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Entry version 218 (18 Sep 2019)
Sequence version 3 (05 Sep 2012)
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Protein

Protein kinase shaggy

Gene

sgg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for several developmental events such as syncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering calcineurin activation via sra phosphorylation. Phosphorylates microtubule-associated protein futsch in axons.8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei83ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei179Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi60 – 68ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Segmentation polarity protein, Serine/threonine-protein kinase, Transferase
Biological processMeiosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.11.26 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-196299 Beta-catenin phosphorylation cascade
R-DME-209155 Phosphorylation of AXN and APC
R-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209387 Phosphorylation of ARR
R-DME-209396 Phosphorylation of ARM
R-DME-209413 Assembly of the 'destruction complex'
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-432553 Phosphorylation of PER and TIM
R-DME-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P18431

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein kinase shaggy (EC:2.7.11.1)
Alternative name(s):
Protein zeste-white 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sgg
Synonyms:gsk3, zw3
ORF Names:CG2621
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003371 sgg

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants display an overdeveloped neuromuscular junction (NMJ), with the number of boutons greatly increased.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi81A → T: Increases the amount of synaptic boutons and microtubule loops when expressed presynaptically. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000866411 – 514Protein kinase shaggyAdd BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei213Phosphoserine1 Publication1
Modified residuei214Phosphotyrosine2 Publications1
Modified residuei217Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P18431

PRoteomics IDEntifications database

More...
PRIDEi
P18431

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P18431

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in ovaries and activated eggs (at protein level). Expression is over all the embryo at all stages, no local accumulation is observed.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform SGG46 is expressed at low levels in 12-24 hours embryos. Isoform Zygotic and isoform SGG39 are expressed in 12-24 hours embryos and present throughout the larval, pupal and adult stages (at protein level). Isoform Zygotic is expressed maternally and zygotically but reduced throughout later embryonic development. Expression persists throughout larval stages.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003371 Expressed in 27 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P18431 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P18431 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with cos.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
cryO770592EBI-242141,EBI-94117

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
57779, 184 interactors

Database of interacting proteins

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DIPi
DIP-39170N

Protein interaction database and analysis system

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IntActi
P18431, 698 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0304140

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P18431

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 338Protein kinasePROSITE-ProRule annotationAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi386 – 509Ala/Gly-richAdd BLAST124

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0658 Eukaryota
COG0515 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00520000055635

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P18431

KEGG Orthology (KO)

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KOi
K03083

Identification of Orthologs from Complete Genome Data

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OMAi
RVAKHYS

Family and domain databases

Conserved Domains Database

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CDDi
cd14137 STKc_GSK3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033573 GSK3B
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3

The PANTHER Classification System

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PANTHERi
PTHR24057:SF8 PTHR24057:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform Zygotic (identifier: P18431-2) [UniParc]FASTAAdd to basket
Also known as: B, C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRPRTSSF AEGNKQSPSL VLGGVKTCSR DGSKITTVVA TPGQGTDRVQ
60 70 80 90 100
EVSYTDTKVI GNGSFGVVFQ AKLCDTGELV AIKKVLQDRR FKNRELQIMR
110 120 130 140 150
KLEHCNIVKL LYFFYSSGEK RDEVFLNLVL EYIPETVYKV ARQYAKTKQT
160 170 180 190 200
IPINFIRLYM YQLFRSLAYI HSLGICHRDI KPQNLLLDPE TAVLKLCDFG
210 220 230 240 250
SAKQLLHGEP NVSYICSRYY RAPELIFGAI NYTTKIDVWS AGCVLAELLL
260 270 280 290 300
GQPIFPGDSG VDQLVEVIKV LGTPTREQIR EMNPNYTEFK FPQIKSHPWQ
310 320 330 340 350
KVFRIRTPTE AINLVSLLLE YTPSARITPL KACAHPFFDE LRMEGNHTLP
360 370 380 390 400
NGRDMPPLFN FTEHELSIQP SLVPQLLPKH LQNASGPGGN RPSAGGAASI
410 420 430 440 450
AASGSTSVSS TGSGASVEGS AQPQSQGTAA AAGSGSGGAT AGTGGASAGG
460 470 480 490 500
PGSGNNSSSG GASGAPSAVA AGGANAAVAG GAGGGGGAGA ATAAATATGA
510
IGATNAGGAN VTDS
Note: Major isoform.
Length:514
Mass (Da):53,872
Last modified:September 5, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i193EE2A1294BE494
GO
Isoform SGG46 (identifier: P18431-1) [UniParc]FASTAAdd to basket
Also known as: Maternal, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MSGRPRTSSFAEGNKQSPSLVLGGVKTCS → MATTTTTQRA...VVQKFKNILG

