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1 to 25 of 29  Show
  1. 1
    "Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme."
    Reuter K.K.H., Ficner R.
    J. Bacteriol. 177:5284-5288(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-7, FUNCTION, CATALYTIC ACTIVITY, PATHWAY, BIOPHYSICOCHEMICAL PROPERTIES.
    Category: Function, Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "Sequence analysis of 44B6 fosmid clone of Zymomonas mobilis ZM4."
    Ahn J.Y., Kang H.S.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).
  3. 3
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1735 other entries.

  4. 4
    "Cloning and molecular characterization of the DNA ligase gene (lig) from Zymomonas mobilis."
    Shark K.B., Conway T.
    FEMS Microbiol. Lett. 75:19-26(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 other entries.

  5. 5
    "Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase reveal aspartate 102 as the active site nucleophile."
    Romier C., Reuter K., Suck D., Ficner R.
    Biochemistry 35:15734-15739(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 1-386 IN COMPLEX WITH ZINC, MUTAGENESIS OF ASP-156.
    Category: Pathology & Biotech, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  6. 6
    "Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange."
    Romier C., Reuter K., Suck D., Ficner R.
    EMBO J. 15:2850-2857(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH ZINC.
    Category: Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  7. 7
    "Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity."
    Graedler U., Ficner R., Garcia G.A., Stubbs M.T., Klebe G., Reuter K.
    FEBS Lett. 454:142-146(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 11-382 IN COMPLEX WITH ZINC, MUTAGENESIS OF SER-103.
    Category: Pathology & Biotech, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  8. 8
    "A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase."
    Graedler U., Gerber H.-D., Goodenough-Lashua D.M., Garcia G.A., Ficner R., Reuter K., Stubbs M.T., Klebe G.
    J. Mol. Biol. 306:455-467(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH ZINC.
    Category: Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  9. 9
    "De novo design, synthesis, and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase: a dramatic sulfur effect on binding affinity."
    Meyer E.A., Brenk R., Castellano R.K., Furler M., Klebe G., Diederich F.
    ChemBioChem 3:250-253(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 12-386 IN COMPLEX WITH ZINC.
    Category: Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  10. 10
    "An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coli."
    Kittendorf J.D., Sgraja T., Reuter K., Klebe G., Garcia G.A.
    J. Biol. Chem. 278:42369-42376(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-383 OF MUTANT E-280 IN COMPLEX WITH ZINC.
    Category: Pathology & Biotech, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 1 other entry.

