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Entry version 207 (13 Nov 2019)
Sequence version 1 (01 Feb 1991)
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Protein

Cytochrome P450 2B6

Gene

CYP2B6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

heme3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=360 µM for 1,4-cineole1 Publication
  1. Vmax=3.4 nmol/min/nmol enzyme toward 1,4-cineole1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi436Iron (heme axial ligand)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:HS09587-MONOMER

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.14.14.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-211935 Fatty acids
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P20813

SIGNOR Signaling Network Open Resource

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SIGNORi
P20813

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001346

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450 2B6 (EC:1.14.13.-)
Alternative name(s):
1,4-cineole 2-exo-monooxygenase
CYPIIB6
Cytochrome P450 IIB1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2B6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2615 CYP2B6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123930 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P20813

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1555

MalaCards human disease database

More...
MalaCardsi
CYP2B6
MIMi614546 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000197408

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
240869 Efavirenz toxicity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA123

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P20813

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4729

Drug and drug target database

More...
DrugBanki
DB08369 1-(biphenyl-4-ylmethyl)-1H-imidazole
DB02974 4-(4-Chlorophenyl)Imidazole
DB00321 Amitriptyline
DB00381 Amlodipine
DB00701 Amprenavir
DB01435 Antipyrine
DB06413 Armodafinil
DB06697 Artemether
DB13132 Artemisinin
DB11586 Asunaprevir
DB01076 Atorvastatin
DB00972 Azelastine
DB04975 Banoxantrone
DB00865 Benzphetamine
DB04794 Bifonazole
DB05541 Brivaracetam
DB00835 Brompheniramine
DB01156 Bupropion
DB00564 Carbamazepine
DB00439 Cerivastatin
DB00169 Cholecalciferol
DB00568 Cinnarizine
DB00604 Cisapride
DB00515 Cisplatin
DB00349 Clobazam
DB00636 Clofibrate
DB06470 Clomethiazole
DB00758 Clopidogrel
DB01559 Clotiazepam
DB00257 Clotrimazole
DB01394 Colchicine
DB05219 Crisaborole
DB08865 Crizotinib
DB11672 Curcumin
DB14635 Curcumin sulfate
DB04664 Cyclohexyl-pentyl-maltoside
DB00531 Cyclophosphamide
DB08912 Dabrafenib
DB01151 Desipramine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB01184 Domperidone
DB00997 Doxorubicin
DB00625 Efavirenz
DB13874 Enasidenib
DB08899 Enzalutamide
DB00751 Epinastine
DB11823 Esketamine
DB00655 Estrone
DB00898 Ethanol
DB01466 Ethylmorphine
DB01544 Flunitrazepam
DB00472 Fluoxetine
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB01320 Fosphenytoin
DB01159 Halothane
DB09054 Idelalisib
DB01181 Ifosfamide
DB00458 Imipramine
DB00762 Irinotecan
DB11633 Isavuconazole
DB00753 Isoflurane
DB01167 Itraconazole
DB14568 Ivosidenib
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB09078 Lenvatinib
DB12070 Letermovir
DB00281 Lidocaine
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB04871 Lorcaserin
DB12130 Lorlatinib
DB09280 Lumacaftor
DB00772 Malathion
DB09238 Manidipine
DB01043 Memantine
DB00454 Meperidine
DB00532 Mephenytoin
DB04817 Metamizole
DB00333 Methadone
DB00763 Methimazole
DB01028 Methoxyflurane
DB00849 Methylphenobarbital
DB06710 Methyltestosterone
DB00379 Mexiletine
DB06148 Mianserin
DB01110 Miconazole
DB06595 Midostaurin
DB00745 Modafinil
DB00220 Nelfinavir
DB00238 Nevirapine
DB00622 Nicardipine
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00435 Nitric Oxide
DB09074 Olaparib
DB01173 Orphenadrine
DB04938 Ospemifene
DB00715 Paroxetine
DB08883 Perampanel
DB01074 Perhexiline
DB04930 Permethrin
DB00850 Perphenazine
DB03575 Phencyclidine
DB01174 Phenobarbital
DB00252 Phenytoin
DB13941 Piperaquine
DB11642 Pitolisant
DB06209 Prasugrel
DB00794 Primidone
DB01069 Promethazine
DB00818 Propofol
DB01589 Quazepam
DB00908 Quinidine
DB00481 Raloxifene
DB08896 Regorafenib
DB00615 Rifabutin
DB01045 Rifampicin
DB11753 Rifamycin
DB01201 Rifapentine
DB08864 Rilpivirine
DB00503 Ritonavir
DB06176 Romidepsin
DB00296 Ropivacaine
DB00778 Roxithromycin
DB06654 Safinamide
DB01037 Selegiline
DB06739 Seratrodast
DB01104 Sertraline
DB01236 Sevoflurane
DB00641 Simvastatin
DB00398 Sorafenib
DB06729 Sulfaphenazole
DB01138 Sulfinpyrazone
DB00675 Tamoxifen
DB00231 Temazepam
DB00624 Testosterone
DB13943 Testosterone cypionate
DB13944 Testosterone enanthate
DB13946 Testosterone undecanoate
DB04572 Thiotepa
DB00208 Ticlopidine
DB00193 Tramadol
DB00755 Tretinoin
DB12245 Triclabendazole
DB00197 Troglitazone
DB00313 Valproic Acid
DB11613 Velpatasvir
DB08881 Vemurafenib
DB00661 Verapamil
DB00582 Voriconazole
DB09068 Vortioxetine

