Ontology

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PROi
PR:P14651
RNActiP14651 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000120093 Expressed in 205 organ(s), highest expression level in endometrium
ExpressionAtlasiP14651 baseline and differential
GenevisibleiP14651 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR025281 DUF4074
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF13293 DUF4074, 1 hit
PF00046 Homeodomain, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P14651
Secondary accession number(s): A8K567
, B7Z5N8, B7Z5P8, B7ZAD0, D3DTV3, O95615, P17484
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: December 11, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  6. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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