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Entry version 194 (18 Sep 2019)
Sequence version 3 (02 Nov 2010)
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Protein

Homeobox protein MSX-2

Gene

MSX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi142 – 201HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processOsteogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8939902 Regulation of RUNX2 expression and activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35548

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein MSX-2
Alternative name(s):
Homeobox protein Hox-8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MSX2
Synonyms:HOX8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7392 MSX2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
123101 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35548

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Parietal foramina 1 (PFM1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_010786154L → P in PFM1. 1 Publication1
Natural variantiVAR_010200159 – 160Missing in PFM1; loss of function. 1 Publication2
Natural variantiVAR_010201172R → H in PFM1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs104893896EnsemblClinVar.1
Parietal foramina with cleidocranial dysplasia (PFMCCD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCombines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles.
Related information in OMIM
Craniosynostosis 2 (CRS2)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability. CRS2 is characterized by either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_003755148P → H in CRS2; gain of function. 1 PublicationCorresponds to variant dbSNP:rs104893895EnsemblClinVar.1
Natural variantiVAR_071634148P → L in CRS2. 2 PublicationsCorresponds to variant dbSNP:rs104893895EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi147T → A: Does not bind DNA but still suppresses OCFRE activation. 1 Publication1

Keywords - Diseasei

Craniosynostosis, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4488

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
MSX2

MalaCards human disease database

More...
MalaCardsi
MSX2
MIMi168500 phenotype
168550 phenotype
604757 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000120149

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
1541 Craniosynostosis, Boston type
60015 Enlarged parietal foramina
251290 Parietal foramina with clavicular hypoplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31197

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MSX2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033429

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000490991 – 267Homeobox protein MSX-2Add BLAST267

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35548

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P35548

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P35548

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35548

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35548

PeptideAtlas

More...
PeptideAtlasi
P35548

PRoteomics IDEntifications database

More...
PRIDEi
P35548

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55080

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35548

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35548

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120149 Expressed in 113 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P35548 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35548 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA005652

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MINT (By similarity).

Interacts with XRCC6 (Ku70) and XRCC5 (Ku80).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110594, 24 interactors

Protein interaction database and analysis system

More...
IntActi
P35548, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000239243

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35548

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0492 Eukaryota
ENOG410YT2J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231922

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35548

KEGG Orthology (KO)

More...
KOi
K09341

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSWIQEA

Database of Orthologous Groups

More...
OrthoDBi
1226077at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35548

TreeFam database of animal gene trees

More...
TreeFami
TF350699

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00024 HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35548-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE
60 70 80 90 100
ALMSDKKPPK EASPLPAESA SAGATLRPLL LSGHGAREAH SPGPLVKPFE
110 120 130 140 150
TASVKSENSE DGAAWMQEPG RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT
160 170 180 190 200
TSQLLALERK FRQKQYLSIA ERAEFSSSLN LTETQVKIWF QNRRAKAKRL
210 220 230 240 250
QEAELEKLKM AAKPMLPSSF SLPFPISSPL QAASIYGASY PFHRPVLPIP
260
PVGLYATPVG YGMYHLS
Length:267
Mass (Da):28,897
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B61B75F4A7C4AFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIS4D6RIS4_HUMAN
Homeobox protein MSX-2
MSX2
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28P → L in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti32E → A in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti62 – 65ASPL → SPAV in CAA49156 (PubMed:8101453).Curated4
Sequence conflicti67A → P in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti69S → G in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti75T → H in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti85G → R in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti107E → G in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti194R → S in CAA49156 (PubMed:8101453).Curated1
Sequence conflicti237G → A in CAA49156 (PubMed:8101453).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010898129M → T8 PublicationsCorresponds to variant dbSNP:rs4242182EnsemblClinVar.1
Natural variantiVAR_003755148P → H in CRS2; gain of function. 1 PublicationCorresponds to variant dbSNP:rs104893895EnsemblClinVar.1
Natural variantiVAR_071634148P → L in CRS2. 2 PublicationsCorresponds to variant dbSNP:rs104893895EnsemblClinVar.1
Natural variantiVAR_010786154L → P in PFM1. 1 Publication1
Natural variantiVAR_010200159 – 160Missing in PFM1; loss of function. 1 Publication2
Natural variantiVAR_010201172R → H in PFM1; loss of function. 2 PublicationsCorresponds to variant dbSNP:rs104893896EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X69295 mRNA Translation: CAA49156.1
L22499, L22498 Genomic DNA Translation: AAB42178.1
S75308 Genomic DNA Translation: AAD14169.1
S75361 mRNA Translation: AAB33867.1
D31771 mRNA Translation: BAA06549.1
D89377 mRNA Translation: BAA13949.1
BT009814 mRNA Translation: AAP88816.1
AC117531 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61381.1
CH471062 Genomic DNA Translation: EAW61382.1
BC015509 mRNA Translation: AAH15509.1
D14970 mRNA Translation: BAA03611.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4392.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A49068