DrugCentral

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DrugCentrali
P20813

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1324

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYP2B6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
117205

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000516831 – 491Cytochrome P450 2B6Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei128Phosphoserine; by PKABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation is accompanied by a decrease in enzyme activity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P20813

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P20813

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P20813

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P20813

PeptideAtlas

More...
PeptideAtlasi
P20813

PRoteomics IDEntifications database

More...
PRIDEi
P20813

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
5366
53803 [P20813-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P20813

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P20813

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, lung and heart right ventricle.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By phenobarbital.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197408 Expressed in 75 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P20813 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P20813 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033866
HPA048124
HPA062973

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107933, 4 interactors

Protein interaction database and analysis system

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IntActi
P20813, 5 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000324648

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P20813

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1491
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P20813

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P20813

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0156 Eukaryota
COG2124 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157162

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000036992

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P20813

KEGG Orthology (KO)

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KOi
K17709

Identification of Orthologs from Complete Genome Data

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OMAi
QRHPNAH

Database of Orthologous Groups

More...
OrthoDBi
702827at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P20813

TreeFam database of animal gene trees

More...
TreeFami
TF352043

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008068 Cyt_P450_E_grp-I_CYP2B-like
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00463 EP450I
PR01685 EP450ICYP2B
PR00385 P450

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P20813-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELSVLLFLA LLTGLLLLLV QRHPNTHDRL PPGPRPLPLL GNLLQMDRRG
60 70 80 90 100
LLKSFLRFRE KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK
110 120 130 140 150
IAMVDPFFRG YGVIFANGNR WKVLRRFSVT TMRDFGMGKR SVEERIQEEA
160 170 180 190 200
QCLIEELRKS KGALMDPTFL FQSITANIIC SIVFGKRFHY QDQEFLKMLN
210 220 230 240 250
LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE INAYIGHSVE
260 270 280 290 300
KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT
310 320 330 340 350
ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE
360 370 380 390 400
AVIYEIQRFS DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH
410 420 430 440 450
YFEKPDAFNP DHFLDANGAL KKTEAFIPFS LGKRICLGEG IARAELFLFF
460 470 480 490
TTILQNFSMA SPVAPEDIDL TPQECGVGKI PPTYQIRFLP R
Length:491
Mass (Da):56,278
Last modified:February 1, 1991 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9799164BE8FBF1D
GO
Isoform 2 (identifier: P20813-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR → MRCMLTNSHPWCGCDWQ
     162-321: Missing.

