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Entry version 205 (13 Feb 2019)
Sequence version 2 (23 Jan 2007)
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Protein

Platelet glycoprotein 4

Gene

CD36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, PubMed:21610069). In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway (By similarity) (PubMed:18753675). Involved in oral fat perception and preferences (PubMed:22240721, PubMed:25822988). Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions (By similarity). In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract (By similarity). Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis (By similarity). Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome (By similarity) (PubMed:20037584). Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (By similarity) (PubMed:16880211).By similarity1 Publication7 Publications
(Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei463Critical for TLR4-TLR6 dimerization and signaling1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCell adhesion, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236974 ER-Phagosome pathway
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-1989781 PPARA activates gene expression
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

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SIGNORi
P16671

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.39.1.4 the long chain fatty acid translocase (lcfat) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001098

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Platelet glycoprotein 4
Alternative name(s):
Fatty acid translocase
Short name:
FAT
Glycoprotein IIIb
Short name:
GPIIIB
Leukocyte differentiation antigen CD36
PAS IV
PAS-4
Platelet collagen receptor
Platelet glycoprotein IV
Short name:
GPIV
Thrombospondin receptor
CD_antigen: CD36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD36
Synonyms:GP3B, GP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000135218.17

Human Gene Nomenclature Database

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HGNCi
HGNC:1663 CD36

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173510 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P16671

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 7CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 29HelicalSequence analysisAdd BLAST22
Topological domaini30 – 439ExtracellularSequence analysisAdd BLAST410
Transmembranei440 – 461HelicalSequence analysisAdd BLAST22
Topological domaini462 – 472CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Platelet glycoprotein IV deficiency (PG4D)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Patients also have postprandial hypertriglyceridemia, insulin resistance and hypertension increasing atherosclerotic risk.1 Publication
Disease descriptionA disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
See also OMIM:608404
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01791390P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant dbSNP:rs75326924EnsemblClinVar.1
Natural variantiVAR_017917254F → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs142186404EnsemblClinVar.1
Natural variantiVAR_017919413I → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs121918035EnsemblClinVar.1
Coronary heart disease 7 (CHDS7)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
See also OMIM:610938

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi462 – 472SYCACRSKTIK → AAAAAAAAAAA: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. 1 PublicationAdd BLAST11
Mutagenesisi463Y → A: No effect on cell surface location. Loss of oxLDL-induced NF-kappa-B activation. Loss of complex formation with TLR4 and TLR6. 1 Publication1
Mutagenesisi464C → S: No effect on cell surface location, nor on oxLDL-induced NF-kappa-B activation. 1 Publication1
Mutagenesisi469 – 472KTIK → ATIA: Abolishes ubiquitination induced by lipids. Enhances fatty acid uptake. 2 Publications4

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
948

MalaCards human disease database

More...
MalaCardsi
CD36
MIMi248310 phenotype
608404 phenotype
610938 phenotype
611162 phenotype

Open Targets

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OpenTargetsi
ENSG00000135218

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26212

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1744526

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CD36

Domain mapping of disease mutations (DMDM)

More...
DMDMi
115982

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001441512 – 472Platelet glycoprotein 4Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi3S-palmitoyl cysteine1 Publication1
Lipidationi7S-palmitoyl cysteine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi205N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi235N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi243 ↔ 311By similarity
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272 ↔ 333By similarity
Disulfide bondi313 ↔ 322By similarity
Glycosylationi321N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi417N-linked (GlcNAc...) asparagine2 Publications1
Lipidationi464S-palmitoyl cysteine1 Publication1
Lipidationi466S-palmitoyl cysteine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki472Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and O-glycosylated with a ratio of 2:1.4 Publications
Ubiquitinated at Lys-469 and Lys-472. Ubiquitination is induced by fatty acids such as oleic acid and leads to degradation by the proteasome (PubMed:21610069, PubMed:18353783). Ubiquitination and degradation are inhibited by insulin which blocks the effect of fatty acids (PubMed:18353783).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P16671