Show »
Length:1,067
Mass (Da):114,440
Checksum:iB4E98AFBF4807979
GO
Isoform SGG39 (identifier: P18431-3) [UniParc]FASTAAdd to basket
Also known as: A, J

The sequence of this isoform differs from the canonical sequence as follows:
     513-514: DS → GSQSNSALNSSGSGGSGNGEAAGSGSGSGSGSGGGNGGDNDAGDSGAIASGGGAAETEAAASG

Show »
Length:575
Mass (Da):58,772
Checksum:i477B3E036464E4D5
GO
Isoform G (identifier: P18431-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MSGRPRTSSFAEGNKQSPSLVLGGVKTCS → MLINRGSLLEG

Note: No experimental confirmation available.
Show »
Length:496
Mass (Da):52,092
Checksum:i8059B6236E7B268D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C0PUX5C0PUX5_DROME
MIP03616p
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
441Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q0KHW6Q0KHW6_DROME
Shaggy, isoform R
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
597Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V3W1A4V3W1_DROME
Shaggy, isoform J
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
575Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8JUV9A8JUV9_DROME
Shaggy, isoform M
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
772Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V3W2A4V3W2_DROME
Shaggy, isoform C
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
514Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGC4M9PGC4_DROME
Shaggy, isoform P
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
1,126Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGV7M9PGV7_DROME
Shaggy, isoform Q
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
1,168Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q7KVY5Q7KVY5_DROME
Shaggy, isoform K
sgg anon-WO03040301.254, Dm Zw3, Dmel\CG2621, DMSGG3, Dmsgg3
416Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA37952 differs from that shown. Reason: Frameshift at position 473.Curated
The sequence CAA50216 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244V → I in CAA37419 (PubMed:8467811).Curated1
Sequence conflicti397A → R in CAA37952 (PubMed:2113617).Curated1
Sequence conflicti406T → A in CAA37419 (PubMed:8467811).Curated1
Sequence conflicti406T → A in AAM50318 (PubMed:2113617).Curated1
Sequence conflicti446A → R in CAA37952 (PubMed:2113617).Curated1
Sequence conflicti462A → R in CAA37952 (PubMed:2113617).Curated1
Sequence conflicti473Missing in CAA37952 (PubMed:2113617).Curated1
Sequence conflicti513 – 514DS → GE in CAA19676 (PubMed:10731137).Curated2
Sequence conflicti513 – 514DS → GE in CAB65860 (PubMed:10731137).Curated2
Isoform SGG46 (identifier: P18431-1)
Sequence conflicti9R → A in AAF45801 (PubMed:10731132).Curated1
Sequence conflicti9R → A in CAA19676 (PubMed:10731137).Curated1
Sequence conflicti9R → A in CAB65860 (PubMed:10731137).Curated1
Sequence conflicti256 – 259EEEE → E in CAA37952 (PubMed:2113617).Curated4
Sequence conflicti258 – 259EE → E in CAA19676 (PubMed:10731137).Curated2
Sequence conflicti258 – 259EE → E in CAB65860 (PubMed:10731137).Curated2
Sequence conflicti539 – 540AD → RI in CAA37952 (PubMed:2113617).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0441041 – 29MSGRP…VKTCS → MLINRGSLLEG in isoform G. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_0441051 – 29MSGRP…VKTCS → MATTTTTQRAGAAPALNLLP ASNNNINNTLINNNNNNNNT SNSNNNNNNVISQPIKIPLT ERFSSQTSTGSADSGVIVSS ASQQQLQLPPPRSSSGSLSL PQAPPGGKWRQKQQRQQLLL SQDSGIENGVTTRPSKAKDN QGAGKASHNATSSKESGAQS NSSSESLGSNCSEAQEQQRV RASSALELSSVDTPVIVGGV VSGGNSILRSRIKYKSTNST GTQGFDVEDRIDEVDICDDD DVDCDDRGSEIEEEEEEEED DGVNVDDDVEEADNQSDNQS GIIINLKSQTEQEEEVDEVD AKPKNRLLPPDQAELTVAAA MARRRDAKSLATDGHIYFPL LKISEDPHIDSKLINRKDGL QDTMYYLDEFGSPKLREKFA RKQKQLLAKQQKQLMKRERR SEEQRKKRNTTVASNLAASG AVVDDTKDDYKQQPHCDTSS RSKNNSVPNPPSSHLHQNHN HLVVDVQEDVDDVNVVATSD VDSGVVKMRRHSHDNHYDRI PRSNAATITTRPQIDQQSSH HQNTEDVEQGAEPQIDGEAD LDADADADSDGSGENVKTAK LARTQSCVSWTKVVQKFKNI LG in isoform SGG46. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_044106513 – 514DS → GSQSNSALNSSGSGGSGNGE AAGSGSGSGSGSGGGNGGDN DAGDSGAIASGGGAAETEAA ASG in isoform SGG39. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X70862 mRNA Translation: CAA50212.1
X70863 mRNA Translation: CAA50213.1
X70864 mRNA Translation: CAA50214.1
X70865 mRNA Translation: CAA50215.1
X70866 mRNA Translation: CAA50216.1 Sequence problems.
X53332 mRNA Translation: CAA37419.1
AE014298 Genomic DNA Translation: AAF45801.2
AE014298 Genomic DNA Translation: AAN09082.1
AE014298 Genomic DNA Translation: AAN09083.1
AE014298 Genomic DNA Translation: AAS65255.1
AL024485, AL034544 Genomic DNA Translation: CAA19676.1
AL121804, AL024485 Genomic DNA Translation: CAB65860.1
AL121804, AL024485 Genomic DNA Translation: CAB72296.1
AY122193 mRNA Translation: AAM52705.1
AY119664 mRNA Translation: AAM50318.1
X54005 mRNA Translation: CAA37951.1
X54006 mRNA Translation: CAA37952.1 Frameshift.

