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Entry version 192 (16 Oct 2019)
Sequence version 2 (01 May 1992)
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Protein

Catechol O-methyltransferase

Gene

Comt

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+Note: Binds 1 Mg2+ ion per subunit.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=30 µM for S-adenosyl-L-methionine1 Publication
  1. Vmax=377 nmol/h/mg enzyme1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei85S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1 Publication1
Binding sitei107S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei115S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei133S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei134S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei162S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi184Magnesium1
Binding sitei184S-adenosyl-L-methioninePROSITE-ProRule annotation1 Publication1
Binding sitei187Substrate1
Metal bindingi212Magnesium1
Metal bindingi213Magnesium1
Binding sitei213Substrate1
Binding sitei242Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processCatecholamine metabolism, Neurotransmitter degradation
LigandMagnesium, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-15100

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.6 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-156581 Methylation
R-RNO-379397 Enzymatic degradation of dopamine by COMT

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P22734

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Catechol O-methyltransferase (EC:2.1.1.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Comt
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Rat genome database

More...
RGDi
2379 Comt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2CytoplasmicSequence analysis2
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 19Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini20 – 264ExtracellularSequence analysisAdd BLAST245

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2372

DrugCentral

More...
DrugCentrali
P22734

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2472

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000209751 – 264Catechol O-methyltransferaseAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei259PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei264PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P22734

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P22734

PRoteomics IDEntifications database

More...
PRIDEi
P22734

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P22734

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P22734

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001889 Expressed in 10 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P22734 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P22734 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000043148

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P22734

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P22734

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P22734

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni160 – 163S-adenosyl-L-methionine binding4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1663 Eukaryota
COG4122 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155317

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046392

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P22734

KEGG Orthology (KO)

More...
KOi
K00545

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTHYSSY

Database of Orthologous Groups

More...
OrthoDBi
1274244at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P22734

TreeFam database of animal gene trees

More...
TreeFami
TF329140

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017128 Catechol_O-MeTrfase_euk
IPR029063 SAM-dependent_MTases
IPR002935 SAM_O-MeTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01596 Methyltransf_3, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037177 Catechol_O-mtfrase_euk, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51682 SAM_OMT_I, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative initiation. AlignAdd to basket
Isoform 1 (identifier: P22734-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound, MB-COMT

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLAAVSLGL LLLALLLLLR HLGWGLVTIF WFEYVLQPVH NLIMGDTKEQ
60 70 80 90 100
RILRYVQQNA KPGDPQSVLE AIDTYCTQKE WAMNVGDAKG QIMDAVIREY
110 120 130 140 150
SPSLVLELGA YCGYSAVRMA RLLQPGARLL TMEMNPDYAA ITQQMLNFAG
160 170 180 190 200
LQDKVTILNG ASQDLIPQLK KKYDVDTLDM VFLDHWKDRY LPDTLLLEKC
210 220 230 240 250
GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY LEYMKVVDGL
260
EKAIYQGPSS PDKS
Length:264
Mass (Da):29,597
Last modified:May 1, 1992 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF535DFF49C062854
GO
Isoform 2 (identifier: P22734-2) [UniParc]FASTAAdd to basket
Also known as: Soluble, S-COMT

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Show »
Length:221
Mass (Da):24,747
Checksum:iC797794F205FA41D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA40881 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA40882 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0187801 – 43Missing in isoform 2. CuratedAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z12651 Genomic DNA Translation: CAA78276.1
M60754 Genomic DNA Translation: AAA40882.1 Different initiation.
BC081850 mRNA Translation: AAH81850.1
M60753 mRNA Translation: AAA40881.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
S22090

NCBI Reference Sequences

More...
RefSeqi
NP_036663.1, NM_012531.2 [P22734-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000050269; ENSRNOP00000043148; ENSRNOG00000001889 [P22734-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24267

