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Entry version 168 (16 Oct 2019)
Sequence version 1 (01 Apr 1993)
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Protein

Clathrin heavy chain

Gene

Chc

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-177504 Retrograde neurotrophin signalling
R-DME-190873 Gap junction degradation
R-DME-196025 Formation of annular gap junctions
R-DME-432720 Lysosome Vesicle Biogenesis
R-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-437239 Recycling pathway of L1
R-DME-5099900 WNT5A-dependent internalization of FZD4
R-DME-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-8866427 VLDLR internalisation and degradation
R-DME-8964038 LDL clearance

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Clathrin heavy chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chc
ORF Names:CG9012
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000319 Chc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002057831 – 1678Clathrin heavy chainAdd BLAST1678

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P29742

PRoteomics IDEntifications database

More...
PRIDEi
P29742

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000319 Expressed in 31 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P29742 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P29742 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat (By similarity).

Interacts with sau (PubMed:24786584).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
P165685EBI-160368,EBI-112159

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
58885, 112 interactors

Database of interacting proteins

More...
DIPi
DIP-17970N

Protein interaction database and analysis system

More...
IntActi
P29742, 10 interactors

Molecular INTeraction database

More...
MINTi
P29742

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0073966

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P29742

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati538 – 684CHCR 1Add BLAST147
Repeati687 – 829CHCR 2Add BLAST143
Repeati834 – 973CHCR 3Add BLAST140
Repeati980 – 1125CHCR 4Add BLAST146
Repeati1129 – 1270CHCR 5Add BLAST142
Repeati1275 – 1421CHCR 6Add BLAST147
Repeati1424 – 1567CHCR 7Add BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 67WD40-like repeat 1Add BLAST44
Regioni68 – 107WD40-like repeat 2Add BLAST40
Regioni108 – 149WD40-like repeat 3Add BLAST42
Regioni150 – 195WD40-like repeat 4Add BLAST46
Regioni196 – 257WD40-like repeat 5Add BLAST62
Regioni258 – 301WD40-like repeat 6Add BLAST44
Regioni302 – 330WD40-like repeat 7Add BLAST29
Regioni1334 – 1643Involved in binding clathrin light chainBy similarityAdd BLAST310
Regioni1552 – 1677TrimerizationBy similarityAdd BLAST126

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the clathrin heavy chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0985 Eukaryota
ENOG410XPH1 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P29742

KEGG Orthology (KO)

