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Entry version 163 (18 Sep 2019)
Sequence version 1 (01 Dec 1992)
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Protein

Sex muscle abnormal protein 5

Gene

sem-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23 (PubMed:1372395, PubMed:16547100). Involved in sex myoblast migration (PubMed:1372395, PubMed:9073451). Negatively regulates fluid homeostasis probably downstream of egl-15 (PubMed:1372395, PubMed:11689700). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl-15 (PubMed:16495308). Involved in cytoskeleton dynamics and is recruited by mig-13 to the leading edge of Q neuroblasts and their descendants to signal downstream to activate the wsp-1 pathway and direct migration along the anteroposterior body axis during larval development (PubMed:27780040). Involved in let-23-mediated regulation of fertility independently of let-60/Ras (PubMed:16547100). Negatively regulates daf-2-mediated repression of dauer formation (PubMed:16547100). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord (PubMed:15990870). May play a role in oocyte development upstream of let-60/Ras and the MAP kinase pathway (PubMed:12169634).8 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-109704 PI3K Cascade
R-CEL-1257604 PIP3 activates AKT signaling
R-CEL-1433557 Signaling by SCF-KIT
R-CEL-1433559 Regulation of KIT signaling
R-CEL-179812 GRB2 events in EGFR signaling
R-CEL-180292 GAB1 signalosome
R-CEL-180336 SHC1 events in EGFR signaling
R-CEL-182971 EGFR downregulation
R-CEL-186763 Downstream signal transduction
R-CEL-1963640 GRB2 events in ERBB2 signaling
R-CEL-1963642 PI3K events in ERBB2 signaling
R-CEL-2029482 Regulation of actin dynamics for phagocytic cup formation
R-CEL-210993 Tie2 Signaling
R-CEL-2179392 EGFR Transactivation by Gastrin
R-CEL-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CEL-375165 NCAM signaling for neurite out-growth
R-CEL-5654688 SHC-mediated cascade:FGFR1
R-CEL-5654689 PI-3K cascade:FGFR1
R-CEL-5654693 FRS-mediated FGFR1 signaling
R-CEL-5654695 PI-3K cascade:FGFR2
R-CEL-5654699 SHC-mediated cascade:FGFR2
R-CEL-5654700 FRS-mediated FGFR2 signaling
R-CEL-5654704 SHC-mediated cascade:FGFR3
R-CEL-5654706 FRS-mediated FGFR3 signaling
R-CEL-5654710 PI-3K cascade:FGFR3
R-CEL-5654712 FRS-mediated FGFR4 signaling
R-CEL-5654720 PI-3K cascade:FGFR4
R-CEL-5654726 Negative regulation of FGFR1 signaling
R-CEL-5654727 Negative regulation of FGFR2 signaling
R-CEL-5654732 Negative regulation of FGFR3 signaling
R-CEL-5663213 RHO GTPases Activate WASPs and WAVEs
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-6807004 Negative regulation of MET activity
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CEL-74751 Insulin receptor signalling cascade
R-CEL-8851805 MET activates RAS signaling
R-CEL-8851907 MET activates PI3K/AKT signaling
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis
R-CEL-8875555 MET activates RAP1 and RAC1
R-CEL-8875656 MET receptor recycling
R-CEL-912631 Regulation of signaling by CBL
R-CEL-9607240 FLT3 Signaling
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P29355

