Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 187 (16 Oct 2019)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Gene

PDE4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation1 PublicationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Isoform 1, isoform 2, isoform 6 and isoform 7 are inhibited by rolipram and cilomilast. Isoform 1, isoform 2 and isoform 6 are inhibited by 4-[(3-butoxy-4-methoxyphenyl)-methyl]-2-imidazolidinone (Ro 20-1724), roflumilast and denbufylline.3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=4.0 µM for cAMP (isoform 2)2 Publications
  2. KM=3 µM for cAMP (isoform 6)2 Publications

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: 3',5'-cyclic AMP degradation

    This protein is involved in step 1 of the subpathway that synthesizes AMP from 3',5'-cyclic AMP.
    Proteins known to be involved in this subpathway in this organism are:
    1. cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C), cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A), cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A), cAMP-specific 3',5'-cyclic phosphodiesterase 7B (PDE7B), High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A), cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B), cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B), High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)
    This subpathway is part of the pathway 3',5'-cyclic AMP degradation, which is itself part of Purine metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from 3',5'-cyclic AMP, the pathway 3',5'-cyclic AMP degradation and in Purine metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei433Proton donorBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi437Divalent metal cation 11
    Metal bindingi473Divalent metal cation 11
    Metal bindingi474Divalent metal cation 11
    Metal bindingi474Divalent metal cation 21
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei474cAMPBy similarity1
    Metal bindingi591Divalent metal cation 11
    Binding sitei591cAMPBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei594Binds AMP, but not cAMPBy similarity1
    Binding sitei642cAMPBy similarity1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi433 – 437cAMPBy similarity5

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    LigandcAMP, Metal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.4.17 2681
    3.1.4.53 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-180024 DARPP-32 events
    R-HSA-418555 G alpha (s) signalling events

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00762;UER00747

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC:3.1.4.53)
    Alternative name(s):
    DPDE2
    PDE46
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PDE4A
    Synonyms:DPDE2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:8780 PDE4A

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600126 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P27815

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    5141

    Open Targets

    More...
    OpenTargetsi
    ENSG00000065989

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33128

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P27815

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL254

    Drug and drug target database

    More...
    DrugBanki
    DB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
    DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
    DB05676 Apremilast
    DB00201 Caffeine
    DB05219 Crisaborole
    DB00975 Dipyridamole
    DB06751 Drotaverine
    DB00651 Dyphylline
    DB00824 Enprofylline
    DB05266 Ibudilast
    DB01088 Iloprost
    DB01303 Oxtriphylline
    DB00806 Pentoxifylline
    DB01791 Piclamilast
    DB06479 Propentofylline
    DB01656 Roflumilast
    DB00277 Theophylline
    DB08811 Tofisopam
    DB09283 Trapidil

    DrugCentral

    More...
    DrugCentrali
    P27815

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    1300

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PDE4A

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    116242706

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988061 – 886cAMP-specific 3',5'-cyclic phosphodiesterase 4AAdd BLAST886

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei13PhosphoserineCombined sources1
    Modified residuei152Phosphoserine; by MAPKAPK2By similarity1
    Modified residuei157PhosphoserineBy similarity1
    Modified residuei165PhosphoserineCombined sources1
    Modified residuei209PhosphoserineCombined sources1
    Modified residuei346PhosphoserineCombined sources1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki358Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
    Modified residuei686Phosphoserine1 Publication1
    Modified residuei688Phosphoserine1 Publication1
    Isoform 2 (identifier: P27815-2)
    Modified residuei119Phosphoserine1 Publication1
    Isoform 7 (identifier: P27815-7)
    Modified residuei123Phosphoserine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.By similarity1 Publication
    Proteolytically cleaved by caspase-3.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sitei69 – 70Cleavage; by caspase-32

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P27815

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    P27815

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P27815

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P27815

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P27815

    PeptideAtlas

    More...
    PeptideAtlasi
    P27815

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P27815

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    54411 [P27815-1]
    54412 [P27815-2]
    54413 [P27815-3]
    54414 [P27815-4]
    54415 [P27815-5]
    54416 [P27815-6]
    54417 [P27815-7]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P27815

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P27815

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).3 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000065989 Expressed in 209 organ(s), highest expression level in occipital lobe

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P27815 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P27815 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB017632
    HPA043310
    HPA076091

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Isoform 1 interacts with LYN. Isoform 2 and isoform 6 interact weakly with LYN. Isoform 1, isoform 2 and isoform 6 interact with ARRB2.

