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Entry version 218 (13 Nov 2019)
Sequence version 1 (01 Mar 1992)
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Protein

Interleukin-4 receptor subunit alpha

Gene

IL4R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.1 Publication
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei38Major IL4 binding determinant1
Sitei64Minor IL4 binding determinant1
Sitei66Minor IL4 binding determinant1
Sitei92Minor IL4 binding determinant1
Sitei94Minor IL4 binding determinant1
Sitei97Major IL4 binding determinant1
Sitei152Minor IL4 binding determinant1
Sitei208Major IL4 binding determinant1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P24394

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P24394

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-4 receptor subunit alpha
Short name:
IL-4 receptor subunit alpha
Short name:
IL-4R subunit alpha
Short name:
IL-4R-alpha
Short name:
IL-4RA
Alternative name(s):
CD_antigen: CD124
Cleaved into the following chain:
Soluble interleukin-4 receptor subunit alpha
Short name:
Soluble IL-4 receptor subunit alpha
Short name:
Soluble IL-4R-alpha
Short name:
sIL4Ralpha/prot
Alternative name(s):
IL-4-binding protein
Short name:
IL4-BP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL4R
Synonyms:IL4RA
ORF Names:582J2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6015 IL4R

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147781 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P24394

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 232ExtracellularSequence analysisAdd BLAST207
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei233 – 256HelicalSequence analysisAdd BLAST24
Topological domaini257 – 825CytoplasmicSequence analysisAdd BLAST569

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi38Y → A: 700-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi38Y → F: 25-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi39M → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi40S → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi64L → A: 100-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi66F → A: 45-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi67L → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi68L → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi91D → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi92D → A: 50-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi93V → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi94V → A: 35-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi95S → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi97D → A or N: >150-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi98N → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi99Y → A: 10-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi116K → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi117P → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi118S → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi119E → A: No effect on IL4 binding. 1 Publication1
Mutagenesisi150D → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi151N → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi152Y → A: 40-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi152Y → F: No effect on IL4 binding. 1 Publication1
Mutagenesisi153L → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi154Y → A: Little effect on IL4 binding. 1 Publication1
Mutagenesisi208Y → A: 500-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi208Y → F: 200-fold reduction in IL4 binding. 1 Publication1
Mutagenesisi497Y → F: Abolishes IRS1 tyrosine phosphorylation. No cell proliferation. 1 Publication1
Mutagenesisi575Y → F: Loss of CD23 gene induction; when associated with F-603 and F-631. 2 Publications1
Mutagenesisi603Y → F: Loss of CD23 gene induction; when associated with F-575 and F-631. 1 Publication1
Mutagenesisi631Y → F: Loss of CD23 gene induction; when associated with F-575 and F-603. 1 Publication1
Mutagenesisi713Y → F: Increased IL4-induced cell proliferation and STAT6 activation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3566

MalaCards human disease database

More...
MalaCardsi
IL4R

Open Targets

More...
OpenTargetsi
ENSG00000077238

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29832

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P24394

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580490

Drug and drug target database

More...
DrugBanki
DB05078 AER001
DB12159 Dupilumab

DrugCentral

More...
DrugCentrali
P24394

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1697

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL4R

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124335

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25By similarityAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001088726 – 825Interleukin-4 receptor subunit alphaAdd BLAST800
ChainiPRO_000001088826 – ?Soluble interleukin-4 receptor subunit alpha

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 44By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi74 ↔ 86By similarity
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi176N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei497Phosphotyrosine1 Publication1
Modified residuei575Phosphotyrosine1 Publication1
Modified residuei603Phosphotyrosine1 Publication1
Modified residuei631Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.1 Publication
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P24394

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P24394

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P24394

PeptideAtlas

More...
PeptideAtlasi
P24394

PRoteomics IDEntifications database

More...
PRIDEi
P24394

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54203 [P24394-1]
54204 [P24394-2]
5656

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2053

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P24394

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P24394

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000077238 Expressed in 192 organ(s), highest expression level in left adrenal gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P24394 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P24394 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004451
HPA050124

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422).

Interacts with PIK3C3 (By similarity).

Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803).

Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5.

Interacts with SOCS5; inhibits IL4 signaling (By similarity).