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sex muscle abnormal protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sem-5
ORF Names:C14F5.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C14F5.5 ; CE01784 ; WBGene00004774 ; sem-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown or RNAi-mediated knockdown in body wall muscles causes ectopic membrane extensions from body wall muscles.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49P → L in n1619; lethal at the larval stage, mild defect in vulva development and partially impaired sex myoblast migration. Rescues fluid accumulation in crl-1 e1745ts mutant. 1 Publication1
Mutagenesisi87R → Q in ay73; partial rod-like larval lethality. Surviving mutant have a thin body and no vulva. Rescues fluid accumulation in clr-1 e1745ts mutant. 1 Publication1
Mutagenesisi90E → K in n1779; mild defect in vulva development and partially impaired sex myoblast migration. Causes ectopic muscle membrane extension. Reduced lev-1 synaptic levels. Moderate increase in resistance to nicotine-induced paralysis. Rescues fluid accumulation in crl-1 e1745ts mutant. 3 Publications1
Mutagenesisi91S → N in n1781; no obvious defects. Partially rescues fluid accumulation in crl-1 e1745ts mutant. 1 Publication1
Mutagenesisi201G → R in n2195; loss of interaction with soc-1. Partially restores normal vulva induction in let-60 n1046gf mutant. Partially rescues fluid accumulation in crl-1 e1745ts mutant. Partially prevents constitutive dauer formation in daf-2 m577 mutant. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000882121 – 228Sex muscle abnormal protein 5Add BLAST228

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29355

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29355

PeptideAtlas

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PeptideAtlasi
P29355

PRoteomics IDEntifications database

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PRIDEi
P29355

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body wall muscles, pharynx, intestine and hypodermis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004774 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (probably via SH3 domain 2) with soc-1 (via C-terminus) (PubMed:16547100).

Interacts with mig-2 (active GTP-bound form) and wsp-1 (PubMed:27780040).

Interacts with mig-13; the interaction is direct (PubMed:27780040).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Sos1Q622452EBI-315286,EBI-1693From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
45979, 114 interactors

Database of interacting proteins

More...
DIPi
DIP-27394N

Protein interaction database and analysis system

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IntActi
P29355, 27 interactors

Molecular INTeraction database

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MINTi
P29355

STRING: functional protein association networks

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STRINGi
6239.C14F5.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29355

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P29355

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 58SH3 1PROSITE-ProRule annotationAdd BLAST58
Domaini60 – 152SH2PROSITE-ProRule annotationAdd BLAST93
Domaini154 – 213SH3 2PROSITE-ProRule annotationAdd BLAST60

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GRB2/sem-5/DRK family.Curated

Keywords - Domaini

Repeat, SH2 domain, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3601 Eukaryota
ENOG410XR1G LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000251625

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P29355

KEGG Orthology (KO)

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KOi
K04364

Identification of Orthologs from Complete Genome Data

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OMAi
HWWHGEI

Database of Orthologous Groups

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OrthoDBi
1091250at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P29355

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.505.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00401 SH2DOMAIN
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P29355-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAVAEHDFQ AGSPDELSFK RGNTLKVLNK DEDPHWYKAE LDGNEGFIPS
60 70 80 90 100
NYIRMTECNW YLGKITRNDA EVLLKKPTVR DGHFLVRQCE SSPGEFSISV
110 120 130 140 150
RFQDSVQHFK VLRDQNGKYY LWAVKFNSLN ELVAYHRTAS VSRTHTILLS
160 170 180 190 200
DMNVETKFVQ ALFDFNPQES GELAFKRGDV ITLINKDDPN WWEGQLNNRR
210 220
GIFPSNYVCP YNSNKSNSNV APGFNFGN
Length:228
Mass (Da):26,210
Last modified:December 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D684C9520646C41
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S88446 mRNA Translation: AAB21850.1
FO080456 Genomic DNA Translation: CCD63850.1

Protein sequence database of the Protein Information Resource

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PIRi
S25730

NCBI Reference Sequences

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RefSeqi
NP_509342.1, NM_076941.5

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
C14F5.5.1; C14F5.5.1; WBGene00004774

Database of genes from NCBI RefSeq genomes

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GeneIDi
181055

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_C14F5.5

UCSC genome browser

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UCSCi
C14F5.5 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S88446 mRNA Translation: AAB21850.1
FO080456 Genomic DNA Translation: CCD63850.1
PIRiS25730
RefSeqiNP_509342.1, NM_076941.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K76NMR-A155-214[»]
1KFZNMR-A155-214[»]
1SEMX-ray2.00A/B155-212[»]
2SEMX-ray2.20A/B155-214[»]
3SEMX-ray2.20A/B155-214[»]
SMRiP29355
ModBaseiSearch...