NCBI Reference Sequences

More...
RefSeqi
NP_002440.2, NM_002449.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000239243; ENSP00000239243; ENSG00000120149

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4488

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4488

UCSC genome browser

More...
UCSCi
uc003mcy.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69295 mRNA Translation: CAA49156.1
L22499, L22498 Genomic DNA Translation: AAB42178.1
S75308 Genomic DNA Translation: AAD14169.1
S75361 mRNA Translation: AAB33867.1
D31771 mRNA Translation: BAA06549.1
D89377 mRNA Translation: BAA13949.1
BT009814 mRNA Translation: AAP88816.1
AC117531 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61381.1
CH471062 Genomic DNA Translation: EAW61382.1
BC015509 mRNA Translation: AAH15509.1
D14970 mRNA Translation: BAA03611.1
CCDSiCCDS4392.1
PIRiA49068
RefSeqiNP_002440.2, NM_002449.4

3D structure databases

SMRiP35548
ModBaseiSearch...

Protein-protein interaction databases

BioGridi110594, 24 interactors
IntActiP35548, 36 interactors
STRINGi9606.ENSP00000239243

PTM databases

iPTMnetiP35548
PhosphoSitePlusiP35548

Polymorphism and mutation databases

BioMutaiMSX2
DMDMi311033429

Proteomic databases

EPDiP35548
jPOSTiP35548
MassIVEiP35548
MaxQBiP35548
PaxDbiP35548
PeptideAtlasiP35548
PRIDEiP35548
ProteomicsDBi55080

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4488
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239243; ENSP00000239243; ENSG00000120149
GeneIDi4488
KEGGihsa:4488
UCSCiuc003mcy.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4488
DisGeNETi4488

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MSX2
GeneReviewsiMSX2
HGNCiHGNC:7392 MSX2
HPAiHPA005652
MalaCardsiMSX2
MIMi123101 gene
168500 phenotype
168550 phenotype
604757 phenotype
neXtProtiNX_P35548
OpenTargetsiENSG00000120149
Orphaneti1541 Craniosynostosis, Boston type
60015 Enlarged parietal foramina
251290 Parietal foramina with clavicular hypoplasia
PharmGKBiPA31197

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00940000159824
HOGENOMiHOG000231922
InParanoidiP35548
KOiK09341
OMAiTSWIQEA
OrthoDBi1226077at2759
PhylomeDBiP35548
TreeFamiTF350699

Enzyme and pathway databases

ReactomeiR-HSA-8939902 Regulation of RUNX2 expression and activity
SIGNORiP35548

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MSX2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Msh_homeobox_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4488

Pharos

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Pharosi
P35548

Protein Ontology

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PROi
PR:P35548

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000120149 Expressed in 113 organ(s), highest expression level in endometrium
ExpressionAtlasiP35548 baseline and differential
GenevisibleiP35548 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMSX2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35548
Secondary accession number(s): D3DQN1, Q53XM4, Q9UD60
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 2, 2010
Last modified: September 18, 2019
This is version 194 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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