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Entry version 176 (18 Sep 2019)
Sequence version 2 (19 Jul 2005)
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Protein

Serendipity locus protein H-1

Gene

wdn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May belong to a complex set of multifingered proteins which play an important role in gene activation or regulation at early embryonic stages through a maximal accumulation of their transcripts (or protein product) in the mature oocyte.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri269 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri331 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 493C2H2-type 8PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serendipity locus protein H-1
Alternative name(s):
Protein pourquoi-pas
Protein wings-down
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wdn
Synonyms:pqp, sry h-1, Sry-c
ORF Names:CG1454
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0005642 wdn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000470511 – 869Serendipity locus protein H-1Add BLAST869

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P15619

PRoteomics IDEntifications database

More...
PRIDEi
P15619

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Distribution varies between nurse cells and the oocyte during oogenesis. Weakly expressed in follicle and border cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Expressed from stage 1 of oogenesis. Expressed at a low level in the embryo from the tenth nuclear division to the end of cellularization in all cell nuclei except those of pole cells. Also weakly expressed in the embryo after germ-band retraction, and in larvae (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0005642 Expressed in 42 organ(s), highest expression level in egg cell

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P15619 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
68274, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P15619, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P15619

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi52 – 85Ser/Thr-richAdd BLAST34
Compositional biasi115 – 162Ser/Thr-richAdd BLAST48
Compositional biasi141 – 213Pro-richAdd BLAST73
Compositional biasi169 – 186Gln-richAdd BLAST18
Compositional biasi519 – 578Ala-richAdd BLAST60
Compositional biasi564 – 670Gln/Pro-richAdd BLAST107

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri269 – 293C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri299 – 321C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri331 – 352C2H2-type 3PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri358 – 380C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 493C2H2-type 8PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168270

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P15619

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAFTNSP

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P15619-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGKGEGKR MKEEAPSKKL PPKIYGGDAG TPTKAAHDEI LSSLLRINNF
60 70 80 90 100
DSISSIKDES LDIDLSACVT ISSASLVNGN SLSSTDFWRV LDESAQNNTE
110 120 130 140 150
LNLSSDVCRD DLAATSSSTV PSTLTSDNHS SSEFSVTFLR PEPPNAFTNS
160 170 180 190 200
PFKKTSSSGT STPVKLSPEQ LHQQHQLQMP QSQLLQRKPK LPAATAVRLK
210 220 230 240 250
VFKEEPPEEK HPPEQVVTKV EVCESELLPP SFTIFQQAKS AESVADAASM
260 270 280 290 300
PPPAASETKP LEVDPAPLHK CLDCNGLLLE TPDEVAKHEA AAHRLRLTYR
310 320 330 340 350
CSECQREFEL LAGLKKHLKT HRTEGRKDTW KKCPDCGKCL KLGSMWMHRK
360 370 380 390 400
IHSDNKKYQC DICGQKFVQK INLTHHARIH SSEKPYECPE CQKRFQERSH
410 420 430 440 450
LQRHQKYHAQ TRSYRCEKCG KMYKTERCLK VHNLVHLEQR PFACTVCDKS
460 470 480 490 500
FISNSKLKQH SNIHTGMRPF KCNYCPRDFT NFPNWLKHTR RRHKVDHKTG
510 520 530 540 550
EHLENIPSYC SKKSTTNKAQ KAAAAAAAAA AASSAVNPNE LSASSELKAK
560 570 580 590 600
ANLTSTAAPA PAKQARKKKQ PQQATLAALG ITLPAGTALQ QVHPVPLAQQ
610 620 630 640 650
HQQELTTVLV PLAPPAPKQT KAKRERKQLA PKQLQQKPQL LQQGQPQQSS
660 670 680 690 700
LEPIPAVPQI KKEPVQTQGP FLDLHGLSLT SAEELIMEQA LEMEECGLYD
710 720 730 740 750
APNANTEMGT SDNAISDSAA ALHFQIKNEL PDELLPDDDF LPCKPSDRLP
760 770 780 790 800
CPSLESSPFS SPASMELTAV SCASSVAIST NALPVRSGNY YLPAFTLNAH
810 820 830 840 850
GKLSSTGNGV QSVTTSLAQT PSVSMVNVPL LVRSNQMLPS VDTLLFTNQT
860
GGSRFFAGKS ATAATPHLT
Length:869
Mass (Da):95,314
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i550D0871C6664E70
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti120V → L in AAA28487 (PubMed:3141791).Curated1
Sequence conflicti247 – 252AASMPP → RLACR in AAA28487 (PubMed:3141791).Curated6
Sequence conflicti706T → N in AAA28487 (PubMed:3141791).Curated1
Sequence conflicti750P → A in AAA28487 (PubMed:3141791).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23391 Genomic DNA Translation: AAA28487.1
AE014297 Genomic DNA Translation: AAF56815.1
AY058690 mRNA Translation: AAL13919.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A30817

NCBI Reference Sequences

More...
RefSeqi
NP_476900.1, NM_057552.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085356; FBpp0084725; FBgn0005642

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43398

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1454

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23391 Genomic DNA Translation: AAA28487.1
AE014297 Genomic DNA Translation: AAF56815.1
AY058690 mRNA Translation: AAL13919.1
PIRiA30817
RefSeqiNP_476900.1, NM_057552.4

3D structure databases

SMRiP15619
ModBaseiSearch...

Protein-protein interaction databases

BioGridi68274, 8 interactors
IntActiP15619, 4 interactors
STRINGi7227.FBpp0084725

Proteomic databases

PaxDbiP15619
PRIDEiP15619

Genome annotation databases

EnsemblMetazoaiFBtr0085356; FBpp0084725; FBgn0005642
GeneIDi43398
KEGGidme:Dmel_CG1454

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43398
FlyBaseiFBgn0005642 wdn

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000168270
InParanoidiP15619
OMAiNAFTNSP
OrthoDBi1318335at2759

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43398

Protein Ontology

More...
PROi
PR:P15619

Gene expression databases

BgeeiFBgn0005642 Expressed in 42 organ(s), highest expression level in egg cell
GenevisibleiP15619 DM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSRYC_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P15619
Secondary accession number(s): Q9VAT4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 19, 2005
Last modified: September 18, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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