Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 182 (16 Oct 2019)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

ETS-related transcription factor Elf-1

Gene

ELF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi208 – 290ETSPROSITE-ProRule annotationAdd BLAST83

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P32519

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS-related transcription factor Elf-1
Alternative name(s):
E74-like factor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ELF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3316 ELF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
189973 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P32519

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1997

Open Targets

More...
OpenTargetsi
ENSG00000120690

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27744

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P32519

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ELF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
212288097

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002040851 – 619ETS-related transcription factor Elf-1Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei110PhosphoserineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei187PhosphoserineCombined sources1
Modified residuei190PhosphothreonineCombined sources1
Modified residuei432PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P32519

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P32519

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P32519

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P32519

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P32519

PeptideAtlas

More...
PeptideAtlasi
P32519

PRoteomics IDEntifications database

More...
PRIDEi
P32519

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19727
54879 [P32519-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P32519

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P32519

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120690 Expressed in 223 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P32519 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P32519 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005172
HPA001755

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to the underphosphorylated form of RB. May interact with other transcription factors in order to regulate specific genes.

Interacts with RUNX1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108312, 10 interactors

Database of interacting proteins

More...
DIPi
DIP-185N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P32519

Protein interaction database and analysis system

More...
IntActi
P32519, 15 interactors

Molecular INTeraction database

More...
MINTi
P32519

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000239882

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P32519

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 80Poly-Asp6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3804 Eukaryota
ENOG4111K4J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157039

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049253

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P32519

KEGG Orthology (KO)

More...
KOi
K09428

Identification of Orthologs from Complete Genome Data

More...
OMAi
MITENSL

Database of Orthologous Groups

More...
OrthoDBi
837296at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P32519

TreeFam database of animal gene trees

More...
TreeFami
TF318679

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00413 ETS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P32519-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG
60 70 80 90 100
LACVEEPNDM ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE
110 120 130 140 150
AAEALLNMDS PGPMLDEKRI NNNIFSSPED DMVVAPVTHV SVTLDGIPEV
160 170 180 190 200
METQQVQEKY ADSPGASSPE QPKRKKGRKT KPPRPDSPAT TPNISVKKKN
210 220 230 240 250
KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL VDSKAVSRLW
260 270 280 290 300
GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN
310 320 330 340 350
DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS
360 370 380 390 400
KAAKPKDPVE VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA
410 420 430 440 450
ARTSTMQDET LNSSVQSIRT IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT
460 470 480 490 500
VIASTDPSAG TGSQKFILQA IPSSQPMTVL KENVMLQSQK AGSPPSIVLG
510 520 530 540 550
PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR SSQLVAHPPG
560 570 580 590 600
TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN
610
GFTSQVAMKQ NELLEPNSF
Length:619
Mass (Da):67,498
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFA0A51B3965616F3
GO
Isoform 2 (identifier: P32519-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-145: Missing.

Note: No experimental confirmation available.
Show »
Length:595
Mass (Da):64,929
Checksum:iCAF5EFA51EFAE710
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRL5A0A0U1RRL5_HUMAN
ETS-related transcription factor El...
ELF1
615Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T9E7Q5T9E7_HUMAN
ETS-related transcription factor El...
ELF1
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG85A0A0D9SG85_HUMAN
ETS-related transcription factor El...
ELF1
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04894258N → S1 PublicationCorresponds to variant dbSNP:rs7799Ensembl.1
Natural variantiVAR_048943343T → S1 PublicationCorresponds to variant dbSNP:rs1056820Ensembl.1
Natural variantiVAR_048944403T → I. Corresponds to variant dbSNP:rs7323148Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045682122 – 145Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M82882 mRNA No translation available.
AK304289 mRNA Translation: BAG65147.1
AL157877 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08640.1
BC030507 mRNA Translation: AAH30507.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45043.1 [P32519-2]
CCDS9374.1 [P32519-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A43361

NCBI Reference Sequences

More...
RefSeqi
NP_001138825.1, NM_001145353.1 [P32519-2]
NP_758961.1, NM_172373.3 [P32519-1]
XP_005266333.1, XM_005266276.1
XP_005266334.1, XM_005266277.3
XP_011533252.1, XM_011534950.1
XP_016875898.1, XM_017020409.1
XP_016875899.1, XM_017020410.1
XP_016875900.1, XM_017020411.1
XP_016875901.1, XM_017020412.1
XP_016875902.1, XM_017020413.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000239882; ENSP00000239882; ENSG00000120690 [P32519-1]
ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1997

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1997

UCSC genome browser

More...
UCSCi
uc001uxs.4 human [P32519-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M82882 mRNA No translation available.
AK304289 mRNA Translation: BAG65147.1
AL157877 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08640.1
BC030507 mRNA Translation: AAH30507.1
CCDSiCCDS45043.1 [P32519-2]
CCDS9374.1 [P32519-1]
PIRiA43361
RefSeqiNP_001138825.1, NM_001145353.1 [P32519-2]
NP_758961.1, NM_172373.3 [P32519-1]
XP_005266333.1, XM_005266276.1
XP_005266334.1, XM_005266277.3
XP_011533252.1, XM_011534950.1
XP_016875898.1, XM_017020409.1
XP_016875899.1, XM_017020410.1
XP_016875900.1, XM_017020411.1
XP_016875901.1, XM_017020412.1
XP_016875902.1, XM_017020413.1

3D structure databases

SMRiP32519
ModBaseiSearch...

Protein-protein interaction databases

BioGridi108312, 10 interactors
DIPiDIP-185N
ELMiP32519
IntActiP32519, 15 interactors
MINTiP32519
STRINGi9606.ENSP00000239882

PTM databases

iPTMnetiP32519
PhosphoSitePlusiP32519

Polymorphism and mutation databases

BioMutaiELF1
DMDMi212288097

Proteomic databases

EPDiP32519
jPOSTiP32519
MassIVEiP32519
MaxQBiP32519
PaxDbiP32519
PeptideAtlasiP32519
PRIDEiP32519
ProteomicsDBi19727
54879 [P32519-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P32519

The DNASU plasmid repository

More...
DNASUi
1997

Genome annotation databases

EnsembliENST00000239882; ENSP00000239882; ENSG00000120690 [P32519-1]
ENST00000625359; ENSP00000486912; ENSG00000120690 [P32519-2]
GeneIDi1997
KEGGihsa:1997
UCSCiuc001uxs.4 human [P32519-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1997
DisGeNETi1997

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ELF1
HGNCiHGNC:3316 ELF1
HPAiCAB005172
HPA001755
MIMi189973 gene
neXtProtiNX_P32519
OpenTargetsiENSG00000120690
PharmGKBiPA27744

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00940000157039
HOGENOMiHOG000049253
InParanoidiP32519
KOiK09428
OMAiMITENSL
OrthoDBi837296at2759
PhylomeDBiP32519
TreeFamiTF318679

Enzyme and pathway databases

ReactomeiR-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling
R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling
SIGNORiP32519

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ELF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1997
PharosiP32519

Protein Ontology

More...
PROi
PR:P32519

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120690 Expressed in 223 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiP32519 baseline and differential
GenevisibleiP32519 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR022084 TF_Elf_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF12310 Elf-1_N, 1 hit
PF00178 Ets, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P32519
Secondary accession number(s): B4E2I5
, E9PDQ9, Q8N6F6, Q9UDE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 22, 2008
Last modified: October 16, 2019
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again