MaxQB - The MaxQuant DataBase

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MaxQBi
P16671

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P16671

PeptideAtlas

More...
PeptideAtlasi
P16671

PRoteomics IDEntifications database

More...
PRIDEi
P16671

ProteomicsDB human proteome resource

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ProteomicsDBi
53392

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1611

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P16671

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P16671

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P16671

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000135218 Expressed in 198 organ(s), highest expression level in adipose tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P16671 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P16671 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB025866
HPA002018
HPA071026

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, PubMed:20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity).By similarity3 Publications
(Microbial infection) Binds to Plasmodium falciparum EMP1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107386, 18 interactors

Protein interaction database and analysis system

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IntActi
P16671, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000308165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1472
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LGDX-ray2.07A1-472[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P16671

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P16671

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni93 – 120Required for interaction with thrombospondins, THBS1 and THBS21 PublicationAdd BLAST28
Regioni460 – 472Interaction with PTK2, PXN and LYN1 PublicationAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD36 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3776 Eukaryota
ENOG410XS17 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153372

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002754

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P16671

KEGG Orthology (KO)

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KOi
K06259

Identification of Orthologs from Complete Genome Data

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OMAi
PNAFVQV

Database of Orthologous Groups

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OrthoDBi
1106566at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P16671

TreeFam database of animal gene trees

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TreeFami
TF317925

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005428 CD36/SCARB1/SNMP1
IPR033076 CD36_chordates
IPR002159 CD36_fam

The PANTHER Classification System

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PANTHERi
PTHR11923 PTHR11923, 1 hit
PTHR11923:SF12 PTHR11923:SF12, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01130 CD36, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01610 CD36ANTIGEN
PR01609 CD36FAMILY

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P16671-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGCDRNCGLI AGAVIGAVLA VFGGILMPVG DLLIQKTIKK QVVLEEGTIA
60 70 80 90 100
FKNWVKTGTE VYRQFWIFDV QNPQEVMMNS SNIQVKQRGP YTYRVRFLAK
110 120 130 140 150
ENVTQDAEDN TVSFLQPNGA IFEPSLSVGT EADNFTVLNL AVAAASHIYQ
160 170 180 190 200
NQFVQMILNS LINKSKSSMF QVRTLRELLW GYRDPFLSLV PYPVTTTVGL
210 220 230 240 250
FYPYNNTADG VYKVFNGKDN ISKVAIIDTY KGKRNLSYWE SHCDMINGTD
260 270 280 290 300
AASFPPFVEK SQVLQFFSSD ICRSIYAVFE SDVNLKGIPV YRFVLPSKAF
310 320 330 340 350
ASPVENPDNY CFCTEKIISK NCTSYGVLDI SKCKEGRPVY ISLPHFLYAS
360 370 380 390 400
PDVSEPIDGL NPNEEEHRTY LDIEPITGFT LQFAKRLQVN LLVKPSEKIQ
410 420 430 440 450
VLKNLKRNYI VPILWLNETG TIGDEKANMF RSQVTGKINL LGLIEMILLS
460 470
VGVVMFVAFM ISYCACRSKT IK
Length:472
Mass (Da):53,053
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i543E748259A094FA
GO
Isoform 2 (identifier: P16671-2) [UniParc]FASTAAdd to basket
Also known as: ex8-del

The sequence of this isoform differs from the canonical sequence as follows:
     274-288: SIYAVFESDVNLKGI → ETCVHFTSSFSVCKS
     289-472: Missing.

Show »
Length:288
Mass (Da):32,265
Checksum:iC82FFEF32AF7A690
GO
Isoform 3 (identifier: P16671-3) [UniParc]FASTAAdd to basket
Also known as: ex6-7-del

The sequence of this isoform differs from the canonical sequence as follows:
     234-272: Missing.

