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Entry version 178 (13 Nov 2019)
Sequence version 3 (11 Jan 2011)
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Protein

HLA class I histocompatibility antigen, alpha chain F

Gene

HLA-F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei91Self-peptide antigen1 Publication1
Binding sitei105Self-peptide antigen1 Publication1
Binding sitei164Self-peptide antigen1 Publication1
Binding sitei168Self-peptide antigen1 Publication1
Binding sitei176Self-peptide antigen1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P30511

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class I histocompatibility antigen, alpha chain F
Alternative name(s):
CDA12
HLA F antigen
Leukocyte antigen F1 Publication
MHC class I antigen F
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-F2 PublicationsImported
Synonyms:HLA-5.42 Publications, HLAF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4963 HLA-F

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
143110 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P30511

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei306 – 329HelicalSequence analysisAdd BLAST24
Topological domaini330 – 346CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane, MHC I

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi83W → R: Impairs peptide binding. 1 Publication1
Mutagenesisi336 – 338RNR → AAA: Impairs the interaction with 14-3-3 proteins. 1 Publication3
Mutagenesisi336 – 338RNR → GKG: Impairs the anterograde ER-to-Golgi transport. 1 Publication3
Mutagenesisi346V → S: Impairs the anterograde ER-to-Golgi transport. 1 Publication1
Mutagenesisi346Missing : Impairs the interaction with coat protein complex II; impairs the anterograde ER-to-Golgi transport. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3134

Open Targets

More...
OpenTargetsi
ENSG00000204642

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35082

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P30511

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HLA-F

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373438

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001888422 – 346HLA class I histocompatibility antigen, alpha chain FAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi107N-linked (GlcNAc...) asparagineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi122 ↔ 185PROSITE-ProRule annotation1 Publication
Disulfide bondi224 ↔ 280PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P30511

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P30511

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P30511

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P30511

PeptideAtlas

More...
PeptideAtlasi
P30511

PRoteomics IDEntifications database

More...
PRIDEi
P30511

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54704 [P30511-1]
54705 [P30511-2]
54706 [P30511-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P30511

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P30511

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in resting B cells (at protein level). Expressed in secondary lymphoid organs rich in B and T cells such as the tonsils, spleen, and thymus (at protein level) (PubMed:10605026, PubMed:11169396). Expressed in the endothelial cells of the tonsils (PubMed:11169396). Expressed on activated lymphoid cells including B cells, NK cells, CD4+ T cells and memory T cells (at protein level) (PubMed:27455421, PubMed:20865824). Expressed in motor neurons of spinal cord (PubMed:26928464).5 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal liver (at protein level) (PubMed:10605026). Expressed in placenta villous mesenchyme, cytotrophoblast, syncytiotrophoblast and invasive extravillous trophoblast (at protein level) (PubMed:28185362).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in CD4+ T cells upon stimulation via TCR and upon HIV-1 infection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204642 Expressed in 237 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P30511 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P30511 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterotrimer with B2M and a self-peptide (PubMed:28636952). Binds a diverse number of peptides ranging from 7 to more than 30 amino acids (PubMed:28636952). Peptide-bound HLA-F-B2M interacts with LILRB1 and LILRB2 but not with KIR3DS1 or KIR3DL2; this interaction is direct (PubMed:28636952, PubMed:11169396). The OC form interacts with KIR3DS1, KIR2DS4 and KIR3DL2; this interaction is direct (PubMed:28636952, PubMed:27455421, PubMed:24018270).

Interacts with TAP1-TAP2 complex and CALR; this interaction is required for appropriate folding and peptide loading (PubMed:10605026, PubMed:11169396).

Interacts with the coat protein complex II and 14-3-3 proteins; these interactions likely control the anterograde ER-to-Golgi transport of HLA-F (PubMed:16709803). HLA-F-B2M complex interacts with the heavy chain of other MHC class I molecules including HLA-A and HLA-E; this interaction may regulate the intracellular trafficking and the stability of peptide-free MHC class I OCs (PubMed:20483783).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109379, 21 interactors

Protein interaction database and analysis system

More...
IntActi
P30511, 19 interactors

Molecular INTeraction database

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MINTi
P30511

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259951

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1346
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P30511

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 296Ig-like C1-typeSequence analysisAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi336 – 338Sorting signal sequence; Golgi-retention signal; ER-retention signal1 Publication3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUXN Eukaryota
ENOG4111K8F LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00970000193340

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000296917

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P30511

KEGG Orthology (KO)