More...
KOi
K04646

Identification of Orthologs from Complete Genome Data

More...
OMAi
NLMSAPQ

Database of Orthologous Groups

More...
OrthoDBi
17940at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P29742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 4 hits
2.130.10.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 5 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002290 Clathrin_H_chain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00299 CLH, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50236 CHCR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P29742-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQPLPIRFQ EHLQLTNVGI NANSFSFSTL TMESDKFICV REKVNDTAQV
60 70 80 90 100
VIIDMNDATN PTRRPISADS AIMNPASKVI ALKAQKTLQI FNIEMKSKMK
110 120 130 140 150
AHTMNEDVVF WKWISLNTLA LVTETSVFHW SMEGDSMPQK MFDRHSSLNG
160 170 180 190 200
CQIINYRCNA SQQWLLLVGI SALPSRVAGA MQLYSVERKV SQAIEGHAAS
210 220 230 240 250
FATFKIDANK EPTTLFCFAV RTATGGKLHI IEVGAPPNGN QPFAKKAVDV
260 270 280 290 300
FFPPEAQNDF PVAMQVSAKY DTIYLITKYG YIHLYDMETA TCIYMNRISA
310 320 330 340 350
DTIFVTAPHE ASGGIIGVNR KGQVLSVTVD EEQIIPYINT VLQNPDLALR
360 370 380 390 400
MAVRNNLAGA EDLFVRKFNK LFTAGQYAEA AKVAALAPKA ILRTPQTIQR
410 420 430 440 450
FQQVQTPAGS TTPPLLQYFG ILLDQGKLNK FESLELCRPV LLQGKKQLCE
460 470 480 490 500
KWLKEEKLEC SEELGDLVKA SDLTLALSIY LRANVPNKVI QCFAETGQFQ
510 520 530 540 550
KIVLYAKKVN YTPDYVFLLR SVMRSNPEQG AGFASMLVAE EEPLADINQI
560 570 580 590 600
VDIFMEHSMV QQCTAFLLDA LKHNRPAEGA LQTRLLEMNL MSAPQVADAI
610 620 630 640 650
LGNAMFTHYD RAHIAQLCEK AGLLQRALEH YTDLYDIKRA VVHTHMLNAE
660 670 680 690 700
WLVSFFGTLS VEDSLECLKA MLTANLRQNL QICVQIATKY HEQLTNKALI
710 720 730 740 750
DLFEGFKSYD GLFYFLSSIV NFSQDPEVHF KYIQAACKTN QIKEVERICR
760 770 780 790 800
ESNCYNPERV KNFLKEAKLT DQLPLIIVCD RFDFVHDLVL YLYRNNLQKY
810 820 830 840 850
IEIYVQKVNP SRLPVVVGGL LDVDCSEDII KNLILVVKGQ FSTDELVEEV
860 870 880 890 900
EKRNRLKLLL PWLESRVHEG CVEPATHNAL AKIYIDSNNN PERYLKENQY
910 920 930 940 950
YDSRVVGRYC EKRDPHLACV AYERGLCDRE LIAVCNENSL FKSEARYLVG
960 970 980 990 1000
RRDAELWAEV LSESNPYKRQ LIDQVVQTAL SETQDPDDIS VTVKAFMTAD
1010 1020 1030 1040 1050
LPNELIELLE KIILDSSVFS DHRNLQNLLI LTAIKADRTR VMDYINRLEN
1060 1070 1080 1090 1100
YDAPDIANIA ISNQLYEEAF AIFKKFDVNT SAIQVLIDQV NNLERANEFA
1110 1120 1130 1140 1150
ERCNEPAVWS QLAKAQLQQG LVKEAIDSYI KADDPSAYVD VVDVASKVES
1160 1170 1180 1190 1200
WDDLVRYLQM ARKKARESYI ESELIYAYAR TGRLADLEEF ISGPNHADIQ
1210 1220 1230 1240 1250
KIGNRCFSDG MYDAAKLLYN NVSNFARLAI TLVYLKEFQG AVDSARKANS
1260 1270 1280 1290 1300
TRTWKEVCFA CVDAEEFRLA QMCGLHIVVH ADELEDLINY YQNRGYFDEL
1310 1320 1330 1340 1350
IALLESALGL ERAHMGMFTE LAILYSKFKP SKMREHLELF WSRVNIPKVL
1360 1370 1380 1390 1400
RAAESAHLWS ELVFLYDKYE EYDNAVLAMM AHPTEAWREG HFKDIITKVA
1410 1420 1430 1440 1450
NIELYYKAIE FYLDFKPLLL NDMLLVLAPR MDHTRAVSYF SKTGYLPLVK
1460 1470 1480 1490 1500
PYLRSVQSLN NKAINEALNG LLIDEEDYQG LRNSIDGFDN FDNIALAQKL
1510 1520 1530 1540 1550
EKHELTEFRR IAAYLYKGNN RWKQSVELCK KDKLYKDAME YAAESCKQDI
1560 1570 1580 1590 1600
AEELLGWFLE RDAYDCFAAC LYQCYDLLRP DVILELAWKH KIVDFAMPYL
1610 1620 1630 1640 1650
IQVLREYTTK VDKLELNEAQ REKEDDSTEH KNIIQMEPQL MITAGPAMGI
1660 1670
PPQYAQNYPP GAATVTAAGG RNMGYPYL
Length:1,678
Mass (Da):191,177
Last modified:April 1, 1993 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73CAF8631BEE9BA3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X2JC31X2JC31_DROME
Clathrin heavy chain
Chc CHC, chc, chc1, Cla, CLH
1,678Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z14133 mRNA Translation: CAA78507.1
AE014298 Genomic DNA Translation: AAF48522.1
AE014298 Genomic DNA Translation: AAN09367.1
AE014298 Genomic DNA Translation: AAS65352.1
AE014298 Genomic DNA Translation: AAS65353.1
AE014298 Genomic DNA Translation: ABW09424.1
AE014298 Genomic DNA Translation: ABW09425.1
AY119615 mRNA Translation: AAM50269.1