Protein sequence database of the Protein Information Resource

More...
PIRi
S35325
S35327
S35328 S35423

NCBI Reference Sequences

More...
RefSeqi
NP_476714.1, NM_057366.5 [P18431-3]
NP_476715.1, NM_057367.5 [P18431-2]
NP_476716.2, NM_057368.5
NP_599105.1, NM_134278.3 [P18431-2]
NP_726822.1, NM_166947.3 [P18431-2]
NP_726823.1, NM_166948.4 [P18431-2]
NP_996335.1, NM_206612.3 [P18431-4]
NP_996336.1, NM_206613.3 [P18431-3]
NP_996337.1, NM_206614.3 [P18431-2]
NP_996338.1, NM_206615.2 [P18431-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070466; FBpp0070449; FBgn0003371 [P18431-2]
FBtr0070467; FBpp0070450; FBgn0003371 [P18431-3]
FBtr0070468; FBpp0070451; FBgn0003371 [P18431-2]
FBtr0070469; FBpp0070452; FBgn0003371 [P18431-2]
FBtr0070470; FBpp0070453; FBgn0003371 [P18431-2]
FBtr0070472; FBpp0089162; FBgn0003371 [P18431-2]
FBtr0070473; FBpp0089158; FBgn0003371 [P18431-2]
FBtr0070474; FBpp0089159; FBgn0003371 [P18431-3]
FBtr0070475; FBpp0089160; FBgn0003371 [P18431-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
31248