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KOi
K06751

Identification of Orthologs from Complete Genome Data

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OMAi
NEQASCL

Database of Orthologous Groups

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OrthoDBi
1390181at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P30511

TreeFam database of animal gene trees

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TreeFami
TF336617

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01638 MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00407 IGc1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 29 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P30511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPRSLLLLL SGALALTDTW AGSHSLRYFS TAVSRPGRGE PRYIAVEYVD
60 70 80 90 100
DTQFLRFDSD AAIPRMEPRE PWVEQEGPQY WEWTTGYAKA NAQTDRVALR
110 120 130 140 150
NLLRRYNQSE AGSHTLQGMN GCDMGPDGRL LRGYHQHAYD GKDYISLNED
160 170 180 190 200
LRSWTAADTV AQITQRFYEA EEYAEEFRTY LEGECLELLR RYLENGKETL
210 220 230 240 250
QRADPPKAHV AHHPISDHEA TLRCWALGFY PAEITLTWQR DGEEQTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PPGEEQRYTC HVQHEGLPQP LILRWEQSPQ
310 320 330 340
PTIPIVGIVA GLVVLGAVVT GAVVAAVMWR KKSSDRNRGS YSQAAV
Length:346
Mass (Da):39,062
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4782968A67E9B7D
GO
Isoform 2 (identifier: P30511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     204-295: Missing.

Show »
Length:254
Mass (Da):28,588
Checksum:iC81F225D409AAED2
GO
Isoform 3 (identifier: P30511-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-346: V → AYSVVSGNLM...MKRVQIKIFD

Show »
Length:442
Mass (Da):50,438
Checksum:i66109DEBE5EF2D57
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 29 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JNV5A0A0G2JNV5_HUMAN
HLA class I histocompatibility anti...
HLA-F
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9J8A0A140T9J8_HUMAN
HLA class I histocompatibility anti...
HLA-F
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8X0A0A140T8X0_HUMAN
HLA class I histocompatibility anti...
HLA-F
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D0EV57D0EV57_HUMAN
HLA class I histocompatibility anti...
HLA-F
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9B7A0A140T9B7_HUMAN
HLA class I histocompatibility anti...
HLA-F
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JH66A0A0G2JH66_HUMAN
HLA class I histocompatibility anti...
HLA-F
442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPA3A0A0G2JPA3_HUMAN
HLA class I histocompatibility anti...
HLA-F
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9V0A0A140T9V0_HUMAN
HLA class I histocompatibility anti...
HLA-F
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T939A0A140T939_HUMAN
HLA class I histocompatibility anti...
HLA-F
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9C2A0A140T9C2_HUMAN
HLA class I histocompatibility anti...
HLA-F
225Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC24827 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH09260 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB63337 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA34947 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB46623 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: P30511-3)
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti353N → L in AAH09260 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05652513A → V. Corresponds to variant dbSNP:rs17875379Ensembl.1
Natural variantiVAR_05652671P → Q. Corresponds to variant dbSNP:rs17875380Ensembl.1
Natural variantiVAR_018327272P → S9 PublicationsCorresponds to variant dbSNP:rs1736924Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_038846204 – 295Missing in isoform 2. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_040349346V → AYSVVSGNLMITWWSSLFLL GVLFQGYLGCLRSHSVLGRR KVGDMWILFFLWLWTSFNTA FLALQSLRFGFGFRRGRSFL LRSWHHLMKRVQIKIFD in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17093 Genomic DNA Translation: CAA34947.1 Sequence problems.
AF055066 Genomic DNA Translation: AAC24827.1 Sequence problems.
AY253269 mRNA Translation: AAO86773.1
AY253270 mRNA Translation: AAO86774.1
AY253271 mRNA Translation: AAO86775.1
AF523284 Genomic DNA Translation: AAM74979.1
AF523285 Genomic DNA Translation: AAM74980.1
AF523286 Genomic DNA Translation: AAM74981.1
AF523287 Genomic DNA Translation: AAM74982.1
AF523288 Genomic DNA Translation: AAM74983.1
AF523289 Genomic DNA Translation: AAM74984.1
AF523290 Genomic DNA Translation: AAM74985.1
AF523291 Genomic DNA Translation: AAM74986.1
AF523292 Genomic DNA Translation: AAM74987.1
AF523293 Genomic DNA Translation: AAM74988.1
AF523294 Genomic DNA Translation: AAM74989.1
AF523295 Genomic DNA Translation: AAM74990.1
AF523296 Genomic DNA Translation: AAM74991.1
AF523297 Genomic DNA Translation: AAM74992.1
AY645742 Genomic DNA Translation: AAT73225.1
AY645743 Genomic DNA Translation: AAT73226.1
AY645744 Genomic DNA Translation: AAT73227.1
AY645745 Genomic DNA Translation: AAT73228.1
AY645746 Genomic DNA Translation: AAT73229.1
AY645748 Genomic DNA Translation: AAT73231.1
AY645749 Genomic DNA Translation: AAT73232.1
AY645750 Genomic DNA Translation: AAT73233.1
AY645751 Genomic DNA Translation: AAT73234.1
AY645752 Genomic DNA Translation: AAT73235.1
AY645753 Genomic DNA Translation: AAT73236.1
AY645754 Genomic DNA Translation: AAT73237.1
AY645756 Genomic DNA Translation: AAT73239.1
AY645757 Genomic DNA Translation: AAT73240.1
AY645758 Genomic DNA Translation: AAT73241.1
AY645759 Genomic DNA Translation: AAT73242.1
DQ367723 mRNA Translation: ABD38924.1
BA000025 Genomic DNA Translation: BAB63337.1 Sequence problems.
AL022723 Genomic DNA Translation: CAB46623.1 Sequence problems.
AL645939 Genomic DNA No translation available.
AL669813 Genomic DNA No translation available.
AL844851 Genomic DNA No translation available.
BX005428 Genomic DNA No translation available.
CR753818 Genomic DNA No translation available.
BX927250 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03223.1
CH471081 Genomic DNA Translation: EAX03226.1
BC009260 mRNA Translation: AAH09260.2 Different initiation.
BC062991 mRNA Translation: AAH62991.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43437.1 [P30511-3]
CCDS43438.1 [P30511-1]
CCDS43439.1 [P30511-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A60384