  11. 11
    "Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design."
    Brenk R., Stubbs M.T., Heine A., Reuter K., Klebe G.
    ChemBioChem 4:1066-1077(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH ZINC.
    Category: Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  12. 12
    "Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis."
    Brenk R., Naerum L., Graedler U., Gerber H.-D., Garcia G.A., Reuter K., Stubbs M.T., Klebe G.
    J. Med. Chem. 46:1133-1143(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 12-386 IN COMPLEX WITH ZINC.
    Category: Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  13. 13
    "Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate."
    Xie W., Liu X., Huang R.H.
    Nat. Struct. Biol. 10:781-788(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 1-386 IN COMPLEX WITH 9-DEAZAGUANINE AND ZINC, SUBUNIT, MUTAGENESIS OF ASP-280.
    Category: Pathology & Biotech, Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  14. 14
    "An integrative approach combining noncovalent mass spectrometry, enzyme kinetics and X-ray crystallography to decipher Tgt protein-protein and protein-RNA interaction."
    Ritschel T., Atmanene C., Reuter K., Van Dorsselaer A., Sanglier-Cianferani S., Klebe G.
    J. Mol. Biol. 393:833-847(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-386 IN COMPLEX WITH ZINC, SUBUNIT.
    Category: Interaction, Structure.
    Source: UniProtKB/Swiss-Prot (reviewed).
  15. 15
    "Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening."
    Brenk R., Meyer E.A., Reuter K., Stubbs M.T., Garcia G.A., Diederich F., Klebe G.
    J. Mol. Biol. 338:55-75(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:1Q63, PDB:1Q4W, PDB:1Q65, PDB:1Q66, PDB:1R5Y.
  16. 16
    "Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding."
    Stengl B., Meyer E.A., Heine A., Brenk R., Diederich F., Klebe G.
    J. Mol. Biol. 370:492-511(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:2BBF, PDB:1Y5X, PDB:1Y5V, PDB:1Y5W.
  17. 17
    "Potent inhibitors of tRNA-guanine transglycosylase, an enzyme linked to the pathogenicity of the Shigella bacterium: charge-assisted hydrogen bonding."
    Hortner S.R., Ritschel T., Stengl B., Kramer C., Schweizer W.B., Wagner B., Kansy M., Klebe G., Diederich F.
    Angew. Chem. Int. Ed. Engl. 46:8266-8269(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:2QZR.
  18. 18
    "Glutamate versus glutamine exchange swaps substrate selectivity in tRNA-guanine transglycosylase: insight into the regulation of substrate selectivity by kinetic and crystallographic studies."
    Tidten N., Stengl B., Heine A., Garcia G.A., Klebe G., Reuter K.
    J. Mol. Biol. 374:764-776(2007) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:2POT, PDB:2Z1V, PDB:2Z1W, PDB:2PWU, PDB:2OKO, PDB:2PWV, PDB:2QII, PDB:2Z1X.
  19. 19
    "Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT."
    Ritschel T., Hoertner S., Heine A., Diederich F., Klebe G.
    Chembiochem 10:716-727(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:2Z7K, PDB:3C2Y.
  20. 20
    "How to replace the residual solvation shell of polar active site residues to achieve nanomolar inhibition of tRNA-guanine transglycosylase."
    Ritschel T., Kohler P.C., Neudert G., Heine A., Diederich F., Klebe G.
    ChemMedChem 4:2012-2023(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:3GC5, PDB:3EOU, PDB:3EOS, PDB:3GE7, PDB:3GC4.
  21. 21
    "From lin-benzoguanines to lin-benzohypoxanthines as ligands for Zymomonas mobilis tRNA-guanine transglycosylase: replacement of protein-ligand hydrogen bonding by importing water clusters."
    Barandun L.J., Immekus F., Kohler P.C., Tonazzi S., Wagner B., Wendelspiess S., Ritschel T., Heine A., Kansy M., Klebe G., Diederich F.
    Chemistry 18:9246-9257(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:3S1G, PDB:3TLL, PDB:3SM0, PDB:3RR4.
  22. 22
    "Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor."
    Biela I., Tidten-Luksch N., Immekus F., Glinca S., Nguyen T.X., Gerber H.D., Heine A., Klebe G., Reuter K.
    PLoS ONE 8:e64240-e64240(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:4GCX, PDB:4HVX, PDB:4H7Z, PDB:3BLO, PDB:3BLD, PDB:2NQZ, PDB:4H6E, PDB:4E2V, PDB:4HSH, PDB:2NSO, PDB:4HQV, PDB:3BL3, PDB:4GD0, PDB:3BLL.

    This publication is mapped to 3 other entries.

  23. 23
    "Chasing protons: how isothermal titration calorimetry, mutagenesis, and pKa calculations trace the locus of charge in ligand binding to a tRNA-binding enzyme."
    Neeb M., Czodrowski P., Heine A., Barandun L.J., Hohn C., Diederich F., Klebe G.
    J. Med. Chem. 57:5554-5565(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:4PUK, PDB:4PUN, PDB:4PUJ, PDB:4PUL, PDB:4PUM.
  24. 24
    "Beyond affinity: enthalpy-entropy factorization unravels complexity of a flat structure-activity relationship for inhibition of a tRNA-modifying enzyme."
    Neeb M., Betz M., Heine A., Barandun L.J., Hohn C., Diederich F., Klebe G.
    J. Med. Chem. 57:5566-5578(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:4Q4R, PDB:4Q4S, PDB:4Q4Q, PDB:4Q4O, PDB:4Q4P.
  25. 25
    "Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme."
    Jakobi S., Nguyen T.X., Debaene F., Metz A., Sanglier-Cianferani S., Reuter K., Klebe G.
    Proteins 82:2713-2732(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:4DXX, PDB:3UNT, PDB:3UVI.
1 to 25 of 29  Show
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