Interacts with JAK3 (PubMed:7538655).

Interacts with CLM1 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109780, 41 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P24394

Database of interacting proteins

More...
DIPi
DIP-3223N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P24394

Protein interaction database and analysis system

More...
IntActi
P24394, 33 interactors

Molecular INTeraction database

More...
MINTi
P24394

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1825
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P24394

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P24394

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 224Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni437 – 557Required for IRS1 activation and IL4-induced cell growthAdd BLAST121
Regioni558 – 657Required for IL4-induced gene expressionAdd BLAST100

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi212 – 216WSXWS motif5
Motifi262 – 270Box 1 motif9
Motifi711 – 716ITIM motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi370 – 380Poly-GluAdd BLAST11
Compositional biasi563 – 566Poly-Ala4
Compositional biasi789 – 794Poly-Ser6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The extracellular domain represents the IL4 binding protein (IL4BP).
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGBQ Eukaryota
ENOG41124QC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000049182

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P24394

KEGG Orthology (KO)

More...
KOi
K05071

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYKPFQN

Database of Orthologous Groups

More...
OrthoDBi
476828at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P24394

TreeFam database of animal gene trees

More...
TreeFami
TF337996

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR015319 IL-4_rcpt-alpha_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09238 IL4Ra_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P24394-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound form

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG
60 70 80 90 100
PTNCSTELRL LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT
110 120 130 140 150
LDLWAGQQLL WKGSFKPSEH VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD
160 170 180 190 200
NYLYNHLTYA VNIWSENDPA DFRIYNVTYL EPSLRIAAST LKSGISYRAR
210 220 230 240 250
VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS CIVILAVCLL
260 270 280 290 300
CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
310 320 330 340 350
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV
360 370 380 390 400
LWPESISVVR CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE
410 420 430 440 450
GIVARLTESL FLDLLGEENG GFCQQDMGES CLLPPSGSTS AHMPWDEFPS
460 470 480 490 500
AGPKEAPPWG KEQPLHLEPS PPASPTQSPD NLTCTETPLV IAGNPAYRSF
510 520 530 540 550
SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT TVPQPEPETW
560 570 580 590 600
EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
610 620 630 640 650
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV
660 670 680 690 700
PLFTFGLDRE PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT
710 720 730 740 750
DPLVDSLGSG IVYSALTCHL CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD
760 770 780 790 800
RSSPPTTPLR APDPSPGGVP LEASLCPASL APSGISEKSK SSSSFHPAPG
810 820
NAQSSSQTPK IVNFVSVGPT YMRVS
Length:825
Mass (Da):89,658
Last modified:March 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F886DF5612297F8
GO
Isoform 2 (identifier: P24394-2) [UniParc]FASTAAdd to basket
Also known as: Soluble form, sIL4Ralpha/splice

The sequence of this isoform differs from the canonical sequence as follows:
     225-227: YRE → NIC
     228-825: Missing.

Show »
Length:227
Mass (Da):25,553
Checksum:i9FE8FCC827717CC5
GO
Isoform 3 (identifier: P24394-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGWLCSGLLFPVSCLVLLQVASS → MQKDARRE