Note: No experimental confirmation available.
Show »
Length:291
Mass (Da):33,385
Checksum:iA4B40F24ED632B8D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZJ2M0QZJ2_HUMAN
Cytochrome P450 2B6
CYP2B6
255Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YFA4A0A2R8YFA4_HUMAN
Cytochrome P450 2B6
CYP2B6
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti146I → T in AAF13602 (Ref. 2) Curated1
Sequence conflicti238L → P in AAF13602 (Ref. 2) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in CYP2B6 are responsible for poor metabolism of efavirenz and, therefore, susceptibility to efavirenz toxicity in the central nervous system [MIMi:614546]. Efavirenz is a non-nucleoside reverse transcriptase inhibitor frequently prescribed with 2 nucleoside reverse transcriptase inhibitors as initial therapy for human immunodeficiency virus (HIV) infection. Up to half of patients treated with efavirenz, experience side effects in the central nervous system, including dizziness, insomnia, impaired concentration, somnolence, and abnormal dreams. Severe depression, aggressive behavior, and paranoid or manic reactions may also occur, depending on efavirenz concentration in the plasma.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02356321Q → L in allele CYP2B6*10. 1 PublicationCorresponds to variant dbSNP:rs34883432Ensembl.1
Natural variantiVAR_01692722R → C in allele CYP2B6*2 and allele CYP2B6*10. 6 PublicationsCorresponds to variant dbSNP:rs8192709Ensembl.1
Natural variantiVAR_02520626T → S1 PublicationCorresponds to variant dbSNP:rs33973337Ensembl.1
Natural variantiVAR_02520728D → G1 PublicationCorresponds to variant dbSNP:rs33980385Ensembl.1
Natural variantiVAR_03381929R → P. Corresponds to variant dbSNP:rs34284776Ensembl.1
Natural variantiVAR_02520829R → S1 PublicationCorresponds to variant dbSNP:rs33926104Ensembl.1
Natural variantiVAR_02356446M → V in allele CYP2B6*11. 1 PublicationCorresponds to variant dbSNP:rs35303484Ensembl.1
Natural variantiVAR_02356599G → E in allele CYP2B6*12. 1 PublicationCorresponds to variant dbSNP:rs36060847Ensembl.1
Natural variantiVAR_016948139K → E in allele CYP2B6*8 and allele CYP2B6*13. 2 PublicationsCorresponds to variant dbSNP:rs12721655Ensembl.1
Natural variantiVAR_023566140R → Q in allele CYP2B6*14. 1 PublicationCorresponds to variant dbSNP:rs35773040Ensembl.1
Natural variantiVAR_016924167P → A2 PublicationsCorresponds to variant dbSNP:rs3826711Ensembl.1
Natural variantiVAR_016925172Q → H in allele CYP2B6*6, allele CYP2B6*7, allele CYP2B6*9 and allele CYP2B6*13. 8 PublicationsCorresponds to variant dbSNP:rs3745274EnsemblClinVar.1
Natural variantiVAR_016928259S → R in allele CYP2B6*3. 2 PublicationsCorresponds to variant dbSNP:rs45482602Ensembl.1
Natural variantiVAR_016926262K → R in allele CYP2B6*4, allele CYP2B6*6, allele CYP2B6*7 and allele CYP2B6*13; slight decrease in activity. 5 PublicationsCorresponds to variant dbSNP:rs2279343EnsemblClinVar.1
Natural variantiVAR_025209289N → K1 PublicationCorresponds to variant dbSNP:rs34277950Ensembl.1
Natural variantiVAR_025210306T → S1 PublicationCorresponds to variant dbSNP:rs34698757Ensembl.1
Natural variantiVAR_024716328I → T2 PublicationsCorresponds to variant dbSNP:rs28399499EnsemblClinVar.1
Natural variantiVAR_023567391I → N in allele CYP2B6*15. 1 PublicationCorresponds to variant dbSNP:rs35979566Ensembl.1
Natural variantiVAR_016929487R → C in allele CYP2B6*5 and allele CYP2B6*7. 6 PublicationsCorresponds to variant dbSNP:rs3211371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0555711 – 57MELSV…KSFLR → MRCMLTNSHPWCGCDWQ in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_055572162 – 321Missing in isoform 2. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M29874 mRNA Translation: AAA52144.1
AF182277 mRNA Translation: AAF13602.1
AK301620 mRNA Translation: BAG63105.1
DQ298753 Genomic DNA Translation: ABB84469.1
AC023172 Genomic DNA Translation: AAF32444.1
AC011541 Genomic DNA No translation available.
X13494 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS12570.1 [P20813-1]

Protein sequence database of the Protein Information Resource

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PIRi
A32969

NCBI Reference Sequences

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RefSeqi
NP_000758.1, NM_000767.4 [P20813-1]
XP_011524852.1, XM_011526550.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000324071; ENSP00000324648; ENSG00000197408 [P20813-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1555

