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Entry version 162 (16 Oct 2019)
Sequence version 2 (01 Jun 1994)
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Protein

Intrastrand cross-link recognition protein

Gene

IXR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Activate the expression of the COX5B gene.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi361 – 429HMG box 1PROSITE-ProRule annotationAdd BLAST69
DNA bindingi434 – 502HMG box 2PROSITE-ProRule annotationAdd BLAST69

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-31835-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-140342 Apoptosis induced DNA fragmentation
R-SCE-5686938 Regulation of TLR by endogenous ligand
R-SCE-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intrastrand cross-link recognition protein
Alternative name(s):
Structure-specific recognition protein
Short name:
SSRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IXR1
Synonyms:ORD1
Ordered Locus Names:YKL032C
ORF Names:YKL245
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YKL032C

Saccharomyces Genome Database

More...
SGDi
S000001515 IXR1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000485731 – 597Intrastrand cross-link recognition proteinAdd BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei532PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P33417

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P33417

PRoteomics IDEntifications database

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PRIDEi
P33417

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P33417

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
34101, 573 interactors

Protein interaction database and analysis system

More...
IntActi
P33417, 52 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YKL032C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P33417

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi52 – 118Gln-richAdd BLAST67
Compositional biasi281 – 336Gln-richAdd BLAST56
Compositional biasi565 – 580Gln-richAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P33417

Identification of Orthologs from Complete Genome Data

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OMAi
KPFYEEF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033311 Ixr1

The PANTHER Classification System

More...
PANTHERi
PTHR13711:SF332 PTHR13711:SF332, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00505 HMG_box, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33417-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTGISPKQD DASNSNLLNI GQDHSLQYQG LEHNDSQYRD ASHQTPHQYL
60 70 80 90 100
NQFQAQPQQQ QQQQQQQQQQ QQQAPYQGHF QQSPQQQQQN VYYPLPPQSL
110 120 130 140 150
TQPTSQSQQQ QQQQQQQQYA NSNSNSNNNV NVNALPQDFG YMQQTGSGQN
160 170 180 190 200
YPTINQQQFS EFYNSFLSHL TQKQTNPSVT GTGASSNNNS NNNNVSSGNN
210 220 230 240 250
STSSNPAQLA ASQLNPATAA AAAANNAAGP ASYLSQLPQV QRYYPNNMNA
260 270 280 290 300
LSSLLDPSSA GNAAGNANTA THPGLLPPNL QPQLTHHQQQ MQQQLQLQQQ
310 320 330 340 350
QQLQQQQQLQ QQHQLQQQQQ LQQQHHHLQQ QQQQQQHPVV KKLSSTQSRI
360 370 380 390 400
ERRKQLKKQG PKRPSSAYFL FSMSIRNELL QQFPEAKVPE LSKLASARWK
410 420 430 440 450
ELTDDQKKPF YEEFRTNWEK YRVVRDAYEK TLPPKRPSGP FIQFTQEIRP
460 470 480 490 500
TVVKENPDKG LIEITKIIGE RWRELDPAKK AEYTETYKKR LKEWESCYPD
510 520 530 540 550
ENDPNGNPTG HSHKAMNMNL NMDTKIMENQ DSIEHITANA IDSVTGSNSN
560 570 580 590
STNPNTPVSP PISLQQQPLQ QQQQQQQQQQ HMLLADPTTN GSIIKNE
Length:597
Mass (Da):67,856
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF3B705AA2C5AC74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti73Missing in AAA02859 (PubMed:8342024).Curated1
Sequence conflicti93Y → F in AAA02859 (PubMed:8342024).Curated1
Sequence conflicti114 – 118Missing (PubMed:8342024).Curated5
Sequence conflicti207A → T in AAA02859 (PubMed:8342024).Curated1
Sequence conflicti220 – 221AA → TT in AAA02859 (PubMed:8342024).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X71622 Genomic DNA Translation: CAB37853.1
L16900 Unassigned DNA Translation: AAA02859.1
Z28032 Genomic DNA Translation: CAA81867.1
BK006944 Genomic DNA Translation: DAA09124.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S37849

NCBI Reference Sequences

More...
RefSeqi
NP_012893.3, NM_001179598.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL032C_mRNA; YKL032C; YKL032C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL032C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71622 Genomic DNA Translation: CAB37853.1
L16900 Unassigned DNA Translation: AAA02859.1
Z28032 Genomic DNA Translation: CAA81867.1
BK006944 Genomic DNA Translation: DAA09124.1
PIRiS37849
RefSeqiNP_012893.3, NM_001179598.3

3D structure databases

SMRiP33417
ModBaseiSearch...

Protein-protein interaction databases

BioGridi34101, 573 interactors
IntActiP33417, 52 interactors
STRINGi4932.YKL032C

PTM databases

iPTMnetiP33417

Proteomic databases

MaxQBiP33417
PaxDbiP33417
PRIDEiP33417

Genome annotation databases

EnsemblFungiiYKL032C_mRNA; YKL032C; YKL032C
GeneIDi853836
KEGGisce:YKL032C

Organism-specific databases

EuPathDBiFungiDB:YKL032C
SGDiS000001515 IXR1

Phylogenomic databases

InParanoidiP33417
OMAiKPFYEEF

Enzyme and pathway databases

BioCyciYEAST:G3O-31835-MONOMER
ReactomeiR-SCE-140342 Apoptosis induced DNA fragmentation
R-SCE-5686938 Regulation of TLR by endogenous ligand
R-SCE-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P33417

Family and domain databases

Gene3Di1.10.30.10, 2 hits
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR033311 Ixr1
PANTHERiPTHR13711:SF332 PTHR13711:SF332, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 2 hits
SMARTiView protein in SMART
SM00398 HMG, 2 hits
SUPFAMiSSF47095 SSF47095, 2 hits
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIXR1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33417
Secondary accession number(s): D6VXQ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: October 16, 2019
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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