NCBI Reference Sequences

More...
RefSeqi
NP_001091948.1, NM_001098478.1 [P30511-2]
NP_001091949.1, NM_001098479.1 [P30511-3]
NP_061823.2, NM_018950.2 [P30511-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259951; ENSP00000259951; ENSG00000204642 [P30511-3]
ENST00000334668; ENSP00000334263; ENSG00000204642 [P30511-1]
ENST00000359076; ENSP00000351977; ENSG00000206509 [P30511-2]
ENST00000376848; ENSP00000366044; ENSG00000229698 [P30511-2]
ENST00000376861; ENSP00000366057; ENSG00000204642 [P30511-1]
ENST00000383515; ENSP00000373007; ENSG00000137403 [P30511-2]
ENST00000420067; ENSP00000393535; ENSG00000235220 [P30511-2]
ENST00000434407; ENSP00000397376; ENSG00000204642 [P30511-2]
ENST00000440590; ENSP00000399835; ENSG00000237508 [P30511-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3134

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3134

UCSC genome browser

More...
UCSCi
uc003nnm.5 human [P30511-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17093 Genomic DNA Translation: CAA34947.1 Sequence problems.
AF055066 Genomic DNA Translation: AAC24827.1 Sequence problems.
AY253269 mRNA Translation: AAO86773.1
AY253270 mRNA Translation: AAO86774.1
AY253271 mRNA Translation: AAO86775.1
AF523284 Genomic DNA Translation: AAM74979.1
AF523285 Genomic DNA Translation: AAM74980.1
AF523286 Genomic DNA Translation: AAM74981.1
AF523287 Genomic DNA Translation: AAM74982.1
AF523288 Genomic DNA Translation: AAM74983.1
AF523289 Genomic DNA Translation: AAM74984.1
AF523290 Genomic DNA Translation: AAM74985.1
AF523291 Genomic DNA Translation: AAM74986.1
AF523292 Genomic DNA Translation: AAM74987.1
AF523293 Genomic DNA Translation: AAM74988.1
AF523294 Genomic DNA Translation: AAM74989.1
AF523295 Genomic DNA Translation: AAM74990.1
AF523296 Genomic DNA Translation: AAM74991.1
AF523297 Genomic DNA Translation: AAM74992.1
AY645742 Genomic DNA Translation: AAT73225.1
AY645743 Genomic DNA Translation: AAT73226.1
AY645744 Genomic DNA Translation: AAT73227.1
AY645745 Genomic DNA Translation: AAT73228.1
AY645746 Genomic DNA Translation: AAT73229.1
AY645748 Genomic DNA Translation: AAT73231.1
AY645749 Genomic DNA Translation: AAT73232.1
AY645750 Genomic DNA Translation: AAT73233.1
AY645751 Genomic DNA Translation: AAT73234.1
AY645752 Genomic DNA Translation: AAT73235.1
AY645753 Genomic DNA Translation: AAT73236.1
AY645754 Genomic DNA Translation: AAT73237.1
AY645756 Genomic DNA Translation: AAT73239.1
AY645757 Genomic DNA Translation: AAT73240.1
AY645758 Genomic DNA Translation: AAT73241.1
AY645759 Genomic DNA Translation: AAT73242.1
DQ367723 mRNA Translation: ABD38924.1
BA000025 Genomic DNA Translation: BAB63337.1 Sequence problems.
AL022723 Genomic DNA Translation: CAB46623.1 Sequence problems.
AL645939 Genomic DNA No translation available.
AL669813 Genomic DNA No translation available.
AL844851 Genomic DNA No translation available.
BX005428 Genomic DNA No translation available.
CR753818 Genomic DNA No translation available.
BX927250 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03223.1
CH471081 Genomic DNA Translation: EAX03226.1
BC009260 mRNA Translation: AAH09260.2 Different initiation.