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1555

UCSC genome browser

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UCSCi
uc002opr.2 human [P20813-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP2B6 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29874 mRNA Translation: AAA52144.1
AF182277 mRNA Translation: AAF13602.1
AK301620 mRNA Translation: BAG63105.1
DQ298753 Genomic DNA Translation: ABB84469.1
AC023172 Genomic DNA Translation: AAF32444.1
AC011541 Genomic DNA No translation available.
X13494 mRNA No translation available.
CCDSiCCDS12570.1 [P20813-1]
PIRiA32969
RefSeqiNP_000758.1, NM_000767.4 [P20813-1]
XP_011524852.1, XM_011526550.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IBDX-ray2.00A30-491[»]
3QOAX-ray2.10A27-491[»]
3QU8X-ray2.80A/B/C/D/E/F27-491[»]
3UA5X-ray2.80A/B27-491[»]
4I91X-ray2.00A27-491[»]
4RQLX-ray2.10A/B27-491[»]
4RRTX-ray2.20A/B27-491[»]
4ZV8X-ray2.24A30-491[»]
5UAPX-ray2.03A/B20-491[»]
5UDAX-ray1.93A/B20-491[»]
5UECX-ray2.27A20-491[»]
5UFGX-ray1.76A20-491[»]
5WBGX-ray2.99A/B/C/D/E/F20-491[»]
SMRiP20813
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107933, 4 interactors
IntActiP20813, 5 interactors
STRINGi9606.ENSP00000324648

Chemistry databases

BindingDBiP20813
ChEMBLiCHEMBL4729
DrugBankiDB08369 1-(biphenyl-4-ylmethyl)-1H-imidazole
DB02974 4-(4-Chlorophenyl)Imidazole
DB00321 Amitriptyline
DB00381 Amlodipine
DB00701 Amprenavir
DB01435 Antipyrine
DB06413 Armodafinil
DB06697 Artemether
DB13132 Artemisinin
DB11586 Asunaprevir
DB01076 Atorvastatin
DB00972 Azelastine
DB04975 Banoxantrone
DB00865 Benzphetamine
DB04794 Bifonazole
DB05541 Brivaracetam
DB00835 Brompheniramine
DB01156 Bupropion
DB00564 Carbamazepine
DB00439 Cerivastatin
DB00169 Cholecalciferol
DB00568 Cinnarizine
DB00604 Cisapride
DB00515 Cisplatin
DB00349 Clobazam
DB00636 Clofibrate
DB06470 Clomethiazole
DB00758 Clopidogrel
DB01559 Clotiazepam
DB00257 Clotrimazole
DB01394 Colchicine
DB05219 Crisaborole
DB08865 Crizotinib
DB11672 Curcumin
DB14635 Curcumin sulfate
DB04664 Cyclohexyl-pentyl-maltoside
DB00531 Cyclophosphamide
DB08912 Dabrafenib
DB01151 Desipramine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB01184 Domperidone
DB00997 Doxorubicin
DB00625 Efavirenz
DB13874 Enasidenib
DB08899 Enzalutamide
DB00751 Epinastine
DB11823 Esketamine
DB00655 Estrone
DB00898 Ethanol
DB01466 Ethylmorphine
DB01544 Flunitrazepam
DB00472 Fluoxetine
DB01095 Fluvastatin
DB00176 Fluvoxamine
DB01320 Fosphenytoin
DB01159 Halothane
DB09054 Idelalisib
DB01181 Ifosfamide
DB00458 Imipramine
DB00762 Irinotecan
DB11633 Isavuconazole
DB00753 Isoflurane
DB01167 Itraconazole
DB14568 Ivosidenib
DB09570 Ixazomib
DB01221 Ketamine
DB06738 Ketobemidone
DB01026 Ketoconazole
DB09078 Lenvatinib
DB12070 Letermovir
DB00281 Lidocaine
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB04871 Lorcaserin
DB12130 Lorlatinib
DB09280 Lumacaftor
DB00772 Malathion
DB09238 Manidipine
DB01043 Memantine
DB00454 Meperidine
DB00532 Mephenytoin
DB04817 Metamizole
DB00333 Methadone
DB00763 Methimazole
DB01028 Methoxyflurane
DB00849 Methylphenobarbital
DB06710 Methyltestosterone
DB00379 Mexiletine
DB06148 Mianserin
DB01110 Miconazole
DB06595 Midostaurin
DB00745 Modafinil
DB00220 Nelfinavir
DB00238 Nevirapine
DB00622 Nicardipine
DB00184 Nicotine
DB01115 Nifedipine
DB04868 Nilotinib
DB00435 Nitric Oxide
DB09074 Olaparib
DB01173 Orphenadrine
DB04938 Ospemifene
DB00715 Paroxetine
DB08883 Perampanel
DB01074 Perhexiline
DB04930 Permethrin
DB00850 Perphenazine
DB03575 Phencyclidine
DB01174 Phenobarbital
DB00252 Phenytoin
DB13941 Piperaquine
DB11642 Pitolisant
DB06209 Prasugrel
DB00794 Primidone
DB01069 Promethazine
DB00818 Propofol
DB01589 Quazepam
DB00908 Quinidine
DB00481 Raloxifene
DB08896 Regorafenib
DB00615 Rifabutin
DB01045 Rifampicin
DB11753 Rifamycin
DB01201 Rifapentine
DB08864 Rilpivirine
DB00503 Ritonavir
DB06176 Romidepsin
DB00296 Ropivacaine
DB00778 Roxithromycin
DB06654 Safinamide
DB01037 Selegiline
DB06739 Seratrodast
DB01104 Sertraline
DB01236 Sevoflurane
DB00641 Simvastatin
DB00398 Sorafenib
DB06729 Sulfaphenazole
DB01138 Sulfinpyrazone
DB00675 Tamoxifen
DB00231 Temazepam
DB00624 Testosterone
DB13943 Testosterone cypionate
DB13944 Testosterone enanthate
DB13946 Testosterone undecanoate
DB04572 Thiotepa
DB00208 Ticlopidine
DB00193 Tramadol
DB00755 Tretinoin
DB12245 Triclabendazole
DB00197 Troglitazone
DB00313 Valproic Acid
DB11613 Velpatasvir
DB08881 Vemurafenib
DB00661 Verapamil
DB00582 Voriconazole
DB09068 Vortioxetine
DrugCentraliP20813
GuidetoPHARMACOLOGYi1324
SwissLipidsiSLP:000001346