Keywords - Coding sequence diversityi

Alternative initiation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12651 Genomic DNA Translation: CAA78276.1
M60754 Genomic DNA Translation: AAA40882.1 Different initiation.
BC081850 mRNA Translation: AAH81850.1
M60753 mRNA Translation: AAA40881.1 Different initiation.
PIRiS22090
RefSeqiNP_036663.1, NM_012531.2 [P22734-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H1DX-ray2.00A44-264[»]
1JR4X-ray2.63A44-264[»]
1VIDX-ray2.00A44-264[»]
2CL5X-ray1.60A/B44-264[»]
2ZLBX-ray2.20A44-264[»]
2ZTHX-ray2.60A44-264[»]
2ZVJX-ray2.30A44-264[»]
3A7DX-ray2.40A44-264[»]
3HVHX-ray1.30A44-264[»]
3HVIX-ray1.20A44-264[»]
3HVJX-ray1.79A/B44-264[»]
3HVKX-ray1.30A44-264[»]
3NW9X-ray1.65A44-264[»]
3NWBX-ray1.30A44-264[»]
3NWEX-ray1.50A44-264[»]
3OE4X-ray1.49A44-264[»]
3OE5X-ray1.52A44-264[»]
3OZRX-ray1.73A44-264[»]
3OZSX-ray1.44A44-264[»]
3OZTX-ray1.48A44-264[»]
3R6TX-ray1.20A44-264[»]
3S68X-ray1.85A44-264[»]
3U81X-ray1.13A44-264[»]
4P7GX-ray2.58A/B/C/D44-264[»]
4P7JX-ray1.45A44-264[»]
4P7KX-ray1.22A44-264[»]
4PYLX-ray2.20A44-264[»]
4PYMX-ray1.19A44-264[»]
4PYNX-ray1.20A44-264[»]
4PYOX-ray2.10A/B44-264[»]
4PYQX-ray1.39A/B44-264[»]
5FHQX-ray1.63A46-258[»]
5FHRX-ray1.63A/B46-258[»]
5K01X-ray1.38A46-258[»]
5K03X-ray1.81A46-259[»]
5K05X-ray2.14A/B46-259[»]
5K09X-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X45-260[»]
5K0BX-ray2.36A/B/C/D/E/F/G/H45-261[»]
5K0CX-ray1.95A/B45-259[»]
5K0EX-ray2.30A45-259[»]
5K0FX-ray1.81A/B45-263[»]
5K0GX-ray1.89A/B45-264[»]
5K0JX-ray1.94A/B45-264[»]
5K0LX-ray2.02A/B/C/D45-263[»]
5K0NX-ray1.99A/B/C/D45-264[»]
5LQAX-ray1.20A46-258[»]
5LQCX-ray1.90A44-264[»]
5LQJX-ray2.41A/B/C/D44-264[»]
5LQKX-ray2.24A44-264[»]
5LQNX-ray1.72A44-264[»]
5LQRX-ray1.50A44-264[»]
5LQUX-ray1.80A/B44-264[»]
5LR6X-ray2.30A/B/C/D44-264[»]
5P8WX-ray2.03A/B/C44-264[»]
5P8XX-ray1.31A44-264[»]
5P8YX-ray1.42A44-264[»]
5P8ZX-ray1.42A44-264[»]
5P90X-ray1.24A44-264[»]
5P91X-ray1.20A44-264[»]
5P92X-ray1.61A44-264[»]
5P93X-ray1.24A44-264[»]
5P94X-ray1.20A44-264[»]
5P95X-ray1.30A44-264[»]
5P96X-ray1.40A44-264[»]
5P97X-ray1.30A44-264[»]
5P98X-ray1.20A44-264[»]
5P99X-ray1.20A44-264[»]
5P9AX-ray1.91A44-264[»]
5P9BX-ray1.45A44-264[»]
5P9CX-ray1.70A44-264[»]
5P9DX-ray1.42A44-264[»]
5P9EX-ray1.50A44-264[»]
5P9NX-ray1.17A44-264[»]
5P9OX-ray1.10A44-264[»]
5P9PX-ray1.12A44-264[»]
5P9QX-ray1.63A44-264[»]
5P9RX-ray1.70A/B44-264[»]
5P9SX-ray2.30A44-264[»]
5P9TX-ray1.24A44-264[»]
5P9UX-ray1.42A44-264[»]
5P9VX-ray1.04A44-264[»]
5P9WX-ray1.43A44-264[»]
5P9XX-ray1.12A44-264[»]
5P9YX-ray1.20A44-264[»]
5P9ZX-ray1.60A44-264[»]
5PA0X-ray1.26A44-264[»]
5PA1X-ray1.24A44-264[»]
5PA2X-ray1.12A44-264[»]
5PA3X-ray1.60A44-264[»]
5PA4X-ray1.99A44-264[»]
5PA5X-ray1.63A44-264[»]
5PA6X-ray1.29A44-264[»]
5PA7X-ray2.12A/B44-264[»]
6GY1X-ray2.10A44-264[»]
SMRiP22734
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043148

Chemistry databases

BindingDBiP22734
ChEMBLiCHEMBL2372
DrugCentraliP22734
GuidetoPHARMACOLOGYi2472

PTM databases

iPTMnetiP22734
PhosphoSitePlusiP22734

Proteomic databases

jPOSTiP22734
PaxDbiP22734
PRIDEiP22734

Genome annotation databases

EnsembliENSRNOT00000050269; ENSRNOP00000043148; ENSRNOG00000001889 [P22734-1]
GeneIDi24267
KEGGirno:24267

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1312
RGDi2379 Comt

Phylogenomic databases

eggNOGiKOG1663 Eukaryota
COG4122 LUCA
GeneTreeiENSGT00940000155317
HOGENOMiHOG000046392
InParanoidiP22734
KOiK00545
OMAiCTHYSSY
OrthoDBi1274244at2759
PhylomeDBiP22734
TreeFamiTF329140

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15100
BRENDAi2.1.1.6 5301
ReactomeiR-RNO-156581 Methylation
R-RNO-379397 Enzymatic degradation of dopamine by COMT
SABIO-RKiP22734

Miscellaneous databases

EvolutionaryTraceiP22734

Protein Ontology

More...
PROi
PR:P22734

Gene expression databases

BgeeiENSRNOG00000001889 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiP22734 baseline and differential
GenevisibleiP22734 RN

Family and domain databases

InterProiView protein in InterPro
IPR017128 Catechol_O-MeTrfase_euk
IPR029063 SAM-dependent_MTases
IPR002935 SAM_O-MeTrfase
PfamiView protein in Pfam
PF01596 Methyltransf_3, 1 hit
PIRSFiPIRSF037177 Catechol_O-mtfrase_euk, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51682 SAM_OMT_I, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOMT_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P22734
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: May 1, 1992
Last modified: October 16, 2019
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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