Protein sequence database of the Protein Information Resource

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PIRi
S52588

NCBI Reference Sequences

More...
RefSeqi
NP_001096993.1, NM_001103523.2
NP_001096994.1, NM_001103524.2
NP_001285300.1, NM_001298371.1
NP_477042.1, NM_057694.3
NP_727901.1, NM_167466.2
NP_996451.1, NM_206728.2
NP_996452.1, NM_206729.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0074179; FBpp0073966; FBgn0000319
FBtr0074180; FBpp0073967; FBgn0000319
FBtr0074181; FBpp0089397; FBgn0000319
FBtr0074182; FBpp0089398; FBgn0000319
FBtr0112797; FBpp0111709; FBgn0000319
FBtr0112798; FBpp0111710; FBgn0000319
FBtr0339445; FBpp0308531; FBgn0000319

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32537

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9012

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14133 mRNA Translation: CAA78507.1
AE014298 Genomic DNA Translation: AAF48522.1
AE014298 Genomic DNA Translation: AAN09367.1
AE014298 Genomic DNA Translation: AAS65352.1
AE014298 Genomic DNA Translation: AAS65353.1
AE014298 Genomic DNA Translation: ABW09424.1
AE014298 Genomic DNA Translation: ABW09425.1
AY119615 mRNA Translation: AAM50269.1
PIRiS52588
RefSeqiNP_001096993.1, NM_001103523.2
NP_001096994.1, NM_001103524.2
NP_001285300.1, NM_001298371.1
NP_477042.1, NM_057694.3
NP_727901.1, NM_167466.2
NP_996451.1, NM_206728.2
NP_996452.1, NM_206729.2

3D structure databases

SMRiP29742
ModBaseiSearch...

Protein-protein interaction databases

BioGridi58885, 112 interactors
DIPiDIP-17970N
IntActiP29742, 10 interactors
MINTiP29742
STRINGi7227.FBpp0073966

Proteomic databases

PaxDbiP29742
PRIDEiP29742

Genome annotation databases

EnsemblMetazoaiFBtr0074179; FBpp0073966; FBgn0000319
FBtr0074180; FBpp0073967; FBgn0000319
FBtr0074181; FBpp0089397; FBgn0000319
FBtr0074182; FBpp0089398; FBgn0000319
FBtr0112797; FBpp0111709; FBgn0000319
FBtr0112798; FBpp0111710; FBgn0000319
FBtr0339445; FBpp0308531; FBgn0000319
GeneIDi32537
KEGGidme:Dmel_CG9012

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32537
FlyBaseiFBgn0000319 Chc

Phylogenomic databases

eggNOGiKOG0985 Eukaryota
ENOG410XPH1 LUCA
InParanoidiP29742
KOiK04646
OMAiNLMSAPQ
OrthoDBi17940at2759
PhylomeDBiP29742

Enzyme and pathway databases

ReactomeiR-DME-177504 Retrograde neurotrophin signalling
R-DME-190873 Gap junction degradation
R-DME-196025 Formation of annular gap junctions
R-DME-432720 Lysosome Vesicle Biogenesis
R-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-437239 Recycling pathway of L1
R-DME-5099900 WNT5A-dependent internalization of FZD4
R-DME-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
R-DME-8866427 VLDLR internalisation and degradation
R-DME-8964038 LDL clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Chc fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
32537

Protein Ontology

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PROi
PR:P29742

Gene expression databases

BgeeiFBgn0000319 Expressed in 31 organ(s), highest expression level in embryonic/larval hemocyte (Drosophila)
ExpressionAtlasiP29742 differential
GenevisibleiP29742 DM

Family and domain databases

Gene3Di1.25.40.10, 4 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 5 hits
PIRSFiPIRSF002290 Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 7 hits
SUPFAMiSSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLH_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P29742
Secondary accession number(s): Q540W2, Q9VXN6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2019
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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