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Entry version 95 (18 Sep 2019)
Sequence version 2 (27 Apr 2001)
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Protein

Dermonecrotic toxin

Gene

toxA

Organism
Pasteurella multocida
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This is a dermonecrotic toxin. This osteolytic toxin, induces bone resorption. Potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs.

Miscellaneous

Closely spaced cysteine and histidine residues may provide the toxin with an affinity for metal.
The sequence shown is that of strain NCTC 12178.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionToxin
Biological processVirulence

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.57.3.1 the clostridial cytotoxin (cct) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dermonecrotic toxin
Short name:
DNT
Alternative name(s):
Mitogenic toxin
PMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:toxA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPasteurella multocida
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri747 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei402 – 422HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Host membrane, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726351 – 1285Dermonecrotic toxinAdd BLAST1285

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17452

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
VimP201524EBI-9541048,EBI-299269From Mus musculus.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P17452, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17452

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P17452

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020972 Dermonecrotic/RTX_toxin_MLD
IPR038765 Papain-like_cys_pep_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11647 MLD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P17452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKHFFNSD FTVKGKSADE IFRRLCTDHP DKQLNNVKWK EVFINRFGQM
60 70 80 90 100
MLDTPNPRKI VEKIINEGLE KQGLKNIDPE TTYFNIFSSS DSSDGNVFHY
110 120 130 140 150
NSLSESYRVT DACLMNIFVE RYFDDWDLLN SLASNGIYSV GKEGAYYPDH
160 170 180 190 200
DYGPEYNPVW GPNEQIYHSR VIADILYARS VWDEFKKYFM EYWQKYAQLY
210 220 230 240 250
TEMLSDTFLA MAIQQYTRQT LTDEGFLMVC NTYYGNKEEV QITLLDIYGY
260 270 280 290 300
PSTDIICIEQ KGLPTPKVIL YIPGGTQPFV EFLNTDDLKQ WIAWHLKDNK
310 320 330 340 350
HMVAFRKHFS LKQRQEGETF TGIDKALQYI AEESPEWPAN KYILYNPTHL
360 370 380 390 400
ETENLFNIMM KRTEQRMLED SDVQIRSNSE ATRDYALSLL ETFISQLSAI
410 420 430 440 450
DMLVPAVGIP INFALSATAL GLSSDIVVNG DSYEKRKYGI GSLVQSALFT
460 470 480 490 500
GINLIPVISE TAEILSSFSR TEEDIPAFFT EEQALAQRFE IVEEELHSIS
510 520 530 540 550
PDDPPREITD ENLHKIRLVR LNNENQPLVV LRRLGGNKFI RIEPITFQEI
560 570 580 590 600
KGSLVSEVIN PVTNKTYYVS NAKLLGGSPY SPFRIGLEGV WTPEVLKARA
610 620 630 640 650
SVIGKPIGES YKRILAKLQR IHNSNILDER QGLMHELMEL IDLYEESQPS
660 670 680 690 700
SERLNAFREL RTQLEKALYL PEMEALKKQI LQIPNKGSGA ARFLLRTAMN
710 720 730 740 750
EMAGKTSEST ADLIRFALQD TVISAPFRGY AGAIPEAIDF PVKYVIEDIS
760 770 780 790 800
VFDKIQTNYW ELPAYESWNE GSNSALLPGL LRESQSKGML SKCRIIENSL
810 820 830 840 850
YIGHSYEEMF YSISPYSNQV GGPYELYPFT FFSMLQEVQG DLGFEQAFAT
860 870 880 890 900
RNFFNTLVSD RLSLMENTML LTESFDYTPW DAIYGDINYD EQFAAMSINE
910 920 930 940 950
RIEKCMNTYR GVAFQNSSKS IDFFLNNLTT FIDNGLTEIA ISDLPYDIVQ
960 970 980 990 1000
QEISQFLQGS NEWKTLDAML FNLDKGDING AFRKLLQSAK DNNIKFRAIG
1010 1020 1030 1040 1050
HSDNSVPPFN NPYKSLYYKG NIIAEAIEKL DREGQKFVVF ADSSLLNSTP
1060 1070 1080 1090 1100
GTGRPMPGLV QYLKIPATVV DSDGAWQFLP DVASSRVPIE VTELENWQVL
1110 1120 1130 1140 1150
TPPQGKILGL KQFKLTAGFP TEQSRLPLLE NSVSEDLREE LMQKIDAIKN
1160 1170 1180 1190 1200
DVKMNSLVCM EAGSCDSVSP KVAARLKDMG LEAGMGASIT WWRREGGMEF
1210 1220 1230 1240 1250
SHQMHTTASF KFAGKEFAVD ASHLQFVHDQ LDTTILILPV DDWALEIAQR
1260 1270 1280
NRAINPFVEY VSKTGNMLAL FMPPLFTKPR LTRAL
Length:1,285
Mass (Da):146,383
Last modified:April 27, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE67A9FCA58C107DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti304A → R in CAA35885 (PubMed:2201870).Curated1
Sequence conflicti775A → R in CAA35885 (PubMed:2201870).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti853F → Y in strain: CVI 47459. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X51512 Genomic DNA Translation: CAA35885.1
X52478 Genomic DNA Translation: CAA36717.1
Z28388 Genomic DNA Translation: CAA82233.1
X57775 Genomic DNA Translation: CAA40921.1
AF240778 Genomic DNA Translation: AAL55665.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S12998 BTQPD

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51512 Genomic DNA Translation: CAA35885.1
X52478 Genomic DNA Translation: CAA36717.1
Z28388 Genomic DNA Translation: CAA82233.1
X57775 Genomic DNA Translation: CAA40921.1
AF240778 Genomic DNA Translation: AAL55665.1
PIRiS12998 BTQPD

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBFX-ray1.90X569-1285[»]
2EBHX-ray2.40X569-1285[»]
2EC5X-ray2.60A/B569-1285[»]
2N9VNMR-A589-668[»]
SMRiP17452
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP17452, 2 interactors

Protein family/group databases

TCDBi1.C.57.3.1 the clostridial cytotoxin (cct) family

Proteomic databases

PRIDEiP17452

Miscellaneous databases

EvolutionaryTraceiP17452

Family and domain databases

InterProiView protein in InterPro
IPR020972 Dermonecrotic/RTX_toxin_MLD
IPR038765 Papain-like_cys_pep_sf
PfamiView protein in Pfam
PF11647 MLD, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOXA_PASMD
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17452
Secondary accession number(s): Q57008
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 27, 2001
Last modified: September 18, 2019
This is version 95 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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