Protein-protein interaction databases

BioGridi45979, 114 interactors
DIPiDIP-27394N
IntActiP29355, 27 interactors
MINTiP29355
STRINGi6239.C14F5.5

Proteomic databases

EPDiP29355
PaxDbiP29355
PeptideAtlasiP29355
PRIDEiP29355

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC14F5.5.1; C14F5.5.1; WBGene00004774
GeneIDi181055
KEGGicel:CELE_C14F5.5
UCSCiC14F5.5 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181055
WormBaseiC14F5.5 ; CE01784 ; WBGene00004774 ; sem-5

Phylogenomic databases

eggNOGiKOG3601 Eukaryota
ENOG410XR1G LUCA
GeneTreeiENSGT00940000155738
HOGENOMiHOG000251625
InParanoidiP29355
KOiK04364
OMAiHWWHGEI
OrthoDBi1091250at2759
PhylomeDBiP29355

Enzyme and pathway databases

ReactomeiR-CEL-109704 PI3K Cascade
R-CEL-1257604 PIP3 activates AKT signaling
R-CEL-1433557 Signaling by SCF-KIT
R-CEL-1433559 Regulation of KIT signaling
R-CEL-179812 GRB2 events in EGFR signaling
R-CEL-180292 GAB1 signalosome
R-CEL-180336 SHC1 events in EGFR signaling
R-CEL-182971 EGFR downregulation
R-CEL-186763 Downstream signal transduction
R-CEL-1963640 GRB2 events in ERBB2 signaling
R-CEL-1963642 PI3K events in ERBB2 signaling
R-CEL-2029482 Regulation of actin dynamics for phagocytic cup formation
R-CEL-210993 Tie2 Signaling
R-CEL-2179392 EGFR Transactivation by Gastrin
R-CEL-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CEL-375165 NCAM signaling for neurite out-growth
R-CEL-5654688 SHC-mediated cascade:FGFR1
R-CEL-5654689 PI-3K cascade:FGFR1
R-CEL-5654693 FRS-mediated FGFR1 signaling
R-CEL-5654695 PI-3K cascade:FGFR2
R-CEL-5654699 SHC-mediated cascade:FGFR2
R-CEL-5654700 FRS-mediated FGFR2 signaling
R-CEL-5654704 SHC-mediated cascade:FGFR3
R-CEL-5654706 FRS-mediated FGFR3 signaling
R-CEL-5654710 PI-3K cascade:FGFR3
R-CEL-5654712 FRS-mediated FGFR4 signaling
R-CEL-5654720 PI-3K cascade:FGFR4
R-CEL-5654726 Negative regulation of FGFR1 signaling
R-CEL-5654727 Negative regulation of FGFR2 signaling
R-CEL-5654732 Negative regulation of FGFR3 signaling
R-CEL-5663213 RHO GTPases Activate WASPs and WAVEs
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-6807004 Negative regulation of MET activity
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-CEL-74751 Insulin receptor signalling cascade
R-CEL-8851805 MET activates RAS signaling
R-CEL-8851907 MET activates PI3K/AKT signaling
R-CEL-8856825 Cargo recognition for clathrin-mediated endocytosis
R-CEL-8856828 Clathrin-mediated endocytosis
R-CEL-8875555 MET activates RAP1 and RAC1
R-CEL-8875656 MET receptor recycling
R-CEL-912631 Regulation of signaling by CBL
R-CEL-9607240 FLT3 Signaling
R-CEL-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
SignaLinkiP29355

Miscellaneous databases

EvolutionaryTraceiP29355

Protein Ontology

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PROi
PR:P29355

Gene expression databases

BgeeiWBGene00004774 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF00018 SH3_1, 2 hits
PRINTSiPR00401 SH2DOMAIN
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
PS50002 SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEM5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29355
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 18, 2019
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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