Show »
Length:433
Mass (Da):48,600
Checksum:i9D4A561C95F1ED4D
GO
Isoform 4 (identifier: P16671-4) [UniParc]FASTAAdd to basket
Also known as: ex4-del

The sequence of this isoform differs from the canonical sequence as follows:
     144-203: Missing.

Show »
Length:412
Mass (Da):46,090
Checksum:i33D8CA7991537066
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLT1E9PLT1_HUMAN
Platelet glycoprotein 4
CD36
396Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EX47E7EX47_HUMAN
Platelet glycoprotein 4
CD36
203Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU05E7EU05_HUMAN
Platelet glycoprotein 4
CD36
463Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERZ9E7ERZ9_HUMAN
Platelet glycoprotein 4
CD36
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EVU1E7EVU1_HUMAN
Platelet glycoprotein 4
CD36
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWI4E7EWI4_HUMAN
Platelet glycoprotein 4
CD36
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJX8E9PJX8_HUMAN
Platelet glycoprotein 4
CD36
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YEE7H0YEE7_HUMAN
Platelet glycoprotein 4
CD36
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PC45E9PC45_HUMAN
Platelet glycoprotein 4
CD36
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM14636 differs from that shown. Reason: Frameshift at position 53.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44L → R in AAD13993 (PubMed:7505064).Curated1
Sequence conflicti238Y → D in AAD13993 (PubMed:7505064).Curated1
Sequence conflicti374E → Q in AAA16068 (PubMed:7693552).Curated1
Sequence conflicti374E → Q AA sequence (PubMed:15242332).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIMi:611162].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01791390P → S in PG4D; type I; degradation in the cytoplasm due to defects in maturation. 2 PublicationsCorresponds to variant dbSNP:rs75326924EnsemblClinVar.1
Natural variantiVAR_017914123E → K in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs183461468Ensembl.1
Natural variantiVAR_019049127S → L1 PublicationCorresponds to variant dbSNP:rs201765331Ensembl.1
Natural variantiVAR_013918154V → F1 PublicationCorresponds to variant dbSNP:rs5957Ensembl.1
Natural variantiVAR_017915174T → A in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs756525492Ensembl.1
Natural variantiVAR_017916232G → GN in individuals from a malaria endemic area in West Africa. 1 Publication1
Natural variantiVAR_017917254F → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs142186404EnsemblClinVar.1
Natural variantiVAR_017918271I → T in individuals from a malaria endemic area in West Africa. 1 PublicationCorresponds to variant dbSNP:rs370072057Ensembl.1
Natural variantiVAR_071161386R → W1 PublicationCorresponds to variant dbSNP:rs148910227Ensembl.1
Natural variantiVAR_017919413I → L in PG4D; type I. 1 PublicationCorresponds to variant dbSNP:rs121918035EnsemblClinVar.1
Natural variantiVAR_071162470T → I1 PublicationCorresponds to variant dbSNP:rs200771788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055976144 – 203Missing in isoform 4. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_055977234 – 272Missing in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_055978274 – 288SIYAV…NLKGI → ETCVHFTSSFSVCKS in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_055979289 – 472Missing in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M24795 mRNA Translation: AAA35534.1
M98398 mRNA Translation: AAA58412.1
M98399 mRNA Translation: AAA58413.1
L06850 mRNA Translation: AAA16068.1
S67532 mRNA Translation: AAD13993.1
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA Translation: CAA83662.1
AY095373 Genomic DNA Translation: AAM14636.2 Frameshift.
HM217023 mRNA Translation: ADI80543.1
HM217024 mRNA Translation: ADI80544.1
HM217025 mRNA Translation: ADI80545.1
HM217026 mRNA Translation: ADI80546.1
AC004862 Genomic DNA No translation available.
AC073182 Genomic DNA No translation available.
AC073850 Genomic DNA No translation available.
AC092108 Genomic DNA No translation available.
AC124834 Genomic DNA No translation available.
BC008406 mRNA Translation: AAH08406.1
AF300626 Genomic DNA Translation: AAG60625.1
AF300627 Genomic DNA Translation: AAG60626.1
AF300628 Genomic DNA Translation: AAG60627.1
AF300633 Genomic DNA Translation: AAG60632.1
AF300634 Genomic DNA Translation: AAG60633.1
AF300635 Genomic DNA Translation: AAG60634.1
AF300639 Genomic DNA Translation: AAG60638.1
AF300640 Genomic DNA Translation: AAG60639.1
S67044 mRNA Translation: AAB28992.1
Z22924 Genomic DNA Translation: CAA80504.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34673.1 [P16671-1]
CCDS78249.1 [P16671-3]
CCDS78250.1 [P16671-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
A54870

