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Entry version 202 (13 Nov 2019)
Sequence version 3 (01 Dec 2000)
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Protein

V-type proton ATPase subunit B, brain isoform

Gene

ATP6V1B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS07429-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556 ROS and RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-9639288 Amino acids regulate mTORC1
R-HSA-983712 Ion channel transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
V-type proton ATPase subunit B, brain isoform
Short name:
V-ATPase subunit B 2
Alternative name(s):
Endomembrane proton pump 58 kDa subunit
HO57
Vacuolar proton pump subunit B 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP6V1B2
Synonyms:ATP6B2, VPP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:854 ATP6V1B2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606939 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P21281

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Zimmermann-Laband syndrome 2 (ZLS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by gingival fibromatosis, dysplastic or absent nails, finger abnormalities, hepatosplenomegaly, and abnormalities of the cartilage of the nose and/or ears.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_073962485R → P in ZLS2. 1 PublicationCorresponds to variant dbSNP:rs730882177EnsemblClinVar.1
Deafness, congenital, with onychodystrophy, autosomal dominant (DDOD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized mainly by congenital sensorineural hearing loss accompanied by dystrophic or absent nails. Coniform teeth, selective tooth agenesis, and hands and feet abnormalities are present in some patients.
Related information in OMIM

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
526

MalaCards human disease database

More...
MalaCardsi
ATP6V1B2
MIMi124480 phenotype
616455 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000147416

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
79499 Autosomal dominant deafness-onychodystrophy syndrome
3473 Zimmermann-Laband syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25155

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P21281

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5641

Drug and drug target database

More...
DrugBanki
DB07347 4-(2-Aminoethyl)Benzenesulfonyl Fluoride
DB05260 Gallium nitrate

DrugCentral

More...
DrugCentrali
P21281

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
812

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATP6V1B2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643271

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001446261 – 511V-type proton ATPase subunit B, brain isoformAdd BLAST511

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P21281

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P21281

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P21281

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P21281

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P21281

PeptideAtlas

More...
PeptideAtlasi
P21281

PRoteomics IDEntifications database

More...
PRIDEi
P21281

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53856

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00007812

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P21281

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P21281

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P21281

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147416 Expressed in 232 organ(s), highest expression level in postcentral gyrus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P21281 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P21281 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008147

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P158843EBI-4290814,EBI-533224

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107009, 122 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P21281

Database of interacting proteins

More...
DIPi
DIP-47433N

Protein interaction database and analysis system

More...
IntActi
P21281, 47 interactors

Molecular INTeraction database

More...
MINTi
P21281

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276390

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P21281

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P21281

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1351 Eukaryota
COG1156 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155068

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000165320

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P21281

KEGG Orthology (KO)

More...
KOi
K02147

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITEGQLY

Database of Orthologous Groups

More...
OrthoDBi
541116at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P21281

TreeFam database of animal gene trees

More...
TreeFami
TF300313

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00310 ATP_synth_B_arch, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta

The PANTHER Classification System

More...
PANTHERi
PTHR43389 PTHR43389, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01040 V-ATPase_V1_B, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P21281-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRAMRGIV NGAAPELPVP TGGPAVGARE QALAVSRNYL SQPRLTYKTV
60 70 80 90 100
SGVNGPLVIL DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE
110 120 130 140 150
GTSGIDAKKT SCEFTGDILR TPVSEDMLGR VFNGSGKPID RGPVVLAEDF
160 170 180 190 200
LDIMGQPINP QCRIYPEEMI QTGISAIDGM NSIARGQKIP IFSAAGLPHN
210 220 230 240 250
EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET ARFFKSDFEE
260 270 280 290 300
NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM
310 320 330 340 350
SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ
360 370 380 390 400
IPILTMPNDD ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR
410 420 430 440 450
LMKSAIGEGM TRKDHADVSN QLYACYAIGK DVQAMKAVVG EEALTSDDLL
460 470 480 490 500
YLEFLQKFER NFIAQGPYEN RTVFETLDIG WQLLRIFPKE MLKRIPQSTL
510
SEFYPRDSAK H
Length:511
Mass (Da):56,501
Last modified:December 1, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE01E85BBA36E5DED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YC04H0YC04_HUMAN
V-type proton ATPase subunit B, bra...
ATP6V1B2
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGH6E5RGH6_HUMAN
V-type proton ATPase subunit B, bra...
ATP6V1B2
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC45H0YC45_HUMAN
V-type proton ATPase subunit B, bra...
ATP6V1B2
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAT8H0YAT8_HUMAN
V-type proton ATPase subunit B, bra...
ATP6V1B2
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28A → S in CAA44721 (PubMed:1373501).Curated1
Sequence conflicti29R → Q in AAH30640 (PubMed:15489334).Curated1
Sequence conflicti171Q → R in AAH30640 (PubMed:15489334).Curated1
Sequence conflicti342E → G in AAH30640 (PubMed:15489334).Curated1
Sequence conflicti376Q → L in AAA58661 (PubMed:7945239).Curated1
Sequence conflicti424 – 425AC → RA in AAA35610 (PubMed:2145275).Curated2
Sequence conflicti435M → V in AAA35610 (PubMed:2145275).Curated1
Sequence conflicti510 – 511KH → ND in AAA35610 (PubMed:2145275).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073962485R → P in ZLS2. 1 PublicationCorresponds to variant dbSNP:rs730882177EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M60346 mRNA Translation: AAA35610.1
L35249 mRNA Translation: AAA58661.1
AK312372 mRNA Translation: BAG35290.1
CH471080 Genomic DNA Translation: EAW63758.1
CH471080 Genomic DNA Translation: EAW63759.1
BC003100 mRNA Translation: AAH03100.1
BC007309 mRNA Translation: AAH07309.1
BC030640 mRNA Translation: AAH30640.1
Z37165 Genomic DNA Translation: CAA85522.1
X62949 mRNA Translation: CAA44721.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6014.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B44138
I39208