BC062991 mRNA Translation: AAH62991.1
CCDSiCCDS43437.1 [P30511-3]
CCDS43438.1 [P30511-1]
CCDS43439.1 [P30511-2]
PIRiA60384
RefSeqiNP_001091948.1, NM_001098478.1 [P30511-2]
NP_001091949.1, NM_001098479.1 [P30511-3]
NP_061823.2, NM_018950.2 [P30511-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IUEX-ray2.62A/E/G/I22-305[»]
5KNMX-ray3.30A22-305[»]
SMRiP30511
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109379, 21 interactors
IntActiP30511, 19 interactors
MINTiP30511
STRINGi9606.ENSP00000259951

PTM databases

iPTMnetiP30511
PhosphoSitePlusiP30511

Polymorphism and mutation databases

BioMutaiHLA-F
DMDMi317373438

Proteomic databases

EPDiP30511
jPOSTiP30511
MassIVEiP30511
PaxDbiP30511
PeptideAtlasiP30511
PRIDEiP30511
ProteomicsDBi54704 [P30511-1]
54705 [P30511-2]
54706 [P30511-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3134

Genome annotation databases

EnsembliENST00000259951; ENSP00000259951; ENSG00000204642 [P30511-3]
ENST00000334668; ENSP00000334263; ENSG00000204642 [P30511-1]
ENST00000359076; ENSP00000351977; ENSG00000206509 [P30511-2]
ENST00000376848; ENSP00000366044; ENSG00000229698 [P30511-2]
ENST00000376861; ENSP00000366057; ENSG00000204642 [P30511-1]
ENST00000383515; ENSP00000373007; ENSG00000137403 [P30511-2]
ENST00000420067; ENSP00000393535; ENSG00000235220 [P30511-2]
ENST00000434407; ENSP00000397376; ENSG00000204642 [P30511-2]
ENST00000440590; ENSP00000399835; ENSG00000237508 [P30511-2]
GeneIDi3134
KEGGihsa:3134
UCSCiuc003nnm.5 human [P30511-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3134
DisGeNETi3134

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HLA-F
HGNCiHGNC:4963 HLA-F
MIMi143110 gene
neXtProtiNX_P30511
OpenTargetsiENSG00000204642
PharmGKBiPA35082

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IUXN Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00970000193340
HOGENOMiHOG000296917
InParanoidiP30511
KOiK06751
OMAiNEQASCL
OrthoDBi1390181at2759
PhylomeDBiP30511
TreeFamiTF336617

Enzyme and pathway databases

ReactomeiR-HSA-1236974 ER-Phagosome pathway
R-HSA-1236977 Endosomal/Vacuolar pathway
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-877300 Interferon gamma signaling
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC
SIGNORiP30511

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-F human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HLA-F

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3134
PharosiP30511

Protein Ontology

More...
PROi
PR:P30511

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000204642 Expressed in 237 organ(s), highest expression level in blood
ExpressionAtlasiP30511 baseline and differential
GenevisibleiP30511 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHLAF_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P30511
Secondary accession number(s): Q5JQI8
, Q5JQJ1, Q5SPT5, Q860R0, Q8MGQ1, Q8WLP5, Q95HC0, Q9TP68
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 11, 2011
Last modified: November 13, 2019
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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