NCBI Reference Sequences

More...
RefSeqi
NP_000063.2, NM_000072.3 [P16671-1]
NP_001001547.1, NM_001001547.2 [P16671-1]
NP_001001548.1, NM_001001548.2 [P16671-1]
NP_001120915.1, NM_001127443.1 [P16671-1]
NP_001120916.1, NM_001127444.1 [P16671-1]
NP_001276837.1, NM_001289908.1 [P16671-3]
NP_001276838.1, NM_001289909.1 [P16671-4]
NP_001276840.1, NM_001289911.1
XP_005250770.1, XM_005250713.1 [P16671-1]
XP_005250771.1, XM_005250714.1 [P16671-1]
XP_005250772.1, XM_005250715.4 [P16671-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.120949

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309881; ENSP00000308165; ENSG00000135218 [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218 [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218 [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218 [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218 [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218 [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218 [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218 [P16671-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:948

UCSC genome browser

More...
UCSCi
uc003uhc.4 human [P16671-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD36 entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24795 mRNA Translation: AAA35534.1
M98398 mRNA Translation: AAA58412.1
M98399 mRNA Translation: AAA58413.1
L06850 mRNA Translation: AAA16068.1
S67532 mRNA Translation: AAD13993.1
Z32770
, Z32754, Z32755, Z32756, Z32757, Z32758, Z32759, Z32760, Z32761, Z32762, Z32763, Z32764 Genomic DNA Translation: CAA83662.1
AY095373 Genomic DNA Translation: AAM14636.2 Frameshift.
HM217023 mRNA Translation: ADI80543.1
HM217024 mRNA Translation: ADI80544.1
HM217025 mRNA Translation: ADI80545.1
HM217026 mRNA Translation: ADI80546.1
AC004862 Genomic DNA No translation available.
AC073182 Genomic DNA No translation available.
AC073850 Genomic DNA No translation available.
AC092108 Genomic DNA No translation available.
AC124834 Genomic DNA No translation available.
BC008406 mRNA Translation: AAH08406.1
AF300626 Genomic DNA Translation: AAG60625.1
AF300627 Genomic DNA Translation: AAG60626.1
AF300628 Genomic DNA Translation: AAG60627.1
AF300633 Genomic DNA Translation: AAG60632.1
AF300634 Genomic DNA Translation: AAG60633.1
AF300635 Genomic DNA Translation: AAG60634.1
AF300639 Genomic DNA Translation: AAG60638.1
AF300640 Genomic DNA Translation: AAG60639.1
S67044 mRNA Translation: AAB28992.1
Z22924 Genomic DNA Translation: CAA80504.1
CCDSiCCDS34673.1 [P16671-1]
CCDS78249.1 [P16671-3]
CCDS78250.1 [P16671-4]
PIRiA54870
RefSeqiNP_000063.2, NM_000072.3 [P16671-1]
NP_001001547.1, NM_001001547.2 [P16671-1]
NP_001001548.1, NM_001001548.2 [P16671-1]
NP_001120915.1, NM_001127443.1 [P16671-1]
NP_001120916.1, NM_001127444.1 [P16671-1]
NP_001276837.1, NM_001289908.1 [P16671-3]
NP_001276838.1, NM_001289909.1 [P16671-4]
NP_001276840.1, NM_001289911.1
XP_005250770.1, XM_005250713.1 [P16671-1]
XP_005250771.1, XM_005250714.1 [P16671-1]
XP_005250772.1, XM_005250715.4 [P16671-1]
UniGeneiHs.120949