    4 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    111167, 10 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P27815, 8 interactors

    Molecular INTeraction database

    More...
    MINTi
    P27815

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000370078

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    P27815

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1886
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P27815

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    P27815

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini357 – 686PDEasePROSITE-ProRule annotationAdd BLAST330

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3689 Eukaryota
    ENOG410XRI7 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159788

    KEGG Orthology (KO)

    More...
    KOi
    K13293

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FAACVHD

    Database of Orthologous Groups

    More...
    OrthoDBi
    904682at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P27815

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF314638

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00077 HDc, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.1300.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003607 HD/PDEase_dom
    IPR040844 PDE4_UCR
    IPR023088 PDEase
    IPR002073 PDEase_catalytic_dom
    IPR036971 PDEase_catalytic_dom_sf
    IPR023174 PDEase_CS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF18100 PDE4_UCR, 1 hit
    PF00233 PDEase_I, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00387 PDIESTERASE1

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00471 HDc, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00126 PDEASE_I_1, 1 hit
    PS51845 PDEASE_I_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Note: Additional isoforms seem to exist.

    This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P27815-1) [UniParc]FASTAAdd to basket
    Also known as: PDE4A4, PDE4A4B, PDE46

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MEPPTVPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYSD
    60 70 80 90 100
    SAERAERERQ PHRPIERADA MDTSDRPGLR TTRMSWPSSF HGTGTGSGGA
    110 120 130 140 150
    GGGSSRRFEA ENGPTPSPGR SPLDSQASPG LVLHAGAATS QRRESFLYRS
    160 170 180 190 200
    DSDYDMSPKT MSRNSSVTSE AHAEDLIVTP FAQVLASLRS VRSNFSLLTN
    210 220 230 240 250
    VPVPSNKRSP LGGPTPVCKA TLSEETCQQL ARETLEELDW CLEQLETMQT
    260 270 280 290 300
    YRSVSEMASH KFKRMLNREL THLSEMSRSG NQVSEYISTT FLDKQNEVEI
    310 320 330 340 350
    PSPTMKEREK QQAPRPRPSQ PPPPPVPHLQ PMSQITGLKK LMHSNSLNNS
    360 370 380 390 400
    NIPRFGVKTD QEELLAQELE NLNKWGLNIF CVSDYAGGRS LTCIMYMIFQ
    410 420 430 440 450
    ERDLLKKFRI PVDTMVTYML TLEDHYHADV AYHNSLHAAD VLQSTHVLLA
    460 470 480 490 500
    TPALDAVFTD LEILAALFAA AIHDVDHPGV SNQFLINTNS ELALMYNDES
    510 520 530 540 550
    VLENHHLAVG FKLLQEDNCD IFQNLSKRQR QSLRKMVIDM VLATDMSKHM
    560 570 580 590 600
    TLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLRNMVHCA DLSNPTKPLE
    610 620 630 640 650
    LYRQWTDRIM AEFFQQGDRE RERGMEISPM CDKHTASVEK SQVGFIDYIV
    660 670 680 690 700
    HPLWETWADL VHPDAQEILD TLEDNRDWYY SAIRQSPSPP PEEESRGPGH
    710 720 730 740 750
    PPLPDKFQFE LTLEEEEEEE ISMAQIPCTA QEALTAQGLS GVEEALDATI
    760 770 780 790 800
    AWEASPAQES LEVMAQEASL EAELEAVYLT QQAQSTGSAP VAPDEFSSRE
    810 820 830 840 850
    EFVVAVSHSS PSALALQSPL LPAWRTLSVS EHAPGLPGLP STAAEVEAQR
    860 870 880
    EHQAAKRACS ACAGTFGEDT SALPAPGGGG SGGDPT
    Length:886
    Mass (Da):98,143
    Last modified:October 17, 2006 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92BB9B98BED711E7
    GO
    Isoform 2 (identifier: P27815-2) [UniParc]FASTAAdd to basket
    Also known as: TM3, PDE4A11

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: MEPPTVPSER...GGAGGGSSRR → MARPRGLGRI...LGRQAWAGAG

    Show »
    Length:860
    Mass (Da):95,236
    Checksum:i6A4FC32E8AF7559D
    GO
    Isoform 3 (identifier: P27815-3) [UniParc]FASTAAdd to basket
    Also known as: PDE4A7, PDE4A6

    The sequence of this isoform differs from the canonical sequence as follows:
         1-209: MEPPTVPSER...NVPVPSNKRS → MCPFPVTTV

