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Entry version 191 (18 Sep 2019)
Sequence version 2 (23 Jan 2002)
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Protein

Serpin B3

Gene

SERPINB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH2-terminal kinase (JNK1).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei354 – 355Reactive bond2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I04.008

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serpin B3
Alternative name(s):
Protein T4-A
Squamous cell carcinoma antigen 1
Short name:
SCCA-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SERPINB3
Synonyms:SCCA, SCCA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10569 SERPINB3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600517 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P29508

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi341A → R: Loss of inhibitory activity. 1 Publication1
Mutagenesisi352F → A: Loss of inhibitory activity. 2 Publications1
Mutagenesisi352F → G: Loss of inhibitory activity to papain but does not decrease the suppression activity to MAPK8. 2 Publications1
Mutagenesisi354 – 355SS → PP: Loss of inhibitory activity. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
6317

Open Targets

More...
OpenTargetsi
ENSG00000057149

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35538

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03929 D-Serine
DB04522 Dexfosfoserine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SERPINB3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20141712

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000941031 – 390Serpin B3Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P29508

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P29508

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P29508

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P29508

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29508

PeptideAtlas

More...
PeptideAtlasi
P29508

PRoteomics IDEntifications database

More...
PRIDEi
P29508

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54582 [P29508-1]
54583 [P29508-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P29508-1 [P29508-1]
P29508-2 [P29508-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
P29508

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P29508

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P29508

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P29508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Strongly up-regulated in the upper epidermis of sun-exposed skin.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000057149 Expressed in 108 organ(s), highest expression level in ectocervix

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29508 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB018772
CAB036006
CAB036007
HPA048341
HPA049988
HPA055992

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAPK8/JNK1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112223, 58 interactors

Protein interaction database and analysis system

More...
IntActi
P29508, 29 interactors

Molecular INTeraction database

More...
MINTi
P29508

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000283752

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1390
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P29508

Database of comparative protein structure models

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ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P29508

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2392 Eukaryota
COG4826 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154520

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29508

KEGG Orthology (KO)

More...
KOi
K13963

Identification of Orthologs from Complete Genome Data

More...
OMAi
NYGSEAR

Database of Orthologous Groups

More...
OrthoDBi
1124079at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29508

TreeFam database of animal gene trees

More...
TreeFami
TF352619

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.39.10, 1 hit
3.30.497.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2

The PANTHER Classification System

More...
PANTHERi
PTHR11461 PTHR11461, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00079 Serpin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00093 SERPIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56574 SSF56574, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00284 SERPIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P29508-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA
60 70 80 90 100
QQIKKVLHFD QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE
110 120 130 140 150
LKIANKLFGE KTYLFLQEYL DAIKKFYQTS VESVDFANAP EESRKKINSW
160 170 180 190 200
VESQTNEKIK NLIPEGNIGS NTTLVLVNAI YFKGQWEKKF NKEDTKEEKF
210 220 230 240 250
WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD LSMIVLLPNE
260 270 280 290 300
IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR
310 320 330 340 350
TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV
360 370 380 390
GFGSSPTSTN EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP
Length:390
Mass (Da):44,565
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5F27F986C752CFA
GO
Isoform 2 (identifier: P29508-2) [UniParc]FASTAAdd to basket
Also known as: SCCA1b

The sequence of this isoform differs from the canonical sequence as follows:
     205-256: Missing.

Show »
Length:338
Mass (Da):38,550
Checksum:i5AA4782FF0C1ABDF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO11731 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16F → S in CAD56658 (PubMed:12975381).Curated1
Sequence conflicti47D → N in CAD56658 (PubMed:12975381).Curated1
Sequence conflicti105N → T in CAD56658 (PubMed:12975381).Curated1
Sequence conflicti185Q → R in AAO92272 (Ref. 5) Curated1
Sequence conflicti202P → S in AAO92272 (Ref. 5) Curated1
Sequence conflicti278T → A in AAO92269 (Ref. 5) Curated1
Sequence conflicti349V → E in AAO92272 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024351351G → A Increased antiprotease activity and increased MAPK8 inhibition activity. 4 PublicationsCorresponds to variant dbSNP:rs3180227Ensembl.1
Natural variantiVAR_024352357T → A3 PublicationsCorresponds to variant dbSNP:rs1065205Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032657205 – 256Missing in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S66896 mRNA Translation: AAB20405.1
U19556 mRNA Translation: AAA97552.1
U19568
, U19559, U19560, U19562, U19565, U19567 Genomic DNA Translation: AAA86317.1
U19562, U19559, U19560 Genomic DNA Translation: AAA86316.1
AB046399 mRNA Translation: BAB40772.1
AJ515706 mRNA Translation: CAD56658.1
AY245778 mRNA Translation: AAO92269.1
AY245781 mRNA Translation: AAO92272.1
EU852041 mRNA Translation: ACF21012.1
BT006748 mRNA Translation: AAP35394.1
AK222746 mRNA Translation: BAD96466.1
AK222753 mRNA Translation: BAD96473.1
AK314805 mRNA Translation: BAG37332.1
AC069356 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63156.1
CH471096 Genomic DNA Translation: EAW63157.1
BC005224 mRNA Translation: AAH05224.1
AY190327 mRNA Translation: AAO11731.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11987.1 [P29508-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I38201