Note: No experimental confirmation available.
Show »
Length:810
Mass (Da):88,267
Checksum:i234ADCAA655651CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BRH7H3BRH7_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTD9H3BTD9_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9JII2J9JII2_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4W9I3L4W9_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSE7H3BSE7_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4H7I3L4H7_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5FC08Q5FC08_HUMAN
IL4R nirs variant 1
IL4R
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLA1A0A0G2JLA1_HUMAN
Interleukin-4 receptor subunit alph...
IL4R
10Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Allelic variants in IL4RA are associated with a susceptibility to atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.
Allelic variants in IL4RA are associated with cedar pollen sensitization. Individuals develop Japanese cedar pollinosis with increased exposure to cedar pollen. Japanese cedar pollinosis is a type I allergic disease with ocular and nasal symptoms that develop paroxysmally on contact with Japanese cedar pollen. These symptoms, which occur seasonally each year, are typical features of allergic rhinitis, such as sneezing, excessive nasal secretion, nasal congestion, and conjunctival itching.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05930275I → F. Corresponds to variant dbSNP:rs1805010EnsemblClinVar.1
Natural variantiVAR_05930375I → L. Corresponds to variant dbSNP:rs1805010EnsemblClinVar.1
Natural variantiVAR_00803475I → V Associated with atopic asthma and cedar pollen sensitization. 5 PublicationsCorresponds to variant dbSNP:rs1805010EnsemblClinVar.1
Natural variantiVAR_019999387S → L. Corresponds to variant dbSNP:rs6413500EnsemblClinVar.1
Natural variantiVAR_011657400E → A Associated with cedar pollen sensitization. 4 PublicationsCorresponds to variant dbSNP:rs1805011Ensembl.1
Natural variantiVAR_011658431C → R3 PublicationsCorresponds to variant dbSNP:rs1805012Ensembl.1
Natural variantiVAR_011659436S → L3 PublicationsCorresponds to variant dbSNP:rs1805013Ensembl.1
Natural variantiVAR_049164492A → T. Corresponds to variant dbSNP:rs35606110Ensembl.1
Natural variantiVAR_049165492A → V. Corresponds to variant dbSNP:rs34727572Ensembl.1
Natural variantiVAR_011660503S → P Lowered total IgE concentration. 3 PublicationsCorresponds to variant dbSNP:rs1805015EnsemblClinVar.1
Natural variantiVAR_008035576Q → R Associated with atopic dermatitis; lowered total IgE concentration; no effect on IL4-induced signal transduction. 6 PublicationsCorresponds to variant dbSNP:rs1801275EnsemblClinVar.1
Natural variantiVAR_011661579V → I2 PublicationsCorresponds to variant dbSNP:rs3024677Ensembl.1
Natural variantiVAR_020000675P → S1 PublicationCorresponds to variant dbSNP:rs3024678Ensembl.1
Natural variantiVAR_011662752S → A2 PublicationsCorresponds to variant dbSNP:rs1805016Ensembl.1
Natural variantiVAR_011663786S → P in 1.8% of the population. 2 PublicationsCorresponds to variant dbSNP:rs1805014Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0537381 – 23MGWLC…QVASS → MQKDARRE in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011116225 – 227YRE → NIC in isoform 2. Curated3
Alternative sequenceiVSP_011117228 – 825Missing in isoform 2. CuratedAdd BLAST598

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52425 mRNA Translation: CAA36672.1
AC004525 Genomic DNA Translation: AAC23495.1
AF421855 Genomic DNA Translation: AAL12163.1
AJ293647 Genomic DNA Translation: CAC20445.1
AJ293648 Genomic DNA Translation: CAC20446.1
AJ293649 Genomic DNA Translation: CAC20447.1
AJ293650 Genomic DNA Translation: CAC20448.1
AJ293651 Genomic DNA Translation: CAC20449.1
AJ293652 Genomic DNA Translation: CAC20450.1
AJ293653 Genomic DNA Translation: CAC20451.1
AK303255 mRNA Translation: BAG64338.1
AC106739 Genomic DNA No translation available.
BC151131 mRNA Translation: AAI51132.1
AJ293654 Genomic DNA Translation: CAC20452.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10629.1 [P24394-1]
CCDS58441.1 [P24394-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A60386

NCBI Reference Sequences

More...
RefSeqi
NP_000409.1, NM_000418.3 [P24394-1]
NP_001244335.1, NM_001257406.1 [P24394-1]
NP_001244336.1, NM_001257407.1 [P24394-3]
XP_011544127.1, XM_011545825.1 [P24394-1]
XP_011544128.1, XM_011545826.2 [P24394-1]
XP_011544129.1, XM_011545827.2 [P24394-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000170630; ENSP00000170630; ENSG00000077238 [P24394-3]
ENST00000395762; ENSP00000379111; ENSG00000077238 [P24394-1]
ENST00000543915; ENSP00000441667; ENSG00000077238 [P24394-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3566