    Show »
    Length:686
    Mass (Da):76,380
    Checksum:i35F0A712804410AF
    GO
    Isoform 4 (identifier: P27815-4) [UniParc]FASTAAdd to basket
    Also known as: PDE4A1, RD1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-261: MEPPTVPSER...RSVSEMASHK → MPLVDFFCETCSKPWLVGWWDQ

    Show »
    Length:647
    Mass (Da):72,222
    Checksum:i622A0BA91B7AC938
    GO
    Isoform 5 (identifier: P27815-5) [UniParc]FASTAAdd to basket
    Also known as: PDE4A8A, 2EL

    The sequence of this isoform differs from the canonical sequence as follows:
         1-367: MEPPTVPSER...KTDQEELLAQ → MVLPSDQGFKLLGNVLQGPEPYRLLTSGLRLHQ
         644-657: GFIDYIVHPLWETW → QARGIDGRAQGGFY
         658-886: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Probably represents a non-functional splice isoform.
    Show »
    Length:323
    Mass (Da):36,706
    Checksum:i14D0EEF3D6CD4BEE
    GO
    Isoform 6 (identifier: P27815-6) [UniParc]FASTAAdd to basket
    Also known as: PDE4A10

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: MEPPTVPSER...GGAGGGSSRR → MRSGAAPRAR...RRHPPGRSVS

    Show »
    Length:825
    Mass (Da):91,323
    Checksum:iB50A342801E605FB
    GO
    Isoform 7 (identifier: P27815-7) [UniParc]FASTAAdd to basket
    Also known as: PDE4A8

    The sequence of this isoform differs from the canonical sequence as follows:
         1-107: MEPPTVPSER...GGAGGGSSRR → MKRSRSALSV...ISITRAENDS

    Show »
    Length:864
    Mass (Da):95,571
    Checksum:i1AB6019FC85E37E4
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    K7ENX7K7ENX7_HUMAN
    cAMP-specific 3',5'-cyclic phosphod...
    PDE4A
    278Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    K7EKV1K7EKV1_HUMAN
    cAMP-specific 3',5'-cyclic phosphod...
    PDE4A
    96Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059544736A → E2 PublicationsCorresponds to variant dbSNP:rs1051738Ensembl.1
    Natural variantiVAR_059545808H → Y. Corresponds to variant dbSNP:rs2230190Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0045591 – 367MEPPT…ELLAQ → MVLPSDQGFKLLGNVLQGPE PYRLLTSGLRLHQ in isoform 5. 2 PublicationsAdd BLAST367
    Alternative sequenceiVSP_0045581 – 261MEPPT…MASHK → MPLVDFFCETCSKPWLVGWW DQ in isoform 4. 2 PublicationsAdd BLAST261
    Alternative sequenceiVSP_0045571 – 209MEPPT…SNKRS → MCPFPVTTV in isoform 3. 3 PublicationsAdd BLAST209
    Alternative sequenceiVSP_0045561 – 107MEPPT…GSSRR → MARPRGLGRIPELQLVAFPV AVAAEDEAFLPEPLAPRAPR RPRSPPSSPVFFASPSPTFR RRLRLLRSCQDLGRQAWAGA G in isoform 2. 2 PublicationsAdd BLAST107
    Alternative sequenceiVSP_0381851 – 107MEPPT…GSSRR → MRSGAAPRARPRPPALALPP TGPESLTHFPFSDEDTRRHP PGRSVS in isoform 6. 1 PublicationAdd BLAST107
    Alternative sequenceiVSP_0381861 – 107MEPPT…GSSRR → MKRSRSALSVAGTGDERSRE TPESDRANMLGADLRRPRRR LSSGPGLGWAQPEPSDPGVP LPPRPTTLPLLIPPRISITR AENDS in isoform 7. 1 PublicationAdd BLAST107
    Alternative sequenceiVSP_004560644 – 657GFIDY…LWETW → QARGIDGRAQGGFY in isoform 5. 2 PublicationsAdd BLAST14
    Alternative sequenceiVSP_004561658 – 886Missing in isoform 5. 2 PublicationsAdd BLAST229