PTM databases

iPTMnetiP20813
PhosphoSitePlusiP20813

Polymorphism and mutation databases

BioMutaiCYP2B6
DMDMi117205

Proteomic databases

EPDiP20813
jPOSTiP20813
MassIVEiP20813
PaxDbiP20813
PeptideAtlasiP20813
PRIDEiP20813
ProteomicsDBi5366
53803 [P20813-1]

Genome annotation databases

EnsembliENST00000324071; ENSP00000324648; ENSG00000197408 [P20813-1]
GeneIDi1555
KEGGihsa:1555
UCSCiuc002opr.2 human [P20813-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1555
DisGeNETi1555

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CYP2B6
HGNCiHGNC:2615 CYP2B6
HPAiCAB033866
HPA048124
HPA062973
MalaCardsiCYP2B6
MIMi123930 gene
614546 phenotype
neXtProtiNX_P20813
OpenTargetsiENSG00000197408
Orphaneti240869 Efavirenz toxicity
PharmGKBiPA123

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
GeneTreeiENSGT00940000157162
HOGENOMiHOG000036992
InParanoidiP20813
KOiK17709
OMAiQRHPNAH
OrthoDBi702827at2759
PhylomeDBiP20813
TreeFamiTF352043

Enzyme and pathway databases

BioCyciMetaCyc:HS09587-MONOMER
BRENDAi1.14.14.1 2681
ReactomeiR-HSA-211935 Fatty acids
R-HSA-211981 Xenobiotics
R-HSA-211999 CYP2E1 reactions
SABIO-RKiP20813
SIGNORiP20813

Miscellaneous databases

EvolutionaryTraceiP20813

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CYP2B6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1555
PharosiP20813

Protein Ontology

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PROi
PR:P20813

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197408 Expressed in 75 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiP20813 baseline and differential
GenevisibleiP20813 HS

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008068 Cyt_P450_E_grp-I_CYP2B-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01685 EP450ICYP2B
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCP2B6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P20813
Secondary accession number(s): B4DWP3, Q2V565, Q9UK46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 13, 2019
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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