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LGDX-ray2.07A1-472[»]
ProteinModelPortaliP16671
SMRiP16671
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107386, 18 interactors
IntActiP16671, 13 interactors
STRINGi9606.ENSP00000308165

Chemistry databases

ChEMBLiCHEMBL1744526
SwissLipidsiSLP:000001098

Protein family/group databases

TCDBi9.B.39.1.4 the long chain fatty acid translocase (lcfat) family

PTM databases

GlyConnecti1611
iPTMnetiP16671
PhosphoSitePlusiP16671
SwissPalmiP16671

Polymorphism and mutation databases

BioMutaiCD36
DMDMi115982

Proteomic databases

jPOSTiP16671
MaxQBiP16671
PaxDbiP16671
PeptideAtlasiP16671
PRIDEiP16671
ProteomicsDBi53392

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
948
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309881; ENSP00000308165; ENSG00000135218 [P16671-1]
ENST00000394788; ENSP00000378268; ENSG00000135218 [P16671-1]
ENST00000432207; ENSP00000411411; ENSG00000135218 [P16671-1]
ENST00000433696; ENSP00000401863; ENSG00000135218 [P16671-3]
ENST00000435819; ENSP00000399421; ENSG00000135218 [P16671-1]
ENST00000447544; ENSP00000415743; ENSG00000135218 [P16671-1]
ENST00000538969; ENSP00000439543; ENSG00000135218 [P16671-4]
ENST00000544133; ENSP00000441956; ENSG00000135218 [P16671-2]
GeneIDi948
KEGGihsa:948
UCSCiuc003uhc.4 human [P16671-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
948
DisGeNETi948
EuPathDBiHostDB:ENSG00000135218.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD36
HGNCiHGNC:1663 CD36
HPAiCAB025866
HPA002018
HPA071026
MalaCardsiCD36
MIMi173510 gene
248310 phenotype
608404 phenotype
610938 phenotype
611162 phenotype
neXtProtiNX_P16671
OpenTargetsiENSG00000135218
PharmGKBiPA26212

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3776 Eukaryota
ENOG410XS17 LUCA
GeneTreeiENSGT00940000153372
HOVERGENiHBG002754
InParanoidiP16671
KOiK06259
OMAiPNAFVQV
OrthoDBi1106566at2759
PhylomeDBiP16671
TreeFamiTF317925

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-1236974 ER-Phagosome pathway
R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-1989781 PPARA activates gene expression
R-HSA-3000471 Scavenging by Class B Receptors
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-5602498 MyD88 deficiency (TLR2/4)
R-HSA-5603041 IRAK4 deficiency (TLR2/4)
R-HSA-5686938 Regulation of TLR by endogenous ligand
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695 Neutrophil degranulation
SIGNORiP16671

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD36 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD36

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
948

Protein Ontology

More...
PROi
PR:P16671

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135218 Expressed in 198 organ(s), highest expression level in adipose tissue
ExpressionAtlasiP16671 baseline and differential
GenevisibleiP16671 HS

Family and domain databases

InterProiView protein in InterPro
IPR005428 CD36/SCARB1/SNMP1
IPR033076 CD36_chordates
IPR002159 CD36_fam
PANTHERiPTHR11923 PTHR11923, 1 hit
PTHR11923:SF12 PTHR11923:SF12, 1 hit
PfamiView protein in Pfam
PF01130 CD36, 1 hit
PRINTSiPR01610 CD36ANTIGEN
PR01609 CD36FAMILY

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD36_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P16671
Secondary accession number(s): D9IX66
, D9IX67, D9IX68, D9IX69, Q13966, Q16093, Q8TCV7, Q9BPZ8, Q9BQC2, Q9BZM8, Q9BZN3, Q9BZN4, Q9BZN5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 205 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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