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    L20965 mRNA Translation: AAA03588.1
    S75213 mRNA Translation: AAB33798.1
    U18087 mRNA Translation: AAC50458.1
    U18088 mRNA Translation: AAA98540.1
    AF069491
    , AF069487, AF069489, AF069490 Genomic DNA Translation: AAC35012.1
    AF069491, AF069489, AF069490 Genomic DNA Translation: AAC35013.1
    AF069491, AF069489, AF069490 Genomic DNA Translation: AAC35014.1
    AF069491
    , AF069488, AF069489, AF069490 Genomic DNA Translation: AAC35015.1
    U68532 mRNA Translation: AAC63832.1
    U97584 mRNA Translation: AAC25679.1
    AF073745 mRNA Translation: AAD34217.2
    AY618547 mRNA Translation: AAU82096.1
    AY593872 mRNA Translation: AAT00628.1
    AC011548 Genomic DNA No translation available.
    AC011529 Genomic DNA No translation available.
    AC011461 Genomic DNA No translation available.
    CH471106 Genomic DNA Translation: EAW84104.1
    CH471106 Genomic DNA Translation: EAW84105.1
    CH471106 Genomic DNA Translation: EAW84108.1
    BC019864 mRNA Translation: AAH19864.1
    BC038234 mRNA Translation: AAH38234.1
    M37744 mRNA Translation: AAA69697.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS12238.1 [P27815-4]
    CCDS45961.1 [P27815-1]
    CCDS45962.1 [P27815-2]
    CCDS45963.1 [P27815-6]
    CCDS58649.1 [P27815-7]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A54442
    S55348

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001104777.1, NM_001111307.1 [P27815-1]
    NP_001104778.1, NM_001111308.1 [P27815-2]
    NP_001104779.1, NM_001111309.1 [P27815-6]
    NP_001230050.1, NM_001243121.1 [P27815-7]
    NP_006193.1, NM_006202.2 [P27815-4]
    XP_011526356.1, XM_011528054.1 [P27815-7]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000293683; ENSP00000293683; ENSG00000065989 [P27815-2]
    ENST00000344979; ENSP00000341007; ENSG00000065989 [P27815-4]
    ENST00000380702; ENSP00000370078; ENSG00000065989 [P27815-1]
    ENST00000440014; ENSP00000394754; ENSG00000065989 [P27815-6]
    ENST00000592685; ENSP00000468507; ENSG00000065989 [P27815-7]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    5141

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:5141

    UCSC genome browser

    More...
    UCSCi
    uc002moj.3 human [P27815-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    L20965 mRNA Translation: AAA03588.1
    S75213 mRNA Translation: AAB33798.1
    U18087 mRNA Translation: AAC50458.1
    U18088 mRNA Translation: AAA98540.1
    AF069491
    , AF069487, AF069489, AF069490 Genomic DNA Translation: AAC35012.1
    AF069491, AF069489, AF069490 Genomic DNA Translation: AAC35013.1
    AF069491, AF069489, AF069490 Genomic DNA Translation: AAC35014.1
    AF069491
    , AF069488, AF069489, AF069490 Genomic DNA Translation: AAC35015.1
    U68532 mRNA Translation: AAC63832.1
    U97584 mRNA Translation: AAC25679.1
    AF073745 mRNA Translation: AAD34217.2
    AY618547 mRNA Translation: AAU82096.1
    AY593872 mRNA Translation: AAT00628.1
    AC011548 Genomic DNA No translation available.
    AC011529 Genomic DNA No translation available.
    AC011461 Genomic DNA No translation available.
    CH471106 Genomic DNA Translation: EAW84104.1
    CH471106 Genomic DNA Translation: EAW84105.1
    CH471106 Genomic DNA Translation: EAW84108.1
    BC019864 mRNA Translation: AAH19864.1
    BC038234 mRNA Translation: AAH38234.1
    M37744 mRNA Translation: AAA69697.1
    CCDSiCCDS12238.1 [P27815-4]
    CCDS45961.1 [P27815-1]
    CCDS45962.1 [P27815-2]
    CCDS45963.1 [P27815-6]
    CCDS58649.1 [P27815-7]
    PIRiA54442
    S55348
    RefSeqiNP_001104777.1, NM_001111307.1 [P27815-1]
    NP_001104778.1, NM_001111308.1 [P27815-2]
    NP_001104779.1, NM_001111309.1 [P27815-6]
    NP_001230050.1, NM_001243121.1 [P27815-7]
    NP_006193.1, NM_006202.2 [P27815-4]
    XP_011526356.1, XM_011528054.1 [P27815-7]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2QYKX-ray2.10A/B351-683[»]
    3I8VX-ray2.25A/B351-683[»]
    3TVXX-ray2.84A/B351-683[»]
    SMRiP27815
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi111167, 10 interactors
    IntActiP27815, 8 interactors
    MINTiP27815
    STRINGi9606.ENSP00000370078