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG2621

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70862 mRNA Translation: CAA50212.1
X70863 mRNA Translation: CAA50213.1
X70864 mRNA Translation: CAA50214.1
X70865 mRNA Translation: CAA50215.1
X70866 mRNA Translation: CAA50216.1 Sequence problems.
X53332 mRNA Translation: CAA37419.1
AE014298 Genomic DNA Translation: AAF45801.2
AE014298 Genomic DNA Translation: AAN09082.1
AE014298 Genomic DNA Translation: AAN09083.1
AE014298 Genomic DNA Translation: AAS65255.1
AL024485, AL034544 Genomic DNA Translation: CAA19676.1
AL121804, AL024485 Genomic DNA Translation: CAB65860.1
AL121804, AL024485 Genomic DNA Translation: CAB72296.1
AY122193 mRNA Translation: AAM52705.1
AY119664 mRNA Translation: AAM50318.1
X54005 mRNA Translation: CAA37951.1
X54006 mRNA Translation: CAA37952.1 Frameshift.
PIRiS35325
S35327
S35328 S35423
RefSeqiNP_476714.1, NM_057366.5 [P18431-3]
NP_476715.1, NM_057367.5 [P18431-2]
NP_476716.2, NM_057368.5
NP_599105.1, NM_134278.3 [P18431-2]
NP_726822.1, NM_166947.3 [P18431-2]
NP_726823.1, NM_166948.4 [P18431-2]
NP_996335.1, NM_206612.3 [P18431-4]
NP_996336.1, NM_206613.3 [P18431-3]
NP_996337.1, NM_206614.3 [P18431-2]
NP_996338.1, NM_206615.2 [P18431-2]

3D structure databases

SMRiP18431
ModBaseiSearch...

Protein-protein interaction databases

BioGridi57779, 184 interactors
DIPiDIP-39170N
IntActiP18431, 698 interactors
STRINGi7227.FBpp0304140

PTM databases

iPTMnetiP18431

Proteomic databases

PaxDbiP18431
PRIDEiP18431

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070466; FBpp0070449; FBgn0003371 [P18431-2]
FBtr0070467; FBpp0070450; FBgn0003371 [P18431-3]
FBtr0070468; FBpp0070451; FBgn0003371 [P18431-2]
FBtr0070469; FBpp0070452; FBgn0003371 [P18431-2]
FBtr0070470; FBpp0070453; FBgn0003371 [P18431-2]
FBtr0070472; FBpp0089162; FBgn0003371 [P18431-2]
FBtr0070473; FBpp0089158; FBgn0003371 [P18431-2]
FBtr0070474; FBpp0089159; FBgn0003371 [P18431-3]
FBtr0070475; FBpp0089160; FBgn0003371 [P18431-4]
GeneIDi31248
KEGGidme:Dmel_CG2621

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31248
FlyBaseiFBgn0003371 sgg

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00520000055635
InParanoidiP18431
KOiK03083
OMAiRVAKHYS

Enzyme and pathway databases

BRENDAi2.7.11.26 1994
ReactomeiR-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-196299 Beta-catenin phosphorylation cascade
R-DME-209155 Phosphorylation of AXN and APC
R-DME-209159 Assembly of the CI containing complexes
R-DME-209190 Phosphorylation of CI
R-DME-209214 Phosphorylation of SMO
R-DME-209360 Ubiquitination and proteolysis of phosphorylated CI
R-DME-209387 Phosphorylation of ARR
R-DME-209396 Phosphorylation of ARM
R-DME-209413 Assembly of the 'destruction complex'
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209461 Ubiquitination and degradation of phosphorylated ARM
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-432553 Phosphorylation of PER and TIM
R-DME-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane
SignaLinkiP18431

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
sgg fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31248

Protein Ontology

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PROi
PR:P18431

Gene expression databases

BgeeiFBgn0003371 Expressed in 27 organ(s), highest expression level in head
ExpressionAtlasiP18431 baseline and differential
GenevisibleiP18431 DM

Family and domain databases

CDDicd14137 STKc_GSK3, 1 hit
InterProiView protein in InterPro
IPR033573 GSK3B
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR039192 STKc_GSK3
PANTHERiPTHR24057:SF8 PTHR24057:SF8, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGG_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P18431
Secondary accession number(s): O76881
, P23646, Q27603, Q27604, Q27605, Q8MRF7, Q9NF42, Q9U094, Q9W4X3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1990
Last sequence update: September 5, 2012
Last modified: September 18, 2019
This is version 218 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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