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3566

UCSC genome browser

More...
UCSCi
uc002don.5 human [P24394-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52425 mRNA Translation: CAA36672.1
AC004525 Genomic DNA Translation: AAC23495.1
AF421855 Genomic DNA Translation: AAL12163.1
AJ293647 Genomic DNA Translation: CAC20445.1
AJ293648 Genomic DNA Translation: CAC20446.1
AJ293649 Genomic DNA Translation: CAC20447.1
AJ293650 Genomic DNA Translation: CAC20448.1
AJ293651 Genomic DNA Translation: CAC20449.1
AJ293652 Genomic DNA Translation: CAC20450.1
AJ293653 Genomic DNA Translation: CAC20451.1
AK303255 mRNA Translation: BAG64338.1
AC106739 Genomic DNA No translation available.
BC151131 mRNA Translation: AAI51132.1
AJ293654 Genomic DNA Translation: CAC20452.1
CCDSiCCDS10629.1 [P24394-1]
CCDS58441.1 [P24394-3]
PIRiA60386
RefSeqiNP_000409.1, NM_000418.3 [P24394-1]
NP_001244335.1, NM_001257406.1 [P24394-1]
NP_001244336.1, NM_001257407.1 [P24394-3]
XP_011544127.1, XM_011545825.1 [P24394-1]
XP_011544128.1, XM_011545826.2 [P24394-1]
XP_011544129.1, XM_011545827.2 [P24394-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IARX-ray2.30B26-232[»]
1IRSNMR-B489-499[»]
1ITEmodel-C26-232[»]
3BPLX-ray2.93B27-227[»]
3BPNX-ray3.02B27-227[»]
3BPOX-ray3.00B27-227[»]
5E4EX-ray3.00B26-228[»]
6OELX-ray3.10B27-224[»]
SMRiP24394
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109780, 41 interactors
CORUMiP24394
DIPiDIP-3223N
ELMiP24394
IntActiP24394, 33 interactors
MINTiP24394
STRINGi9606.ENSP00000379111

Chemistry databases

ChEMBLiCHEMBL3580490
DrugBankiDB05078 AER001
DB12159 Dupilumab
DrugCentraliP24394
GuidetoPHARMACOLOGYi1697

PTM databases

GlyConnecti2053
iPTMnetiP24394
PhosphoSitePlusiP24394

Polymorphism and mutation databases

BioMutaiIL4R
DMDMi124335

Proteomic databases

jPOSTiP24394
MassIVEiP24394
PaxDbiP24394
PeptideAtlasiP24394
PRIDEiP24394
ProteomicsDBi54203 [P24394-1]
54204 [P24394-2]
5656

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P24394

Genome annotation databases

EnsembliENST00000170630; ENSP00000170630; ENSG00000077238 [P24394-3]
ENST00000395762; ENSP00000379111; ENSG00000077238 [P24394-1]
ENST00000543915; ENSP00000441667; ENSG00000077238 [P24394-1]
GeneIDi3566
KEGGihsa:3566
UCSCiuc002don.5 human [P24394-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3566
DisGeNETi3566

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL4R
HGNCiHGNC:6015 IL4R
HPAiCAB004451
HPA050124
MalaCardsiIL4R
MIMi147781 gene
neXtProtiNX_P24394
OpenTargetsiENSG00000077238
PharmGKBiPA29832

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGBQ Eukaryota
ENOG41124QC LUCA
GeneTreeiENSGT00510000049182
InParanoidiP24394
KOiK05071
OMAiGYKPFQN
OrthoDBi476828at2759
PhylomeDBiP24394
TreeFamiTF337996

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkiP24394
SIGNORiP24394

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL4R human
EvolutionaryTraceiP24394

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Interleukin-4_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3566
PharosiP24394

Protein Ontology

More...
PROi
PR:P24394

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000077238 Expressed in 192 organ(s), highest expression level in left adrenal gland
ExpressionAtlasiP24394 baseline and differential
GenevisibleiP24394 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR015319 IL-4_rcpt-alpha_N
PfamiView protein in Pfam
PF09238 IL4Ra_N, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01355 HEMATOPO_REC_S_F1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL4RA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P24394
Secondary accession number(s): B4E076
, B9EKU8, H3BSY5, Q96P01, Q9H181, Q9H182, Q9H183, Q9H184, Q9H185, Q9H186, Q9H187, Q9H188
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 13, 2019
This is version 218 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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