NCBI Reference Sequences

More...
RefSeqi
NP_001684.2, NM_001693.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276390; ENSP00000276390; ENSG00000147416

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:526

UCSC genome browser

More...
UCSCi
uc003wzp.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60346 mRNA Translation: AAA35610.1
L35249 mRNA Translation: AAA58661.1
AK312372 mRNA Translation: BAG35290.1
CH471080 Genomic DNA Translation: EAW63758.1
CH471080 Genomic DNA Translation: EAW63759.1
BC003100 mRNA Translation: AAH03100.1
BC007309 mRNA Translation: AAH07309.1
BC030640 mRNA Translation: AAH30640.1
Z37165 Genomic DNA Translation: CAA85522.1
X62949 mRNA Translation: CAA44721.1
CCDSiCCDS6014.1
PIRiB44138
I39208
RefSeqiNP_001684.2, NM_001693.3

3D structure databases

SMRiP21281
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107009, 122 interactors
CORUMiP21281
DIPiDIP-47433N
IntActiP21281, 47 interactors
MINTiP21281
STRINGi9606.ENSP00000276390

Chemistry databases

BindingDBiP21281
ChEMBLiCHEMBL5641
DrugBankiDB07347 4-(2-Aminoethyl)Benzenesulfonyl Fluoride
DB05260 Gallium nitrate
DrugCentraliP21281
GuidetoPHARMACOLOGYi812

Protein family/group databases

TCDBi3.A.2.2.4 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

PTM databases

iPTMnetiP21281
PhosphoSitePlusiP21281
SwissPalmiP21281

Polymorphism and mutation databases

BioMutaiATP6V1B2
DMDMi12643271

2D gel databases

REPRODUCTION-2DPAGEiIPI00007812

Proteomic databases

EPDiP21281
jPOSTiP21281
MassIVEiP21281
MaxQBiP21281
PaxDbiP21281
PeptideAtlasiP21281
PRIDEiP21281
ProteomicsDBi53856

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
526

Genome annotation databases

EnsembliENST00000276390; ENSP00000276390; ENSG00000147416
GeneIDi526
KEGGihsa:526
UCSCiuc003wzp.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
526
DisGeNETi526

GeneCards: human genes, protein and diseases

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GeneCardsi
ATP6V1B2
HGNCiHGNC:854 ATP6V1B2
HPAiHPA008147
MalaCardsiATP6V1B2
MIMi124480 phenotype
606939 gene
616455 phenotype
neXtProtiNX_P21281
OpenTargetsiENSG00000147416
Orphaneti79499 Autosomal dominant deafness-onychodystrophy syndrome
3473 Zimmermann-Laband syndrome
PharmGKBiPA25155

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1351 Eukaryota
COG1156 LUCA
GeneTreeiENSGT00940000155068
HOGENOMiHOG000165320
InParanoidiP21281
KOiK02147
OMAiITEGQLY
OrthoDBi541116at2759
PhylomeDBiP21281
TreeFamiTF300313

Enzyme and pathway databases

BioCyciMetaCyc:HS07429-MONOMER
ReactomeiR-HSA-1222556 ROS and RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-9639288 Amino acids regulate mTORC1
R-HSA-983712 Ion channel transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ATP6V1B2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ATP6V1B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
526
PharosiP21281

Protein Ontology

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PROi
PR:P21281

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000147416 Expressed in 232 organ(s), highest expression level in postcentral gyrus
ExpressionAtlasiP21281 baseline and differential
GenevisibleiP21281 HS

Family and domain databases

HAMAPiMF_00310 ATP_synth_B_arch, 1 hit
InterProiView protein in InterPro
IPR020003 ATPase_a/bsu_AS
IPR004100 ATPase_F1/V1/A1_a/bsu_N
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR005723 ATPase_V1-cplx_bsu
IPR027417 P-loop_NTPase
IPR022879 V-ATPase_su_B/beta
PANTHERiPTHR43389 PTHR43389, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF02874 ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039114 V-ATPsynth_beta/V-ATPase_B, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01040 V-ATPase_V1_B, 1 hit
PROSITEiView protein in PROSITE
PS00152 ATPASE_ALPHA_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVATB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P21281
Secondary accession number(s): B2R5Z3
, D3DSQ5, Q14544, Q15859, Q96IR0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1991
Last sequence update: December 1, 2000
Last modified: November 13, 2019
This is version 202 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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