    Chemistry databases

    BindingDBiP27815
    ChEMBLiCHEMBL254
    DrugBankiDB06842 (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
    DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
    DB05676 Apremilast
    DB00201 Caffeine
    DB05219 Crisaborole
    DB00975 Dipyridamole
    DB06751 Drotaverine
    DB00651 Dyphylline
    DB00824 Enprofylline
    DB05266 Ibudilast
    DB01088 Iloprost
    DB01303 Oxtriphylline
    DB00806 Pentoxifylline
    DB01791 Piclamilast
    DB06479 Propentofylline
    DB01656 Roflumilast
    DB00277 Theophylline
    DB08811 Tofisopam
    DB09283 Trapidil
    DrugCentraliP27815
    GuidetoPHARMACOLOGYi1300

    PTM databases

    iPTMnetiP27815
    PhosphoSitePlusiP27815

    Polymorphism and mutation databases

    BioMutaiPDE4A
    DMDMi116242706

    Proteomic databases

    EPDiP27815
    jPOSTiP27815
    MassIVEiP27815
    MaxQBiP27815
    PaxDbiP27815
    PeptideAtlasiP27815
    PRIDEiP27815
    ProteomicsDBi54411 [P27815-1]
    54412 [P27815-2]
    54413 [P27815-3]
    54414 [P27815-4]
    54415 [P27815-5]
    54416 [P27815-6]
    54417 [P27815-7]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    5141

    Genome annotation databases

    EnsembliENST00000293683; ENSP00000293683; ENSG00000065989 [P27815-2]
    ENST00000344979; ENSP00000341007; ENSG00000065989 [P27815-4]
    ENST00000380702; ENSP00000370078; ENSG00000065989 [P27815-1]
    ENST00000440014; ENSP00000394754; ENSG00000065989 [P27815-6]
    ENST00000592685; ENSP00000468507; ENSG00000065989 [P27815-7]
    GeneIDi5141
    KEGGihsa:5141
    UCSCiuc002moj.3 human [P27815-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    5141
    DisGeNETi5141

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PDE4A
    HGNCiHGNC:8780 PDE4A
    HPAiCAB017632
    HPA043310
    HPA076091
    MIMi600126 gene
    neXtProtiNX_P27815
    OpenTargetsiENSG00000065989
    PharmGKBiPA33128

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3689 Eukaryota
    ENOG410XRI7 LUCA
    GeneTreeiENSGT00940000159788
    KOiK13293
    OMAiFAACVHD
    OrthoDBi904682at2759
    PhylomeDBiP27815
    TreeFamiTF314638

    Enzyme and pathway databases

    UniPathwayiUPA00762;UER00747
    BRENDAi3.1.4.17 2681
    3.1.4.53 2681
    ReactomeiR-HSA-180024 DARPP-32 events
    R-HSA-418555 G alpha (s) signalling events

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PDE4A human
    EvolutionaryTraceiP27815

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    PDE4A

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    5141
    PharosiP27815

    Protein Ontology

    More...
    PROi
    PR:P27815

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000065989 Expressed in 209 organ(s), highest expression level in occipital lobe
    ExpressionAtlasiP27815 baseline and differential
    GenevisibleiP27815 HS

    Family and domain databases

    CDDicd00077 HDc, 1 hit
    Gene3Di1.10.1300.10, 1 hit
    InterProiView protein in InterPro
    IPR003607 HD/PDEase_dom
    IPR040844 PDE4_UCR
    IPR023088 PDEase
    IPR002073 PDEase_catalytic_dom
    IPR036971 PDEase_catalytic_dom_sf
    IPR023174 PDEase_CS
    PfamiView protein in Pfam
    PF18100 PDE4_UCR, 1 hit
    PF00233 PDEase_I, 1 hit
    PRINTSiPR00387 PDIESTERASE1
    SMARTiView protein in SMART
    SM00471 HDc, 1 hit
    PROSITEiView protein in PROSITE
    PS00126 PDEASE_I_1, 1 hit
    PS51845 PDEASE_I_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDE4A_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P27815
    Secondary accession number(s): O75522
    , O76092, Q16255, Q16691, Q5DM53, Q6PMT2, Q8IVA7, Q8WUQ3, Q9H3H2
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
    Last sequence update: October 17, 2006
    Last modified: October 16, 2019
    This is version 187 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again