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Entry version 153 (16 Oct 2019)
Sequence version 1 (01 Feb 1991)
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Protein

Exocyst complex component EXO70

Gene

EXO70

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in the assembly of the exocyst.1 Publication

Miscellaneous

Present with 4280 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31542-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-264876 Insulin processing

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.F.2.1.1 the octameric exocyst (exocyst) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component EXO70
Alternative name(s):
Exocyst complex protein of 70 kDa
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXO70
Ordered Locus Names:YJL085W
ORF Names:J0932
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YJL085W

Saccharomyces Genome Database

More...
SGDi
S000003621 EXO70

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189751 – 623Exocyst complex component EXO70Add BLAST623

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P19658

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P19658

PRoteomics IDEntifications database

More...
PRIDEi
P19658

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P19658

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

Interacts with RHO3.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
33671, 526 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1890 Exocyst

Database of interacting proteins

More...
DIPi
DIP-2934N

Protein interaction database and analysis system

More...
IntActi
P19658, 10 interactors

Molecular INTeraction database

More...
MINTi
P19658

STRING: functional protein association networks

More...
STRINGi
4932.YJL085W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1623
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P19658

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P19658

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the EXO70 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000000807

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P19658

KEGG Orthology (KO)

More...
KOi
K07195

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHDLSTQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70

The PANTHER Classification System

More...
PANTHERi
PTHR12542 PTHR12542, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03081 Exo70, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74788 SSF74788, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P19658-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAEIDIDEA DVLVLSQELQ KTSKLTFEIN KSLKKIAATS NQSSQLFTPI
60 70 80 90 100
LARNNVLTTL QRNIESTLNS VASVKDLANE ASKYEIILQK GINQVGLKQY
110 120 130 140 150
TQVVHKLDDM LEDIQSGQAN REENSEFHGI LTHLEQLIKR SEAQLRVYFI
160 170 180 190 200
SILNSIKPFD PQINITKKMP FPYYEDQQLG ALSWILDYFH GNSEGSIIQD
210 220 230 240 250
ILVGERSKLI LKCMAFLEPF AKEISTAKNA PYEKGSSGMN SYTEALLGFI
260 270 280 290 300
ANEKSLVDDL YSQYTESKPH VLSQILSPLI SAYAKLFGAN LKIVRSNLEN
310 320 330 340 350
FGFFSFELVE SINDVKKSLR GKELQNYNLL QDCTQEVRQV TQSLFRDAID
360 370 380 390 400
RIIKKANSIS TIPSNNGVTE ATVDTMSRLR KFSEYKNGCL GAMDNITREN
410 420 430 440 450
WLPSNYKEKE YTLQNEALNW EDHNVLLSCF ISDCIDTLAV NLERKAQIAL
460 470 480 490 500
MPNQEPDVAN PNSSKNKHKQ RIGFFILMNL TLVEQIVEKS ELNLMLAGEG
510 520 530 540 550
HSRLERLKKR YISYMVSDWR DLTANLMDSV FIDSSGKKSK DKEQIKEKFR
560 570 580 590 600
KFNEGFEDLV SKTKQYKLSD PSLKVTLKSE IISLVMPMYE RFYSRYKDSF
610 620
KNPRKHIKYT PDELTTVLNQ LVR
Length:623
Mass (Da):71,294
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i277D89176FC2837D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti497A → S in AAU09750 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y08787 Genomic DNA Translation: CAA70039.1
Y00473 Genomic DNA Translation: CAA68535.1
X83502 Genomic DNA Translation: CAA58485.1
Z49362 Genomic DNA Translation: CAA89380.1
AY723833 Genomic DNA Translation: AAU09750.1
J03546 Genomic DNA Translation: AAA66919.1
BK006943 Genomic DNA Translation: DAA08714.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27300

NCBI Reference Sequences

More...
RefSeqi
NP_012450.1, NM_001181518.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YJL085W_mRNA; YJL085W; YJL085W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853359

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YJL085W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08787 Genomic DNA Translation: CAA70039.1
Y00473 Genomic DNA Translation: CAA68535.1
X83502 Genomic DNA Translation: CAA58485.1
Z49362 Genomic DNA Translation: CAA89380.1
AY723833 Genomic DNA Translation: AAU09750.1
J03546 Genomic DNA Translation: AAA66919.1
BK006943 Genomic DNA Translation: DAA08714.1
PIRiA27300
RefSeqiNP_012450.1, NM_001181518.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B1EX-ray2.00A63-623[»]
2B7MX-ray3.50A/B/C/D63-623[»]
2PFVX-ray2.10A63-623[»]
5YFPelectron microscopy4.40G1-623[»]
SMRiP19658
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi33671, 526 interactors
ComplexPortaliCPX-1890 Exocyst
DIPiDIP-2934N
IntActiP19658, 10 interactors
MINTiP19658
STRINGi4932.YJL085W

Protein family/group databases

TCDBi1.F.2.1.1 the octameric exocyst (exocyst) family

PTM databases

iPTMnetiP19658

Proteomic databases

MaxQBiP19658
PaxDbiP19658
PRIDEiP19658

Genome annotation databases

EnsemblFungiiYJL085W_mRNA; YJL085W; YJL085W
GeneIDi853359
KEGGisce:YJL085W

Organism-specific databases

EuPathDBiFungiDB:YJL085W
SGDiS000003621 EXO70

Phylogenomic databases

HOGENOMiHOG000000807
InParanoidiP19658
KOiK07195
OMAiYHDLSTQ

Enzyme and pathway databases

BioCyciYEAST:G3O-31542-MONOMER
ReactomeiR-SCE-264876 Insulin processing

Miscellaneous databases

EvolutionaryTraceiP19658

Protein Ontology

More...
PROi
PR:P19658

Family and domain databases

InterProiView protein in InterPro
IPR016159 Cullin_repeat-like_dom_sf
IPR004140 Exo70
PANTHERiPTHR12542 PTHR12542, 1 hit
PfamiView protein in Pfam
PF03081 Exo70, 1 hit
SUPFAMiSSF74788 SSF74788, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXO70_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P19658
Secondary accession number(s): D6VW98, E9P961
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 16, 2019
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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