NCBI Reference Sequences

More...
RefSeqi
NP_008850.1, NM_006919.2 [P29508-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000283752; ENSP00000283752; ENSG00000057149 [P29508-1]
ENST00000332821; ENSP00000329498; ENSG00000057149 [P29508-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6317

UCSC genome browser

More...
UCSCi
uc002lji.3 human [P29508-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S66896 mRNA Translation: AAB20405.1
U19556 mRNA Translation: AAA97552.1
U19568
, U19559, U19560, U19562, U19565, U19567 Genomic DNA Translation: AAA86317.1
U19562, U19559, U19560 Genomic DNA Translation: AAA86316.1
AB046399 mRNA Translation: BAB40772.1
AJ515706 mRNA Translation: CAD56658.1
AY245778 mRNA Translation: AAO92269.1
AY245781 mRNA Translation: AAO92272.1
EU852041 mRNA Translation: ACF21012.1
BT006748 mRNA Translation: AAP35394.1
AK222746 mRNA Translation: BAD96466.1
AK222753 mRNA Translation: BAD96473.1
AK314805 mRNA Translation: BAG37332.1
AC069356 Genomic DNA No translation available.
CH471096 Genomic DNA Translation: EAW63156.1
CH471096 Genomic DNA Translation: EAW63157.1
BC005224 mRNA Translation: AAH05224.1
AY190327 mRNA Translation: AAO11731.1 Different initiation.
CCDSiCCDS11987.1 [P29508-1]
PIRiI38201
RefSeqiNP_008850.1, NM_006919.2 [P29508-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZV6X-ray2.70A/B/C2-390[»]
4ZK0X-ray2.15A1-390[»]
4ZK3X-ray2.00A1-390[»]
SMRiP29508
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112223, 58 interactors
IntActiP29508, 29 interactors
MINTiP29508
STRINGi9606.ENSP00000283752

Chemistry databases

DrugBankiDB03929 D-Serine
DB04522 Dexfosfoserine

Protein family/group databases

MEROPSiI04.008

PTM databases

iPTMnetiP29508
PhosphoSitePlusiP29508

Polymorphism and mutation databases

BioMutaiSERPINB3
DMDMi20141712

2D gel databases

SWISS-2DPAGEiP29508
UCD-2DPAGEiP29508

Proteomic databases

EPDiP29508
jPOSTiP29508
MassIVEiP29508
MaxQBiP29508
PaxDbiP29508
PeptideAtlasiP29508
PRIDEiP29508
ProteomicsDBi54582 [P29508-1]
54583 [P29508-2]
TopDownProteomicsiP29508-1 [P29508-1]
P29508-2 [P29508-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6317
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283752; ENSP00000283752; ENSG00000057149 [P29508-1]
ENST00000332821; ENSP00000329498; ENSG00000057149 [P29508-2]
GeneIDi6317
KEGGihsa:6317
UCSCiuc002lji.3 human [P29508-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6317
DisGeNETi6317

GeneCards: human genes, protein and diseases

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GeneCardsi
SERPINB3
HGNCiHGNC:10569 SERPINB3
HPAiCAB018772
CAB036006
CAB036007
HPA048341
HPA049988
HPA055992
MIMi600517 gene
neXtProtiNX_P29508
OpenTargetsiENSG00000057149
PharmGKBiPA35538

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00940000154520
InParanoidiP29508
KOiK13963
OMAiNYGSEAR
OrthoDBi1124079at2759
PhylomeDBiP29508
TreeFamiTF352619

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SERPINB3 human
EvolutionaryTraceiP29508

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SERPINB3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6317

Pharos

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Pharosi
P29508

Protein Ontology

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PROi
PR:P29508

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000057149 Expressed in 108 organ(s), highest expression level in ectocervix
GenevisibleiP29508 HS

Family and domain databases

Gene3Di2.30.39.10, 1 hit
3.30.497.10, 1 hit
InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
IPR042178 Serpin_sf_1
IPR042185 Serpin_sf_2
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPB3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29508
Secondary accession number(s): A6NDM2
, B2RBT5, B3W5Y6, Q53H28, Q53YB5, Q86VF3, Q86W04, Q8IWL4, Q8IXI3, Q96J21, Q9BYF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2002
Last modified: September 18, 2019
This is version 191 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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